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Search Results for "her1"

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Anti-Breast Cancer Compound Library Anti-Pancreatic Cancer Compound Library High Solubility Pharmacophore Fragment Library Tibetan medicine Compound Library Chinese Pharmacopoeia Natural Product Library Traditional Chinese Medicine Monomer Library Selectable Natural Product Library

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Compounds

Cat No.	Product Name
T6039	TAK-285	TAK 285 , TAK285	EGFR , MEK , HER , Aurora Kinase
	TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor with IC50 of 17 nM and 23 nM, >10-fold selectivity for HER1/2 than...		EGFR , MEK , HER , Aurora Kinase
T5398	BMS 599626 2HCl (873837-23-1(HCl))	AC480 dihydrochloride	HER
	BMS-599626 (AC480) is a selective inhibitor of HER1 and HER2 (IC50s: 20 nM and 30 nM), ~8-fold less potent to HER4, >100...		HER
T8758	Poziotinib hydrochloride	HM 781-36B hydrochloride , NOV120101 hydrochloride	EGFR
	Poziotinib hydrochloride irreversibly inhibits EGFR (HER1 or ErbB1), including EGFR mutants, HER2, and HER4, thereby inh...		EGFR
T9912	Trastuzumab		EGFR
	Trastuzumab is a humanized monoclonal antibody for patients with invasive breast cancers that overexpress HER2. Trastuzu...		EGFR
T22974	Methyl 2,5-dihydroxycinnamate		EGFR
	EGF receptor-associated tyrosine kinases inhibitor		EGFR
T3466	FIIN-3		EGFR , FGFR
	FIIN-3 is an irreversible inhibitor of FGFR.		EGFR , FGFR
T3545	RG13022	RG 13022 , Tyrphostin RG13022	EGFR
	RG13022 is a tyrosine kinase inhibitor; inhibits the autophosphorylation reaction of the EGF receptor (IC50: 4 μM).		EGFR
T39275	Befotertinib	D-0316	EGFR
	Befotertinib is an inhibitor of EGFR tyrosine kinase and can be used for studies about EGFR T790M-positive non-small cel...		EGFR
T21954	EGFR/ErbB-2/ErbB-4 inhibitor-2	EGFR/ErbB2 Inhibitor	EGFR
	EGFR/ErbB2 Inhibitor is a cell-permeable inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM, respectively)		EGFR
T60076	Oritinib	SH-1028	EGFR
	Oritinib is an inhibitor of EGFR with IC50s of 18, 0.7, 4, 0.1, 1.4 and 0.89 nM for EGFR (wt), EGFR (L858R), EGFR (L861Q...		EGFR
TQ0166	Tesevatinib	XL-647 , EXEL-7647 , KD-019	VEGFR , EGFR , FLT , Ephrin Receptor
	Tesevatinib is an orally available, multi-target tyrosine kinase inhibitor (IC50s: 0.3, 16, 1.5, 8.7, and 1.4 nM for EGF...		VEGFR , EGFR , FLT , Ephrin Receptor
T21641	Vandetanib hydrochloride
	Vandetanib hydrochloride (D6474 hydrochloride) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activi...
T22610	BMS 599626 dihydrochloride (714971-09-2 free base)	BMS 599626 dihydrochloride	Others
	BMS 599626 dihydrochloride is a potent and selective EGFR and ErbB2 inhibitor. BMS-599626 inhibited HER4 (IC50: 190 nM)....		Others
T22272	Lifirafenib	BGB-283 , Beigene-283	EGFR , Raf
	Lifirafenib is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM fo...		EGFR , Raf
T9922	Matuzumab		EGFR
	Matuzumab is a humanized monoclonal antibody used in cancer treatment. It has a high affinity for EGFR frequently associ...		EGFR
T9927	Panitumumab		EGFR
	Panitumumab is a fully human IgG2 monoclonal antibody targeting the epidermal growth factor receptor EGFR).		EGFR
T2630	Poziotinib	HM781-36B , NOV120101	EGFR , Apoptosis , HER
	Poziotinib(NOV120101; HM781-36B) is an irreversible HER1/2/4 inhibitor (IC50s: 3/5/23 nM).		EGFR , Apoptosis , HER
T5390	BMS-599626 Hydrochloride		HER
	BMS-599626 Hydrochloride (AC480 Hydrochloride) is a selective and orally bioavailable HER1 and HER2 inhibitor, with IC 5...		HER
T6719	Varlitinib	ARRY-334543 , ASLAN001	HER
	Varlitinib is a potent, reversible, small molecule pan-EGFR inhibitor with IC50s of 7, 2, 4 nM for HER1, HER2 and HER4, ...		HER
T64176	Vandetanib trifluoroacetate
	Vandetanib trifluoroacetate (D6474 trifluoroacetate) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase ...