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Cat No. | Product Name | Synonyms | Targets |
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T9882 | RUVBL1/2 ATPase-IN-1 | Others | |
RUVBL1/2 ATPase-IN-1 is an effective RUVBL1/2 ATPase inhibitor with IC50 values of 6.0 and 7.7 μM, respectively. RUVBL1/2 ATPase-IN-1 can be used in cancer disease studies. | |||
T83967 | ATPase-IN-3 | ATPase | |
ATPase-IN-3 is an ATPase (ATPase) inhibitor that can be used in the study of metabolism-related diseases. | |||
T61553 | ATPase-IN-2 | ||
ATPase-IN-2 is a compound that acts as an inhibitor of ATPase, with an IC50 value of 0.9 μM. It also inhibits the glycohydrolase activity of C. difficile toxin B (TcdB) with an AC50 value of 30.91 μM. ATPase-IN-2 is comm... | |||
T0712 | Suloctidil | ATPase , Platelet aggregation | |
Suloctidil is a peripheral vasodilator that was formerly used in the management of peripheral and cerebral vascular disorders. It is hepatotoxic and fatalities have occurred. | |||
T6443 | Chloroprocaine hydrochloride | Chloroprocaine HCl | ATPase , Others |
Chloroprocaine hydrochloride (Chloroprocaine HCl) is a local anesthetic during surgical procedures. | |||
T2176 | 2,3-Butanedione 2-Monoxime | Diacetyl monoxime,2,3-Butanedione-2-monoxime | Akt |
2,3-Butanedione 2-Monoxime (Diacetyl monoxime) is an inhibitor of skeletal and cardiac muscle contraction. | |||
T20626 | Esomeprazole | Proton pump , Cysteine Protease | |
Esomeprazole is the S-isomer of omeprazole, inhibits the lysosomal cysteine protease legumain to prevent cancer metastasis. Esomeprazole is a proton pump inhibitors (PPI). | |||
T0490 | Chlorpropamide | Diabinese | ATPase , ABC |
Chlorpropamide (Diabinese) is a sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. | |||
T9008 | NPD8733 | Others | |
NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration. It specifically binds to valosin-containing protein (VCP)/p97. | |||
T6796 | CB-5083 | CB5083,CB 5083 | p97 |
CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor ( IC50=11 nM). | |||
T3293 | Apoptozole | Apoptosis Activator VII | Apoptosis , HSP |
Apoptozole (Apoptosis Activator VII) is an inhibitor of the ATPase domain of Hsc70 and Hsp70, and can induce apoptosis. | |||
T9230 | KM 91104 | ATPase | |
KM 91104 is a cell permeable inhibitor of V-ATPase. KM91104 specifically targets the interaction between V-ATPase subunit A3 and subunit B2. | |||
T2686L | Esomeprazole Sodium | (S)-Omeprazole sodium | ATPase , Proton pump |
Esomeprazole Sodium ((S)-Omeprazole sodium) is the S-isomer of omeprazole with selective and irreversible proton pump inhibitor activity.Esomeprazole acts as an exosome inhibitor by blocking the exosome release via the i... | |||
T9168 | NSC 617145 | NSC617145,NSC-617145 | DNA/RNA Synthesis |
NSC 617145 (NSC617145) is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner. | |||
T2621 | Rostafuroxin | PST 2238 | ATPase , RSV |
Rostafuroxin (PST 2238) has been used in trials studying the treatment of Essential Hypertension. | |||
T6700 | Tenatoprazole | TU-199 | Proton pump |
Tenatoprazole (TU-199), a prodrug of the proton pump inhibitor (PPI) class, can inhibit proton transport (IC50: 3.2 μM). | |||
T36816 | S-trityl-L-Cysteine | STLC | Kinesin |
S-trityl-L-Cysteine is a non-natural amino acid and an inhibitor of Eg5, also known as KSP and Kif11, a mitotic kinesin necessary for mitotic spindle formation. S-trityl-L-Cysteine inhibits the ATPase activity of Eg5 in ... | |||
T6953 | Prilocaine | Citanest,Propitocaine,NSC 40027 | ATPase , Sodium Channel |
Prilocaine (NSC-40027) is a local anesthetic of the amino amide type, which acts on the sodium channel on the neuronal membrane and limits the spread of seizures. | |||
T1734 | Rabeprazole Sulfide | Rabeprazole Related Compound E | Proton pump , Antibacterial |
Rabeprazole Sulfide (Rabeprazole Related Compound E) is an antiulcer drug in the class of proton pump inhibitors. | |||
T10616 | BRM/BRG1 ATP Inhibitor-1 | Epigenetic Reader Domain | |
BRM/BRG1 ATP Inhibitor-1 is an allosteric dual Brahma homolog (BRM)/SWI/SNF related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SMARCA2) and BRG1/SMARCA4 ATPase activity inhibitor (IC50... | |||
T0796 | Prilocaine hydrochloride | Prilocaine HCl,Propitocaine hydrochloride,Xylonest | ATPase , Sodium Channel |
Prilocaine hydrochloride (Prilocaine HCl) is a local anesthetic of the amino amide type, binds to voltage-gated sodium ion channels in the neuronal membrane, thereby preventing the permeability of sodium ions. | |||
T7144 | BTS | N-Tosylbenzylamine,N-Benzyl-p-toluenesulfonamide | ATPase , Myosin |
BTS (N-Tosylbenzylamine) is a potent inhibitor of Ca2+-stimulated myosin S1 ATPase (IC50 : 5 μM) . | |||
T2686 | Esomeprazole Magnesium | (S)-Omeprazole magnesium,NEXIUM,(-)-Omeprazole magnesium | ATPase , Proton pump |
Esomeprazole Magnesium (NEXIUM) is the S-isomer of omeprazole, can reduce gastric acid secretion with selective and irreversible proton pump inhibitor activity.Esomeprazole magnesium acts as an exosome inhibitor by block... | |||
T6928 | Pantoprazole | SKF96022,BY1023 | Apoptosis , Proton pump , Autophagy |
Pantoprazole (BY1023) is a proton pump inhibitor used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. | |||
T1651 | Rabeprazole sodium | Dexrabeprazole Sodium,LY307640 sodium,Habeprazole Sodium,Rebeprazole sodium,Aciphex Sodium | Apoptosis , Proton pump |
Rabeprazole sodium (Habeprazole Sodium) is a 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of stomach ulcers and Zollinger-Ellison syndrome. The drug inhibits H(+)-K(+)-exch... | |||
T8386 | Esomeprazole Magnesium trihydrate | (S)-Omeprazole magnesium trihydrate | Proton pump |
Esomeprazole Magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) is a proton pump inhibitor indicated for the short-term treatment of gastroesophageal reflux disease in patients with a history of erosive esophagit... | |||
T0161 | Pantoprazole Sodium Hydrate | SKF96022 sodium hydrate,BY1023 (sodium hydrate),SKF96022 (sodium hydrate) | Apoptosis , Potassium Channel , Proton pump , Autophagy |
Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. | |||
T6929 | Pantoprazole sodium | Pantecta,SKF96022 sodium,SKF96022 (sodium),BY1023 (sodium),BY-1023 sodium,Pantoloc | Apoptosis , Others , Proton pump , HIF , Autophagy |
Pantoprazole sodium (Pantecta) is the sodium salt form of a substituted benzimidazole with proton pump inhibitor activity. Pantoprazole sodium is a lipophilic, weak base that crosses the parietal cell membrane and enters... | |||
T7540 | 2,5-Di-tert-butylhydroquinone | BHQ | Calcium Channel , Lipoxygenase , COX |
2,5-Di-tert-butylhydroquinone (BHQ) is an effective and selective endoplasmic reticulum Ca2+-ATPase inhibitor. | |||
T27812 | Leminoprazole | ATPase | |
Leminoprazole is an orally available H+,K(+)-ATPase inhibitor that protects gastric mucosal cells from various cellular damages. | |||
T22280 | BRITE-338733 | BRITE338733 | ATPase , Antibacterial |
BRITE-338733 is a novel inhibitor of ATPase. BRITE 338733 inhibits the expression of RecA in bacteria with IC50 value of 4.7 μM for the bacterial infections treatment. | |||
T17030 | Tegoprazan | ATPase , Proton pump | |
Tegoprazan is a potassium-competitive acid blocker and is a potent, oral active, and highly selective inhibitor of gastric H+/K+-ATPase. That could control gastric acid secretion and motility (IC50: ranging from 0.29-0.5... | |||
T2404 | Vonoprazan fumarate | TAK-438 | ATPase |
Vonoprazan fumarate (TAK-438) is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase. | |||
T7134 | Mavacamten | MYK-461,SAR439152 | Myosin |
Mavacamten (MYK-461) is an orally bioavailable inhibitor of cardiac myosin ATPase,( IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively) | |||
T21254 | Vonoprazan Fumarate | TAK-438,TAK 438,Vonoprazan Fumurate,TAK438 | Proton pump |
Vonoprazan Fumarate (TAK438) , a novel potassium-competitive acid blocker, inhibits gastric acid secretion. Vonoprazan Fumarate (TAK438) inhibited H+,K+-ATPase activity in porcine gastric microsomes with IC50 value of 19... | |||
T16865 | SCH28080 | ATPase , Proton pump | |
SCH28080 is a reversible and K+-competitive inhibitor of gastric H+/K+-ATPase with an IC50 value of 20 nM (rabbit microsomal membrane).SCH28080 is a potent inhibitor of acid secretion in vivo with anti-ulcer activity, an... | |||
T12503 | (+)-Blebbistatin | Others | |
(+)-Blebbistatin is the inactive enantiomer of (–)-Blebbistatin. (–)-Blebbistatin is a selective myosin II ATPase inhibitor. | |||
T27303 | Farglitazar | GI-262570,GI 262570,GI262570 | |
Farglitazar is a PPAR-γ agonist. GI262570 stimulates the ENaC and Na,K-ATPase system resulting in the increasing of water and sodium reabsorption in distal nephron. | |||
T17313 | (+)-SJ733 | SJ000557733 | ATPase , Parasite |
(+)-SJ733 (SJ000557733) is a potent Na+-ATPase PfATP4 inhibitor with antimalarial activity for the study of malaria. | |||
T14965 | Ciliobrevin D | ATPase , Hedgehog/Smoothened | |
Ciliobrevin D is a AAA+ ATPase motor cytoplasmic dynein inhibitor. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation and it also inhibits dynein-dependent microtubule gliding and ATPase activity ... | |||
T67763 | PK095 | ATPase | |
PK095 is a proprietary compound in the guanidine - based F1F0-ATPase inhibitor family. | |||
T13890 | SMARCA-BD ligand 1 for Protac dihydrochloride | Epigenetic Reader Domain | |
SMARCA-BD ligand 1 for Protac dihydrochloride binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC. | |||
T9553 | 8-[(2,6-dimethylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid | Others | |
8-[(2,6-dimethylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyridine-6-car is a H+/K+ ATPase inhibitor with IC50 of 0.38μM. | |||
T10435 | Linaprazan | AZD0865 | Potassium Channel |
Linaprazan (AZD0865) inhibits gastric H+,K+-ATPase by K+-competitive binding with an IC50 of 1.0 μM. | |||
T7373 | CDN1163 | Calcium Channel | |
CDN1163 is a small molecule activator of sarco/endoplasmic reticulum Ca2+-ATPase (SERCA). | |||
T20436 | DHQ | 2,3-dihydroxy-quinoxalin | ATPase |
DHQ (2,3-dihydroxy-quinoxalin) is an inducer of ATPase activity that of Herpes Simplex Virus thymidine kinase. | |||
T28136 | NC-1300-B | NC1300B,NC 1300 B | ATPase |
NC-1300-B inhibits H(+)-K(+)-ATPase and is used in the study of gastric ulcers. | |||
T60032 | BRM/BRG1 ATP Inhibitor-2 | Epigenetic Reader Domain | |
BRM/BRG1 ATP Inhibitor-2 is an inhibitor of BRG1/BRM ATPase and can be used in studies about the treatment of BAF-related disorders. | |||
T11191 | EN6 | Proton pump , Autophagy | |
EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative ... | |||
T13848 | SMARCA-BD ligand 1 for Protac | Epigenetic Reader Domain | |
SMARCA-BD ligand 1 for Protac is a compound capable of binding to SMARCA2, the BAF ATPase subunit, based on the Protac technology for degrading SMARCA2 |
Cat No. | Product Name | Synonyms | Targets |
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T1719 | Bufalin | ATPase | |
Bufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu; it is also a bufadienolide toxin originally isolated from the venom of the Chinese toad Bufo gargarizans, with potenti... | |||
TJP2872 | Acevaltrate | Acevaltratum,Acetoxyvaltrate | ATPase , Others |
1. Acevaltrate (Acevaltratum) displays high cytotoxicity against GLC(4), a human small-cell lung cancer cell line, and against COLO 320, a human colorectal cancer cell line, with IC50 values of 1-6 uM. | |||
T0295 | Digitoxin | Digitoxoside,Unidigin,Digitoxinum | ATPase , Others |
Digitoxin (Digitoxinum) is an effective Na+/K+-ATPase inhibitor (EC50 value: 0.78 μM). | |||
T5S0890 | Oleandrin | Neriostene,Folinerin,Foliandrin | Apoptosis , ATPase , Potassium Channel , Sodium Channel |
1. Oleandrin (Folinerin), the principal cardiac glycoside component of PBI-524, can quantitatively account for regulation of BDNF at both the protein and transcriptional levels. 2. Oleandrin are known to inhibit the Na, ... | |||
TN5073 | Strophanthidin | Strophanthidine | ATPase , Calcium Channel |
Strophanthidin (Strophanthidine) can induce calcium overload in vivo. | |||
T2922 | Phlorizin | Floridzin,NSC 2833,Phloridzin | ATPase , SGLT |
Phlorizin (Phloridzin) is a non-selective SGLT inhibitor found in apple, for hSGLT1( Ki=300 nM) and hSGLT2( Ki=39 nM) . | |||
T8183 | Deslanoside | Desacetyllanatoside C,Deacetyllanatoside C | ATPase , Drug Metabolite |
Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms. Deslanoside inhibits the Na-K-ATPase membrane p... | |||
T6368 | Abscisic Acid | Abscisin II,Dormin,(+)-ABA,Abscisic Acid (Dormin) | Others , Proton pump , Endogenous Metabolite |
Abscisic Acid (Dormin) is a plant hormone, which is involved in many plant developmental processes, modulates ion homeostasis and metabolism, and inhibits germination and seedling growth. | |||
T2O2668 | Oleic acid | Elaidoic acid,9Z-Octadecenoic acid,Oleate,9-Octadecenoic Acid,Glycon Wo,9-cis-Octadecenoic acid | Apoptosis , ATPase , Others , Endogenous Metabolite |
Oleic acid (Glycon Wo) is a natural product, a common saturated fatty acid found in a variety of animal and vegetable fats and oils. Palmitic acid is a Na+/K+ ATPase activator. | |||
T2822 | Ginsenoside Rb1 | Gypenoside Ⅲ,Gypenoside III | ATPase , Mitophagy , IRAK , NF-κB , Autophagy , HSV |
Ginsenoside Rb1 (Gypenoside Ⅲ) is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors. | |||
T6062 | Brefeldin A | BFA,Ascotoxin,Cyanein,Decumbin | ATPase , Mitophagy , Antibiotic , Autophagy , HSV , CRISPR/Cas9 |
Brefeldin A (Cyanein) belongs to the class of macrolide antibiotics and is an ATPase inhibitor (IC50=0.2 μM). Brefeldin A can induce tumor cell differentiation and apoptosis, and also possesses autophagy inhibitory activ... | |||
TN1103 | Diphyllin | ATPase , Proton pump , Influenza Virus , HIV Protease | |
Diphyllin could be characterized as a new V-ATPase inhibitor in treating gastric cancer and inhibiting the phosphorylation of LRP6 in Wnt/β-catenin signaling. | |||
TN1860 | Licoflavone B | ATPase , Anti-infection , Parasite | |
Licoflavone B has schistosomicidal activity, it showed high S. mansoni ATPase (IC50 of 23.78 μM) and ADPase (IC50 of 31.50 μM) inhibitory activities. | |||
T15027 | Cyclopiazonic acid | Calcium Channel | |
Cyclopiazonic acid (CPA) is a neurotoxic secondary metabolite (SM) made by A. flavus. Cyclopiazonic acid (CPA) is an endoplasmic reticulum calcium ATPase (Ca2+ATPase; SERCA)nanomolar inhibitor and a potent inducer of ce... | |||
TQ0184 | Chebulinic acid | ATPase , Proton pump , DNA/RNA Synthesis , Antibacterial , TGF-beta/Smad | |
Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity. | |||
T3432 | Cinobufagin | Cinobufagine | Apoptosis , ATPase , Autophagy |
Cinobufagin (Cinobufagine) is a selective Na+/K+-ATPase inhibitor. The activity of Cinobufagin is same as ouabain. | |||
T6323 | Oligomycin A | MCH 32 | ATPase , Antibiotic , Antifungal |
Oligomycin A (MCH 32) is an inhibitor of ATP synthase, inhibits oxidative phosphorylation and all the ATP-dependent processes occurring on the coupling membrane of mitochondria. | |||
T0974 | Novobiocin Sodium | Albamycinsodium,Cathomycin,Albamycin | Potassium Channel , DNA gyrase , Topoisomerase , Antibacterial , Antibiotic , ABC , Autophagy |
Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure sim... | |||
T6740 | Bafilomycin A1 | Apoptosis , Proton pump , Antibacterial , Antibiotic , Autophagy | |
Bafilomycin A1 belongs to the macrolide class of antibiotics and is a V-ATPase (IC50=0.44 nM) that is specific and reversible. Bafilomycin A1 is an inhibitor of the late phase of autophagy, blocking the fusion of autopha... | |||
T3926 | Echinatin | Retrochalcone | Free radical scavengers |
Echinatin (Retrochalcone) disturb the mitochondrial energy transfer reactions and membrane permeability, at a low concentration cause deterioration of respiratory control and oxidative phosphorylation of isolated rat liv... | |||
T36390 | Sodium oleate | Oleic acid sodium salt,Sodium oleate,cis-9-Octadecenoic acid sodium salt | ATPase |
Sodium oleate (cis-9-Octadecenoic acid sodium salt) (Oleic acid sodium) is an abundant monounsaturated fatty acid sodium. Sodium oleate is a Na+/K+ ATPase activator. | |||
T3868 | Agnuside | chasteberry oil | COX , Prostaglandin Receptor , P-gp |
Agnuside (chasteberry oil) inhibits COX-2 (IC50: 0.026 mg/ml) but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3, 66.8, and 82.1% of P-glycoprotein (P-gp) ATPase activity at conce... | |||
T4897 | Inosine-5'-triphosphate trisodium salt | ITP,Inosine 5'-triphosphate trisodium salt | Others , Endogenous Metabolite |
Inosine-5'-triphosphate trisodium salt (ITP) is used in studies on the impact of deamination of ATP and GTP by various enzymes and chemical processes. Inosine-5'-triphosphate trisodium salt (ITP) may be used as a substra... | |||
TQ0302 | Thapsigargin | Apoptosis , SARS-CoV , Calcium Channel | |
Thapsigargin is a natural product, an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) and an endoplasmic reticulum stress inducer. Thapsigargin increases cytoplasmic calcium concentration by blocking ... | |||
T10662L | Calcimycin | Antibiotic A-23187,A-23187 | Apoptosis , Antibacterial , Antibiotic , Autophagy , Antifungal |
Calcimycin (A-23187) is an ionophorous, polyether carboxylic antibiotic from Streptomyces chartreusensis. It binds and transports calcium and other divalent cations across membranes and uncouples oxidative phosphorylatio... | |||
T4973 | Paraxanthine | 1,7-DIMETHYLXANTHINE | Endogenous Metabolite |
Paraxanthine (1,7-dimethylxanthine) is a metabolite of caffeine (sc-202514) which functions as an adenosine receptor ligand and a PARP-1 inhibitor in pulmonary epithelial cells. Studies suggest that Paraxanthine is struc... | |||
T5079 | Adenosine 5'-diphosphate sodium salt | Adenosine-5'-diphosphate trisodium salt,ADP sodium salt | Others , Endogenous Metabolite |
Adenosine 5'-diphosphate sodium salt (ADP sodium salt) is an adenine nucleotide that is phosphorylated into ATP by ATPase. This phosphorylation is a key part of cellular homeostatis as it allows for energy storage and is... | |||
T5075 | Phytic acid potassium | Inositol hexakisphosphate dipotassium salt,Phytic acid dipotassium salt,Fytic Acid dipotassium salt,Inositol polyphosphate dipotassium salt | Others , Endogenous Metabolite |
Phytic acid potassium (Inositol polyphosphate dipotassium salt) exists in all eukaryotic cells. In plants, it is known to function as a [PO4]3 storage depot and precursor for other inositol phosphates and pyrophosphates.... | |||
T6S1049 | Wilforine | ATPase | |
Wilforine is a sesquiterpene pyridine alkaloid; important bioactive compound in T. wilfordii plants, and is effective in treating idiopathic pulmonary fibrosis. Wilforine has anti-inflammatory effect, which might be medi... | |||
T7190 | Actein | Apoptosis , Akt , JNK , Autophagy | |
Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblasts in osteoporotic patients. Actein's ability to pathways in... | |||
T5S1982 | Periplocin | Periplocoside | Apoptosis , Others |
1. Periplocin (Periplocoside) has anti-cancer effects on lung cancer cells, induces apoptosis and inhibits growth of cancer cells by the beta-catenin/Tcf signaling pathway. 2. Periplocin is used for treatment of rheumato... | |||
T13618 | Citreoviridin | Others | |
Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na+/K+-ATPase whereas, in microsomes, both Na+/K+-ATPase and Mg2+-ATPase activities are significantly stimulated in a dose-depen... | |||
T14995 | Concanamycin A | X 4357B,Antibiotic X 4357B,Concanamycin | Others |
Concanamycin A is a macrolide antibiotic. It also is a specific inhibitor of vacuolar-type H+-ATPase (V-ATPase). | |||
T38609 | Mycalolide B | ||
Mycalolide-B is a marine sponge-derived compound that functions as a selective inhibitor of actomyosin ATPase. It effectively hinders ATP-induced contraction and Mg2+-ATPase activity in the absence of Ca2+. | |||
TN6631 | Chamigrenol | ||
Chamigrenol is a promising candidate for the development of potent Na+/K+ ATPase inhibitors and antimicrobial agents. It inhibited the activities of Na+/K+-ATPase, with the IC50 value of 15.9 ± 0.54 μg/mL. | |||
T10455 | Bafilomycin B1 | Others | |
Bafilomycin B1, a macrolide antibiotic isolated from Streptomyces sp, acts as an inhibitor of K+-dependent ATPase of E. coli. It also inhibits Gram-positive bacteria and fungi. | |||
T25211 | CC 1014 | CC1014,CC-1014,NSC-356885,NSC356885,NSC 356885 | |
CC 1014 is a polypeptide antibiotic isolated from Penicillium lilacinum that inhibits phosphorylation of ADP, Mg ATPase. | |||
TN4697 | Odoroside H | ATPase , Potassium Channel , Sodium Channel | |
Odoroside H has anticancer activities, the cytotoxic effects are induced by the inhibition of the plasma membrane bound Na(+)/K(+)-ATPase. | |||
T16719 | Radicicol | Monorden | HSP |
Radicicol is an antifungal antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB. Radicicol is an inhibitor of Hsp90 (IC50: 1 μM). Radicicol binds to the ATPase domain of Hsp90 and pr... | |||
TN5141 | Thevetin B | ATPase , Potassium Channel , Sodium Channel | |
Thevetin B is a cardiac glycoside and an inhibitor of Na+-, K+-dependent adenosinetriphosphatase (Na+,K+-ATPase) from Thevetia peruviana. | |||
T35605 | Apoptolidin | ||
Apoptolidin is an apoptosis inducer originally isolated from Nocardiopsis bacteria. It inhibits the mitochondrial F1FO ATPase (Ki = 4-5 μM). Apoptolidin selectively kills transformed glial cells without significantly aff... | |||
TN5060 | Stauntosaponin A | ATPase , Potassium Channel , Sodium Channel | |
Stauntosaponin A and stauntosaponin B show moderate inhibitory activities against Na+/K+-ATPase with IC50 values of 21 and 29 uM, respectively. | |||
T14293 | Annonacin | Others | |
Annonacin is an Acetogenin and promotes cytotoxicity via a pathway inhibiting the mitochondrial complex and it is the active agent found in Graviola leaf extract to act as an inhibitor of sodium/potassium (NKA) and sarco... | |||
T23610 | Acerinol | ||
Acerinol is an active ingredient from traditional Chinese medicinal herbs. It could be used as a cancer multidrug resistance reversal agent. Acerinol can significantly stimulate the activity of ABCB1 ATPase without affec... | |||
TN2306 | Wilfordine | ATPase , Potassium Channel , Sodium Channel | |
Wilfordine is an insecticidally active alkaloid, Na+-K+-ATPase may be an acting target of wilfordine against some larvae of insect. | |||
TN3914 | Echinatine | ATPase , IL Receptor , TNF | |
Echinatin exerts a protective effect against ischemia/reperfusion (I/R)-induced myocardial injury on hearts, this effect may be attributed to the antioxidant and anti-inflammatory activities of this compound. Echinatin c... | |||
T27977 | Manzamine A | Keramamine A | |
Manzamine A is a GSK-3 inhibitor and vacuolar ATPase uncoupler found in marine sponges. It inhibits autophagy and tumor growth in cancer models, suppresses foam cell formation in macrophages, prevents growth of gram nega... | |||
TN3075 | 5,2',6'-Trihydroxy-6,7,8-trimethoxyflavone | ATPase | |
5,2',6'-Trihydroxy-6,7,8-trimethoxyflavone (ED 50 =4.5 ug/ml ) shows cytotoxicity against L1210 cell and has inhibiting effects on ATPase from the cell. | |||
T38069 | Aquastatin A | ||
Aquastatin A is a fungal metabolite originally isolated fromF. aquaeductuumthat has diverse biological activities.1It is active againstS. aureus(MIC = 32 μg/ml) and inhibits enoyl-acyl carrier protein reductase (Fabl; IC... | |||
T72645 | Norbatzelladine L | ||
Norbatzelladine L, an inhibitor of both the catalytic and functional activities of the Pdr5p transporter, suppresses Pdr5p ATPase activity with an IC50 of 3.8 µM. Additionally, it exhibits antifungal, antiparasitic, anti... | |||
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Cat No. | Product Name | Species | Expression System |
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TMPH-00226 | ATPase subunit g Protein, Bovine, Recombinant (His & Myc) | Bovine | E. coli |
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respirator... | |||
TMPJ-01013 | VCP Protein, Human, Recombinant (His) | Human | E. coli |
Valosin-Containing Protein (VCP) is a nuclear protein that belongs to the AAA ATPase family. VCP is a putative ATP-binding protein involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxi... | |||
TMPH-01892 | ATP4A Protein, Human, Recombinant (His & Myc) | Human | E. coli |
The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Uses ATP as an energy source to pump H(+) ions to the gastric ... | |||
TMPY-06599 | ATP1B4 Protein, Human, Recombinant (His) | Human | E. coli |
ATP1B4 is a member of the X(+)/potassium ATPases subunit beta family. It is highly expressed in skeletal muscle and at a lower level in heart. ATP1B4 gene can be found in all vertebrate genomes sequenced to date. However... | |||
TMPY-03788 | ATP1B1 Protein, Human, Recombinant (His) | Human | HEK293 |
ATP1B1 belongs to the family of Na+/K+and H+/K+-ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. ATP1B1 is a subunit of Na+/K+-ATPase. Na+/K+-ATPase is an integral membrane protein responsible for es... | |||
TMPY-04927 | ATP1B2 Protein, Human, Recombinant (His) | Human | HEK293 |
TMPH-02059 | ATP2A2 Protein, Human, Recombinant (His) | Human | E. coli |
ATP2A2 Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPH-01893 | ATP4B Protein, Human, Recombinant (GST) | Human | E. coli |
The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane... | |||
TMPH-01894 | ATP4B Protein, Human, Recombinant | Human | E. coli |
The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane... | |||
TMPH-02310 | ATP6V0D1 Protein, Human, Recombinant (GST) | Human | E. coli |
Subunit of the integral membrane V0 complex of the lysosomal proton-transporting V-type ATPase (v-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providin... | |||
TMPY-04137 | ATP6V1F Protein, Human, Recombinant (GST) | Human | E. coli |
ATP6V1F encodes a component of vacuolar ATPase mediating acidification. The cDNA and the genomic sequences of ATP6V1F were cloned successfully for the first time from the Giant Panda (Ailuropoda melanoleuca) using revers... | |||
TMPJ-00703 | Gankyrin Protein, Human, Recombinant | Human | E. coli |
Gankyrin is a multicatalytic proteinase oncoprotein consists of 7 ankyrin repeats. Gankyrin overexpressed in most hepatocellular carcinomas. Gankyrin is involved in theregulation of the phosphorylation of the retinoblast... | |||
TMPH-00786 | BtuD Protein, Halobacterium salinarum, Recombinant (His) | Halobacterium salinarum | E. coli |
Required for corrinoid utilization. Probably part of the ABC transporter complex BtuCDF involved in cobalamin (vitamin B12) import. Probably responsible for energy coupling to the transport system. | |||
TMPH-00787 | BtuD Protein, Halobacterium salinarum, Recombinant | Halobacterium salinarum | E. coli |
Required for corrinoid utilization. Probably part of the ABC transporter complex BtuCDF involved in cobalamin (vitamin B12) import. Probably responsible for energy coupling to the transport system. | |||
TMPH-00887 | AHSA1 Protein, Human, Recombinant (GST) | Human | E. coli |
Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a re... | |||
TMPY-03263 | RUVBL1 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
RUVBL1, also known as RVB1, is a component of the NuA4 histone acetyltransferase complex and belongs to the RuvB family. RUVBL1 is ubiquitously expressed with high expression in heart, skeletal muscle and testis. It poss... | |||
TMPH-00968 | ATP5C1 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
ATP5C1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli. | |||
TMPJ-01179 | SWSAP1 Protein, Human, Recombinant (His) | Human | E. coli |
SWSAP1 is a nucleus ATPase protein, interacts with ZSWIM7 and forms a functional complex. The complexs involved in homologous recombination repair and stabilizes each other. SWS1AP1 also interacts with RAD51, RAD51B, RAD... | |||
TMPH-01711 | ABCC1 Protein, Human, Recombinant (His) | Human | E. coli |
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs a... | |||
TMPH-03284 | CD39 Protein, Rat, Recombinant (E. coli, His) | Rat | E. coli |
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP.... | |||
TMPH-03283 | CD39 Protein, Rat, Recombinant (His) | Rat | Baculovirus |
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP.... | |||
TMPY-00541 | LON PROTEASE Protein, E. coli, Recombinant (His) | E. coli | E. coli |
Lon protease, an ATP-dependent mitochondrial protease, is important in mitochondrial protein maintenance. Lon protease is a multifunctional enzyme, and its functions include the degradation of damaged proteins and natura... | |||
TMPY-02443 | HSP70 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
HSPA1A is a member of the Hsp70 protein family. The 70 kilodalton heat shock proteins (Hsp70s) are a family of ubiquitously expressed heat shock proteins. HSP are abundant and conserved proteins present in all cells. Upo... | |||
TMPH-00594 | HtpG Protein, E. coli, Recombinant (His) | E. coli | E. coli |
Molecular chaperone. Has ATPase activity. | |||
TMPH-00595 | HtpG Protein, E. coli, Recombinant | E. coli | E. coli |
Molecular chaperone. Has ATPase activity. | |||
TMPH-02956 | TNNI1 Protein, Mouse, Recombinant (Flag & His & Myc) | Mouse | E. coli |
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | |||
TMPH-01024 | Calbindin Protein, Human, Recombinant (His) | Human | Yeast |
Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. | |||
TMPH-01358 | FXYD3 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus... | |||
TMPH-00307 | TnTf Protein, Bovine, Recombinant (His & Myc) | Bovine | E. coli |
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | |||
TMPH-02954 | TNNI3 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | |||
TMPH-02955 | TNNI2 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. | |||
TMPJ-00717 | BAG2 Protein, Human, Recombinant (His) | Human | E. coli |
BAG Family Molecular Chaperone Regulator 2 (BAG2) is a member of the Bag family whose members compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. BAG2 contains 1 BAG domain and is... | |||
TMPY-03612 | PSME1 Protein, Human, Recombinant (His) | Human | E. coli |
PA28A, also known as PSME1, is a subunit of proteasome. The 26S proteasome multicatalytic proteinase complex has a highly ordered structure composed of 2 complexes, a 2S core and a 19S regulator. The 2S core is composed ... | |||
TMPJ-00915 | HSP40 Protein, Human, Recombinant (His) | Human | E. coli |
DnaJ Homolog Subfamily B Member 1 (DNAJB1) is a member of the heat shock protein family. Heat shock proteins (HSPs) are a highly conserved family of stress response proteins. HSPs function primarily as molecular chaperon... | |||
TMPH-01730 | MYBPC3 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATP... | |||
TMPH-01240 | MCM2 Protein, Human, Recombinant (His) | Human | E. coli |
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites ... | |||
TMPH-01032 | Calponin-2/CNN2 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inh... | |||
TMPH-00741 | Rho Protein, E. coli, Recombinant (His) | E. coli | E. coli |
Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template. RNA-dependent NTPase wh... | |||
TMPY-03614 | PSME3 Protein, Human, Recombinant (His) | Human | E. coli |
PSME3, also known as PA28-gamma, is a subunit of proteasome. The 26S proteasome multicatalytic proteinase complex has a highly ordered structure composed of 2 complexes, a 2S core and a 19S regulator. The 2S core is comp... | |||
TMPH-00583 | Rep Protein, E. coli, Recombinant (GST) | E. coli | E. coli |
Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in t... | |||
TMPH-02133 | DDX39B Protein, Human, Recombinant (GST) | Human | E. coli |
Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mR... | |||
TMPY-03610 | PSME2 Protein, Human, Recombinant (His) | Human | E. coli |
PSME2, also known as PA28b, is a subunit of proteasome. The 26S proteasome multicatalytic proteinase complex has a highly ordered structure composed of 2 complexes, a 2S core and a 19S regulator. The 2S core is composed ... | |||
TMPH-01731 | MYBPC2 Protein, Human, Recombinant (His) | Human | E. coli |
Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATP... | |||
TMPH-00611 | DNA helicase II Protein, E. coli, Recombinant | E. coli | E. coli |
A helicase with DNA-dependent ATPase activity. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand. Initiates unwinding more efficiently from a nicked substrate than ds duplex DNA. Involved in th... | |||
TMPH-00612 | MutL Protein, E. coli, Recombinant (His) | E. coli | E. coli |
This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable co... | |||
TMPJ-00965 | TIM16 Protein, S. cerevisiae, Recombinant | S. cerevisiae | E. coli |
Mitochondrial import inner membrane translocase subunit TIM16 (TIM16) is an ssential component of the PAM complex. PAM complex is required for the translocation of transit peptide-containing proteins from the inner membr... | |||
TMPH-00637 | RuvA Protein, E. coli, Recombinant (His & SUMO) | E. coli | E. coli |
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a he... | |||
TMPY-03461 | GABARAPL2 Protein, Human, Recombinant (His) | Human | E. coli |
GATE-16, also known as ATG8, belongs to the MAP1 LC3 family. It is expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. GATE-16 is expressed at very low levels in lung, thymus and... | |||
TMPH-01049 | Cardiac phospholamban/PLN Protein, Human, Recombinant (GST) | Human | Yeast |
Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stim... | |||
TMPH-00745 | TsaE Protein, E. coli, Recombinant | E. coli | E. coli |
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of thre... | |||
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