Search Result

Search Results for " ck2 "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T23090	CK2-IN-1		Others
	CK2 inhibitor		Others
T35557	CK2 inhibitor 2		Casein Kinase
	CK2 Inhibitor 2, characterized as a potent, selective, and orally active inhibitor of CK2, demonstrates an impressive IC50 value of 0.66 nM. It exhibits high selectivity towards Clk2 with an IC50 of 32.69 nM in compariso...		Casein Kinase
T10827	CK2/ERK8-IN-1	TMCB	Apoptosis , ERK , Casein Kinase , Pim , DYRK
	CK2/ERK8-IN-1 (TMCB) is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 µM) and ERK8 (IC50s: 0.50 μM) with pro-apoptotic efficacy. CK2/ERK8-IN-1 also binds to PIM1, DYRK1A, and HIPK2 (Kis: 8.65 µM, 11.9 µM, and 15.25...		Apoptosis , ERK , Casein Kinase , Pim , DYRK
T40131	SGC-CK2-1	SGC-CK2-1
	SGC-CK2-1 is an ATP-competitive chemical compound that acts as a highly potent and cell-active CK2 inhibitor. It demonstrates excellent selectivity towards both isoforms of human CK2, with IC50 values of 36 nM for CK2α a...
T73375	CK2-IN-4		Casein Kinase
	CK2-IN-4 is a protein kinase (CK2) inhibitor with an IC50 value of 8.6 µM. CK2-IN-4 has potential anticancer ah and anti-inflammatory activity for the study of viral infections and glomerulonephritis diseases.		Casein Kinase
T7390	DMAT	Casein kinase II Inhibitor,CK2 Inhibitor	Casein Kinase
	DMAT (Casein kinase II Inhibitor) is a potent and specific inhibitor of CK2(IC50 value of 130 nM).		Casein Kinase
T10828	CK2/PIM1-IN-1		Others
	CK2/PIM1-IN-1 is an inhibitor of CK2 and PIM1 (IC50s: 3.787 μM and 4.327 μM). It is developed for the research of proliferative disorders such as cancer, as well as other kinase-associated conditions.		Others
T61629	CK2 inhibitor 3
	CK2 inhibitor 3 is a highly potent inhibitor of protein kinase CK2, exhibiting an IC50 value of 280 nM. It effectively inhibits the intracellular activity of CK2 and displays a notable impact on the viability of tumor ce...
T78599	CK2-IN-9
	CK2-IN-9, a potent and selective CK2 kinase inhibitor, exhibits an inhibitory concentration (IC50) of 3 nM against its target enzyme and hampers Wnt reporter activity with an IC50 of 75 nM. In rats, it demonstrates low e...
T62862	CK2-IN-3
	CK2-IN-3 is a potent and selective CK2 inhibitor (Kd: 12 nM) with IC50 values of 1.51 μM for CK2α and 7.64 μM for CK2α'. CK2-IN-3 can be used in cancer research.
T73380	CK2-IN-6
	CK2-IN-6, a powerful inhibitor of protein kinase CK2, shows promise for research in cancer, along with conditions related to kinases such as inflammation, pain, and specific immune diseases.
T63991	BRD4/CK2-IN-1
	BRD4/CK2-IN-1 is the first potent, orally active dual-target inhibitor of BRD4/CK2 (bromodomain-containing protein 4/casein kinase 2), acting on both BRD4 (IC50: 180 nM) and CK2 (IC50: 230 nM). In triple-negative breast ...
T73269	CK2α-IN-1		Casein Kinase
	CK2α-IN-1 is a selective non-ATP-competitive CK2α inhibitor with an IC50 of 7.0 µM and a Ki of 1.6 µM.CK2α-IN-1 exhibits potential anticancer activity and can be used in cancer research.		Casein Kinase
T12747	ROCK2-IN-2		ROCK
	ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).		ROCK
T72695	UCK2 Inhibitor-1
	UCK2 Inhibitor-1 is a non-competitive UCK2 inhibitor with an IC 50 of 4.7 µM .
T81261	ROCK2-IN-7		ROCK
	ROCK2 inhibitor is a chemical compound associated with the therapeutic management of psoriasis. It exhibits its efficacy in targeting ROCK2 enzymes within HaCaT cells and has demonstrated beneficial effects in a psoriasi...		ROCK
T73117	ROCK2-IN-5
	ROCK2-IN-5, a compound integrating structural elements from the Rho kinase inhibitor fasudil and the NRF2 inducers caffeic and ferulic acids, exhibits a favorable multitarget profile and tolerability. It shows potential ...
T79832	ROCK2-IN-6		ROCK
	ROCK2-IN-6 (Comp A) is a selective inhibitor of ROCK2, applicable in the study and treatment of ROCK-mediated, autoimmune, and inflammatory diseases [1].		ROCK
T73194	DOCK2-IN-1
	DOCK2-IN-1, an analogue of CPYPP, effectively inhibits DOCK2 (IC50 = 19.1 μM) by reversibly binding to its DHR-2 domain, thereby hindering its catalytic function. This compound obstructs the activation of Rac in lymphocy...
T17727	CCK2R Ligand-Linker Conjugates 1		Others
	CCK2R Ligand-Linker Conjugate 1 is a hydrophilic peptide linker that conjugates to the cytotoxic antimicrotubule agents Desacetyl Vinblastine Hydrazide (DAVBH) and Tubulysin B Hydrazide (TubBH) as ligand-linker conjugate...		Others
T29161	STOCK2S-26016	WNK IN B,WNK-IN-B,Compound B
	WNK-IN-B is an inhibitor of Wnk signalling. WNK-IN-B is a cell-permeable diaminoacridine derivative that targets the CCT domain of SPAK and OSR1 via reversible binding. WNK-IN-B selectively suppress hypotonic shock-induc...
T72696	UCK2 Inhibitor-3
	UCK2 Inhibitor-3 is a non-competitive inhibitor targeting uridine-cytidine kinase 2 (UCK2), a key enzyme in the pyrimidine salvage pathway, with an IC50 value of 16.6 μM. Notably, UCK2 can partially substitute for dihydr...
T68498	UCK2 Inhibitor-2
	UCK2 Inhibitor-2, a non-competitive inhibitor of uridine-cytidine kinase 2 (UCK2), exhibits an IC50 of 3.8 µM and effectively suppresses uridine salvage within cells.
T78205	ROCK2-IN-6 hydrochloride		ROCK
	ROCK2-IN-6 hydrochloride (Comp A) serves as a selective inhibitor of ROCK2, applicable for research into ROCK-mediated diseases, autoimmune disorders, and inflammation [1].		ROCK
T2259	Silmitasertib	CX-4945	Casein Kinase , Autophagy
	Silmitasertib (CX-4945) is a potent, orally bioavailable inhibitor of casein kinase 2 (CK2; Ki: 0.38 nM).		Casein Kinase , Autophagy
T1828	TTP 22		Casein Kinase
	TTP 22 is a high affinity, ATP-competitive casein kinase 2 (CK2) inhibitor with IC50/Ki of 0.1 uM/40 nM, and shows selectivity >250-fold for CK2 over JNK3, ROCK1, and MET(IC50> 10 uM).		Casein Kinase
T2695	TBB	Casein Kinase II Inhibitor I,NSC 231634,4,5,6,7-tetrabromobenzotriazole	GSK-3 , Casein Kinase , CDK
	TBB (NSC-231634)(NSC-231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2).		GSK-3 , Casein Kinase , CDK
T60067	WAY-297174		Casein Kinase
	WAY-297174 is a human protein kinase CK2 inhibitor with IC50 of > 33 μM.		Casein Kinase
T21915	TBCA	Casein Kinase II Inhibitor III, TBCA	Casein Kinase
	TBCA (Casein Kinase II Inhibitor III, TBCA) is a highly selective CK2 (casein kinase II) inhibitor, IC50 = 110 nM, Ki = 77 nM. TBCA shows selectivity for CK2 over CK1, DYRK1A and a panel of 27 other kinases.		Casein Kinase
T6735	XL413 hydrochloride	BMS-863233 Hydrochloride,XL413,BMS-863233	cholecystokinin , Casein Kinase , Pim , CDK
	XL413 hydrochloride (BMS-863233 Hydrochloride) is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC 50 of 3.4 nM. XL413 hydrochloride also exhibits potent effect with IC 50 s of 215, 42 nM on CK2, PIM...		cholecystokinin , Casein Kinase , Pim , CDK
T71339	BMS-863233 HCl	XL413 hydrochloride	Casein Kinase , Pim , CDK
	BMS-863233 HCl is an ATP-competitive Cdc7 inhibitor (IC50: 3.4 nM) that is potent and selective.BMS-863233 HCl inhibited CK2 and PIM1 with IC50 values of 215 and 42 nM, respectively.BMS-863233 HCl showed an EC50 value of...		Casein Kinase , Pim , CDK
T15024	Silmitasertib sodium salt	CX-4945 sodium salt	Casein Kinase , Autophagy
	Silmitasertib sodium salt (CX-4945 sodium salt) is a potent and orally bioavailable, highly selective inhibitor of CK2(IC50 of 1 nM, CK2α).		Casein Kinase , Autophagy
T6745	5-Iodotubercidin	5-ITu,NSC 113939	Adenosine Receptor
	5-Iodotubercidin (NSC-113939) is a potent adenosine kinase inhibitor with IC50 of 26 nM. It inhibits nucleoside transporter, CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC.		Adenosine Receptor
T2008	LY294002	LY 294002,NSC 697286,SF 1101	Apoptosis , DNA-PK , Casein Kinase , PI3K , Autophagy
	LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM). LY294002 is also an inhibitor of DNA-PK (IC50=1.4 μM) and an inhibitor of CK2 (IC50=98 nM). LY294002 ...		Apoptosis , DNA-PK , Casein Kinase , PI3K , Autophagy
T1877	LH846	LH-846,LH 846	Casein Kinase
	LH846 is a selective inhibitor of CK1δ (IC50 values are 290 nM, 1.3 uM and 2.5 uM for CK1δ, ε and α); exhibits no inhibitory activity at CK2.		Casein Kinase
T6458	CYC-116		VEGFR , FLT , CDK , S6 Kinase , Aurora Kinase
	CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK2, Plk1 ...		VEGFR , FLT , CDK , S6 Kinase , Aurora Kinase
T9356	(E/Z)-GO289		Casein Kinase
	(E/Z)-GO289, which strongly lengthened circadian period, is a potent and selective inhibitor of CK2. (E/Z)-GO289 exhibited cell type-dependent inhibition of cancer cell growth that correlated with cellular clock function...		Casein Kinase
T3352	XL413		cholecystokinin , Casein Kinase , Pim , CDK
	XL-413 is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. XL-413 binds to and inhibits the activity of CDC7, which may result in the inhibition of DNA ...		cholecystokinin , Casein Kinase , Pim , CDK
T15469	Hematein	Hydroxybrasilein	Wnt/beta-catenin , Akt
	Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway, and increases apoptosis in lung cancer cells. Hematein is an oxidation product of hematoxylin acted as a dye and it also is an allosteric casein kina...		Wnt/beta-catenin , Akt
T23461	TMCB		Others
	CK2 and ERK8 inhibitor		Others
T20791	Quinalizarin
	Quinalizarin, the most selective CK2 inhibitor, is superior to CX-4945 which is the first-in-class CK2 inhibitor.
T24832	SRPIN-803	SRPIN803
	SRPIN-803 is a selective dual SRPK1 and CK2 inhibitor.
T69307	IQA
	IQA is a casein kinase 2 (CK2) inhibitor.
T71190	FLC26
	FLC26 is a CK2 inhibitor with IC50 = 9 nM
T76475	Casein Kinase II Substrate
	Casein Kinase II Substrate, a peptide substrate, is selectively phosphorylated by casein kinase II (CK2) [1].
T76411	Casein Kinase 2 Substrate Peptide
	Casein Kinase 2 Substrate Peptide, a widely recognized CK2 substrate, is synthesized with its C-terminus conjugated to 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid (EDANS). This peptide serves as a tool for determi...
T21642	4,5,6,7-Tetrabromobenzimidazole
	4,5,6,7-Tetrabromobenzimidazole is a selective and ATP-competitive inhibitor of protein kinase CK2 [1].
T71627	CX-5011		Casein Kinase
	CX-5011, a CK2 inhibitor, induces Rac1 activation and promotes apoptosis, effectively causing cancer cell death [1] [2].		Casein Kinase
T16528	PI-828	LY 294002, 4gamma-NH2	Casein Kinase , PI3K
	PI-828 is a phosphatidylinositol 3-kinase (PI3K) inhibitor, which is widely used to study the physiological function of PI3K and also promotes stem cell differentiation into mesoderm.		Casein Kinase , PI3K
T79908	ON 108600		Casein Kinase
	ON 108600 is a chemical inhibitor targeting CK2 (Casein Kinase 2), TNIK, and DYRK1, demonstrating IC50 values of 0.016 μM and 0.007 μM for DYRK1A and DYRK1B, 0.028 μM for DYRK2, 0.05 μM and 0.005 μM for CK2α1 and CK2α2, ...		Casein Kinase

Compounds

Target: Casein Kinase

CK2/ERK8-IN-1

T10827

Synonym: TMCB

Target: Apoptosis, ERK, Casein Kinase, Pim, DYRK

Target: Casein Kinase

DMAT

T7390

Synonym: Casein kinase II Inhibitor,CK2 Inhibitor

Target: Casein Kinase

Target: Casein Kinase

CCK2R Ligand-Linker Conjugates 1

Synonym: WNK IN B,WNK-IN-B,Compound B

ROCK2-IN-6 hydrochloride

Target: Casein Kinase, Autophagy

TTP 22

T1828

Synonym:

Target: Casein Kinase

TBB

T2695

Synonym: Casein Kinase II Inhibitor I,NSC 231634,4,5,6,7-tetrabromobenzotriazole

Target: GSK-3, Casein Kinase, CDK

WAY-297174

T60067

Synonym:

Target: Casein Kinase

TBCA

T21915

Synonym: Casein Kinase II Inhibitor III, TBCA

Target: Casein Kinase

XL413 hydrochloride

T6735

Synonym: BMS-863233 Hydrochloride,XL413,BMS-863233

Target: cholecystokinin, Casein Kinase, Pim, CDK

BMS-863233 HCl

T71339

Synonym: XL413 hydrochloride

Target: Casein Kinase, Pim, CDK

Silmitasertib sodium salt

T15024

Synonym: CX-4945 sodium salt

Target: Casein Kinase, Autophagy

5-Iodotubercidin

T6745

Synonym: 5-ITu,NSC 113939

Target: Adenosine Receptor

LY294002

T2008

Synonym: LY 294002,NSC 697286,SF 1101

Target: Apoptosis, DNA-PK, Casein Kinase, PI3K, Autophagy

LH846

T1877

Synonym: LH-846,LH 846

Target: Casein Kinase

CYC-116

T6458

Synonym:

Target: VEGFR, FLT, CDK, S6 Kinase, Aurora Kinase

(E/Z)-GO289

T9356

Synonym:

Target: Casein Kinase

XL413

T3352

Synonym:

Target: cholecystokinin, Casein Kinase, Pim, CDK

Hematein

T15469

Synonym: Hydroxybrasilein

Target: Wnt/beta-catenin, Akt

Casein Kinase II Substrate

T76475

Synonym:

Target:

Casein Kinase 2 Substrate Peptide

T76411

Synonym:

Target:

4,5,6,7-Tetrabromobenzimidazole

Target: Casein Kinase

PI-828

T16528

Synonym: LY 294002, 4gamma-NH2

Target: Casein Kinase, PI3K

ON 108600

T79908

Synonym:

Target: Casein Kinase

Cat No.	Product Name	Synonyms	Targets
T2869	Emodin	Frangula emodin	SARS-CoV , Casein Kinase , Autophagy
	Emodin (Frangula emodin) is a naturally occurring anthraquinone present in the roots and barks of numerous plants; exerts antiproliferative effects in Y cells that are regulated by different signaling pathways.		SARS-CoV , Casein Kinase , Autophagy
T0465	Ellagic acid	Gallogen,Elagostasine	Hedgehog/Smoothened , Casein Kinase , Reactive Oxygen Species , Topoisomerase , Endogenous Metabolite , PKA , Syk , PKC , Carbonic Anhydrase
	Ellagic acid (Gallogen) is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clotting system which also causes kinin release; used...
T8305	Ellagic acid (hydrate)	Ellagic Acid hydrate	Antioxidant , Casein Kinase
	Ellagic acid (hydrate) is a natural antioxidant and acts as a potent and ATP-competitive CK2 inhibitor (IC50:40 nM, Ki: 20 nM).		Antioxidant , Casein Kinase
T16791	Rottlerin	Mallotoxin,NSC 56346,NSC 94525	CaMK , Apoptosis , Others , HIV Protease , PKA , PKC , Autophagy
	Rottlerin (NSC-56346) is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM). Rottlerin causes apoptosis via caspase...

Natural Products

Emodin

T2869

Synonym: Frangula emodin

Target: SARS-CoV, Casein Kinase, Autophagy

Ellagic acid

T0465

Synonym: Gallogen,Elagostasine

Target: Hedgehog/Smoothened, Casein Kinase, Reactive Oxygen Species, Topoisomerase, Endogenous Metabolite, PKA, Syk, PKC, Carbonic Anhydrase

Ellagic acid (hydrate)

T8305

Synonym: Ellagic Acid hydrate

Target: Antioxidant, Casein Kinase

Rottlerin

T16791

Synonym: Mallotoxin,NSC 56346,NSC 94525

Target: CaMK, Apoptosis, Others, HIV Protease, PKA, PKC, Autophagy

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-04441	CK2 alpha/CSNK2A1 Protein, Mouse, Recombinant (His & GST)	Mouse	Baculovirus-Insect Cells
	Casein kinase II subunit alpha, also known as CK II alpha, CSNK2A1 and CK2A1, is a member of the protein kinase superfamily, Ser / Thr protein kinase family and CK2 subfamily. Casein kinase II (CSNK2A1) is a serine / thr...
TMPY-04758	CK2 alpha/CSNK2A1 Protein, Mouse, Recombinant	Mouse	Baculovirus-Insect Cells
	Casein kinase II subunit alpha, also known as CK II alpha, CSNK2A1 and CK2A1, is a member of the protein kinase superfamily, Ser / Thr protein kinase family and CK2 subfamily. Casein kinase II (CSNK2A1) is a serine / thr...
TMPY-04372	CK2 alpha/CSNK2A1 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	Casein kinase II subunit alpha, also known as CK II alpha, CSNK2A1 and CK2A1, is a member of the protein kinase superfamily, Ser / Thr protein kinase family and CK2 subfamily. Casein kinase II (CSNK2A1) is a serine / thr...
TMPY-04764	PCK2 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	PCK2 promotes tumor initiation by lowering acetyl-CoA level through reducing the mitochondrial tricarboxylic acid (TCA) cycle. The levels of phosphoenolpyruvate carboxykinase isoform 2 (PCK2) are critical for the metabol...
TMPY-04750	CSNK2A2 Protein, Human, Recombinant	Human	Baculovirus-Insect Cells
	Casein kinase II subunit alpha', also known as CSNK2A2 and CK2A2, is a member of the protein kinase superfamily, Ser/Thr protein kinase family and CK2 subfamily. Casein kinases are operationally defined by their prefer...
TMPY-04393	CSNK2A2 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	Casein kinase II subunit alpha', also known as CSNK2A2 and CK2A2, is a member of the protein kinase superfamily, Ser/Thr protein kinase family and CK2 subfamily. Casein kinases are operationally defined by their prefer...
TMPJ-01307	PACSIN1 Protein, Human, Recombinant (His)	Human	Human Cells
	Protein Kinase C and Casein Kinase Substrate in Neurons Protein 1 (PACSIN1) belongs to the PACSIN family. PACSIN1 contains one FCH domain and one SH3 domain. PACSIN1 is highly expressed in the brain and at lower leves in...