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Cat No. | Product Name | Synonyms | Targets |
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T8182L | Guan-fu base A hydrochloride(1394-48-5 free base) | P450 | |
Guan-fu base A hydrochloride is an antiarrhythmic alkaloid was isolated from Aconitum coreanum. Guanfu base A is hydrochloride a CYP2D6 inhibitor of human, monkey, and dog isoforms. | |||
T0984 | 5-Fluorouracil | 5-FU,Fluorouracil,NSC 19893,5-Fluoracil | Apoptosis , Nucleoside Antimetabolite/Analog , HIV Protease , DNA/RNA Synthesis , Endogenous Metabolite |
5-Fluorouracil (5-FU) is a uracil analog, an inhibitor of DNA synthesis. 5-Fluorouracil has antitumor activity and affects pyrimidine synthesis through inhibition of thymidylate synthase. 5-Fluorouracil causes apoptosis ... | |||
T7614 | Eniluracil | GW776C85,5-Ethynyluracil | Others |
Eniluracil (GW776C85) is an orally activedihydropyrimidine dehydrogenase (DPD) inhibitor,increases the oral bioavailability of 5-FU to 100%, facilitating uniform absorption and predictable toxicity. | |||
T33762 | Fosifloxuridine nafalbenamide | NUC-3373,NUC3373,NUC 3373 | DNA/RNA Synthesis |
Fosifloxuridine nafalbenamide (NUC 3373), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor. NUC-3373 has anticancer activity. NUC-3373 is a ProTide transformation of 5-FU that generates much higher c... | |||
T10013 | 1-Acetyl-3-o-toluyl-5-fluorouracil | A-OT-Fu | Others |
1-Acetyl-3-o-toluyl-5-fluorouracil is a potent antineoplastic agent. | |||
TNU1475 | 5’-O-DMTr-2’-FU-methyl phosphonamidite | ||
5’-O-DMTr-2’-FU-methyl phosphonamidite is a useful organic compound for research related to life sciences and the catalog number is TNU1475. | |||
T1600 | Doxifluridine | Ro 21-9738,AMC 0101,5'-DFUR,5-Fluoro-5'-deoxyuridine | Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis |
Doxifluridine (AMC 0101) is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid degradation of 5-FU by... | |||
T4374 | Edoxudine | Aedurid,EUDR,Epoxudine | Antiviral , Antibacterial |
Edoxudine (Epoxudine), an antiviral drug, is an analogue of thymidine and shows effectiveness against the herpes simplex virus. Edoxudine is used as a 5-fluorouracil (FU) modulator. Edoxudine may be used to enhance the t... | |||
T1408 | Capecitabine | Xeloda,Capecitibine,Capiibine,RO 09-1978 | Apoptosis , Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis |
Capecitabine (Capecitibine) is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moie... | |||
T21327 | Uridine triacetate | RG 2133 triacetate,PN-401,Tri-O-acetyluridine,PN401,RG 2133,RG-2133,PN 401,RG2133,RG2133 triacetate | Others |
Uridine triacetate (RG 2133 triacetate) (Tri-O-acetyl uridine) is an orally active prodrug of Uridine. Uridine triacetate is quickly absorbed in the gut, and is rapidly deacetylated in the circulation to yield free uridi... | |||
T5987 | Potassium oxonate | Oxonic Acid (potassium salt),Potassium otastat,Potassium azaorotate | Others |
Potassium oxonate (Potassium azaorotate) is a uricase inhibitor that prevents metabolism and excretion of uric acid and induces embryotoxicity and nephrotoxicity in rats. | |||
T72991 | Bis-Pro-5FU | ||
Bis-Pro-5FU is a 5-FU precursor that confers oral bioavailability and increase the safety profile of 5-Fluorouracil (5-FU) chemotherapy regimens. 5-FU is an antineoplastic antimetabolite that is widely used for the resea... | |||
T33686 | Nitrocaphane | AT 1258,AT-1258,AT1258 | |
Nitrocaphane, in combination with 5-FU (fluorouracil), chemotherapy is considered as a protocol of choice in the treatment of malignant trophoblastic tumor. | |||
T36870 | 5,6-dihydro-5-Fluorouracil | 5-fluorodihydrouracil,5-Fluoro-dihydro-pyrimidine-2,4-dione | Others |
5,6-dihydro-5-Fluorouracil (5-FUH2) is an inactive metabolite of 5-FU and can be used for the study of organismal metabolism. | |||
T63868 | α5β1 integrin agonist-1 | ||
α5β1 integrin agonist-1 is an α5β1 integrin agonist that selectively delivers 5-FU to tumour cells and induces tumour cell death. | |||
T40932 | Benzylacyclouridine | 5-Benzylacyclouridine,BAU | |
Benzylacyclouridine (BAU) is a powerful and selective inhibitor of uridine phosphorylase, the initial enzyme involved in uridine catabolism. Additionally, it can regulate the cytotoxic adverse effects of 5-fluorouracil (... | |||
TP2108 | TAPI 2 | ||
ADAM-17 (TACE) and MMP inhibitor (Ki = 120 nM at ADAM-17). Sensitizes cancer stem cells to the lethal effects of 5-FU in vitro. Blocks shedding of TNF-α from cell membranes. | |||
T30095 | APG-1387 | SM 1387,SM-1387,SM1387,APG 1387l | |
APG-1387 (SM-1387) is an IAP inhibitor that promotes the rapid degradation of cIAP1/2 and XIAP and exerts an anti-tumor effect on nasopharyngeal carcinoma stem cells. Studies have shown that APG-1387 combined with NPC's ... | |||
T39792 | AMPC | ||
AMPC, a powerful and efficient inhibitor of TFF3, demonstrates inhibitory effects on cell proliferation, survival, oncogenicity, and CSC-like behavior in TFF3-positive CMS4 CRC cells. It acts as a promising standalone an... | |||
T73558 | W1131 | ||
W1131 is a potent STAT3 inhibitor, triggering ferroptosis . W1131 suppresses cancer progression in gastric cancer cell subcutaneous xenograft model, organoids model, and PDX model. W1131 effectively alleviates chemical r... | |||
T80847 | W1131 TFA | STAT | |
W1131 TFA is a potent STAT3 inhibitor inducing ferroptosis, effectively halting cancer progression in subcutaneous xenograft, organoid, and PDX models of gastric cancer. Besides mitigating chemoresistance to 5-FU in canc... | |||
T63074 | Ivaltinostat formic | ||
Ivaltinostat (CG-200745) formic is an oral active panHDAC inhibitor with an isohydroxamic acid component that binds zinc at the bottom of the catalytic pocket. Ivaltinostat formic inhibited the deacetylation of histone H... | |||
T71549 | RKS-262 | ||
RKS262 is a specific cyclin/CDK inhibitor. RKS262 was identified by structural optimization of Nifurtimox which is currently undergoing phase II clinical trials to treat high-risk neuroblastoma. In a NCI(60) cell-line as... | |||
T36679 | Rp-cAMPS sodium salt | ||
Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 μM and 4.5 μM, respectively) antagonist. Rp-cAMPS sodium salt is resistant to hydrolysis b... | |||
T35432 | α-Conotoxin ImI (trifluoroacetate salt) | ||
α-Conotoxin ImI is a conotoxin that has been found inC. imperialisand has receptor antagonist and anticancer activities.1It is a peptide antagonist of homomeric α7 nicotinic acetylcholine receptors (nAChRs; IC50= 220 nM)... |
Cat No. | Product Name | Synonyms | Targets |
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T2911 | Stevioside | TLR | |
A natural, noncaloric sweetener with a potency 300 times more than that of regular sucrose. Exhibits transepithelial p-aminohippurate transport via organic anion transport system interference. | |||
T4720 | 6-Hydroxypyridin-2(1H)-one hydrochloride | 2,6-Dihydroxypyridine hydrochloride | Others , Endogenous Metabolite |
6-Hydroxypyridin-2(1H)-one hydrochloride (2,6-Dihydroxypyridine hydrochloride) is used as a reagent to synthesize uridine phosphorylase inhibitors that increase Uridine (Urd) (U829910) levels. Uridine is a promising bioc... | |||
T4S1551 | Cinnamaldehyde | Cinnamic Aldehyde | HIF |
1. Cinnamaldehyde (Cinnamic Aldehyde) has antipyretic activity. 2. Cinnamaldehyde is a sedative agent. 3. Cinnamaldehyde inhibits invasive capabilities of MDA-MB-435S cells was correlated with down-regulating the express... | |||
TN3152 | 6-Acetonyldihydrochelerythrine | ERK , BCL , Akt , HIV Protease , PPAR , p53 | |
6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therapeutic Index) values of 1.77 microg/mL and 14.6, respectively... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-03048 | PRAP1 Protein, Human, Recombinant (mFc) | Human | HEK293 |
PRAP1 is a protein interacting partner of MAD1 and that PRAP1 is able to down-regulate MAD1 and suppress mitotic checkpoint signalling in HCC. PRAP1 is a novel p53 target gene. The induction of PRAP1 expression by p53 ma... | |||
TMPY-03076 | PRAP1 Protein, Human, Recombinant (His) | Human | HEK293 |
PRAP1 is a protein interacting partner of MAD1 and that PRAP1 is able to down-regulate MAD1 and suppress mitotic checkpoint signalling in HCC. PRAP1 is a novel p53 target gene. The induction of PRAP1 expression by p53 ma... | |||
TMPY-05308 | CD45 Protein, Human, Recombinant (aa 1-529, His) | Human | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu... | |||
TMPY-05387 | SLAMF7 Protein, Human, Recombinant (hFc) | Human | HEK293 |
SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 ... | |||
TMPY-05498 | SR-BI/SCARB1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Scavenger receptor class B, member 1 (SCARB1), also known as CD36L1, is a member of the scavenger receptor family. SCARB1 is expressed primarily in liver and non placental steroidogenic tissues, and predominantly localiz... | |||
TMPJ-00854 | ETS1 Protein, Human, Recombinant (His) | Human | E. coli |
ETS1 Protein (ETS1) is a nuclear protein that belongs to the ETS family. Members of this family recognize the core consensus DNA sequence GGAA/T in target genes. Proteins function either as transcriptional activators or ... | |||
TMPY-05547 | SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated | Human | HEK293 |
SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 ... | |||
TMPY-04318 | GRIK2 Protein, Human, Recombinant (hFc) | Human | HEK293 |
GRIK2 (Glutamate Ionotropic Receptor Kainate Type Subunit 2, also known as GluR6) is a Protein Coding gene. The GRIK2 (one of the kainate receptors) gene resides in a genetic linkage region (6q21) associated with bipolar... | |||
TMPK-01363 | SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadl... | |||
TMPK-01357 | SIRP alpha V5 Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadl... |