PI3K-Akt-mTOR-Signaling Pathway- Targetmol

Cat.No.	Product Name	Information	Area
T4958	Alkannin	Shikonin is a natural red naphthoquinone pigment, has antimicrobial, anti-tumor, and ...
T4976	TGR-1202	TGR-1202 is a PI3Kδ inhibitor.	Chronic lymphocytic leukaemia
T5S0896	Loureirin A	Loureirin A has an inhibitory effect on platelet activation, perhaps through an impai...
T3921	Punicalagin	Punicalagin is a major ellagitannin found in pomegranates that is reported to produce...
T4639	MSDC 0602	MSDC-0602 is an insulin sensitizer potentially for the treatment of diabetes.	Non-alcoholic steatohepatitis
T2S0410	Euphorbia factor L1	Euphorbiasteroid是Euphorbia lathyris L.的成分之一，通过激活AMPK信号通路抑制3T3-L1细胞的脂肪形成，并通过促进Bcl-2/Ba...	Cancer
T3S0195	Nootkatone	1. Nootkatone can provide effective tick control. 2. (+)-Nootkatone has antiallergic,...	Metabolism/Cardiovascular system
T2P2919	(4S)-4-Hydroxy-L-isoleucine	4-Hydroxyisoleucine (HIL) from fenugreek (Trigonella foenum-graecum) seeds is a poten...
T4488	GSK-25	GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and ...
T4489	AZD-26	AZD-26 is an allosteric AKT inhibitor (IC50: 1.04 μM).
T6283	Wortmannin	Wortmannin is a multi-target inhibitor of PI3K and MLCK with IC50s of 3 nM and 200...	Cancer;Immune disease
T4444	A-674563 HCl (552325-73-2(free base))	A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki...
T4427	PF-06409577	PF-06409577 is an effective, orally active, and specific allosteric activator of AMPK...	Diabetes
T4423	LY303511 hydrochloride	LY303511 (NV-128)is a potent mTOR inhibitor
T4220	BQR-695	BQR-695 is a phosphatidylinositol 4-kinase (PI4K) inhibitor with IC50s of 80 and 3.5 ...	Others
T4199	Desmethyl-VS-5584	Desmethyl-VS-5584 is a dimethyl analog of VS-5584, which is a novel and highly select...	Others
T4079	LY-294002 hydrochloride	LY294002 is a synthetic molecule inhibitor of PI3Kα/δ/β (IC50: 0.5/0.57/0.97 μM, i...	Others
T4046	BX-517	BX-517 is a potent and selective inhibitor of PDK1.	Cancer
T3986	SF2523	SF2523 is a highly selective and potent inhibitor.	Cancer
T3985	GDC-0326	GDC-0326 is a potent and selective inhibitor of α-Isoform of Phosphoinositide 3-Kinas...	Others
T3586	Compound 401	Compound 401 is a synthetic DNA-PK inhibitor (IC50 = 0.28 μM) that also targets mTOR ...	Others
T3560	Desmethylanethol trithione	ADT-OH is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfid...	Others
T3541	CC-115	CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).	Cancer
T3775	Armepavine	Armepavine, a major bioactive compound of a Chinese medicinal plant,?Nelumbo nucifera...
T3514	CZ415	CZ415 is a potent and highly selective mTOR inhibitor.
T3777	Praeruptorin A	Praeruptorin A has the potential to inhibit migration/fusion of preosteoclasts in ...	Immunology/Cardiovascular system/
T3890	Verbenalin	Verbenalin induces angiogenesis via a programmed PI3K/Akt/eNOS/VEGF signaling axis.	Others
T3881	Vaccarin	Vaccarin is a major flavonoid glycoside in Vaccariae semen, its biotransformation pat...
T3752	4-Hydroxybenzyl alcohol	4-Hydroxybenzyl alcohol exhibits beneficial effects in cerebral ischemic injury, has ...	Others
T3490	alpha-(3,4-Dihydroxyphenyl)lactic acid	Danshensu has antioxidant activity, can enhance HO-1 expression to suppress 6-OHDA-in...	Others