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Tau-E Protein, Human, Recombinant (His) is expressed in E. coli. The accession number is P10636-7.
Pack Size | Price | Availability | Quantity |
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Biological Activity | Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
Description | Tau-E Protein, Human, Recombinant (His) is expressed in E. coli. The accession number is P10636-7. |
Protein Purity | ≥ 95% as determined by SDS-PAGE. ≥ 90% as determined by SEC-HPLC. |
Molecular Weight | 43.8 kDa (predicted) |
Research Background | MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease. Tau protein is a highly soluble microtubule-associated protein (MAP). In humans, these proteins are mostly found in neurons compared to non-neuronal cells. One of tau's main functions is to modulate the stability of axonal microtubules. Other nervous system MAPs may perform similar functions, as suggested by tau knockout mice, who did not show abnormalities in brain development - possibly because of compensation in tau deficiency by other MAPs. |
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