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Search Results for " c2c12 "

Targets

19

Compounds

2

Natural Products

1

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T9031 MCU-i4 Others , Mitochondrial Metabolism
MCU-i4 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth.
T1889 CP-640186 CP 640186 Acetyl-CoA Carboxylase
CP-640186 is an isozyme-nonselective Acetyl-CoA carboxylase (ACCase) inhibitor. The IC50s of CP-640186(CP 640186) is 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively.
T3622 CP-640186 hydrochloride CP 640186 HCl Acetyl-CoA Carboxylase
CP-640186 hydrochloride (CP 640186 HCl) is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor, including rat liver ACC1 (IC50: 53 nM) and rat skeletal muscle ACC2 (IC50: 61 nM); with higher metabolic stabilit...
T11048L DIPQUO hydrochloride DIPQUO hydrochloride(1269365-82-3 Free base) Phosphorylase
DIPQUO hydrochloride is an activator of the bone marker alkaline phosphatase (ALP), with an EC50 of 6.27 μM in C2C12 cells. DIPQUO hydrochloride promotes mouse and human osteoblast differentiation via activation of p38 M...
T35348 LDN-193189 2HCl LDN-193189 2HCl,DM-3189 2HCl ALK , TGF-beta/Smad
LDN-193189 2HCl (DM-3189 2HCl) is a selective BMP signaling inhibitor that inhibits ALK1,ALK2,ALK3 and ALK6, showing IC50s of 0.8 nM, 0.8 nM, 5.3 nM, and 16.7 nM, respectively, in kinase assays.LDN-193189 2HCl inhibited ...
T77697 BML-278 BML278,BML 278 Sirtuin , Histone Methyltransferase
BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, and can be used to improve early embryonic development.BML-278 ind...
T60127 Chlorantraniliprole Rynaxypyr,Chlorantranilipole,Rynaxpyr Others
Chlorantraniliprole (Rynaxypyr) is an insecticide. Chlorantraniliprole potently and selectively activates insect ryanodine receptor, with EC50s of 40 nM and 50 nM for Drosophila melanogaster and H. virescens ryanodine re...
T23351 Shz 1 Others
induces phenotypic differentiation
TP1895L1 KYL acetate(676657-00-4 free base) Ephrin Receptor
KYL acetate is a EphA4 receptor tyrosine kinase inhibitor (Kd = 0.8 μM). KYL inhibits EphA4-EphrinA5 interactions (IC50 = 6.34 μM).
T1935 LDN193189 LDN-193189,DM-3189,LDN 193189 ALK , TGF-beta/Smad
LDN193189 (LDN-193189) (DM 3189) is a selective BMP signaling inhibitor, inhibiting the transcriptional activity of ALK2 and ALK3 (IC50s: 0.8/0.8/5.3/16.7 nM for ALK1/2/3/6).
T11048 DIPQUO Others
DIPQUO is an activator of bone marker alkaline phosphatase (ALP). DIPQUO promotes the differentiation of mouse and human osteoblasts by activating p38MAPK-β. The EC50 in C2C12 cells was 6.27 μM.
T40481 IBS008738
IBS008738, a potent TAZ activator, stabilizes TAZ, elevates the unphosphorylated TAZ level, enhances the interaction of MyoD with the myogenin promoter, upregulates gene transcription regulated by MyoD, and competes with...
T24512 MyomiR-IN-1 myomiR inhibitor-1,myomiR inhibitor 1,myomiRIN1
myomiR-IN-1 is a myomiRs inhibitor that acts by inhibiting the translation of myoD in C2C12 cells without changing the expression level of myoD mRNA and downregulating the expression of differentiation markers.
T79546 BMP agonist 1
BMP Agonist 1 (compound 2 b) is a small-molecule stimulator of bone morphogenic protein (BMP) signaling, crucial for the differentiation of C2C12 cells. It acts by inhibiting GSK3β and enhancing β-catenin signaling, ther...
T78703 PTP1B/AKR1B1-IN-2 Phosphatase
PTP1B/AKR1B1-IN-2 (Compound 7f) is a potent inhibitor targeting both PTP1B and AKR1B1 with IC50 values of 3.2 and 2.1 μM, respectively, and K i values of 4.0 and 0.9 μM. This compound acts as an insulin mimetic and enhan...
T36064 N-Oleoyl Glutamine
N-Oleoyl glutamine is an endogenous N-acyl amine.1,2It is both formed and degraded by peptidase M20 domain-containing 1 (PM20D1), a factor secreted by thermogenic adipose cells. N-Oleoyl glutamine (50 μM) induces mitocho...
T60365 SY-LB-35
SY-LB-35, a potent bone morphogenetic protein (BMP) receptor agonist, significantly enhances cell number and viability in the C2C12 myoblast cell line. It promotes cell cycle progression, particularly towards the S and G...
TP1895 KYL peptide KYL
KYL peptide is a EphA4 receptor tyrosine kinase inhibitor (Kd = 0.8 μM). KYL inhibits EphA4-EphrinA5 interactions (IC50 = 6.34 μM).
T35874 CC260
CC260, a selective inhibitor for PI5P4Kα and PI5P4Kβ with Kis of 40 nM and 30 nM respectively, exhibits minimal to no inhibition against other protein kinases like Plk1 and RSK2. It is applicable in the research of cell ...
Cat No. Product Name Synonyms Targets
T2834 Nobiletin Hexamethoxyflavone Apoptosis , MMP , Reactive Oxygen Species , ROR , Autophagy
Nobiletin (Hexamethoxyflavone) is a natural polymethoxylated flavone isolated from citrus peels with anti-inflammatory and anti-tumor activities. Nobiletin is practically insoluble (in water) and an extremely weak acidic...
TN4997 Serpentine IGF-1R
Serpentine is an alkaloid found in the roots of Rosa Centifolia that acts as an insulin sensitizer to assist insulin in lowering blood glucose.Serpentine activates the phosphorylation of AMPK, which stimulates glucose up...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPJ-00521 CHL2 Protein, Mouse, Recombinant (His) Mouse Human Cells
Mouse Chordin-Like 2, also known as CHL2, is a novel chordin family member with structural homology to CHL1 which is implicated in tumor angiogenesis. The mouse CHL2 gene encodes a 426 amino acids (aa) protein with a 25...
TargetMol