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PROTAC Selection

PROTAC Selection

Cat No. product name
T5436 MZ 1 MZ 1 is a BRD4 protein degrader based on PROTAC technology.
T17996 VH032-PEG5-C6-Cl VH032-PEG5-C6-Cl (HaloPROTAC 2) is a small molecule HaloPROTAC that incorporates the VH032 based VHL ligand and 5-unit PEG linker. VH032-PEG5-C6-Cl is capable o...
T4495 dBET1 dBET1 is a hybrid molecule that combines (+)-JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430 nM) and induces apop...
T18597 dFKBP-1 dFKBP-1 is a potent and PROTAC-based FKBP12 degrader. dFKBP-1 incorporates the ligand SLF of FKBP12, the Thalidomide based cereblon ligand and a linker[1].
T13846 PROTAC RIPK degrader-2 PROTAC RIPK degrader-2 is a nonpeptidic PROTAC ,and potently targets serine-threonine kinase RIPK2 and has highly selective for RIPK2 degradation.
T5434 ARV-825 ARV-825, a heterobifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon leading to fast, efficient, and prol...
T17911 (S,R,S)-AHPC-C6-PEG3-C4-Cl (S,R,S)-AHPC-C6-PEG3-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker. (S,R,S)-AHPC-C6-PEG3-C4-Cl ...
T17910 (S,R,S)-AHPC-PEG2-C4-Cl (S,R,S)-AHPC-PEG2-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-PEG2-C4-Cl is cap...
T17926 (S,R,S)-AHPC-PEG6-C4-Cl (S,R,S)-AHPC-PEG6-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 6-unit PEG linker. (S,R,S)-AHPC-PEG6-C4-Cl is cap...
T5440 Dbet57 dBET57 is heterobifunctional degrader of BRD4 based on the PROTAC technology, exhibits significant degradation of BRD4BD1 with a DC50/5h of 500 nM ,and inactive...
T5435 ARV-771 ARV-771 is a potent BET degrader based on PROTAC technology with Kds of 34, 4.7, 8.3, 7.6, 9.6, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and ...
T5130 dBET6 dBET6 is a selective and cell-permeable degrader of BET based on PROTAC (IC50: 14 nM). It has antitumor activity.
T14318 ARCC-4 ARCC-4 is an enzalutamide-based von Hippel-Lindau (VHL)-recruiting AR PROTAC and outperforms enzalutamide and it is a low-nanomolar androgen receptor (AR) degra...
T13785 MZP-54 MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology(Kd of 4 nM for Brd4BD2)
T13786 MZP-55 MZP-55 is a selective BRD3/4 degrader based on PROTAC technology(Brd4BD2 with Kd of 8 nM)
T11292 FKBP12 PROTAC dTAG-7 FKBP12 PROTAC dTAG-7 (dTAG-7) also is a selective degrader of BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to an E3 ubiquitin ...
T11291 FKBP12 PROTAC dTAG-13 FKBP12 PROTAC dTAG-13 (dTAG-13) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 (dTAG-13) ...
T5442 A1874 A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells. Effective in inhibiting many cancer cell lines proliferation.
T18610 PROTAC FKBP Degrader-3 PROTAC FKBP Degrader-3 is a PROTAC that comprises a FKBP ligand binding group, a linker and an VHL binding group. PROTAC FKBP Degrader-3 is a potent FKBP degrad...
T13849 PROTAC BET Degrader-1 PROTAC BET Degrader-1 is a potent degrader of BET based on PROTAC.
T12559 PROTAC BET degrader-2 PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins (IC50 of 9.6 nM ).
T14550 BETd-260 BETd-260 is a potent degrader of BET based on PROTAC technology, with as low as 30 pM against BRD4 protein in RS4;11 leukemia cell line.
T12560 PROTAC BRD9 Degrader-1 PROTAC BRD9 Degrader-1 is a lead PROTAC BRD9 chemical degrader with IC50 of 13.5 nM.
T16667 PROTAC Sirt2 Degrader-1 PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a ...
T5439 BRD4 degrader AT1 BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells.
T13561 AT6 AT6 is a PROTAC AT1 analog which is a highly selective bromodomain (Brd4) degrader.
T5438 PROTAC CDK9 Degrader-1 PROTAC CDK9 Degrader-1 is a selective CDK9 degrader.
T13833 PROTAC BRD4 Degrader-1 PROTAC BRD4 Degrader-1 is an efficacious degrader of BRD4(BRD4 BD1,IC50 of 41.8 nM).
T11980 MD-224 MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent.
T14549 BETd-246 BETd-246 is an inhibitor of second-generation and PROTAC-based BET bromodomain (BRD), show antitumor activity.
T18607 PROTAC ER Degrader-3 PROTAC ER Degrader-3 is an intermediate for synthesis of PAC. PAC, consists the ADCs linker and PROTACs, conjugated to an antibody. PAC extracts from patent WO2...
T15178 dTRIM24 dTRIM24, based on PROTAC, is a selective bifunctional TRIM24 degrader.
T13834 PROTAC BRD4 Degrader-2 PROTAC BRD4 Degrader-2 is an efficacious degrader of PROTAC BRD4(BRD4 BD1,IC50 of 14.2 nM).
T14908 CCT367766 CCT367766 is the PROTAC-based pirin targeting protein degradation probe, depletes pirin protein expression at low concentration. It shows a moderate affinity fo...
T13781 MS4077 MS4077 is an degrader of anaplastic lymphoma kinase (ALK) PROTAC(Kd of 37 nM for binding affinity to ALK).
T5437 Gefitinib-based PROTAC 3 Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827...
T12555 PROTAC FLT-3 degrader 1 PROTAC FLT-3 degrader 1 is a PROTAC FLT-3 degrader of internal tandem duplication (ITD)(IC50 0.6 nM),with anti-proliferative activity.
T17995 Halo PROTAC 1 Halo PROTAC 1 is a PROTAC, which is a ligand having activity to bind to an intracellular proteins fused with HaloTag and a structure having activity to induce a...
T18633 PROTAC MDM2 Degrader-3 PROTAC MDM2 Degrader-3 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-3 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand fo...
T18634 PROTAC MDM2 Degrader-4 PROTAC MDM2 Degrader-4 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-4 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand fo...
T18631 PROTAC MDM2 Degrader-1 PROTAC MDM2 Degrader-1 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-1 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand fo...
T18632 PROTAC MDM2 Degrader-2 PROTAC MDM2 Degrader-2 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-2 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand fo...
T18682 SJFδ SJFδ is a 10-atom linker PROTAC. SJFδ degrades p38δ with a DC50 of 46.17 nM, but does not degrade p38α, p38β, or p38γ[1].
T18681 SJFα SJFα is a 13-atom linker PROTAC. SJFα degrades p38α with a DC50 of 7.16  nM, but is far less effective at degrading p38δ (DC50=299 nM) and does not de...
T13840 PROTAC FAK degrader 1 PROTAC FAK degrader 1 is a selective and potent degrader of focal adhesion kinase (Fak) (IC50 of 6.5 nM).
T18787 TD-165 TD-165 is a PROTAC-based cereblon (CRBN) degrader. TD-165 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding ...
T18608 PROTAC ERRα Degrader-1 PROTAC ERRα Degrader-1 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRα Degrader-1 is ...
T18609 PROTAC ERRα Degrader-2 PROTAC ERRα Degrader-2 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRα Degrader-2 is ...
T13835 PROTAC BRD4 Degrader-3 PROTAC BRD4 Degrader-3 is an efficacious degrader of PROTAC BRD4.
T13685 ERD-308  ERD-308 induces >95% of ER degradation at concentrations as low as 5 nM in both cell lines (DC50 (concentration causing 50% of protein degradation) of 0.17 nM...
T17543 BI-3663 BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation. BI-3663 inhibits PTK2 with an IC50 of 18 nM. BI-...
T13657 dMCL1-2 dMCL1-2 is a potent and selective myeloid leukemia 1 (MCL1) degrading agent based on PROTAC, which binds to MCL1 with a KD of 30 nM. dmcl-2 activates the apopto...
T18604 PROTAC CRBN Degrader-1 PROTAC CRBN Degrader-1 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group. PROTAC CRBN Degrader-1 is an cer...
T13842 PROTAC IRAK4 degrader-1 PROTAC IRAK4 degrader-1 is a degrader of PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4).
T13839 PROTAC ER Degrader-4 PROTAC ER Degrader-4 is a PROATC degrader of estrogen receptor (ER)(IC50 of 0.8 nM).
T12556 PROTAC B-Raf degrader 1 PROTAC B-Raf degrader 1 is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf,PROTAC B-Raf degrader 1 With anti-cancer activity.
T13665 DT2216 DT2216 inhibits various Bcl-XL-dependent leukemias and cancer cells, but is significantly less toxic to platelets.DT2216 is a selective B-cell lymphoma, extreme...
T13845 PROTAC PARP1 degrader PROTAC PARP1 degrader is a degrader of PARP1 based on the PROTAC technology. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line (IC50 of 6.12...
T13694 FKBP12 PROTAC RC32 FKBP12 PROTAC RC32 contains conjugation of Rapamycin and a ligand for an E3 ubiquitin ligase.FKBP12 PROTAC RC32 (RC32) is a potent FKBP12 degrader based on PROT...
T17350 ACBI1 ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s...
T12907 SIAIS178 SIAIS178 is a potent and selective degrader of BCR-ABL based on PROTAC technology (IC50 of 24 nM).
T13887 SJF620 SJF620 is a potent degrader of PROTAC BTK(DC50 : 7.9 nM).
T13844 PROTAC K-Ras Degrader-1 PROTAC K-Ras Degrader-1 is potent degrader of K-Ras based PROTAC.
T13847 PROTAC SGK3 degrader-1 PROTAC SGK3 degrader-1, is a potent SKG3 degrader based on PROTAC.
T12552 PROTAC CDK2/9 Degrader-1 PROTAC CDK2/9 Degrader-1 is a potent CDK2 and CDK9 dual degrader(DC50 of 62 nM and 33 nM).
T12027 MG-277 MG-277 is a molecular glue compound transformed from PROTAC degradation agent, MG-277 potently inhibits tumor cell growth in a p53-independent manner.
T12553 PROTAC EED degrader-1 PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.
T12554 PROTAC EED degrader-2 PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11.
T12798 (S)-GNE-987 (S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC).
T13105 TD-428 TD-428 is a highly specific degrader of BRD4(DC50 of 0.32 nM). TD-428 is a BET PROTAC, which comprises TD-106 (a CRBN ligand) linked to JQ1 (a BET inhibit...
T13552 ARD-266 ARD-266 is a highly potent and VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. ARD-266 effectively induces the degradation of AR protein in AR-posit...
T13782 MS432 MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.
T13850 PROTAC BET degrader-3 PROTAC BET Degrader-3 is a potent degrader OF BET based on PROTAC.
T17728 PROTAC CDK9 degrader-2 PROTAC CDK9 degrader-2 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogo...
T18060 KB02-JQ1 KB02-JQ1 is a highly selective and PROTAC-based BRD4 degrader (molecular glue), but does not degrade BRD2 or BRD3. KB02-JQ1 promotes BRD4 degradation by covalen...
T18061 KB02-SLF KB02-SLF is a PROTAC-based nuclear FKBP12 degrader (molecular glue). KB02-SLF promotes nuclear FKBP12 degradation by covalently modifying DCAF16 (E3 ligase) and...
T18598 PROTAC BRD2/BRD4 degrader-1 PROTAC BRD2/BRD4 degrader-1 (compound 15) is a potent and selective BET protein BRD4 and BRD2 degrader. PROTAC BRD2/BRD4 degrader-1 rapidly induces reversible, ...
T18606 PROTAC ER Degrader-2 PROTAC ER Degrader-2 is an intermediate for synthesis of PAC. PAC, consists the ADCs linker and PROTACs, conjugated to an antibody. PAC extracts from patent WO2...
T18636 PROTAC ERα Degrader-1 PROTAC ERα Degrader-1 comprises an ubiquitin E3 ligase binding group, a linker and a protein binding group. PROTAC ERα Degrader-1 extracts from patent WO20172...
T18680 SD-36 SD-36 is a potent and efficacious PROTAC STAT3 degrader (Kd=~50 nM), and demonstrates high selectivity over other STAT members. SD-36 also effectively degrades ...
T5395 BSJ-03-123 BSJ-03-123 is a potent and novel CDK6-selective small-molecule degrader (PROTAC).
MZ 1
T5436CAS 1797406-69-9
MZ 1 is a BRD4 protein degrader based on PROTAC technology.
VH032-PEG5-C6-Cl
T17996CAS 1799506-06-1
VH032-PEG5-C6-Cl (HaloPROTAC 2) is a small molecule HaloPROTAC that incorporates the VH032 based VHL ligand and 5-unit PEG linker. VH032-PEG5-C6-Cl is capable o...
dBET1
T4495CAS 1799711-21-9
dBET1 is a hybrid molecule that combines (+)-JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430 nM) and induces apop...
dFKBP-1
T18597CAS 1799711-22-0
dFKBP-1 is a potent and PROTAC-based FKBP12 degrader. dFKBP-1 incorporates the ligand SLF of FKBP12, the Thalidomide based cereblon ligand and a linker[1].
PROTAC RIPK degrader-2
T13846CAS 1801547-16-9
PROTAC RIPK degrader-2 is a nonpeptidic PROTAC ,and potently targets serine-threonine kinase RIPK2 and has highly selective for RIPK2 degradation.
ARV-825
T5434CAS 1818885-28-7
ARV-825, a heterobifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon leading to fast, efficient, and prol...
(S,R,S)-AHPC-C6-PEG3-C4-Cl
T17911CAS 1835705-55-9
(S,R,S)-AHPC-C6-PEG3-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker. (S,R,S)-AHPC-C6-PEG3-C4-Cl ...
(S,R,S)-AHPC-PEG2-C4-Cl
T17910CAS 1835705-57-1
(S,R,S)-AHPC-PEG2-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-PEG2-C4-Cl is cap...
(S,R,S)-AHPC-PEG6-C4-Cl
T17926CAS 1835705-59-3
(S,R,S)-AHPC-PEG6-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 6-unit PEG linker. (S,R,S)-AHPC-PEG6-C4-Cl is cap...
Dbet57
T5440CAS 1883863-52-2
dBET57 is heterobifunctional degrader of BRD4 based on the PROTAC technology, exhibits significant degradation of BRD4BD1 with a DC50/5h of 500 nM ,and inactive...
ARV-771
T5435CAS 1949837-12-0
ARV-771 is a potent BET degrader based on PROTAC technology with Kds of 34, 4.7, 8.3, 7.6, 9.6, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and ...
dBET6
T5130CAS 1950634-92-0
dBET6 is a selective and cell-permeable degrader of BET based on PROTAC (IC50: 14 nM). It has antitumor activity.
ARCC-4
T14318CAS 1973403-00-7
ARCC-4 is an enzalutamide-based von Hippel-Lindau (VHL)-recruiting AR PROTAC and outperforms enzalutamide and it is a low-nanomolar androgen receptor (AR) degra...
MZP-54
T13785CAS 2010159-47-2
MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology(Kd of 4 nM for Brd4BD2)
MZP-55
T13786CAS 2010159-48-3
MZP-55 is a selective BRD3/4 degrader based on PROTAC technology(Brd4BD2 with Kd of 8 nM)
FKBP12 PROTAC dTAG-7
T11292CAS 2064175-32-0
FKBP12 PROTAC dTAG-7 (dTAG-7) also is a selective degrader of BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to an E3 ubiquitin ...
FKBP12 PROTAC dTAG-13
T11291CAS 2064175-41-1
FKBP12 PROTAC dTAG-13 (dTAG-13) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 (dTAG-13) ...
A1874
T5442CAS 2064292-12-0
A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells. Effective in inhibiting many cancer cell lines proliferation.
PROTAC FKBP Degrader-3
T18610CAS 2079056-43-0
PROTAC FKBP Degrader-3 is a PROTAC that comprises a FKBP ligand binding group, a linker and an VHL binding group. PROTAC FKBP Degrader-3 is a potent FKBP degrad...
PROTAC BET Degrader-1
T13849CAS 2093386-22-0
PROTAC BET Degrader-1 is a potent degrader of BET based on PROTAC.
PROTAC BET degrader-2
T12559CAS 2093388-33-9
PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins (IC50 of 9.6 nM ).
BETd-260
T14550CAS 2093388-62-4
BETd-260 is a potent degrader of BET based on PROTAC technology, with as low as 30 pM against BRD4 protein in RS4;11 leukemia cell line.
PROTAC BRD9 Degrader-1
T12560CAS 2097971-01-0
PROTAC BRD9 Degrader-1 is a lead PROTAC BRD9 chemical degrader with IC50 of 13.5 nM.
PROTAC Sirt2 Degrader-1
T16667CAS 2098487-75-1
PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a ...
BRD4 degrader AT1
T5439CAS 2098836-45-2
BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells.
AT6
T13561CAS 2098836-50-9
AT6 is a PROTAC AT1 analog which is a highly selective bromodomain (Brd4) degrader.
PROTAC CDK9 Degrader-1
T5438CAS 2118356-96-8
PROTAC CDK9 Degrader-1 is a selective CDK9 degrader.
PROTAC BRD4 Degrader-1
T13833CAS 2133360-00-4
PROTAC BRD4 Degrader-1 is an efficacious degrader of BRD4(BRD4 BD1,IC50 of 41.8 nM).
MD-224
T11980CAS 2136247-12-4
MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent.
BETd-246
T14549CAS 2140289-17-2
BETd-246 is an inhibitor of second-generation and PROTAC-based BET bromodomain (BRD), show antitumor activity.
PROTAC ER Degrader-3
T18607CAS 2158322-29-1
PROTAC ER Degrader-3 is an intermediate for synthesis of PAC. PAC, consists the ADCs linker and PROTACs, conjugated to an antibody. PAC extracts from patent WO2...
dTRIM24
T15178CAS 2170695-14-2
dTRIM24, based on PROTAC, is a selective bifunctional TRIM24 degrader.
PROTAC BRD4 Degrader-2
T13834CAS 2185795-53-1
PROTAC BRD4 Degrader-2 is an efficacious degrader of PROTAC BRD4(BRD4 BD1,IC50 of 14.2 nM).
CCT367766
T14908CAS 2229856-58-8
CCT367766 is the PROTAC-based pirin targeting protein degradation probe, depletes pirin protein expression at low concentration. It shows a moderate affinity fo...
MS4077
T13781CAS 2230077-10-6
MS4077 is an degrader of anaplastic lymphoma kinase (ALK) PROTAC(Kd of 37 nM for binding affinity to ALK).
Gefitinib-based PROTAC 3
T5437CAS 2230821-27-7
Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827...
PROTAC FLT-3 degrader 1
T12555CAS 2230826-81-8
PROTAC FLT-3 degrader 1 is a PROTAC FLT-3 degrader of internal tandem duplication (ITD)(IC50 0.6 nM),with anti-proliferative activity.
Halo PROTAC 1
T17995CAS 2241668-45-9
Halo PROTAC 1 is a PROTAC, which is a ligand having activity to bind to an intracellular proteins fused with HaloTag and a structure having activity to induce a...
PROTAC MDM2 Degrader-3
T18633CAS 2249750-23-8
PROTAC MDM2 Degrader-3 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-3 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand fo...
PROTAC MDM2 Degrader-4
T18634CAS 2249750-24-9
PROTAC MDM2 Degrader-4 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-4 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand fo...
PROTAC MDM2 Degrader-1
T18631CAS 2249944-98-5
PROTAC MDM2 Degrader-1 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-1 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand fo...
PROTAC MDM2 Degrader-2
T18632CAS 2249944-99-6
PROTAC MDM2 Degrader-2 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-2 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand fo...
SJFδ
T18682CAS 2254609-23-7
SJFδ is a 10-atom linker PROTAC. SJFδ degrades p38δ with a DC50 of 46.17 nM, but does not degrade p38α, p38β, or p38γ[1].
SJFα
T18681CAS 2254609-27-1
SJFα is a 13-atom linker PROTAC. SJFα degrades p38α with a DC50 of 7.16  nM, but is far less effective at degrading p38δ (DC50=299 nM) and does not de...
PROTAC FAK degrader 1
T13840CAS 2301916-69-6
PROTAC FAK degrader 1 is a selective and potent degrader of focal adhesion kinase (Fak) (IC50 of 6.5 nM).
TD-165
T18787CAS 2305936-56-3
TD-165 is a PROTAC-based cereblon (CRBN) degrader. TD-165 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding ...
PROTAC ERRα Degrader-1
T18608CAS 2306388-84-9
PROTAC ERRα Degrader-1 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRα Degrader-1 is ...
PROTAC ERRα Degrader-2
T18609CAS 2306388-85-0
PROTAC ERRα Degrader-2 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRα Degrader-2 is ...
PROTAC BRD4 Degrader-3
T13835CAS 2313234-00-1
PROTAC BRD4 Degrader-3 is an efficacious degrader of PROTAC BRD4.
ERD-308
T13685CAS 2320561-35-9
 ERD-308 induces >95% of ER degradation at concentrations as low as 5 nM in both cell lines (DC50 (concentration causing 50% of protein degradation) of 0.17 nM...
BI-3663
T17543CAS 2341740-84-7
BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation. BI-3663 inhibits PTK2 with an IC50 of 18 nM. BI-...
dMCL1-2
T13657CAS 2351218-88-5
dMCL1-2 is a potent and selective myeloid leukemia 1 (MCL1) degrading agent based on PROTAC, which binds to MCL1 with a KD of 30 nM. dmcl-2 activates the apopto...
PROTAC CRBN Degrader-1
T18604CAS 2358775-70-7
PROTAC CRBN Degrader-1 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group. PROTAC CRBN Degrader-1 is an cer...
PROTAC IRAK4 degrader-1
T13842CAS 2360533-90-8
PROTAC IRAK4 degrader-1 is a degrader of PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4).
PROTAC ER Degrader-4
T13839CAS 2361114-15-8
PROTAC ER Degrader-4 is a PROATC degrader of estrogen receptor (ER)(IC50 of 0.8 nM).
PROTAC B-Raf degrader 1
T12556CAS 2364367-27-9
PROTAC B-Raf degrader 1 is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf,PROTAC B-Raf degrader 1 With anti-cancer activity.
DT2216
T13665CAS 2365172-42-3
DT2216 inhibits various Bcl-XL-dependent leukemias and cancer cells, but is significantly less toxic to platelets.DT2216 is a selective B-cell lymphoma, extreme...
PROTAC PARP1 degrader
T13845CAS 2369022-68-2
PROTAC PARP1 degrader is a degrader of PARP1 based on the PROTAC technology. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line (IC50 of 6.12...
FKBP12 PROTAC RC32
T13694CAS 2375555-66-9
FKBP12 PROTAC RC32 contains conjugation of Rapamycin and a ligand for an E3 ubiquitin ligase.FKBP12 PROTAC RC32 (RC32) is a potent FKBP12 degrader based on PROT...
ACBI1
T17350CAS 2375564-55-7
ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s...
SIAIS178
T12907CAS 2376047-73-1
SIAIS178 is a potent and selective degrader of BCR-ABL based on PROTAC technology (IC50 of 24 nM).
SJF620
T13887CAS 2376187-16-3
SJF620 is a potent degrader of PROTAC BTK(DC50 : 7.9 nM).
PROTAC K-Ras Degrader-1
T13844CAS 2378258-52-5
PROTAC K-Ras Degrader-1 is potent degrader of K-Ras based PROTAC.
PROTAC SGK3 degrader-1
T13847CAS 2381320-35-8
PROTAC SGK3 degrader-1, is a potent SKG3 degrader based on PROTAC.
PROTAC CDK2/9 Degrader-1
T12552CAS 2408641-24-5
PROTAC CDK2/9 Degrader-1 is a potent CDK2 and CDK9 dual degrader(DC50 of 62 nM and 33 nM).
MG-277
T12027CAS T12027
MG-277 is a molecular glue compound transformed from PROTAC degradation agent, MG-277 potently inhibits tumor cell growth in a p53-independent manner.
PROTAC EED degrader-1
T12553CAS T12553
PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.
PROTAC EED degrader-2
T12554CAS T12554
PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11.
(S)-GNE-987
T12798CAS T12798
(S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC).
TD-428
T13105CAS T13105
TD-428 is a highly specific degrader of BRD4(DC50 of 0.32 nM). TD-428 is a BET PROTAC, which comprises TD-106 (a CRBN ligand) linked to JQ1 (a BET inhibit...
ARD-266
T13552CAS T13552
ARD-266 is a highly potent and VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. ARD-266 effectively induces the degradation of AR protein in AR-posit...
MS432
T13782CAS T13782
MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.
PROTAC BET degrader-3
T13850CAS T13850
PROTAC BET Degrader-3 is a potent degrader OF BET based on PROTAC.
PROTAC CDK9 degrader-2
T17728CAS T17728
PROTAC CDK9 degrader-2 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogo...
KB02-JQ1
T18060CAS T18060
KB02-JQ1 is a highly selective and PROTAC-based BRD4 degrader (molecular glue), but does not degrade BRD2 or BRD3. KB02-JQ1 promotes BRD4 degradation by covalen...
KB02-SLF
T18061CAS T18061
KB02-SLF is a PROTAC-based nuclear FKBP12 degrader (molecular glue). KB02-SLF promotes nuclear FKBP12 degradation by covalently modifying DCAF16 (E3 ligase) and...
PROTAC BRD2/BRD4 degrader-1
T18598CAS T18598
PROTAC BRD2/BRD4 degrader-1 (compound 15) is a potent and selective BET protein BRD4 and BRD2 degrader. PROTAC BRD2/BRD4 degrader-1 rapidly induces reversible, ...
PROTAC ER Degrader-2
T18606CAS T18606
PROTAC ER Degrader-2 is an intermediate for synthesis of PAC. PAC, consists the ADCs linker and PROTACs, conjugated to an antibody. PAC extracts from patent WO2...
PROTAC ERα Degrader-1
T18636CAS T18636
PROTAC ERα Degrader-1 comprises an ubiquitin E3 ligase binding group, a linker and a protein binding group. PROTAC ERα Degrader-1 extracts from patent WO20172...
SD-36
T18680CAS T18680
SD-36 is a potent and efficacious PROTAC STAT3 degrader (Kd=~50 nM), and demonstrates high selectivity over other STAT members. SD-36 also effectively degrades ...
BSJ-03-123
T5395CAS T5395
BSJ-03-123 is a potent and novel CDK6-selective small-molecule degrader (PROTAC).