dna损伤和修复 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2516	Amuvatinib	MP470,HPK 56	Apoptosis , FLT , c-Met/HGFR , c-RET , DNA/RNA Synthesis , PDGFR , c-Kit
	Amuvatinib (MP470) is an orally bioavailable synthetic carbothioamide with potential antineoplastic activity.
T50098	TIQ-A		PARP
	TIQ-A is a PARP1 inhibitor which involved in DNA single-strand break repair via the base excision repair pathway. PARP1 is triggered by DNA damage and its excessive activation has been proposed as a causative factor in m...		PARP
T6892	Niraparib tosylate	MK-4827 (tosylate),MK 4827 tosylate,Niraparib (MK-4827) tosylate	Apoptosis , PARP
	Niraparib tosylate (MK-4827 (tosylate))(with IC50 of 3.8 nM/2.1 nM) is a selective PARP1/PARP2 inhibitor.		Apoptosis , PARP
T3231	Niraparib	MK-4827	Apoptosis , Others , PARP
	Niraparib (MK-4827) is a PARP inhibitor that selectively inhibits PARP1 and PARP2 (IC50=3.8/2.1 nM). Niraparib has antitumor activity, inhibits DNA damage repair, and induces apoptosis.		Apoptosis , Others , PARP
T70873	M3541		Apoptosis , ATM/ATR
	M3541 is a selectively potent and orally active ATM inhibitor with potential antitumor activity.M-3541 inhibits ATM kinase activity and ATM-mediated signaling by binding to ATM.M3541 prevents activation of DNA damage che...		Apoptosis , ATM/ATR
T23974	DDRI-18	DDRI18,DDRI 18	DNA/RNA Synthesis
	DDRI-18 is a novel small molecule inhibitor that regulates the DNA damage response with sensitizing and anticancer activities, inhibits non-homologous end-joining (NHEJ) DNA repair and enhances the cytotoxicity of antica...		DNA/RNA Synthesis
T3353	Niraparib hydrochloride	MK-4827 hydrochloride,MK-4827 (hydrochloride)	Apoptosis , Others , PARP
	Niraparib hydrochloride (MK-4827 hydrochloride) is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. Niraparib hydrochloride inhibits PARP activity, enhancing the accumulation of...		Apoptosis , Others , PARP
T5425	ML367		Epigenetic Reader Domain
	ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization and acts as a probe molecule that has low micromolar inhibitory activity		Epigenetic Reader Domain
T21320	Methoxyamine HCl	TRC102,TRC 102,Methoxyamine,TRC-102	Others
	Methoxyamine HCl (Methoxyamine) covalently binds to apurinic/apyrimidinic (AP) DNA damage sites and inhibits base excision repair (BER), which may result in an increase in DNA strand breaks and apoptosis. Methoxyamine is...		Others
T10406	Tuvusertib	M1774,ATR inhibitor 1	Apoptosis , ATM/ATR , Others , Chk
	Tuvusertib (M1774) is an orally available ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor (Ki< 1 µΜ) with selective and potentially antitumor activity.Tuvusertib selectively inhibits ATR activity and blocks...		Apoptosis , ATM/ATR , Others , Chk
T80207	Tetrapeptide		DNA/RNA Synthesis
	Tetrapeptide, an α-MSH analogue, stimulates melanin production and mitigates DNA damage by attenuating reactive oxidative species generation and augmenting DNA photoproduct repair [1].		DNA/RNA Synthesis
T40931	FEN1-IN-2	FEN1-IN-2	Others
	FEN1-IN-2 is a selective and potent inhibitor of flap endonuclease 1 (FEN1), inhibits FEN1 and XPG, has potential anticancer activity, and can be used to study DNA damage repair.		Others
T62511	AZ3391
	AZ3391 is a quinoxaline derivative that is a potent inhibitor of PARP. AZ3391 has potential for the study of diseases and conditions occurring in central nervous system tissues (e.g., brain and spinal cord).
T63555	ATR-IN-6
	ATR-IN-6 is a potent inhibitor of ATR. ATR is a protein kinase that is involved in genome stability and DNA damage repair and is a member of the PIKK family. aTR-IN-6 has shown potential for ATR kinase-mediated diseases ...
T63923	ATR-IN-5
	ATR-IN-5 is a potent inhibitor of ATR, a member of the PIKK family of proteins involved in genome stability and DNA damage repair. ATR is a member of the PIKK family, a class of protein kinases involved in genome stabili...
T78787	PARP-1/2-IN-2		PARP
	PARP-1/2-IN-2-IN-1 (Compound 12e) effectively inhibits PARP1/2 and CDK12 with IC 50 values of 34 nM, 30 nM, and 285 nM respectively, impairing DNA damage repair and inducing cell cycle arrest and apoptosis. This compound...		PARP
T60649	AV-153 free base
	AV-153 free base is a 1,4-dihydropyridine (1,4-DHP) derivative. AV-153 free base is an antimutagenic with anti-cancer activity. AV-153 free base interacts with cytosine and thymine and has an influence on poly(ADP)ribosy...
T79647	VEGFR/PARP-IN-1		PARP
	VEGFR/PARP-IN-1 (Compound 14b) is a dual inhibitor of VEGFR and PARP with IC50 values of 191 nM and 60.9 nM, respectively. It impairs DNA damage repair pathways, promotes apoptosis, and halts cells in the G2/M phase. Thi...		PARP
T83854	BRC4wt TFA
	BRC4wt, an acetylated peptide originating from the BRC4 repeat within human BRCA2 (1521-1536), acts as an inhibitor of the BRCA2 and RAD51 protein-protein interaction. When linked to the cationic cell-penetrating peptide...
T62540	PARP1/BRD4-IN-2
	PARP1/BRD4-IN-2 is a potent and selective inhibitor of PARP1 (IC50: 197 nM) and BRD4 (IC50: 238 nM).PARP1/BRD4-IN-2 inhibits DNA damage repair, blocks the G0/G1 cell cycle transition, and induces apoptosis.PARP1/BRD4-IN-...

Compounds

Amuvatinib

T2516

Synonym: MP470,HPK 56

Target: Apoptosis, FLT, c-Met/HGFR, c-RET, DNA/RNA Synthesis, PDGFR, c-Kit

Synonym: MK-4827 (tosylate),MK 4827 tosylate,Niraparib (MK-4827) tosylate

Target: Apoptosis, PARP

Niraparib

T3231

Synonym: MK-4827

Target: Apoptosis, Others, PARP

M3541

T70873

Synonym:

Target: Apoptosis, ATM/ATR

DDRI-18

T23974

Synonym: DDRI18,DDRI 18

Target: DNA/RNA Synthesis

Niraparib hydrochloride

T3353

Synonym: MK-4827 hydrochloride,MK-4827 (hydrochloride)

Target: Apoptosis, Others, PARP

ML367

T5425

Synonym:

Target: Epigenetic Reader Domain

Methoxyamine HCl

T21320

Synonym: TRC102,TRC 102,Methoxyamine,TRC-102

Target: Others

Tuvusertib

T10406

Synonym: M1774,ATR inhibitor 1

Target: Apoptosis, ATM/ATR, Others, Chk

Tetrapeptide

T80207

Synonym:

Target: DNA/RNA Synthesis

Cat No.	Product Name
L3900	DNA Damage & Repair Compound Library	937 compounds
	A unique collection of 937 DNA Damage & Repair related compounds for high throughput screening (HTS) and high content screening (HCS);
L3980	DNA Damage and Repair Compound Library Plus	667 compounds
	Well-chosen 667 compounds with unique structures targeting DNA damage & repair;
L8600	Ubiquitination Compound Library	214 compounds
	A unique collection of 214 ubiquitination related small chemicals can be used for high throughput and high content screening；

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