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Search Results for " antifolate "

Targets

40

Compounds

4

Natural Products

1

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T26636 Antifolate C2 AGF 154,AGF154,AGF-154 Others
Antifolate C2 (AGF 154) has antitumor activity with an IC of 0.14 nM measured in a growth inhibition assay of human tumor cells.Antifolate C2 can be used for the study of cancer and autoimmune diseases.
T26635 Antifolate C1 AGF 94,AGF94,AGF-94
Antifolate C1 is an inhibitor of de novo purine biosynthesis. Antifolate C1 has selectivity for cellular uptake by high affinity folate receptors and the proton-coupled folate transporter (PCFT) over the reduced folate c...
T36692 Fanotaprim DHFR
Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor. Fanotaprim inhibits the growth of T. gondii strains with a TgDHFR IC50 of 1.57 ± 0.11 nM and a hDHFR IC50 of 308 ± 71 nM and a hDHFR to TgDHFR selectivity ratio o...
T16045 Methotrexate metabolite DAMPA Antifolate , Drug Metabolite
Methotrexate metabolite (DAMPA) (DAMPA) is the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist. Methotrexate is used as a chemotherapeutic agent and immunosuppressant.
T8548 Metoprine Histone Methyltransferase , Antifolate , Histamine Receptor
Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity.
T7593 Levomefolate calcium Antifolate
Levomefolate calcium is an artificial form of folate. It is a coenzymated form of folic acid and a more bioavailable alternative in dietary supplements.
T8003 Methotrexate disodium Apoptosis , Dehydrogenase , DNA/RNA Synthesis , Antifolate
Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor
T0849 Pyrimethamine Pirimecidan,RP 4753,Pirimetamin DHFR , Antifolate , Parasite
Pyrimethamine (Pirimecidan) is a competitive inhibitor of dihydrofolate reductase (DHFR), used as an antimalarial drug.
T4382 Proguanil hydrochloride Paludrine hydrochloride,Chlorguanide hydrochloride,Chloroquanil Others , Dehydrogenase , DNA/RNA Synthesis , Antifolate , Parasite
Proguanil hydrochloride (Chloroquanil) is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, Proguanil hydrochloride is converted to its active cyclic triazine ...
T3693 DHFR-IN-3 7-bromoquinazoline-2,4-diamine Others
DHFR-IN-3 (7-bromoquinazoline-2,4-diamine) is an active biochemical.
T0189L Pemetrexed disodium LY-231514,LY231514 disodium,Pemetrexed Apoptosis , DHFR , DNA/RNA Synthesis , Antifolate , Autophagy
Pemetrexed disodium (LY-231514) is a parenterally administered folate antagonist and antineoplastic agent, used in the treatment of non-small cell lung cancer and malignant mesothelioma. Pemetrexed disodium therapy has b...
T2204 Diaveridine EGIS-5645,CCRIS-3784,AI3-23935 DHFR , Antifolate , Antibacterial
Diaveridine (AI3-23935) (DVD) is a popular antibacterial synergist that is widely used in combination with sulfonamide. It has been reported to be genotoxic to mammalian cells, but more studies are required to clarify th...
T0189 Pemetrexed Pemetrexed acid,LY231514,LY-231514 Disodium Hydrate DHFR , DNA/RNA Synthesis , Antifolate , Autophagy
Pemetrexed (LY-231514 Disodium Hydrate), a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).
T7598 Calcium N5-methyltetrahydrofolate NSC173328 Others , Antifolate
Calcium N5-methyltetrahydrofolate (NSC-173328) is the calcium salt of levomefolic acid, which has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers
T6120 Pralatrexate Folotyn,10-Propargyl-10-deazaaminopterin Apoptosis , DHFR , Antifolate , TAM Receptor
Pralatrexate (10-Propargyl-10-deazaaminopterin) is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive act...
T17257 WR99210 DHFR , Antifolate , Antibacterial
WR99210 is a potent, orally available and less toxic dihydrofolate reductase (DHFR) inhibitor (IC50<0.075 nM). WR99210 has good antiparasitic activity against P. vivax and P. falciparum strains (including P. falciparum s...
T0148L Folinic Acid Calcium Salt Pentahydrate Folinic acid,Leucovorin Calcium Pentahydrate,Leucovorin calcium salt pentahydrate Others , Antifolate
Folinic Acid Calcium Salt Pentahydrate (Leucovorin Calcium Pentahydrate), a reduced folic acid, is used in combination with other chemotherapeutics.
T1485 Methotrexate NCI-C04671,WR19039,Amethopterin,CL14377 Apoptosis , Dehydrogenase , DNA/RNA Synthesis , Antifolate
Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive activities, and is commonly used in rheumatoid arthritis and v...
T6226 Pemetrexed disodium hemipenta hydrate Pemetrexed Disodium Hydrate,LY-231514 Disodium Hydrate,Pemetrexed sodium hydrate Apoptosis , DHFR , DNA/RNA Synthesis , Antifolate , Autophagy
Pemetrexed disodium hemipenta hydrate (LY-231514 Disodium Hydrate) is a new-type antifolate and antimetabolite for TS, DHFR, and GARFT. The Ki of Pemetrexed Disodium Hydrate for TS, DHFR and GARFT is 1.3 nM, 7.2 nM and 6...
T15826 Lometrexol LY 264618,DDATHF DHFR
Lometrexol (LY 264618), an antipurine Antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol can further inhibit ...
T64295 Talotrexin ammonium DHFR
Talotrexin ammonium is a non-polyglutamic acid antifolate. Talotrexin ammonium inhibits tumor growth by targeting dihydrofolate reductase (DHFR), thereby improving anti-tumor activity in a wide range of cancer models, he...
T26654 Arfolitixorin
Arfolitixorin is an antifolate modulator.
T28326 PD 130883 PD-130883,PD130883
PD 130883 is a potent lipophilic quinazoline antifolate.
T25519 ICI 198583 CB 3819,ICI198583,ICI-198583
ICI 198583 is an inhibitor of antifolate thymidylate synthase.
T26283 TNP-351 Tnp 351
Tnp 351 is a novel antifolate drug being assessed for chemotherapy of lung cancer.
T24966 11-Oxahomoaminopterin NSC-325304,NSC 325304,NSC325304
11-Oxahomoaminopterin exhibits antifolate activity against two folate-requiring microorganisms and inhibited Lactobacillus casei DHFR.
T11922 LY 254155 Others
LY 254155, an antifolate,binds to mFBP and inhibits hGARFT with Kis of 1.7±0.1 and 2.1±0.2 nM, respectively.
T25296 DDCPPB-Glu
DDCPPB-Glu is a 6-5 fused ring heterocycle antifolate that shows antitumor activity.
T74009 1,1,3-Tribromoacetone
1,1,3-Tribromoacetone is an impurity of Methotrexate [1] . Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase , thereby preventing the conversion of folic acid into tetrahy...
T74111 N-Methyl pemetrexed
N-Methyl pemetrexed is an impurity of Pemetrexed. Pemetrexed is an antifolate cytotoxic agent that can be used for the research of cancer [1] .
T11884 LSN 3213128 Others
LSN 3213128, anti-tumor activity. is a selective, nonclassical, orally bioavailable antifolate with potent and specific inhibitory activity for aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT), wi...
T73085 Talotrexin PT523
Talotrexin (PT523), an analog of Aminopterin , is a nonpolyglutamatable classic antifolate . Talotrexin is a RFC (reduced folate carrier) specific inhibitor and selectively inhibits RFC transport. Talotrexin shows antitu...
T60726 OYYF-175
OYYF-175 is an antimicrobial antifolate. OYYF-175 exhibits potent broad-spectrum antibacterial activities, especially against multi-drug resistant Gram-Negative-strains. OYYF-175 is an inhibitor of dihydrofolate reductas...
T41148 Phototrexate
Phototrexate is a photoswitchable potent inhibitor of human dihydrofolate reductase (DHFR). Phototrexate is a photochromic analog of Methotrexate. Antifolate activity is switched on (cis-Phototrexate) by UVA (375 nm) lig...
T41297 Lometrexol hydrate
Lometrexol hydrate (DDATHF hydrate) is an antipurine antifolate which inhibits the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol hyd...
T70304 CI-898 HCl
CI-898 HCl is a lipophilic antifolate inhibitor of dihydrofolate reductase (DHFR). It has enhanced binding to DHFR in the presence of the cofactor NADPH. Cl-898 HCl inhibits cell growth and halts the cell cycle at the G1...
T63240 Lometrexol disodium
Lometrexol (DDATHF) disodium is a potent inhibitor of human serine hydroxymethyltransferase 1/2 (hSHMT1/2) and antifolate, which reduces the activity of glycinamide ribonucleotide formyltransferase (GARFT) without causin...
T79192 DQn-1
DQn-1, a potent antifolate, demonstrates efficacy against Mycobacterium tuberculosis (Mtb) with an MIC 90 of 0.03 µM. It inhibits the DHFR enzyme, exhibiting IC 50 values of 8.7 nM for Mtb DHFR and 7.6 nM for the human c...
T68661 Edatrexate CGP 30694
Edatrexate (CGP 30694), as known as 10-Ethyl-10-deazaaminopterin, is Methotrexate analog, exhibits antitumor activity against MTX-resistant tumors. Edatrexate is an antifolate antimetabolite, can be used for reasearch o...
T79633 Antileishmanial agent-22 Parasite
Antileishmanial agent-22 (compound 15b) serves as an antiparasitic and antibacterial, exhibiting activities against Leishmania (IC50 = 0.408 μM), malaria, and tuberculosis. It operates on an antifolate mechanism, suppres...

Compounds

Antifolate C2
T26636
Synonym: AGF 154,AGF154,AGF-154
Target: Others
Antifolate C1
T26635
Synonym: AGF 94,AGF94,AGF-94
Target:
Fanotaprim
T36692
Synonym:
Target: DHFR
Methotrexate metabolite
T16045
Synonym: DAMPA
Target: Antifolate, Drug Metabolite
Metoprine
T8548
Synonym:
Target: Histone Methyltransferase, Antifolate, Histamine Receptor
Levomefolate calcium
T7593
Synonym:
Target: Antifolate
Methotrexate disodium
T8003
Synonym:
Target: Apoptosis, Dehydrogenase, DNA/RNA Synthesis, Antifolate
Pyrimethamine
T0849
Synonym: Pirimecidan,RP 4753,Pirimetamin
Target: DHFR, Antifolate, Parasite
Proguanil hydrochloride
T4382
Synonym: Paludrine hydrochloride,Chlorguanide hydrochloride,Chloroquanil
Target: Others, Dehydrogenase, DNA/RNA Synthesis, Antifolate, Parasite
DHFR-IN-3
T3693
Synonym: 7-bromoquinazoline-2,4-diamine
Target: Others
Pemetrexed disodium
T0189L
Synonym: LY-231514,LY231514 disodium,Pemetrexed
Target: Apoptosis, DHFR, DNA/RNA Synthesis, Antifolate, Autophagy
Diaveridine
T2204
Synonym: EGIS-5645,CCRIS-3784,AI3-23935
Target: DHFR, Antifolate, Antibacterial
Pemetrexed
T0189
Synonym: Pemetrexed acid,LY231514,LY-231514 Disodium Hydrate
Target: DHFR, DNA/RNA Synthesis, Antifolate, Autophagy
Calcium N5-methyltetrahydrofolate
T7598
Synonym: NSC173328
Target: Others, Antifolate
Pralatrexate
T6120
Synonym: Folotyn,10-Propargyl-10-deazaaminopterin
Target: Apoptosis, DHFR, Antifolate, TAM Receptor
WR99210
T17257
Synonym:
Target: DHFR, Antifolate, Antibacterial
Folinic Acid Calcium Salt Pentahydrate
T0148L
Synonym: Folinic acid,Leucovorin Calcium Pentahydrate,Leucovorin calcium salt pentahydrate
Target: Others, Antifolate
Methotrexate
T1485
Synonym: NCI-C04671,WR19039,Amethopterin,CL14377
Target: Apoptosis, Dehydrogenase, DNA/RNA Synthesis, Antifolate
Pemetrexed disodium hemipenta hydrate
T6226
Synonym: Pemetrexed Disodium Hydrate,LY-231514 Disodium Hydrate,Pemetrexed sodium hydrate
Target: Apoptosis, DHFR, DNA/RNA Synthesis, Antifolate, Autophagy
Lometrexol
T15826
Synonym: LY 264618,DDATHF
Target: DHFR
Talotrexin ammonium
T64295
Synonym:
Target: DHFR
Arfolitixorin
T26654
Synonym:
Target:
PD 130883
T28326
Synonym: PD-130883,PD130883
Target:
ICI 198583
T25519
Synonym: CB 3819,ICI198583,ICI-198583
Target:
TNP-351
T26283
Synonym: Tnp 351
Target:
11-Oxahomoaminopterin
T24966
Synonym: NSC-325304,NSC 325304,NSC325304
Target:
LY 254155
T11922
Synonym:
Target: Others
DDCPPB-Glu
T25296
Synonym:
Target:
1,1,3-Tribromoacetone
T74009
Synonym:
Target:
N-Methyl pemetrexed
T74111
Synonym:
Target:
LSN 3213128
T11884
Synonym:
Target: Others
Talotrexin
T73085
Synonym: PT523
Target:
OYYF-175
T60726
Synonym:
Target:
Phototrexate
T41148
Synonym:
Target:
Lometrexol hydrate
T41297
Synonym:
Target:
CI-898 HCl
T70304
Synonym:
Target:
Lometrexol disodium
T63240
Synonym:
Target:
DQn-1
T79192
Synonym:
Target:
Edatrexate
T68661
Synonym: CGP 30694
Target:
Antileishmanial agent-22
T79633
Synonym:
Target: Parasite
Cat No. Product Name Synonyms Targets
T7730 Aminopterin APGA,4-Aminofolic acid Antifolate
Aminopterin (4-Aminofolic acid) is a synthetic folic acid derivative whose metabolite is a competitive inhibitor of dihydrofolate reductase
T6431 Levoleucovorin Calcium Calcium Levofolinate,CL307782 Others , Antifolate
Levoleucovorin Calcium (CL307782), a calcium salt of the folinic acid, is used in cancer chemotherapy as an adjuvant.
T0148 Folinic acid calcium Wellcovorin,Calcium folinate,Leucovorin Calcium,Folinic acid calcium salt DNA/RNA Synthesis , Endogenous Metabolite , Antifolate
Folinic acid calcium (Leucovorin Calcium) is the active metabolite of folic acid. Leucovorin is used principally as an antidote to folic acid antagonists.
T1153 Trimethoprim NIH 204,BW 56-72,NSC-106568 DHFR , DNA/RNA Synthesis , Antifolate , Antibacterial , Antibiotic
Trimethoprim (NSC-106568) is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytochrome P450 2C8 Inhibitor, and Organic Cation Tra...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-05055 GGH/Glutamyl hydrolase gamma Protein, Human, Recombinant (His) Human HEK293
gamma-Glutamyl hydrolase (GGH) regulates intracellular folates and antifolates such as methotrexate (MTX) for proper nucleotide biosynthesis and antifolate-induced cytotoxicity, respectively. GGH is a ubiquitously-expres...
TargetMol