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Ligand for Target Protein for PROTAC

Ligand for Target Protein for PROTAC

Cat No. product name
T18053 Ipatasertib-NH2 Ipatasertib-NH2 (GDC-0068-NH2;RG7440-NH2) is a ligand for target protein AKT for PROTAC, binds to lenalidomide, a ligand of ubiquitin E3 ligase cereblon (CRBN),...
T13914 SLF-amido-C2-COOH SLF-amido-C2-COOH is a synthetic ligand for FKBP (SLF), and can be used in the synthesis of PROTACs.
T14288 Androstanolone acetate Androstanolone acetate is an androgen ligand, which targets androgen receptor (AR). Androstanolone acetate binds to cIAP1 ligand Bestatin via a linker to form P...
T5480 BI-4464 BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC
T2110 (+)-JQ-1 (+)-JQ1 is a BET bromodomain inhibitor (IC50: 77 nM/33 nM for BRD4 (1/2)).
T13086 I-BET762 carboxylic acid I-BET762 carboxylic acid is an inhibitor of BRD4(pIC50 of 5.1).
T10320 Androgen receptor antagonist 1 Androgen receptor antagonist 1 is an orally available full androgen receptor antagonist (IC50: 59 nM). It can be used in the synthesis of PROTAC AR degraders, w...
T17733 ATRA-hydroxyimino ATRA-hydroxyimino (CRABP-II ligand 1), the Retinoic acid (ATRA)-based moiety, binds to cIAP1 ligand (Bestatin) via a linker to form SNIPER to degrade CRABP-II i...
T17940 Estrone-N-O-C1-amido Estrone-N-O-C1-amido (ERα ligand 1) is an Estrone-based estrogen ligand, which targets estrogen receptor α (ERα). Estrone-N-O-C1-amido (ERα ligand 1) binds ...
T18592 Imatinib carbaldehyde Imatinib carbaldehyde (CGP-57148B carbaldehyde), the Imatinib (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER[1].
T18650 Ch55-O-C3-NH2 Ch55-O-C3-NH2 (RAR ligand 1) is a Ch 55-based ligand, which targets RAR. Ch55-O-C3-NH2 (RAR ligand 1) binds to cIAP1 ligand Bestatin via a linker to form SNIPER...
T13841 PROTAC Her3-binding moiety 1 PROTAC Her3-binding moiety 1 is a Her3 Ligand for PROTAC.
T10345 Apcin-A Apcin-A is an anaphase-promoting complex (APC) inhibitor. It interacts strongly with Cdc20 and inhibits the ubiquitination of Cdc20 substrates. Apcin-A can be u...
T18641 SirReal1-O-propargyl SirReal1-O-propargyl is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. SirReal1-O-propargyl, the SirReal1-based moiety, bin...
T13888 SLF SLF is a synthetic ligand for FK506-binding protein (FKBP)( with an affinity of 3.1 μM for FKBP51 and an IC50 of 0.22 μM for FKBP12). SLF can be used in the s...
T13848 SMARCA-BD ligand 1 for Protac SMARCA-BD ligand 1 for Protac is a compound capable of binding to SMARCA2, the BAF ATPase subunit, based on the Protac technology for degrading SMARCA2
T12557 PROTAC BET-binding moiety 1 PROTAC BET-binding moiety 1 is a key intermediate in the synthesis of high affinity BET inhibitors
T13915 PROTAC BRD9-binding moiety 1 PROTAC BRD9-binding moiety 1 that binds to BRD9, and used for inhibiting BRD9 activity, based on PROTAC.
T18599 PROTAC BRD4-binding moiety 1 PROTAC BRD4-binding moiety 1 is a ligand for BRD4. PROTAC BRD4-binding moiety 1 binds to cereblon ligand via a linker to form PROTAC to degrade BRD4[1].
T18595 Dasatinib carbaldehyde Dasatinib carbaldehyde (BMS-354825 carbaldehyde), the Dasatinib (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER [1].
T18601 Desmethyl-QCA276 Desmethyl-QCA276, the QCA276-based moiety, binds to cereblon ligand via a linker to form PROTAC to degrade BET. QCA276 is a BET inhibitor with an IC50 of 10 nM,...
T13549 AP1867-3-(aminoethoxy) AP1867-3-(aminoethoxy) is a synthetic ligand for FKBP and can be used in the synthesis of PROTAC FKBP12 F36V degrader.
T12186 Navitoclax-piperazine Navitoclax-piperazine is an inhibitor of B-cell lymphoma extra large (BCL-XL).
T18611 AP1867-2-(carboxymethoxy) AP1867-2-(carboxymethoxy), the AP1867 (a synthetic FKBP12F36V-directed ligand) based moiety, binds to CRBN ligand via a linker to form dTAG molecules[1].
T12152 N-piperidine Ibrutinib hydrochloride N-piperidine Ibrutinib hydrochloride is an potent inhibitor of BTK (WT BTK and C481S BTK with IC50s of 51.0 and 30.7 nM, respectively).
T12551 PROTAC BRD4 ligand-1 PROTAC BRD4 ligand-1 is a potent inhibitor of BET .
T19172 A-1210477-piperazinyl A-1210477-piperazinyl is a compound binds to protein myeloid cell leukemia 1 (MCL1) used for PROTAC technology.
T13843 PROTAC IRAK4 ligand-1 PROTAC IRAK4 ligand-1 is a synthetic ligand for interleukin-1 receptor-associated kinase 4.
T18515 Palbociclib-propargyl Palbociclib-propargyl is a ligand for target protein CDK6 for PROTAC, and binds to CRBN ligand via a PEG linker to make a PROTAC CP-10. CP-10 shows a DC50 of 2....
T13890 SMARCA-BD ligand 1 for Protac dihydrochloride SMARCA-BD ligand 1 for Protac dihydrochloride binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC.
T13696 FN-1501-propionic acid  FN-1501-propionic acid and a CRBN ligand have been used to design PROTAC CDK2/9 degrader . FN-1501-propionic acid is a CDK2/9 ligand for PROTAC.
T19301 DUPA DUPA selectively delivers cytotoxic drugs to prostate cancer cells [1][2], belonging to the glutamate class, as a targeted part of drug coupling.
T10716 CCR7 Ligand 1 CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a Kd of 3 nM. CCR7 Ligand 1, thiadiazole-dioxi...
T18593 GNF5-amido-Me GNF5-amido-Me, the GNF5 (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER[1].
T18750 N-Deshydroxyethyl Dasatinib N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825), the Dasatinib-based moiety, binds to IAP ligand via a linker to form SNIPER to degrade ABL[1].
T12558 PROTAC BET-binding moiety 2 PROTAC BET-binding moiety 2 is an BET bromodomain inhibitor.
T1835 Ibrutinib Ibrutinib is an irreversible inhibitor of BTK (IC50: 0.5 nM) that selectively blocks B cell activation.
T2066 Quizartinib Quizartinib is an inhibitor of FLT3 (Kd: 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases.
T10522 BET-IN-6 BET-IN-6 is an effective and high-affinity inhibitor of BRD2/BRD4. It is the ligand for target protein BRD2/4 and is used for the synthesis of PROTAC BRD2/BRD4 ...
T12905 SI-109 SI-109 is a potent inhibitor of STAT3 SH2 domain (Ki=9 nM),and with antitumor activity.
T13915L PROTAC BRD9-binding moiety 1 hydrochloride PROTAC BRD9-binding moiety 1 hydrochloride binds to BRD9, and used for inhibiting BRD9 activity, based on PROTAC.
T17931 EED226-COOH EED226-COOH is an EED226-derived ligand for target protein EED ligand for PROTAC, binds to a ligand for VHL via linker to form UNC6852 to degrade PRC2[1].
T18594 HG-7-85-01-Decyclopropane HG-7-85-01-Decyclopropane, the HG-7-85-01 (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER [1].
Ipatasertib-NH2
T18053CAS 1001382-14-4
Ipatasertib-NH2 (GDC-0068-NH2;RG7440-NH2) is a ligand for target protein AKT for PROTAC, binds to lenalidomide, a ligand of ubiquitin E3 ligase cereblon (CRBN),...
SLF-amido-C2-COOH
T13914CAS 1092369-24-8
SLF-amido-C2-COOH is a synthetic ligand for FKBP (SLF), and can be used in the synthesis of PROTACs.
Androstanolone acetate
T14288CAS 1164-91-6
Androstanolone acetate is an androgen ligand, which targets androgen receptor (AR). Androstanolone acetate binds to cIAP1 ligand Bestatin via a linker to form P...
BI-4464
T5480CAS 1227948-02-8
BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC
(+)-JQ-1
T2110CAS 1268524-70-4
(+)-JQ1 is a BET bromodomain inhibitor (IC50: 77 nM/33 nM for BRD4 (1/2)).
I-BET762 carboxylic acid
T13086CAS 1300019-38-8
I-BET762 carboxylic acid is an inhibitor of BRD4(pIC50 of 5.1).
Androgen receptor antagonist 1
T10320CAS 1338812-36-4
Androgen receptor antagonist 1 is an orally available full androgen receptor antagonist (IC50: 59 nM). It can be used in the synthesis of PROTAC AR degraders, w...
ATRA-hydroxyimino
T17733CAS 135325-47-2
ATRA-hydroxyimino (CRABP-II ligand 1), the Retinoic acid (ATRA)-based moiety, binds to cIAP1 ligand (Bestatin) via a linker to form SNIPER to degrade CRABP-II i...
Estrone-N-O-C1-amido
T17940CAS 138219-84-8
Estrone-N-O-C1-amido (ERα ligand 1) is an Estrone-based estrogen ligand, which targets estrogen receptor α (ERα). Estrone-N-O-C1-amido (ERα ligand 1) binds ...
Imatinib carbaldehyde
T18592CAS 1436868-85-7
Imatinib carbaldehyde (CGP-57148B carbaldehyde), the Imatinib (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER[1].
Ch55-O-C3-NH2
T18650CAS 144298-98-6
Ch55-O-C3-NH2 (RAR ligand 1) is a Ch 55-based ligand, which targets RAR. Ch55-O-C3-NH2 (RAR ligand 1) binds to cIAP1 ligand Bestatin via a linker to form SNIPER...
PROTAC Her3-binding moiety 1
T13841CAS 1603845-36-8
PROTAC Her3-binding moiety 1 is a Her3 Ligand for PROTAC.
Apcin-A
T10345CAS 1683617-62-0
Apcin-A is an anaphase-promoting complex (APC) inhibitor. It interacts strongly with Cdc20 and inhibits the ubiquitination of Cdc20 substrates. Apcin-A can be u...
SirReal1-O-propargyl
T18641CAS 1862237-99-7
SirReal1-O-propargyl is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. SirReal1-O-propargyl, the SirReal1-based moiety, bin...
SLF
T13888CAS 195513-96-3
SLF is a synthetic ligand for FK506-binding protein (FKBP)( with an affinity of 3.1 μM for FKBP51 and an IC50 of 0.22 μM for FKBP12). SLF can be used in the s...
SMARCA-BD ligand 1 for Protac
T13848CAS 1997319-92-2
SMARCA-BD ligand 1 for Protac is a compound capable of binding to SMARCA2, the BAF ATPase subunit, based on the Protac technology for degrading SMARCA2
PROTAC BET-binding moiety 1
T12557CAS 2093387-77-8
PROTAC BET-binding moiety 1 is a key intermediate in the synthesis of high affinity BET inhibitors
PROTAC BRD9-binding moiety 1
T13915CAS 2097512-23-5
PROTAC BRD9-binding moiety 1 that binds to BRD9, and used for inhibiting BRD9 activity, based on PROTAC.
PROTAC BRD4-binding moiety 1
T18599CAS 2101200-10-4
PROTAC BRD4-binding moiety 1 is a ligand for BRD4. PROTAC BRD4-binding moiety 1 binds to cereblon ligand via a linker to form PROTAC to degrade BRD4[1].
Dasatinib carbaldehyde
T18595CAS 2112837-79-1
Dasatinib carbaldehyde (BMS-354825 carbaldehyde), the Dasatinib (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER [1].
Desmethyl-QCA276
T18601CAS 2126819-55-2
Desmethyl-QCA276, the QCA276-based moiety, binds to cereblon ligand via a linker to form PROTAC to degrade BET. QCA276 is a BET inhibitor with an IC50 of 10 nM,...
AP1867-3-(aminoethoxy)
T13549CAS 2127390-15-0
AP1867-3-(aminoethoxy) is a synthetic ligand for FKBP and can be used in the synthesis of PROTAC FKBP12 F36V degrader.
Navitoclax-piperazine
T12186CAS 2143096-93-7
Navitoclax-piperazine is an inhibitor of B-cell lymphoma extra large (BCL-XL).
AP1867-2-(carboxymethoxy)
T18611CAS 2230613-03-1
AP1867-2-(carboxymethoxy), the AP1867 (a synthetic FKBP12F36V-directed ligand) based moiety, binds to CRBN ligand via a linker to form dTAG molecules[1].
N-piperidine Ibrutinib hydrochloride
T12152CAS 2231747-18-3
N-piperidine Ibrutinib hydrochloride is an potent inhibitor of BTK (WT BTK and C481S BTK with IC50s of 51.0 and 30.7 nM, respectively).
PROTAC BRD4 ligand-1
T12551CAS 2313230-51-0
PROTAC BRD4 ligand-1 is a potent inhibitor of BET .
A-1210477-piperazinyl
T19172CAS 2351218-72-7
A-1210477-piperazinyl is a compound binds to protein myeloid cell leukemia 1 (MCL1) used for PROTAC technology.
PROTAC IRAK4 ligand-1
T13843CAS 2357108-39-3
PROTAC IRAK4 ligand-1 is a synthetic ligand for interleukin-1 receptor-associated kinase 4.
Palbociclib-propargyl
T18515CAS 2366269-23-8
Palbociclib-propargyl is a ligand for target protein CDK6 for PROTAC, and binds to CRBN ligand via a PEG linker to make a PROTAC CP-10. CP-10 shows a DC50 of 2....
SMARCA-BD ligand 1 for Protac dihydrochloride
T13890CAS 2369053-68-7
SMARCA-BD ligand 1 for Protac dihydrochloride binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC.
FN-1501-propionic acid
T13696CAS 2408642-48-6
 FN-1501-propionic acid and a CRBN ligand have been used to design PROTAC CDK2/9 degrader . FN-1501-propionic acid is a CDK2/9 ligand for PROTAC.
DUPA
T19301CAS 302941-52-2
DUPA selectively delivers cytotoxic drugs to prostate cancer cells [1][2], belonging to the glutamate class, as a targeted part of drug coupling.
CCR7 Ligand 1
T10716CAS 681514-83-0
CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a Kd of 3 nM. CCR7 Ligand 1, thiadiazole-dioxi...
GNF5-amido-Me
T18593CAS 778277-37-5
GNF5-amido-Me, the GNF5 (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER[1].
N-Deshydroxyethyl Dasatinib
T18750CAS 910297-51-7
N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825), the Dasatinib-based moiety, binds to IAP ligand via a linker to form SNIPER to degrade ABL[1].
PROTAC BET-binding moiety 2
T12558CAS 916493-82-8
PROTAC BET-binding moiety 2 is an BET bromodomain inhibitor.
Ibrutinib
T1835CAS 936563-96-1
Ibrutinib is an irreversible inhibitor of BTK (IC50: 0.5 nM) that selectively blocks B cell activation.
Quizartinib
T2066CAS 950769-58-1
Quizartinib is an inhibitor of FLT3 (Kd: 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases.
BET-IN-6
T10522CAS T10522
BET-IN-6 is an effective and high-affinity inhibitor of BRD2/BRD4. It is the ligand for target protein BRD2/4 and is used for the synthesis of PROTAC BRD2/BRD4 ...
SI-109
T12905CAS T12905
SI-109 is a potent inhibitor of STAT3 SH2 domain (Ki=9 nM),and with antitumor activity.
PROTAC BRD9-binding moiety 1 hydrochloride
T13915LCAS T13915L
PROTAC BRD9-binding moiety 1 hydrochloride binds to BRD9, and used for inhibiting BRD9 activity, based on PROTAC.
EED226-COOH
T17931CAS T17931
EED226-COOH is an EED226-derived ligand for target protein EED ligand for PROTAC, binds to a ligand for VHL via linker to form UNC6852 to degrade PRC2[1].
HG-7-85-01-Decyclopropane
T18594CAS T18594
HG-7-85-01-Decyclopropane, the HG-7-85-01 (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER [1].