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Search Result

Search Results for " gamma-secretase "

Targets

Gamma-secretase Gamma-secretase

40

Compounds

4

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T11358 gamma-secretase modulator 1 N-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-4-phenyl-4,5,6,7-tetrahydro-1,3-benzothiazol-2-amine Gamma-secretase
gamma-secretase modulator 1 is a modulator of γ secretase and can be used in studies about the treatment of Alzheimer's disease.
T11360 gamma-secretase modulator 3 Others
gamma-secretase modulator 3 is a gamma-secretase modulator.
T11359 gamma-secretase modulator 2 Others
Gamma-secretase modulator 2 is a potent, selective compound for the treatment of Alzheimer's disease, specifically designed to modulate γ-secretase activity. This modulation selectively attenuates the production of Aβ(1-...
T11362 gamma-Secretase Modulators γ-Secretase Modulators,Amyloid-β production inhibitor Others
gamma-Secretase Modulators serves as a useful treatment for Alzheimer's disease by inhibiting the production of Amyloid-β. Specifically, it acts as a gamma-Secretase Modulators with an IC50 value.
T6135 YO-01027 gamma-Secretase Inhibitor XX,Dibenzazepine,DBZ Gamma-secretase
YO-01027 (DBZ) is a potent γ-secretase inhibitor.
T11358L gamma-secretase modulator 1 hydrochloride gamma-secretase modulator 1 hydrochloride (1172637-87-4 free base) Others
gamma-secretase inhibitior-1 is a gamma-secretase modulator that is useful to Alzheimer's disease [1].
T9422 Fosciclopirox CPX-POM Gamma-secretase
Fosciclopirox (CPX-POM), the phosphoryloxymethyl ester of CPX (Ciclopirox Prodrug, CPX-POM), selectively delivers the active metabolite, CPX, to the entire urinary tract following parenteral administration.
T16294 NGP555 Gamma-secretase
NGP555 is a modulator of γ-secretase.
T6063 LY-411575 LY411575 Apoptosis , Gamma-secretase
LY-411575, a potent γ-secretase inhibitor, is with IC50 of 0.078 nM in the membrane and 0.082 nM in cell-based. It also suppresses Notch clevage with IC50 of 0.39 nM.
T2625 MK-0752 Beta Amyloid , Gamma-secretase
MK-0752, a γ-secretase inhibitor, reduces Aβ40 production(IC50=5 nM).
T6249 Avagacestat BMS-708163 Gamma-secretase
Avagacestat (BMS-708163) (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2.
T3633 Crenigacestat LY3039478 Gamma-secretase
Crenigacestat (LY3039478) is an orally bioavailable Notch inhibitor with an IC50 of ~1 nM in most of the tumor cell lines tested. Crenigacestat effectively inhibits mutant Notch receptor activity. In a xenograft tumor mo...
T6870 L-685458 L-685,458 Apoptosis , Gamma-secretase
L-685458 (L-685,458) is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.
T16133 MRK-560 Gamma-secretase
MRK-560 is an effective and brain-penetrant inhibitor of γ-secretase.
T6274 RO4929097 RG-4733 Beta Amyloid , Gamma-secretase
RO4929097 (RG-4733), a γ secretase inhibitor (IC50: 4 nM), inhibits cellular processing of Aβ40 and Notch (EC50: 14/5 nM).
T6125 Semagacestat LY450139 Beta Amyloid , Gamma-secretase
Semagacestat (LY450139) (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM).
T2262 Itanapraced CHF5074,CSP-1103 Beta Amyloid , Gamma-secretase
Itanapraced (CHF5074), a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM).
T6202 DAPT LY-374973,GSI-IX Apoptosis , Beta Amyloid , Gamma-secretase , Autophagy
DAPT (LY-374973) is a γ-secretase inhibitor that inhibits total Aβ and Aβ42 (IC50=115/200 nM) and is orally active. DAPT is also a Notch inhibitor. DAPT induces cell differentiation, autophagy and apoptosis.
T64258 gamma-secretase modulator 5
gamma-secretase modulator 5 (compound 22d) is a gamma-secretase modulator (GSMs) that crosses the blood-brain barrier and exhibits an inhibitory effect on the production of the aggregated amyloid β peptide Aβ42 (IC50: 60...
T6935 Nirogacestat PF-03084014,PF-3084014,PF03084014,PF 03084014 Apoptosis , Gamma-secretase
Nirogacestat (PF 03084014) is a specific γ-secretase inhibitor (IC50: 6.2 nM, in a cell-free assay).
T22678 3,5-Bis(4-nitrophenoxy)benzoic acid Compound W Gamma-secretase
3,5-Bis(4-nitrophenoxy)benzoic acid (Compound W) is an inhibitor of γ-secretase. It also causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25).
T15184 E 2012 Gamma-secretase
E2012 is a γ-secretase modulator (GSM). E2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at Alzheimer's disease by reduction of amyloid β-42, and induc...
T40315 γ-Secretase modulator 10
γ-Secretase modulator 10 is a novel γ-secretase modulator.
T11361 γ-Secretase modulator 4 Others
γ-Secretase modulator 4 is a potent γ-secretase modulator, reduces the Aβ42 level with IC50s of 0.017 μM and 0.014 μM in mouse and human, respectively.
T24116 GSM-1 gamma Secretase modulator 1,GSM 1 (enzyme modulator),J2.559.799K
GSM-1 is a modulator of γ-Secretase.
T17281 Z-Ile-Leu-aldehyde Z-IL-CHO,GSI-XII,γ-Secretase inhibitor XII Others
Z-Ile-Leu-aldehyde is an effective and competitive peptide aldehyde inhibitor of γ-secretase and notch.
T39702 RO7185876 RO7185876
RO7185876 is a potent and selective gamma secretase modulator as a potential treatment for Alzheimer's disease.
T21890 JLK6 Gamma-secretase
JLK6 was a gamma-secretase inhibitor that does not interfere with Notch signalling
T13037 Sulindac sulfide cis-Sulindac sulfide Raf , Others , AChR
Sulindac sulfide (cis-Sulindac sulfide) is a non-steroidal anti-inflammatory compound that has a high affinity for COX-1 and acts as an inhibitor in Ras activation of Raf-1. Sulindac sulfide is a non-competitive inhibito...
T31999 GSI-136
GSI-136 is a gamma secretase inhibitor.
T70635 ELND007
ELND007 is a Gamma secretase inhibitor.
T26706 AZ4800 AZ-4800,AZ 4800
AZD4800 is a gamma secretase modulators.
T14525 Begacestat GSI-953 Beta Amyloid
Begacestat is a selective thiophene sulfonamide amyloid precursor protein gamma-secretase inhibitor (Aβ40,IC50=15 nM),and for the treatment of Alzheimer's disease.
T2625L MK-0752 Sodium MK 0752,MK0752,MK-0752
Sodium MK-0752 is a novel and potent gamma-secretase inhibitor that has been evaluated in clinical trials for the treatment of various types of cancer.
T31733 EVP-0015962
EVP-0015962, which is bioavailable orally, is a potent and selective gamma-secretase regulator in vitro and in vivo, detectable in the brain.
T39492 FRM-024
FRM-024 is a powerful gamma secretase modulator with the ability to penetrate the central nervous system (CNS), designed specifically for the treatment of familial Alzheimer's disease.
T29233 Z-LLNle-CHO
Z-LLNle-CHO is a cell permeable inhibitor of gamma-secretase. Z-LLNle-CHO induces apoptosis of human glioblastoma tumor-initiating cells by proteasome inhibition and mitotic arrest response.
T38266 Nirogacestat dihydrobromide
Potent γ-secretase inhibitor (IC50 values are 1.2 and 6.2 nM in whole cell and cell-free assays, respectively). Reduces Aβ in brain, CSF and plasma in mice and guinea pigs. Lanz et al (2010) Pharmacodynamics and pharmaco...
T70951 ELND006
ELND006 is a novel gamma secretase inhibitor previously under investigation for the oral treatment of Alzheimer's disease. ELND006 shows poor solubility and has moderate to high permeability. The in vivo performance of t...
T76393 Amyloid 17-42
Amyloid 17-42 (Aβ(17-42)), a significant component of diffuse plaques in Alzheimer's disease and cerebellar pre-amyloid in Down's syndrome, results from the alpha- and gamma-secretase cleavage of amyloid precursor protei...

Compounds

gamma-secretase modulator 1
T11358
Synonym: N-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-4-phenyl-4,5,6,7-tetrahydro-1,3-benzothiazol-2-amine
Target: Gamma-secretase
gamma-secretase modulator 3
T11360
Synonym:
Target: Others
gamma-secretase modulator 2
T11359
Synonym:
Target: Others
gamma-Secretase Modulators
T11362
Synonym: γ-Secretase Modulators,Amyloid-β production inhibitor
Target: Others
YO-01027
T6135
Synonym: gamma-Secretase Inhibitor XX,Dibenzazepine,DBZ
Target: Gamma-secretase
gamma-secretase modulator 1 hydrochloride
T11358L
Synonym: gamma-secretase modulator 1 hydrochloride (1172637-87-4 free base)
Target: Others
Fosciclopirox
T9422
Synonym: CPX-POM
Target: Gamma-secretase
NGP555
T16294
Synonym:
Target: Gamma-secretase
LY-411575
T6063
Synonym: LY411575
Target: Apoptosis, Gamma-secretase
MK-0752
T2625
Synonym:
Target: Beta Amyloid, Gamma-secretase
Avagacestat
T6249
Synonym: BMS-708163
Target: Gamma-secretase
Crenigacestat
T3633
Synonym: LY3039478
Target: Gamma-secretase
L-685458
T6870
Synonym: L-685,458
Target: Apoptosis, Gamma-secretase
MRK-560
T16133
Synonym:
Target: Gamma-secretase
RO4929097
T6274
Synonym: RG-4733
Target: Beta Amyloid, Gamma-secretase
Semagacestat
T6125
Synonym: LY450139
Target: Beta Amyloid, Gamma-secretase
Itanapraced
T2262
Synonym: CHF5074,CSP-1103
Target: Beta Amyloid, Gamma-secretase
DAPT
T6202
Synonym: LY-374973,GSI-IX
Target: Apoptosis, Beta Amyloid, Gamma-secretase, Autophagy
gamma-secretase modulator 5
T64258
Synonym:
Target:
Nirogacestat
T6935
Synonym: PF-03084014,PF-3084014,PF03084014,PF 03084014
Target: Apoptosis, Gamma-secretase
3,5-Bis(4-nitrophenoxy)benzoic acid
T22678
Synonym: Compound W
Target: Gamma-secretase
E 2012
T15184
Synonym:
Target: Gamma-secretase
γ-Secretase modulator 10
T40315
Synonym:
Target:
γ-Secretase modulator 4
T11361
Synonym:
Target: Others
GSM-1
T24116
Synonym: gamma Secretase modulator 1,GSM 1 (enzyme modulator),J2.559.799K
Target:
Z-Ile-Leu-aldehyde
T17281
Synonym: Z-IL-CHO,GSI-XII,γ-Secretase inhibitor XII
Target: Others
RO7185876
T39702
Synonym: RO7185876
Target:
JLK6
T21890
Synonym:
Target: Gamma-secretase
Sulindac sulfide
T13037
Synonym: cis-Sulindac sulfide
Target: Raf, Others, AChR
GSI-136
T31999
Synonym:
Target:
ELND007
T70635
Synonym:
Target:
AZ4800
T26706
Synonym: AZ-4800,AZ 4800
Target:
Begacestat
T14525
Synonym: GSI-953
Target: Beta Amyloid
MK-0752 Sodium
T2625L
Synonym: MK 0752,MK0752,MK-0752
Target:
EVP-0015962
T31733
Synonym:
Target:
FRM-024
T39492
Synonym:
Target:
Z-LLNle-CHO
T29233
Synonym:
Target:
Nirogacestat dihydrobromide
T38266
Synonym:
Target:
ELND006
T70951
Synonym:
Target:
Amyloid 17-42
T76393
Synonym:
Target:

Recombinant Proteins

Species：
Human (2)
Mouse (2)
Expression System：
HEK293 (3)
in vitro E. coli expression system (1)
Tag：
His (2)
N-terminal 10xHis-tagged (1)
hFc (1)
Cat No. Product Name Species Expression System
TMPH-01369 PSENEN Protein, Human, Recombinant (His) Human in vitro E. coli expression system
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamm...
TMPY-03074 Nicastrin Protein, Mouse, Recombinant (hFc) Mouse HEK293
Nicastrin (NCST, or NCT), a single-pass membrane glycoprotein that harbors a large extracellular domain, is an essential component of the gamma-secretase complex. Several lines of evidence indicate that the members of th...
TMPY-01297 Nicastrin Protein, Human, Recombinant (His) Human HEK293
Nicastrin (NCST, or NCT), a single-pass membrane glycoprotein that harbors a large extracellular domain, is an essential component of the gamma-secretase complex. Several lines of evidence indicate that the members of th...
TMPY-02910 Nicastrin Protein, Mouse, Recombinant (His) Mouse HEK293
Nicastrin (NCST, or NCT), a single-pass membrane glycoprotein that harbors a large extracellular domain, is an essential component of the gamma-secretase complex. Several lines of evidence indicate that the members of th...
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