chk — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T13148	CHK-IN-1		Chk
	CHK-IN-1 is a dual inhibitor of CHK1 and CHK2 with antiproliferative activity.		Chk
T79874	CHK-336
	CHK-336 (Example 1), an orally active LDHA inhibitor (IC50 <1 nM), suppresses lactate production in mouse hepatocytes and is applicable in hyperoxaluria research [1].
T10791	CHK1-IN-3		Chk
	CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).		Chk
T6093	AZD-7762	AZD7762	Chk
	AZD-7762, an effective and specific inhibitor of Chk1（IC50=5 nM）, is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck.		Chk
T7080	CCT245737	SRA737	Chk
	CCT245737 (SRA737) is an orally active and selective Chk1 inhibitor (IC50: 1.3 nM); CCT245737 shows much less activity against Chk2 (IC50: 2440 nM).		Chk
T21331	SAR-020106		Chk
	SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.		Chk
T2517	SCH900776	MK 8776,MK-8776	Chk , CDK
	SCH900776 (MK-8776) is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities.		Chk , CDK
T6084	Rabusertib	LY2603618,IC-83	Chk , PDK , Autophagy
	Rabusertib (IC-83) is an inhibitor of the cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiating activity. Rabusertib has been used in trials studying the treatment of Cancer, Solid Tumors, Advanced Cance...		Chk , PDK , Autophagy
T6350	CHIR-124	CHIR124,CHIR 124	Apoptosis , GSK-3 , FLT , Chk , PDGFR , Src
	CHIR-124 is an effective Chk1 inhibitor (IC50: 0.3 nM). It has 2, 000-fold selectivity against Chk2, 500- to 5, 000-fold less activity against Cdc2 and CDK2/4.		Apoptosis , GSK-3 , FLT , Chk , PDGFR , Src
T2033	BML-277	C 3742,Chk2 Inhibitor II,BML 277	Apoptosis , Chk
	BML-277 (C 3742) is a selective checkpoint kinase 2 (Chk2) inhibitor.		Apoptosis , Chk
T7300	GDC-0575	ARRY-575,RG7741	Chk
	GDC-0575 (ARRY-575) is a highly-selective oral small-molecule Chk1 inhibitor(IC50 of 1.2 nM).		Chk
T10792	CHK1-IN-4		Chk
	CHK1-IN-4 is a potent inhibitor of checkpoint kinase 1 (chk1) and potently inhibits chk1 phosphorylation in the tumor cells with anti-tumor activity.		Chk
T10790	CHK1-IN-2		Chk
	CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 6 nM).		Chk
T10793	CHK1 inhibitor	GDC-0575 analog	Chk
	CHK1 inhibitor (GDC-0575 analog) is a CHK1 inhibitor.		Chk
T37098	Chk1-IN-5	Chk1-IN-5
	Chk1-IN-5 is a highly effective inhibitor of checkpoint kinase 1 (Chk1), which hinders the phosphorylation of Chk1 and effectively suppresses tumor growth in a colon cancer xenograft model[1].
T4327	Prexasertib dihydrochloride	LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368	Apoptosis , Chk , S6 Kinase
	Prexasertib dihydrochloride (LY2606368) is an ATP-competitive CHK1 inhibitor (Ki: 0.9 nmol/L). in the cell-free assay, its IC50 values are 8 nM and 9 nM for CHK2 and RSK, respectively.		Apoptosis , Chk , S6 Kinase
T40091	Chk1-IN-6	Chk1-IN-6
	Chk1-IN-6 is a potent, selective, and orally bioavailable CHK1 inhibitor candidate.
T4310	Prexasertib	LY2606368	Apoptosis , Chk
	Prexasertib (LY2606368) is an inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity.		Apoptosis , Chk
T6028	PF 477736	PF 00477736,PF-477736,PF-736,PF-00477736,PF477736	c-Fms , VEGFR , FGFR , FLT , c-RET , Chk , CDK , Src , Aurora Kinase
	PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CSF1R), Ret and Yes.
T10792L	CHK1-IN-4 hydrochloride	CHK1-IN-4 hydrochloride（2120398-41-4 Free base）	Chk
	CHK1-IN-4 hydrochloride is a potent inhibitor of checkpoint kinase 1 (chk1). CHK1-IN-4 hydrochloride potently inhibits chk1 phosphorylation in the tumor cells. CHK1-IN-4 hydrochloride has anti-tumor activity.		Chk
T82393	FLT3/CHK1-IN-1
	Compound 18, also known as FLT3/CHK-IN-1, is a dual inhibitor targeting FLT3 and CHK1, exhibiting over 1700-fold selectivity towards c-KIT and significantly diminishing hERG affinity, with an IC50 of 58.4 μM. It demonstr...
T34577	Schkuhriolide
	Schkuhriolide is a melampolide.
T29083	V-11-0711	V 11-0711,V110711,V-110711,V11-0711,V 110711
	V-11-0711 is an inhibitor of Chk-α, which may be essential in cancer cell proliferation.
T80132	CBP501 Affinity Peptide
	CBP501 Affinity Peptide, a Chk kinase inhibitor, disrupts G2 arrest triggered by DNA-damaging agents and is utilized in cancer research [1].

Compounds

CHK-IN-1

T13148

Synonym: MK 8776,MK-8776

Target: Chk, CDK

Rabusertib

T6084

Synonym: LY2603618,IC-83

Target: Chk, PDK, Autophagy

CHIR-124

T6350

Synonym: CHIR124,CHIR 124

Target: Apoptosis, GSK-3, FLT, Chk, PDGFR, Src

BML-277

T2033

Synonym: C 3742,Chk2 Inhibitor II,BML 277

Target: Apoptosis, Chk

GDC-0575

T7300

Synonym: ARRY-575,RG7741

Synonym: GDC-0575 analog

Prexasertib dihydrochloride

T4327

Synonym: LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368

Target: Apoptosis, Chk, S6 Kinase

Target: Apoptosis, Chk

PF 477736

T6028

Synonym: PF 00477736,PF-477736,PF-736,PF-00477736,PF477736

Target: c-Fms, VEGFR, FGFR, FLT, c-RET, Chk, CDK, Src, Aurora Kinase

CHK1-IN-4 hydrochloride

T10792L

Synonym: CHK1-IN-4 hydrochloride（2120398-41-4 Free base）

Synonym: V 11-0711,V110711,V-110711,V11-0711,V 110711

Target:

CBP501 Affinity Peptide

T80132

Synonym:

Target:

Cat No.	Product Name	Synonyms	Targets
T83321	4-Demethyldeoxypodophyllotoxin		Chk
	4-Demethyldeoxypodophyllotoxin, an aryl tetrahydronaphthalenyl lignan analog from the roots of Podophyllum peltatum, has anticancer activity and modulates the Chk-2 signaling pathway in MCF-7 breast cancer cells.

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-04368	Chk1 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	CHK1 / CHEK1 contains 1 protein kinase domain and belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, NIM1 subfamily. It is a member of checkpoint kinases (Chks). Chks Checkpoint kinases (Chks)...
TMPY-04435	CHEK2 Protein, Mouse, Recombinant (His & GST)	Mouse	Baculovirus-Insect Cells
	In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by CHEK2 gene is a cell cycle checkpoint regulator and putativ...
TMPY-04681	CHEK2 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by CHEK2 gene is a cell cycle checkpoint regulator and putativ...
TMPY-04433	Chk1 Protein, Mouse, Recombinant (His & GST)	Mouse	Baculovirus-Insect Cells
	CHK1 / CHEK1 contains 1 protein kinase domain and belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, NIM1 subfamily. It is a member of checkpoint kinases (Chks). Chks Checkpoint kinases (Chks)...