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Pyrazoloacridine
🥰Excellent
Catalog No. T28475Cas No. 99009-20-8
Alias PD-115934, PD 115934, PD 115,934, NSC-366140, NSC 366140
Pyrazoloacridine (PD 115934) is a nucleic acid binding agent that inhibits the activity of topo I and II with an IC50 of 1.25 μM in K562 cells. Pyrazoloacridine shows anti-cancer activity.
Pyrazoloacridine
🥰Excellent
Purity: 98.99%
Catalog No. T28475Alias PD-115934, PD 115934, PD 115,934, NSC-366140, NSC 366140Cas No. 99009-20-8
Pyrazoloacridine (PD 115934) is a nucleic acid binding agent that inhibits the activity of topo I and II with an IC50 of 1.25 μM in K562 cells. Pyrazoloacridine shows anti-cancer activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $36 | In Stock | |
| 5 mg | $88 | In Stock | |
| 10 mg | $143 | In Stock | |
| 25 mg | $286 | In Stock | |
| 50 mg | $413 | In Stock | |
| 100 mg | $589 | In Stock | |
| 500 mg | $1,170 | In Stock |
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Purity:98.99%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Pyrazoloacridine (PD 115934) is a nucleic acid binding agent that inhibits the activity of topo I and II with an IC50 of 1.25 μM in K562 cells. Pyrazoloacridine shows anti-cancer activity. |
| In vitro | In oxic and hypoxic HCT-8 cells, Pyrazoloacridine exhibits IC50 values of 10.7 μM and 4.5 μM[2]. Pyrazoloacridine causes delayed DNA fragmentation in MCF-7 cells and induces apoptosis in P53-deficient Hep 3B cells. Pyrazoloacridine exhibits activities against cisplatin- and paclitaxel-resistant ovarian cancer[3]. |
| Alias | PD-115934, PD 115934, PD 115,934, NSC-366140, NSC 366140 |
| Molecular Weight | 367.4 |
| Formula | C19H21N5O3 |
| Cas No. | 99009-20-8 |
| Smiles | COc1ccc2[nH]c3c(ccc4n(CCCN(C)C)nc(c34)c2c1)[N+]([O-])=O |
| Relative Density. | 1.314g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: 1 mg/ml, Sonication is recommended.  |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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