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Search Result

Search Results for " 11β-hsd1 "

Targets

Dehydrogenase

33

Compounds

1

Natural Products

Cat No. Product Name Synonyms Targets
T10160 11β-HSD1-IN-1 Dehydrogenase
11β-HSD1-IN-1 is an inhibitor of 11β-hydroxydehydrogenase 1 (11β-HSD1, IC50: 52 nM), and used for the treatment of pain.
T72814 11β-HSD1-IN-12 Dehydrogenase
11β-HSD1-IN-12 is an 11β-HSD1 inhibitor.11β-HSD1-IN-12 is implicated in the conversion of glucocorticoids in vivo and can be used to study metabolic syndrome and obesity.
T60149 11β-HSD1-IN-11 Dehydrogenase
11β-HSd1-in-11 is a potent and competitive inhibitor of 11-β-hydroxysteroid dehydrogenase 1 (11β-HSD1) IN rats and humans with IC50 values of 0.34 μM and 0.13 μM, respectively. 11β-Hsvd1-in-11 is a compound used as a che...
T67903 11β-HSD1 inibitor 17 Dehydrogenase
11β-HSD1 inibitor 17 is an inhibitor of 11β-hydroxysteroid dehydrogenase (11β-HSD1).
T72022 11β-HSD1 inibitor 19
11β-HSD1 inibitor 19 shows inhibitory activities for hHSD1 and mHSD1 with IC50s of 16 nM and 10 nM.
T64321 Octyl-beta-D-glucopyranoside Octyl glucoside,11β-HSD1-IN-11 Others
Octyl-beta-D-glucopyranoside (11β-HSD1-IN-11) is a non-ionic detergent, it can be widely used in the research of biotechnical, biochemical applications, solubilization and crystallization of membrane proteins.
T67622 11β-HSD1-IN-7
11β-HSD1-IN-7 is a useful organic compound for research related to life sciences. The catalog number is T67622 and the CAS number is 728-86-9.
T72911 11β-HSD1-IN-9
11β-HSD1-IN-9 is a potent inhibitor of 11β-HSD1, displaying IC50 values of 0.48 µM for human and 1.3 µM for murine variants, respectively. It exhibits competitive interaction with rat 11β-HSD1. This compound holds potent...
T72859 11β-HSD1-IN-10
11β-HSD1-IN-10, a potent inhibitor of 11β-HSD1 with an IC50 value of 1.8 µM for humans, is suitable for research into obesity, hyperglycemia, and cognitive impairment.
T61593 11β-HSD1-IN-6
11β-HSD1-IN-6 is a potent inhibitor of 11β hydroxysteroid dehydrogenase enzymes (11β-HSDs). These enzymes are responsible for catalyzing the conversion of the active glucocorticoids, corticosterone or cortisol, to their ...
T65743 11β-HSD1-IN-8
11β-HSD1-IN-8 is a useful organic compound for research related to life sciences. The catalog number is T65743 and the CAS number is 386704-15-0.
T2057 BVT 2733 Dehydrogenase
BVT 2733 is a new, non-steroidal, isoform-specific inhibitor of 11β-HSD1.
T14388 AZD 4017 Dehydrogenase
AZD 4017 is an inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1(11β-HSD1) (IC50: 7 nM).
T3542 BVT-14225 BVT 14225 Dehydrogenase
BVT-14225 is a selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor (IC50=52 nM).
T77606 WAY-311610 Dehydrogenase
WAY-311610 is an 11β-hydroxysteroid dehydrogenase HSD11B1 inhibitor that inhibits the 11β-HSD1 enzyme with an IC = 0.34 μM.It can be used to study neuropathic pain, inflammatory pain, and occipital neuralgia.
T64349 Necroptosis-IN-3 Cyclohexanecarboxamide, N-(2-thienylmethyl)- Necroptosis
Necroptosis-IN-3 (Cyclohexanecarboxamide, N-(2-thienylmethyl)-) (Compound 69) is a Necroptosis inhibitor that inhibits TNF-α induced necroptosis. Necroptosis-IN-3 (Compound STX1638) also inhibits 11β-HSD1.
T0293 Metyrapone NSC-25265,Su-4885 Others , P450 , Dehydrogenase , Autophagy
Metyrapone (NSC-25265) is an inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.
T16510 PF-915275 Dehydrogenase
The dose-dependent effect of PF-915275 on the conversion of cortisone to cortisol in primary human and monkey hepatocytes (EC50: 20 and 100 nM, respectively). PF-915275 is an effective and selective human 11β-hydroxyster...
T14383 AZD8329 Dehydrogenase
AZD8329 is a selectable and potent inhibitor of human recombinant 11β-HSD1 and isolated human adipocyte 11ß-HSD1 and is an inhibitor of rat 11β-HSD1 (IC50 - 89nM) and dog recombinant 11β-HSD1. AZD8329 has a higher affini...
T26794 BI-135585
BI-135585 is a potent and selective inhibitor of 11β-HSD1.
T26724 AZD-9164 bromide AZD9164,AZD-9164,AZD 9164
AMG-221 is a potent and selective 11β-HSD1 inhibitor. AMG 221 potently blocked 11β-HSD1 activity, producing sustained inhibition for the 24-hour study duration as measured in ex vivo adipose samples. AMG-221 decreased fe...
T12663 (Rac)-BMS-816336 Dehydrogenase
(Rac)-BMS-816336 (Compound 6n), a racemate of BMS-816336, is a potent inhibitor of the human and mouse 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme, demonstrating IC50 values of 10 nM and 68 nM, respectively...
T28796 SKI2852 SK I2852,SKI-2852
SKI2852 is a highly Potent, selective, and orally bioavailable inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1). hHSD1 IC50 = 2.9nM; mHSD1 IC50 = 1.6nM.
T26617 AMG-221 AMG221
AMG-221 is a potent and selective 11β-HSD1 inhibitor. AMG-221 decreased fed blood glucose and insulin levels and reduced body weight in diet-induced obesity mice.
T71243 ASP3662
ASP3662, also known as SPI-62, is a potent, selective and CNS-penetrable inhibitor of 11β-HSD1. The effects of ASP3662 suggest that selective inhibition of 11β-HSD1 may be an attractive approach for the treatment of neu...
T63569 HSD-016
HSD-016 is a selective, potent, orally active inhibitor of type 1 11β-hydroxysteroid dehydrogenase (11β-HSD1), capable of acting on human 11β-HSD1 (IC50: 11 nM), mouse 11β-HSD1 (IC50: 1 nM), and rat 11β-HSD1 (IC50: 8 nM)...
T23845 BVT-116429
BVT-116429 is an inhibitor of 11β-HSD1.
T60203 INCB13739
INCB13739 is an orally active, potent, selective, and tissue-specific inhibitor of 11β-HSD1 (11β-hydroxysteroid dehydrogenase 1), demonstrating IC50 values of 3.2 nM (11β-HSD1 enzymatic) and 1.1 nM (11β-HSD1 PBMC). It is...
T72249 BMS-823778 hydrochloride
BMS-823778 hydrochloride is a potent, selective, and orally active inhibitor of 11β-HSD1 (11β-Hydroxysteroid Dehydrogenase Type 1), demonstrating an IC50 (half maximal inhibitory concentration) of 2.3 nM against the huma...
T80817 WAY-328127
WAY-328127 is an active molecule, exhibiting an inhibitory effect on the (11β-hydroxysteroid dehydrogenase type 1) [(11β-HSD1)] enzyme. This modulation potentially leads to therapeutic applications in metabolic disorders...
T70509 INU-101
INU-101 is an 11β-HSD1 inhibitor. In KKAy mice, ob/ob mice, and ZDF rats, oral administration of INU-101 led to enhanced insulin sensitivity and the lowering of the fasting level of glucose in the blood. INU-101 therefor...
T70763 KR-67607
KR-67607, also known as NTX-101 is novel selective 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitor. KR-67607 decreased 4-hydroxynonenal expression and increased antioxidant and mucus secretion in BAC-treated rat ...
T26528 ABT-384
ABT-384 is an inhibitor of 11β-hydroxysteroid dehydrogenase type 1.

Compounds

11β-HSD1-IN-1
T10160
Synonym:
Target: Dehydrogenase
11β-HSD1-IN-12
T72814
Synonym:
Target: Dehydrogenase
11β-HSD1-IN-11
T60149
Synonym:
Target: Dehydrogenase
11β-HSD1 inibitor 17
T67903
Synonym:
Target: Dehydrogenase
11β-HSD1 inibitor 19
T72022
Synonym:
Target:
Octyl-beta-D-glucopyranoside
T64321
Synonym: Octyl glucoside,11β-HSD1-IN-11
Target: Others
11β-HSD1-IN-7
T67622
Synonym:
Target:
11β-HSD1-IN-9
T72911
Synonym:
Target:
11β-HSD1-IN-10
T72859
Synonym:
Target:
11β-HSD1-IN-6
T61593
Synonym:
Target:
11β-HSD1-IN-8
T65743
Synonym:
Target:
BVT 2733
T2057
Synonym:
Target: Dehydrogenase
AZD 4017
T14388
Synonym:
Target: Dehydrogenase
BVT-14225
T3542
Synonym: BVT 14225
Target: Dehydrogenase
WAY-311610
T77606
Synonym:
Target: Dehydrogenase
Necroptosis-IN-3
T64349
Synonym: Cyclohexanecarboxamide, N-(2-thienylmethyl)-
Target: Necroptosis
Metyrapone
T0293
Synonym: NSC-25265,Su-4885
Target: Others, P450, Dehydrogenase, Autophagy
PF-915275
T16510
Synonym:
Target: Dehydrogenase
AZD8329
T14383
Synonym:
Target: Dehydrogenase
BI-135585
T26794
Synonym:
Target:
AZD-9164 bromide
T26724
Synonym: AZD9164,AZD-9164,AZD 9164
Target:
(Rac)-BMS-816336
T12663
Synonym:
Target: Dehydrogenase
SKI2852
T28796
Synonym: SK I2852,SKI-2852
Target:
AMG-221
T26617
Synonym: AMG221
Target:
ASP3662
T71243
Synonym:
Target:
HSD-016
T63569
Synonym:
Target:
BVT-116429
T23845
Synonym:
Target:
INCB13739
T60203
Synonym:
Target:
BMS-823778 hydrochloride
T72249
Synonym:
Target:
WAY-328127
T80817
Synonym:
Target:
INU-101
T70509
Synonym:
Target:
KR-67607
T70763
Synonym:
Target:
ABT-384
T26528
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T2869 Emodin Frangula emodin SARS-CoV , Casein Kinase , Autophagy
Emodin (Frangula emodin) is a naturally occurring anthraquinone present in the roots and barks of numerous plants; exerts antiproliferative effects in Y cells that are regulated by different signaling pathways.

Natural Products

Emodin
T2869
Synonym: Frangula emodin
Target: SARS-CoV, Casein Kinase, Autophagy
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