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Search Results for " gsk25 "

Targets

12

Compounds

Cat No. Product Name Synonyms Targets
T4488 GSK-25 GSK25 ROCK , S6 Kinase , mTOR
GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested).
T15432 GSK256073 GPR , Others
GSK256073 is an orally active GPR109A agonist. GSK256073 also is a long-lasting and non-flushing HCA2 (hydroxy-carboxylic acid receptor 2) full agonist (pEC50: 7.5). GSK256073 acutely improves glucose homeostasis via inh...
T6054 GSK256066 PDE
GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7.Phase 2.
T9830 GSK2556286 GSK286 Antibacterial
GSK2556286 (GSK286) is an orally active inhibitor of Mycobacterium tuberculosis (M. tuberculosis).GSK2556286 inhibits the growth of human macrophages with an IC50 value of 0.07 μM.GSK2556286 is effective against both mul...
T11484 GSK2593074A GSK'074 TNF , RIP kinase
GSK2593074A (GSK'074) is a programmed necrosis inhibitor that displays inhibitory effects on RIP1 and RIP3.
T39573 GSK251 PI3K
GSK251 is a novel, orally bioavailable inhibitor of PI3Kδ, exhibiting high potency and selectivity, with a unique binding mode.
T2240 GSK2578215A Mitophagy , LRRK2 , Autophagy
GSK2578215A is a potent and selective LRRK2 kinase inhibitor.
T71181 GSK256073 Tris
GSK256073 is an agonist of G-protein coupled receptor 109A (GPR109A). It acts by reducing serum glucose in subjects with type 2 diabetes mellitus.
T27465 GSK2578999A
GSK2578999A is a betulin derivative with antitumor activity.
T27464 GSK2565363C
GSK2565363C is a betulin derivative wth antitumor activity.
T32007 GSK256471 GSK 256471,GSK-256471
GSK256471 is a potent selective NK(3) antagonist that shows a high affinity for recombinant human (PK (I) value 8.9) and native guinea pig (PK (I) value 8.4) tachykinin NK(3) receptors. In vitro functional assessment sho...
T11483 GSK256066 Trifluoroacetate GSK 256066 Trifluoroacetate,GSK256066 (2,2,2-trifluoroacetic acid) PDE
GSK 256066 Trifluoroacetate is a selective and high-affinity phosphodiesterase 4 (PDE) inhibitor (IC50: 3.2 pM for PDE4B). It can be used for the treatment of chronic obstructive pulmonary disease.
TargetMol