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type II collagen fragment

Catalog No. TP2301 CAS TP2301

Type II collagen is composed of a triple helix of three identical α chains. These molecules associate to form a fibril that is stabilized by intermolecular crosslinks1. Damage to the fibrillar meshwork, made up of primarily type II collagen (z 90–95%), maybe a critical event in the pathology of many arthritides, due in part to the very slow rate of collagen turnover within the cartilage2.

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type II collagen fragment Chemical Structure

type II collagen fragment, CAS TP2301

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Biological Description

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Description

In vitro

Type II collagen and aggrecan (a large, aggregating proteoglycan) are the two major components of the extracellular matrix of cartilage. The collagen, which is present in a fibrillar form, provides tensile strength whereas the aggrecan is responsible for compressive stiffness of cartilage3-5. Early damage to type II collagen is predominantly pericellular/ territorial suggests that in the majority of cases collagen damage was mediated by the chondrocyte.

Molecular Weight	1471.61
Formula	C65H102N18O21
CAS No.	TP2301

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keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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