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Search Results for " 5-fu "

Targets

25

Compounds

4

Natural Products

10

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T8182L Guan-fu base A hydrochloride(1394-48-5 free base) P450
Guan-fu base A hydrochloride is an antiarrhythmic alkaloid was isolated from Aconitum coreanum. Guanfu base A is hydrochloride a CYP2D6 inhibitor of human, monkey, and dog isoforms.
T0984 5-Fluorouracil 5-FU,Fluorouracil,NSC 19893,5-Fluoracil Apoptosis , Nucleoside Antimetabolite/Analog , HIV Protease , DNA/RNA Synthesis , Endogenous Metabolite
5-Fluorouracil (5-FU) is a uracil analog, an inhibitor of DNA synthesis. 5-Fluorouracil has antitumor activity and affects pyrimidine synthesis through inhibition of thymidylate synthase. 5-Fluorouracil causes apoptosis ...
T7614 Eniluracil GW776C85,5-Ethynyluracil Others
Eniluracil (GW776C85) is an orally activedihydropyrimidine dehydrogenase (DPD) inhibitor,increases the oral bioavailability of 5-FU to 100%, facilitating uniform absorption and predictable toxicity.
T33762 Fosifloxuridine nafalbenamide NUC-3373,NUC3373,NUC 3373 DNA/RNA Synthesis
Fosifloxuridine nafalbenamide (NUC 3373), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor. NUC-3373 has anticancer activity. NUC-3373 is a ProTide transformation of 5-FU that generates much higher c...
T10013 1-Acetyl-3-o-toluyl-5-fluorouracil A-​OT-​Fu Others
1-Acetyl-3-o-toluyl-5-fluorouracil is a potent antineoplastic agent.
TNU1475 5’-O-DMTr-2’-FU-methyl   phosphonamidite
5’-O-DMTr-2’-FU-methyl   phosphonamidite is a useful organic compound for research related to life sciences and the catalog number is TNU1475.
T1600 Doxifluridine Ro 21-9738,AMC 0101,5'-DFUR,5-Fluoro-5'-deoxyuridine Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis
Doxifluridine (AMC 0101) is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid degradation of 5-FU by...
T4374 Edoxudine Aedurid,EUDR,Epoxudine Antiviral , Antibacterial
Edoxudine (Epoxudine), an antiviral drug, is an analogue of thymidine and shows effectiveness against the herpes simplex virus. Edoxudine is used as a 5-fluorouracil (FU) modulator. Edoxudine may be used to enhance the t...
T1408 Capecitabine Xeloda,Capecitibine,Capiibine,RO 09-1978 Apoptosis , Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis
Capecitabine (Capecitibine) is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moie...
T21327 Uridine triacetate RG 2133 triacetate,PN-401,Tri-O-acetyluridine,PN401,RG 2133,RG-2133,PN 401,RG2133,RG2133 triacetate Others
Uridine triacetate (RG 2133 triacetate) (Tri-O-acetyl uridine) is an orally active prodrug of Uridine. Uridine triacetate is quickly absorbed in the gut, and is rapidly deacetylated in the circulation to yield free uridi...
T5987 Potassium oxonate Oxonic Acid (potassium salt),Potassium otastat,Potassium azaorotate Others
Potassium oxonate (Potassium azaorotate) is a uricase inhibitor that prevents metabolism and excretion of uric acid and induces embryotoxicity and nephrotoxicity in rats.
T72991 Bis-Pro-5FU
Bis-Pro-5FU is a 5-FU precursor that confers oral bioavailability and increase the safety profile of 5-Fluorouracil (5-FU) chemotherapy regimens. 5-FU is an antineoplastic antimetabolite that is widely used for the resea...
T33686 Nitrocaphane AT 1258,AT-1258,AT1258
Nitrocaphane, in combination with 5-FU (fluorouracil), chemotherapy is considered as a protocol of choice in the treatment of malignant trophoblastic tumor.
T36870 5,6-dihydro-5-Fluorouracil 5-fluorodihydrouracil,5-Fluoro-dihydro-pyrimidine-2,4-dione Others
5,6-dihydro-5-Fluorouracil (5-FUH2) is an inactive metabolite of 5-FU and can be used for the study of organismal metabolism.
T63868 α5β1 integrin agonist-1
α5β1 integrin agonist-1 is an α5β1 integrin agonist that selectively delivers 5-FU to tumour cells and induces tumour cell death.
T40932 Benzylacyclouridine 5-Benzylacyclouridine,BAU
Benzylacyclouridine (BAU) is a powerful and selective inhibitor of uridine phosphorylase, the initial enzyme involved in uridine catabolism. Additionally, it can regulate the cytotoxic adverse effects of 5-fluorouracil (...
TP2108 TAPI 2
ADAM-17 (TACE) and MMP inhibitor (Ki = 120 nM at ADAM-17). Sensitizes cancer stem cells to the lethal effects of 5-FU in vitro. Blocks shedding of TNF-α from cell membranes.
T30095 APG-1387 SM 1387,SM-1387,SM1387,APG 1387l
APG-1387 (SM-1387) is an IAP inhibitor that promotes the rapid degradation of cIAP1/2 and XIAP and exerts an anti-tumor effect on nasopharyngeal carcinoma stem cells. Studies have shown that APG-1387 combined with NPC's ...
T39792 AMPC
AMPC, a powerful and efficient inhibitor of TFF3, demonstrates inhibitory effects on cell proliferation, survival, oncogenicity, and CSC-like behavior in TFF3-positive CMS4 CRC cells. It acts as a promising standalone an...
T73558 W1131
W1131 is a potent STAT3 inhibitor, triggering ferroptosis . W1131 suppresses cancer progression in gastric cancer cell subcutaneous xenograft model, organoids model, and PDX model. W1131 effectively alleviates chemical r...
T80847 W1131 TFA STAT
W1131 TFA is a potent STAT3 inhibitor inducing ferroptosis, effectively halting cancer progression in subcutaneous xenograft, organoid, and PDX models of gastric cancer. Besides mitigating chemoresistance to 5-FU in canc...
T63074 Ivaltinostat formic
Ivaltinostat (CG-200745) formic is an oral active panHDAC inhibitor with an isohydroxamic acid component that binds zinc at the bottom of the catalytic pocket. Ivaltinostat formic inhibited the deacetylation of histone H...
T71549 RKS-262
RKS262 is a specific cyclin/CDK inhibitor. RKS262 was identified by structural optimization of Nifurtimox which is currently undergoing phase II clinical trials to treat high-risk neuroblastoma. In a NCI(60) cell-line as...
T36679 Rp-cAMPS sodium salt
Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 μM and 4.5 μM, respectively) antagonist. Rp-cAMPS sodium salt is resistant to hydrolysis b...
T35432 α-Conotoxin ImI (trifluoroacetate salt)
α-Conotoxin ImI is a conotoxin that has been found inC. imperialisand has receptor antagonist and anticancer activities.1It is a peptide antagonist of homomeric α7 nicotinic acetylcholine receptors (nAChRs; IC50= 220 nM)...

Compounds

Guan-fu base A hydrochloride(1394-48-5 free base)
T8182L
Synonym:
Target: P450
5-Fluorouracil
T0984
Synonym: 5-FU,Fluorouracil,NSC 19893,5-Fluoracil
Target: Apoptosis, Nucleoside Antimetabolite/Analog, HIV Protease, DNA/RNA Synthesis, Endogenous Metabolite
Eniluracil
T7614
Synonym: GW776C85,5-Ethynyluracil
Target: Others
Fosifloxuridine nafalbenamide
T33762
Synonym: NUC-3373,NUC3373,NUC 3373
Target: DNA/RNA Synthesis
1-Acetyl-3-o-toluyl-5-fluorouracil
T10013
Synonym: A-​OT-​Fu
Target: Others
5’-O-DMTr-2’-FU-methyl   phosphonamidite
TNU1475
Synonym:
Target:
Doxifluridine
T1600
Synonym: Ro 21-9738,AMC 0101,5'-DFUR,5-Fluoro-5'-deoxyuridine
Target: Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis
Edoxudine
T4374
Synonym: Aedurid,EUDR,Epoxudine
Target: Antiviral, Antibacterial
Capecitabine
T1408
Synonym: Xeloda,Capecitibine,Capiibine,RO 09-1978
Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis
Uridine triacetate
T21327
Synonym: RG 2133 triacetate,PN-401,Tri-O-acetyluridine,PN401,RG 2133,RG-2133,PN 401,RG2133,RG2133 triacetate
Target: Others
Potassium oxonate
T5987
Synonym: Oxonic Acid (potassium salt),Potassium otastat,Potassium azaorotate
Target: Others
Bis-Pro-5FU
T72991
Synonym:
Target:
Nitrocaphane
T33686
Synonym: AT 1258,AT-1258,AT1258
Target:
5,6-dihydro-5-Fluorouracil
T36870
Synonym: 5-fluorodihydrouracil,5-Fluoro-dihydro-pyrimidine-2,4-dione
Target: Others
α5β1 integrin agonist-1
T63868
Synonym:
Target:
Benzylacyclouridine
T40932
Synonym: 5-Benzylacyclouridine,BAU
Target:
TAPI 2
TP2108
Synonym:
Target:
APG-1387
T30095
Synonym: SM 1387,SM-1387,SM1387,APG 1387l
Target:
AMPC
T39792
Synonym:
Target:
W1131
T73558
Synonym:
Target:
W1131 TFA
T80847
Synonym:
Target: STAT
Ivaltinostat formic
T63074
Synonym:
Target:
RKS-262
T71549
Synonym:
Target:
Rp-cAMPS sodium salt
T36679
Synonym:
Target:
α-Conotoxin ImI (trifluoroacetate salt)
T35432
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T2911 Stevioside TLR
A natural, noncaloric sweetener with a potency 300 times more than that of regular sucrose. Exhibits transepithelial p-aminohippurate transport via organic anion transport system interference.
T4720 6-Hydroxypyridin-2(1H)-one hydrochloride 2,6-Dihydroxypyridine hydrochloride Others , Endogenous Metabolite
6-Hydroxypyridin-2(1H)-one hydrochloride (2,6-Dihydroxypyridine hydrochloride) is used as a reagent to synthesize uridine phosphorylase inhibitors that increase Uridine (Urd) (U829910) levels. Uridine is a promising bioc...
T4S1551 Cinnamaldehyde Cinnamic Aldehyde HIF
1. Cinnamaldehyde (Cinnamic Aldehyde) has antipyretic activity. 2. Cinnamaldehyde is a sedative agent. 3. Cinnamaldehyde inhibits invasive capabilities of MDA-MB-435S cells was correlated with down-regulating the express...
TN3152 6-Acetonyldihydrochelerythrine ERK , BCL , Akt , HIV Protease , PPAR , p53
6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therapeutic Index) values of 1.77 microg/mL and 14.6, respectively...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-03048 PRAP1 Protein, Human, Recombinant (mFc) Human HEK293
PRAP1 is a protein interacting partner of MAD1 and that PRAP1 is able to down-regulate MAD1 and suppress mitotic checkpoint signalling in HCC. PRAP1 is a novel p53 target gene. The induction of PRAP1 expression by p53 ma...
TMPY-03076 PRAP1 Protein, Human, Recombinant (His) Human HEK293
PRAP1 is a protein interacting partner of MAD1 and that PRAP1 is able to down-regulate MAD1 and suppress mitotic checkpoint signalling in HCC. PRAP1 is a novel p53 target gene. The induction of PRAP1 expression by p53 ma...
TMPY-05308 CD45 Protein, Human, Recombinant (aa 1-529, His) Human HEK293
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-05387 SLAMF7 Protein, Human, Recombinant (hFc) Human HEK293
SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 ...
TMPY-05498 SR-BI/SCARB1 Protein, Human, Recombinant (hFc) Human HEK293
Scavenger receptor class B, member 1 (SCARB1), also known as CD36L1, is a member of the scavenger receptor family. SCARB1 is expressed primarily in liver and non placental steroidogenic tissues, and predominantly localiz...
TMPJ-00854 ETS1 Protein, Human, Recombinant (His) Human E. coli
ETS1 Protein (ETS1) is a nuclear protein that belongs to the ETS family. Members of this family recognize the core consensus DNA sequence GGAA/T in target genes. Proteins function either as transcriptional activators or ...
TMPY-05547 SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated Human HEK293
SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 ...
TMPY-04318 GRIK2 Protein, Human, Recombinant (hFc) Human HEK293
GRIK2 (Glutamate Ionotropic Receptor Kainate Type Subunit 2, also known as GluR6) is a Protein Coding gene. The GRIK2 (one of the kainate receptors) gene resides in a genetic linkage region (6q21) associated with bipolar...
TMPK-01363 SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadl...
TMPK-01357 SIRP alpha V5 Protein, Human, Recombinant (His & Avi) Human HEK293
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadl...
TargetMol