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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T4488 | GSK-25 | GSK25 | ROCK , S6 Kinase , mTOR |
GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested). | |||
T15432 | GSK256073 | GPR , Others | |
GSK256073 is an orally active GPR109A agonist. GSK256073 also is a long-lasting and non-flushing HCA2 (hydroxy-carboxylic acid receptor 2) full agonist (pEC50: 7.5). GSK256073 acutely improves glucose homeostasis via inh... | |||
T6054 | GSK256066 | PDE | |
GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7.Phase 2. | |||
T9830 | GSK2556286 | GSK286 | Antibacterial |
GSK2556286 (GSK286) is an orally active inhibitor of Mycobacterium tuberculosis (M. tuberculosis).GSK2556286 inhibits the growth of human macrophages with an IC50 value of 0.07 μM.GSK2556286 is effective against both mul... | |||
T11484 | GSK2593074A | GSK'074 | TNF , RIP kinase |
GSK2593074A (GSK'074) is a programmed necrosis inhibitor that displays inhibitory effects on RIP1 and RIP3. | |||
T39573 | GSK251 | PI3K | |
GSK251 is a novel, orally bioavailable inhibitor of PI3Kδ, exhibiting high potency and selectivity, with a unique binding mode. | |||
T2240 | GSK2578215A | Mitophagy , LRRK2 , Autophagy | |
GSK2578215A is a potent and selective LRRK2 kinase inhibitor. | |||
T71181 | GSK256073 Tris | ||
GSK256073 is an agonist of G-protein coupled receptor 109A (GPR109A). It acts by reducing serum glucose in subjects with type 2 diabetes mellitus. | |||
T27465 | GSK2578999A | ||
GSK2578999A is a betulin derivative with antitumor activity. | |||
T27464 | GSK2565363C | ||
GSK2565363C is a betulin derivative wth antitumor activity. | |||
T32007 | GSK256471 | GSK 256471,GSK-256471 | |
GSK256471 is a potent selective NK(3) antagonist that shows a high affinity for recombinant human (PK (I) value 8.9) and native guinea pig (PK (I) value 8.4) tachykinin NK(3) receptors. In vitro functional assessment sho... | |||
T11483 | GSK256066 Trifluoroacetate | GSK 256066 Trifluoroacetate,GSK256066 (2,2,2-trifluoroacetic acid) | PDE |
GSK 256066 Trifluoroacetate is a selective and high-affinity phosphodiesterase 4 (PDE) inhibitor (IC50: 3.2 pM for PDE4B). It can be used for the treatment of chronic obstructive pulmonary disease. |