Search Result

Search Results for " hif "

Targets

141

Compounds

Natural Products

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T67767	HIF-1 inhibitor-4	HIF-1 inhibitor-4	HIF
	HIF-1 inhibitor-4 (HIF-1 inhibitor-4) is a HIF-1 inhibitor with IC50 of 560 nM. HIF-1 inhibitor-4 reduces the HIF-1α protein level without affecting its mRNA level.		HIF
T11561	HIF-2α-IN-2		HIF/HIF Prolyl-Hydroxylase , HIF
	HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).		HIF/HIF Prolyl-Hydroxylase , HIF
T15482	HIF-2α-IN-1		HIF
	HIF-2α-IN-1 is a potent HIF-2α inhibitor with IC50 values less than 500 nM.		HIF
T50099	HIF-2α-IN-4		Others , HIF/HIF Prolyl-Hydroxylase
	HIF-2a translation inhibitor is a compound used as a molecular building block.		Others , HIF/HIF Prolyl-Hydroxylase
T67831	HIF-2α agonist 2		HIF/HIF Prolyl-Hydroxylase , HIF
	HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α. HIF-2α agonist 2 can promote the stability of the ARNT A/B ring in the 3z structure of HIF-2a-ARNT complex without cytotoxicity to 786-o-Reh...		HIF/HIF Prolyl-Hydroxylase , HIF
T3180	JNJ-42041935	HIF-PHD Inhibitor II	HIF/HIF Prolyl-Hydroxylase
	JNJ-42041935 (HIF-PHD Inhibitor II) is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.		HIF/HIF Prolyl-Hydroxylase
T61349	HIF-1α-IN-2		HIF
	HIF-1α-IN-2 is a novel and highly potent HIF-1α inhibitor with anticancer and antitumor activity that inhibits the expression of HIF-1α and VEGF in a dose-dependent manner and inhibits cell migration.		HIF
T75098	HIF-PHD-IN-3		Reactive Oxygen Species
	HIF-PHD-IN-3 is a potent hiPSC-CM cardioprotective scaffold with potential inhibitory effects on HIF-PHD, regulates heme oxygenase-1, and can be used to study anaemia.		Reactive Oxygen Species
T25502	HIF-IN-33	HIF IN 33,HIF Pathway Inhibitor 33
	HIF-IN-33 is an inhibitor of HIF pathway.
T3494	LW6	HIF-1α inhibitor,CAY10585,LW8	Apoptosis , Dehydrogenase , HIF/HIF Prolyl-Hydroxylase , HIF
	LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor.
T36711	FM19G11	FM19G11,HIF-1alpha/2alpha Inhibitor	HIF
	FM19G11 is an inhibitor of hypoxia inducible factor (HIF) α-subunit (IC50 = 80 nM in hypoxia induced luciferase assay).		HIF
TP1533	HIF-1 alpha (556-574)	HIF-1 alpha 556-574
	HIF-1 alpha (556-574) is a hypoxia-inducible factor-1 19-mer fragment. HIF-1 functions as master regulator of response to oxygen homeostasis. Hypoxia-induced gene expression is initiated when HIF-1subunit is stabilized i...
T36290	HIF-1 inhibitor-1
	HIF-1 inhibitor-1 is an aryl carboxamide compound and a potent hypoxia-inducible factor 1 (HIF-1) inhibitor with an IC50 of 0.32 μM for the cancer metastasi[1]. [1]. Liu M, et al. Discovery of Novel Aryl Carboxamide Deri...
T39040	HIF-PHD-IN-1
	HIF-PHD-IN-1 is a pharmacological compound that acts as an orally active inhibitor of the hypoxia-inducible factor prolyl hydroxylase domain (HIF-PHD), displaying an IC50 of 54 nM for hHIF-PHD2. Its potential as a therap...
T11562	HIF-2α-IN-3		HIF
	HIF-2α-IN-3 is an allosteric inhibitor of HIF-2α (IC50: 0.4 μM; KD: 1.1 μM) with anticancer activity.		HIF
TP1546	HIF-1 alpha (556-574) TFA (1201633-99-9 free base)	HIF-1 alpha (556-574) TFA
	This is a hypoxia-inducible factor-1 (HIF-1 a) 19-mer fragment. HIF-1 functions as master regulator of response to oxygen homeostasis. Hypoxia-induced gene expression is initiated when HIF-1 subunit is stabilized in resp...
T60413	HIF-IN-1		HIF
	HIF-IN-1 is a potent inhibitor of hypoxia-inducible factor (HIF-1), which is associated with tumor and cancer cell proliferation and inhibits HIF-1α protein aggregation.		HIF
T22022	Adaptaquin		HIF
	Adaptaquin is an inhibitor of the hypoxia-inducing factor prolyl hydroxylase (HIF-PH) [1] [2].		HIF
T61367	HIF-2α-IN-6
	HIF-2α-IN-6 (117) is a HIF-2α inhibitor [1].
T72997	HIF-2α-IN-7
	HIF-2α-IN-7 is a hypoxia inducible factor 2α (HIF-2α) inhibitor. HIF-2α-IN-7 can inhibit HIF-2α with an EC 50 value of 6 nM. HIF-2α-IN-7 can be used for the research of various types of diseases including cancer , liver ...
T60524	HIF-1α-IN-4
	HIF-1α-IN-4 is an inhibitor of HIF-1α with IC50 of 24 nM in HEK293T cells which has potential antitumor effects. HIF-1α-IN-4 downregulates VEGF and PDK1 mRNA expressions under hypoxia [1].
T60532	HIF-1α-IN-5
	HIF-1α-IN-5 is an inhibitor of HIF-1α with an IC 50 value of 24 nM in HEK293T cells that also inhibits the activity of MAO-A. HIF-1α-IN-5 downregulates the mRNA expressions of VEGF and PDK1 under hypoxia. HIF-1α-IN-5 has...
T61161	HIF-1α-IN-3
	HIF-1α-IN-3, also known as Compound (S)-3f, is a hypoxia-selective inhibitor of HIF-1α. It exhibits potent antiestrogenic activity [1].
T64336	Izilendustat		HIF/HIF Prolyl-Hydroxylase
	Tert-butyl 4-[[1-[(4-chlorophenyl)methyl]-3-hydroxy-2-oxopyridin-4-yl]methyl]piperazine-1-carboxylate inhibit of human recombinant EGLN-1 as substrate after 20 mins by mass spectrophotometric analysis.		HIF/HIF Prolyl-Hydroxylase
T71661	HIF-1α inhibitor-1
	HIF-1α inhibitor-1 is a HIF-1 alpha inhibitor.
T61614	HIF-2α-IN-5
	HIF-2α-IN-5 is a potent HIF-2α inhibitor with an IC 50 of < 50 nM [1].
T78937	HIF-2α-IN-9		HIF/HIF Prolyl-Hydroxylase
	HIF-2α-IN-9 (compound 35r) serves as an HIF-2α inhibitor, effectively suppressing VEGF-A with an IC50 of 305 nM, and modulating growth-promoting genes within tumor cells while reactivating macrophage-mediated tumor immun...		HIF/HIF Prolyl-Hydroxylase
T82198	HIF-1α-IN-6		HIF/HIF Prolyl-Hydroxylase
	HIF-1α-IN-6 (compound 3s) is a potent inhibitor of HIF-1α, demonstrating IC50 values of 0.6 nM and 53.3 nM in MiaPaCa-2 and MDA-MB-231 cells, respectively. It suppresses HIF-1α expression through the reduction of HIF-1α ...		HIF/HIF Prolyl-Hydroxylase
T74804	HIF-1 inhibitor-5
	HIF-1 inhibitor-5 (Compound 16e) is a potent inhibitor of HIF-1, exhibiting an IC50 value of 2.38 μM and demonstrating significant anti-angiogenic potential [1].
T61458	HIF-PHD-IN-2
	HIF-PHD-IN-2 (compound 25) is a highly effective PHD inhibitor, displaying IC50 values below 100 nM for PHD1, PHD2, and PHD3 [1].
T3169	KC7F2		HIF/HIF Prolyl-Hydroxylase , HIF
	KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.		HIF/HIF Prolyl-Hydroxylase , HIF
T21653	1,4-DPCA		HIF/HIF Prolyl-Hydroxylase
	1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting HIF (FIH).		HIF/HIF Prolyl-Hydroxylase
T0244	Tilorone dihydrochloride		Influenza Virus , HIF/HIF Prolyl-Hydroxylase , IFNAR
	Tilorone dihydrochloride is an orally active interferon inducer, and has antineoplastic and anti-inflammatory actions.		Influenza Virus , HIF/HIF Prolyl-Hydroxylase , IFNAR
T13050	SYP-5		HIF/HIF Prolyl-Hydroxylase , HIF
	SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.		HIF/HIF Prolyl-Hydroxylase , HIF
T61442	HIF-1/2α-IN-1
	HIF-1/2α-IN-1, an orally active compound, functions as an inhibitor of HIF-2α. Its inhibitory effect on HIF-2α activity is significant, with an IC 50 value of 0.92 μM. Furthermore, HIF-1/2α-IN-1 has the ability to decrea...
T61102	HIF-1/2α-IN-2
	HIF-1/2α-IN-2 is a potent inhibitor of HIF-1/2α, which effectively reduces the levels of HIF-1/2α. This compound elicits an iron starvation response by specifically targeting ISCA2, a key protein involved in Iron Sulfur ...
T78123	HIF-1α-IN-2 hydrochloride		HIF/HIF Prolyl-Hydroxylase
	HIF-1α-IN-2 hydrochloride is a potent HIF-1α inhibitor exhibiting anticancer activity, demonstrated by IC50 values of 28 nM in MDA-MB-231 cells and 15 nM in MiaPaCa-2 cells. It effectively suppresses HIF-1α expression by...		HIF/HIF Prolyl-Hydroxylase
T29797	AKB-6899	AKB6899	VEGFR , HIF/HIF Prolyl-Hydroxylase , HIF
	AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages. AKB-6899 leads to stabilization of HIF-2α which in...		VEGFR , HIF/HIF Prolyl-Hydroxylase , HIF
T12675L	PT2399		HIF/HIF Prolyl-Hydroxylase , HIF
	PT2399 shows effective antitumor activity in vivo. PT2399 is an effective and selective HIF-2α antagonist, which directly binds to the HIF-2α PAS B domain (IC50: 6 nM).		HIF/HIF Prolyl-Hydroxylase , HIF
T5537	IDF-11774		HIF/HIF Prolyl-Hydroxylase , HIF
	IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).		HIF/HIF Prolyl-Hydroxylase , HIF
T7848	PT-2385		HIF/HIF Prolyl-Hydroxylase , HIF
	PT-2385 is a selective HIF-2α inhibitor (Kd<50 nM).		HIF/HIF Prolyl-Hydroxylase , HIF
T13398	ZINC13466751		HIF
	ZINC13466751 is a potent HIF-1α/von Hippel-Lindau interaction inhibitor(IC50 of 2.0 µM).		HIF
T5392	TP0463518		HIF/HIF Prolyl-Hydroxylase
	TP-0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor (IC50s: 13 nM and 18 nM for human and rat PHD2, respectively).		HIF/HIF Prolyl-Hydroxylase
T7880	IOX4		HIF/HIF Prolyl-Hydroxylase
	IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM)		HIF/HIF Prolyl-Hydroxylase
T4106	MK-8617	MK8617	HIF/HIF Prolyl-Hydroxylase
	MK-8617 is an orally available HIF PHD1 3 pan-inhibitor, inhibiting PHD1/2/3 (IC50: 1.0/1.0/14 nM).		HIF/HIF Prolyl-Hydroxylase
T2488	BAY 87-2243		Ferroptosis , HIF/HIF Prolyl-Hydroxylase , HIF
	BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).		Ferroptosis , HIF/HIF Prolyl-Hydroxylase , HIF
T15219	Enarodustat	JTZ-951	Others , HIF/HIF Prolyl-Hydroxylase
	Enarodustat (JTZ-951) is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.		Others , HIF/HIF Prolyl-Hydroxylase
T82199	HIF-1 alpha (556-574) (TFA)		HIF/HIF Prolyl-Hydroxylase
	HIF-1 alpha (556-574) TFA is a 19-residue fragment of hypoxia-inducible factor-1 (HIF-1), which serves as the master regulator of oxygen homeostasis [1].		HIF/HIF Prolyl-Hydroxylase
T7802	M1001		HIF/HIF Prolyl-Hydroxylase , HIF
	M1001 is a HIF-2α agonist.		HIF/HIF Prolyl-Hydroxylase , HIF
T6961	PX-478	PX-478 2HCl	HIF/HIF Prolyl-Hydroxylase , HIF , Autophagy
	PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability. PX-478 has antitumor activity and also protects pancreatic β-cell function in diabetes mellitus and is used in type 2 di...		HIF/HIF Prolyl-Hydroxylase , HIF , Autophagy

Compounds

HIF-1 inhibitor-4

T67767

Synonym: HIF-1 inhibitor-4

Target: HIF/HIF Prolyl-Hydroxylase, HIF

Target: Others, HIF/HIF Prolyl-Hydroxylase

HIF-2α agonist 2

T67831

Synonym:

Target: HIF/HIF Prolyl-Hydroxylase, HIF

JNJ-42041935

T3180

Synonym: HIF-PHD Inhibitor II

Target: HIF/HIF Prolyl-Hydroxylase

Target: Reactive Oxygen Species

HIF-IN-33

T25502

Synonym: HIF IN 33,HIF Pathway Inhibitor 33

Target:

LW6

T3494

Synonym: HIF-1α inhibitor,CAY10585,LW8

Target: Apoptosis, Dehydrogenase, HIF/HIF Prolyl-Hydroxylase, HIF

FM19G11

T36711

Synonym: FM19G11,HIF-1alpha/2alpha Inhibitor

Target: HIF

HIF-1 alpha (556-574)

TP1533

Synonym: HIF-1 alpha 556-574

HIF-1 alpha (556-574) TFA (1201633-99-9 free base)

TP1546

Synonym: HIF-1 alpha (556-574) TFA

Target: HIF/HIF Prolyl-Hydroxylase

Target: HIF/HIF Prolyl-Hydroxylase

HIF-1α-IN-6

T82198

Synonym:

Target: HIF/HIF Prolyl-Hydroxylase

Target: HIF/HIF Prolyl-Hydroxylase, HIF

1,4-DPCA

T21653

Synonym:

Target: HIF/HIF Prolyl-Hydroxylase

Tilorone dihydrochloride

T0244

Synonym:

Target: Influenza Virus, HIF/HIF Prolyl-Hydroxylase, IFNAR

SYP-5

T13050

Synonym:

Target: HIF/HIF Prolyl-Hydroxylase, HIF

HIF-1α-IN-2 hydrochloride

T78123

Synonym:

Target: HIF/HIF Prolyl-Hydroxylase

AKB-6899

T29797

Synonym: AKB6899

Target: VEGFR, HIF/HIF Prolyl-Hydroxylase, HIF

PT2399

T12675L

Synonym:

Target: HIF/HIF Prolyl-Hydroxylase, HIF

IDF-11774

T5537

Synonym:

Target: HIF/HIF Prolyl-Hydroxylase, HIF

PT-2385

T7848

Synonym:

Target: HIF/HIF Prolyl-Hydroxylase, HIF

Target: HIF/HIF Prolyl-Hydroxylase

IOX4

T7880

Synonym:

Target: HIF/HIF Prolyl-Hydroxylase

MK-8617

T4106

Synonym: MK8617

Target: HIF/HIF Prolyl-Hydroxylase

BAY 87-2243

T2488

Synonym:

Target: Ferroptosis, HIF/HIF Prolyl-Hydroxylase, HIF

Enarodustat

T15219

Synonym: JTZ-951

Target: Others, HIF/HIF Prolyl-Hydroxylase

HIF-1 alpha (556-574) (TFA)

T82199

Synonym:

Target: HIF/HIF Prolyl-Hydroxylase

M1001

T7802

Synonym:

Target: HIF/HIF Prolyl-Hydroxylase, HIF

PX-478

T6961

Synonym: PX-478 2HCl

Target: HIF/HIF Prolyl-Hydroxylase, HIF, Autophagy

Cat No.	Product Name	Synonyms	Targets
T6S0071	Fraxinellone		HIF/HIF Prolyl-Hydroxylase , STAT , PD-1/PD-L1
	1. Fraxinellone significantly reduced weight loss and diarrhea in mice and alleviated the macroscopic and microscopic signs of the disease. 2. Fraxinellone exhibited a variety of insecticidal activities including feeding...		HIF/HIF Prolyl-Hydroxylase , STAT , PD-1/PD-L1
T5S2347	Deoxyshikonin	Arnebin 7	Others , HIF/HIF Prolyl-Hydroxylase , Antibacterial
	1. Deoxyshikonin (Arnebin 7) may be a new drug candidate for wound healing and treatment of lymphatic diseases. 2. Deoxyshikonin enhances the ability of human dermal lymphatic microvascular endothelial cells (HMVEC-dLy) ...		Others , HIF/HIF Prolyl-Hydroxylase , Antibacterial
TL0001	Dencichine	L-Dencichin,ODAP,Dencichin	Others , HIF/HIF Prolyl-Hydroxylase
	Dencichine (ODAP) is a neurotoxic agent. Dencichine is a haemostatic agent, the hemostatic effect relates to modulation of the coagulation system, platelet aggregation and fibrinolytic system. It has renoprotective effec...		Others , HIF/HIF Prolyl-Hydroxylase
T2763	Panaxadiol	20(R)-Panaxadiol	Others , HIF/HIF Prolyl-Hydroxylase
	Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.		Others , HIF/HIF Prolyl-Hydroxylase
T0429	Glucosamine	Chitosamine,D-Glucosamine	MMP , Others , TNF , NF-κB , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , Endogenous Metabolite , CFTR , Autophagy
	Glucosamine (Chitosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to rebuild cartilage and treat arthritis.
T5684	Ethyl 3,4-dihydroxybenzoate		Apoptosis , Others , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , NO Synthase , Autophagy
	Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.
T6S1315	Oroxylin A	6-Methoxybaicalein,Baicalein 6-methyl ether	Virus Protease , HIF/HIF Prolyl-Hydroxylase , Autophagy
	1. Oroxylin A (Baicalein 6-methyl ether) has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting the ATRA-induced IL-6 production v...		Virus Protease , HIF/HIF Prolyl-Hydroxylase , Autophagy
T11589	Hydroxycitric acid tripotassium hydrate	Potassium citrate monohydrate	ATP Citrate Lyase , HIF/HIF Prolyl-Hydroxylase , HIF
	Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation, and anti-tumor effects. Hydroxycitric acid tr...		ATP Citrate Lyase , HIF/HIF Prolyl-Hydroxylase , HIF
T1152	Albendazole	SKF-62979	HIF/HIF Prolyl-Hydroxylase , Microtubule Associated , Antibiotic , Parasite
	Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.
T2792	Glucosamine sulfate	D-Glucosamine sulphate,D-Glucosaminesulfate	MMP , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , Endogenous Metabolite , Autophagy
	Glucosamine sulfate (D-Glucosaminesulfate) was extracted from synthetic product;Store the product in sealed, cool and dry condition.
T2805	Chlorogenic Acid	NSC-407296,3-O-Caffeoylquinic acid,Heriguard	Others , Influenza Virus , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , Endogenous Metabolite , Antibacterial
	Chlorogenic Acid (NSC-407296) is a naturally occurring phenolic acid which is a carcinogenic inhibitor. It has also been shown to prevent paraquat-induced oxidative stress in rats.
T1205	Chloramphenicol	Chlornitromycin,Levomycetin,Chloromycetin	ribosome , HIF/HIF Prolyl-Hydroxylase , Antibacterial , Antibiotic
	Chloramphenicol (Chloromycetin), a broad-spectrum antibiotic, blocks bacterial protein synthesis.
T0256	Citric acid trilithium salt tetrahydrate	Lithium citrate tribasic tetrahydrate,Trilithium citrate tetrahydrate	Dehydrogenase , GSK-3 , HIF/HIF Prolyl-Hydroxylase , Antibacterial , GluR
	Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) , the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways...
T2941	Glucosamine hydrochloride	Chitosamine hydrochloride,2-Amino-2-deoxy-glucose HCl,Chitosamine HCl,D-(+)-Glucosamine hydrochloride	Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , Endogenous Metabolite , Autophagy
	Glucosamine hydrochloride (Chitosamine hydrochloride) is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.
T3860	Isoliquiritin apioside		MMP , p38 MAPK , NF-κB
	Isoliquiritin apioside, isolated from Glycyrrhizae radix rhizome, significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresse...		MMP , p38 MAPK , NF-κB
T12045	(-)-Hydroxycitric acid lactone	Garcinia lactone	ATP Citrate Lyase
	(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent.(-)-Hydroxycitric acid lactone was a potent inhibitor of ATP citrate lyase, which catalyzes the extramitochondrial cleavage of citrate to oxaloac...		ATP Citrate Lyase
T5S1569	AKBA	3-O-Acetyl-11-keto-β-boswellic acid,3-O-Acetyl-11-keto-beta-boswellic acid,Acetyl-11-keto-β-boswellic acid	Others , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , Endogenous Metabolite
	AKBA (3-O-Acetyl-11-keto-beta-boswellic acid), a natural component from frankincense, is a novel activator of Nrf2.
T1123	Camptothecin	NSC-100880,Campathecin,(S)-(+)-Camptothecin,CPT	Apoptosis , Influenza Virus , Topoisomerase , Antibiotic , Antifungal
	Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA topoisomerase I (Topo I) inhibitor (IC50=679 nM) with specificity. Camptothecin has antitumor activity and induces apoptosis.
TN3826	Demethylsonchifolin		Others
	Demethylsonchifolin is a natural product for research related to life sciences. The catalog number is TN3826 and the CAS number is 956384-55-7.		Others
TN1484	Cheilanthifoline		NF-κB , Antifection
	Cheilanthifoline has anti-osteoclastogenic property, it gives significant inhibitions on receptor activator of nuclear factor-κB ligand-induced differentiation of mouse bone marrow-derived macrophages into multinucleated...		NF-κB , Antifection
T10233	Acetylarenobufagin		HIF
	Acetylarenobufagin is a steroidal hypoxia-inducible factor-1 (HIF-1) modulator.		HIF
TN1480	Cephaeline		Virus Protease , Influenza Virus , HIF
	Cephaeline was highly active against protected primary CLL cells (relative IC50's 35nM ) and acted by repressing HIF-1α± and disturbing intracellular redox homeostasis.		Virus Protease , Influenza Virus , HIF
T21494	Oligomycin		HIF
	Oligomycin is an antifungal antibiotic that is an inhibitor of H+-ATP synthetase. The Oligomycin blocks oxidative phosphorylation and the electron transport chain. Oligomycin inhibited HIF-1alpha expression in hypoxic tu...		HIF
T5429	Theaflavin 3,3'-digallate	8-Gingerol,TFDG	Virus Protease , Antioxidant , HIV Protease , HSV
	Theaflavin 3,3'-digallate (8-Gingerol) , a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions, it reduces tumor angiogenesis by downregul...		Virus Protease , Antioxidant , HIV Protease , HSV
T3404	Cucurbitacin B	Cuc B,DATISCACIN,Amarine	Apoptosis , PTEN , Integrin , Endogenous Metabolite , HIF , STAT , Autophagy
	Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inh...
T5740	25(R,S)-Ruscogenin	(25RS)-Ruscogenin	Others , HIF
	25(R,S)-Ruscogenin is a natual product.		Others , HIF
T6429	Caffeic Acid Phenethyl Ester	Phenylethyl Caffeate,CAPE	Apoptosis , NF-κB
	Caffeic Acid Phenethyl Ester (Phenylethyl Caffeate) (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways, with antineoplastic, cytoprotective...		Apoptosis , NF-κB
T4S1551	Cinnamaldehyde	Cinnamic Aldehyde	HIF
	1. Cinnamaldehyde (Cinnamic Aldehyde) has antipyretic activity. 2. Cinnamaldehyde is a sedative agent. 3. Cinnamaldehyde inhibits invasive capabilities of MDA-MB-435S cells was correlated with down-regulating the express...		HIF
T3816	Velutin		NF-κB , HIF/HIF Prolyl-Hydroxylase
	Velutin shows the strongest inhibitory effect in NF-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well as in inhibiting mitogen-activated protein kinase p38 and JNK ...		NF-κB , HIF/HIF Prolyl-Hydroxylase
T3S2344	β,β-Dimethylacrylshikonin	Dimethylacrylshikonin,β, β-Dimethylacrylshikonin	ERK , HIF/HIF Prolyl-Hydroxylase
	1. β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combined with IR treatment significant...		ERK , HIF/HIF Prolyl-Hydroxylase
T6569L	Mimocine	Mimocine
	Mimosine, a plant amino acid, is known to act as a normoxic inducer of hypoxia-inducible factor (HIF).
T75487	7-Hydroxyneolamellarin A
	7-Hydroxyneolamellarin A, a natural product from the sponge Dendrilla nigra, serves as a potent inhibitor of hypoxia-inducible factor-1α (HIF-1α). It effectively reduces the accumulation of HIF-1α protein and suppresses ...
TN1952	Moracin P		Others , ROS , HIF
	Moracin P exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tumour hypoxia.		Others , ROS , HIF
T36439	Gramicidin A		Antibacterial , HIF , Parasite
	Gramicidin A is a peptide antibiotic isolated from B. brevis.Gramicidin A is a highly hydrophobic channel-forming ion carrier that forms monovalent cation-permeable channels in artificial membranes.Gramicidin A induces t...		Antibacterial , HIF , Parasite
T36749	Herboxidiene
	Herboxidiene is a polyketide originally isolated from S. chromofuscus that has diverse biological activities.[1],[2,][3],[4],[5] It inhibits growth of HeLa S3, SK-MEL-2, PC3, A549, and EBC-1 cells with GI50 values rangin...
TN4489	Manassantin A		ERK , cAMP , TNF , NF-κB , MAPK , COX , HIF , Prostaglandin Receptor , JNK , STAT
	Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effects might be associated with COX/PGE2 stimulation, inhibitio...
TN1951	Moracin O		HIF
	Moracin O shows significant neuroprotective, and analgesic activities, it also has a strong protective influence against doxorubicin-induced cardiomyopathy in H9c2 cells with the EC50 value of 4.5 ± 1.3 μM. Moracin O exh...		HIF

Natural Products

Fraxinellone

T6S0071

Synonym:

Target: HIF/HIF Prolyl-Hydroxylase, STAT, PD-1/PD-L1

Deoxyshikonin

T5S2347

Synonym: Arnebin 7

Target: Others, HIF/HIF Prolyl-Hydroxylase, Antibacterial

dencichine

TL0001

Synonym: L-Dencichin,ODAP,Dencichin

Target: Others, HIF/HIF Prolyl-Hydroxylase

Panaxadiol

T2763

Synonym: 20(R)-Panaxadiol

Target: Others, HIF/HIF Prolyl-Hydroxylase

Glucosamine

T0429

Synonym: Chitosamine,D-Glucosamine

Target: MMP, Others, TNF, NF-κB, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, Endogenous Metabolite, CFTR, Autophagy

Ethyl 3,4-dihydroxybenzoate

T5684

Synonym:

Target: Apoptosis, Others, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, NO Synthase, Autophagy

Oroxylin A

T6S1315

Synonym: 6-Methoxybaicalein,Baicalein 6-methyl ether

Target: Virus Protease, HIF/HIF Prolyl-Hydroxylase, Autophagy

Hydroxycitric acid tripotassium hydrate

T11589

Synonym: Potassium citrate monohydrate

Target: ATP Citrate Lyase, HIF/HIF Prolyl-Hydroxylase, HIF

Albendazole

T1152

Synonym: SKF-62979

Target: HIF/HIF Prolyl-Hydroxylase, Microtubule Associated, Antibiotic, Parasite

Glucosamine sulfate

T2792

Synonym: D-Glucosamine sulphate,D-Glucosaminesulfate

Target: MMP, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, Endogenous Metabolite, Autophagy

Chlorogenic Acid

T2805

Synonym: NSC-407296,3-O-Caffeoylquinic acid,Heriguard

Target: Others, Influenza Virus, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, Endogenous Metabolite, Antibacterial

Chloramphenicol

T1205

Synonym: Chlornitromycin,Levomycetin,Chloromycetin

Target: ribosome, HIF/HIF Prolyl-Hydroxylase, Antibacterial, Antibiotic

Citric acid trilithium salt tetrahydrate

T0256

Synonym: Lithium citrate tribasic tetrahydrate,Trilithium citrate tetrahydrate

Target: Dehydrogenase, GSK-3, HIF/HIF Prolyl-Hydroxylase, Antibacterial, GluR

Glucosamine hydrochloride

T2941

Synonym: Chitosamine hydrochloride,2-Amino-2-deoxy-glucose HCl,Chitosamine HCl,D-(+)-Glucosamine hydrochloride

Target: Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, Endogenous Metabolite, Autophagy

Isoliquiritin apioside

T3860

Synonym:

Target: MMP, p38 MAPK, NF-κB

(-)-Hydroxycitric acid lactone

T12045

Synonym: Garcinia lactone

Target: ATP Citrate Lyase

AKBA

T5S1569

Synonym: 3-O-Acetyl-11-keto-β-boswellic acid,3-O-Acetyl-11-keto-beta-boswellic acid,Acetyl-11-keto-β-boswellic acid

Target: Others, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, Endogenous Metabolite

Camptothecin

T1123

Synonym: NSC-100880,Campathecin,(S)-(+)-Camptothecin,CPT

Target: Apoptosis, Influenza Virus, Topoisomerase, Antibiotic, Antifungal

Target: NF-κB, Antifection

Target: Virus Protease, Influenza Virus, HIF

Theaflavin 3,3'-digallate

T5429

Synonym: 8-Gingerol,TFDG

Target: Virus Protease, Antioxidant, HIV Protease, HSV

Cucurbitacin B

T3404

Synonym: Cuc B,DATISCACIN,Amarine

Target: Apoptosis, PTEN, Integrin, Endogenous Metabolite, HIF, STAT, Autophagy

25(R,S)-Ruscogenin

T5740

Synonym: (25RS)-Ruscogenin

Target: Others, HIF

Caffeic Acid Phenethyl Ester

T6429

Synonym: Phenylethyl Caffeate,CAPE

Target: Apoptosis, NF-κB

Cinnamaldehyde

T4S1551

Synonym: Cinnamic Aldehyde

Target: NF-κB, HIF/HIF Prolyl-Hydroxylase

β,β-Dimethylacrylshikonin

T3S2344

Synonym: Dimethylacrylshikonin,β, β-Dimethylacrylshikonin

Target: ERK, HIF/HIF Prolyl-Hydroxylase

7-Hydroxyneolamellarin A

Target: Others, ROS, HIF

Gramicidin A

T36439

Synonym:

Target: Antibacterial, HIF, Parasite

Target: ERK, cAMP, TNF, NF-κB, MAPK, COX, HIF, Prostaglandin Receptor, JNK, STAT

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-01709	HIF-1 alpha Protein, Human, Recombinant (His)	Human	E. coli
	HIF-1 alpha, also known as HIF1A, contains 1 basic helix-loop-helix (bHLH) domain, 1 PAC (PAS-associated C-terminal) domain, and 2 PAS (PER-ARNT-SIM) domains. It is one of the two subunits of Hypoxia-inducible factor-1 (...
TMPH-01280	EGLN1 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of th...
TMPH-00957	ARNT Protein, Human, Recombinant (His)	Human	Yeast
	ARNT Protein, Human, Recombinant (His) is expressed in Yeast.
TMPH-01512	HIF1AN Protein, Human, Recombinant (His)	Human	Yeast
	Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coa...
TMPH-02233	P4HTM Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic...
TMPY-04671	MCP-5 Protein, Mouse, Recombinant (His)	Mouse	Yeast
	Ccl12 prevented initiation of the reparative response by prolonging inflammation and inhibiting fibroblast conversion to myofibroblasts, resulting in diminished scar formation. Macrophage secretion of Ccl12 directly impa...
TMPK-00563	EPHB2 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	EphB2, a receptor tyrosine kinase for ephrin ligands, is overexpressed in various cancers and plays an important role in tumor progression. EPHB2 promotes endothelial-mesenchymal transition (EMT) and elicits associated p...
TMPY-02376	BNIP3L Protein, Human, Recombinant	Human	E. coli
	The deletion of BNIP3L results in retention of mitochondria during lens fiber cell remodeling, and that deletion of BNIP3L also results in the retention of endoplasmic reticulum and Golgi apparatus. BNIP3L localizes to t...
TMPY-00585	Annexin A8 Protein, Human, Recombinant (His)	Human	E. coli
	We have previously shown that Annexin A8 (ANXA8) is strongly associated with the basal-like subgroup of breast cancers, including BRCA1-associated breast cancers, and poor prognosis; while in the mouse mammary gland AnxA...
TMPY-01576	Artemin Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Artemin (ARTN) is a member of glial cell line-derived neurotrophic factor (GDNF) family of ligands, and its signaling is mediated via a multi-component receptor complex including the glycosylphosphatidylinositol-anchored...

HIF-1 alpha Protein, Human, Recombinant (His)

TMPY-01709

Species: Human

Expression System: E. coli

EGLN1 Protein, Human, Recombinant (His & Myc)

TMPH-01280

Species: Human

Expression System: E. coli

ARNT Protein, Human, Recombinant (His)

TMPH-00957

Species: Human

Expression System: Yeast

HIF1AN Protein, Human, Recombinant (His)

TMPH-01512

Species: Human

Expression System: Yeast

P4HTM Protein, Human, Recombinant (His & SUMO)

TMPH-02233

Species: Human

Expression System: E. coli

MCP-5 Protein, Mouse, Recombinant (His)

TMPY-04671

Species: Mouse

Expression System: Yeast

EPHB2 Protein, Cynomolgus, Recombinant (His)

TMPK-00563

Species: Cynomolgus

Expression System: HEK293

BNIP3L Protein, Human, Recombinant

TMPY-02376

Species: Human

Expression System: E. coli

Annexin A8 Protein, Human, Recombinant (His)

TMPY-00585

Species: Human

Expression System: E. coli

Artemin Protein, Mouse, Recombinant (hFc)

TMPY-01576

Species: Mouse

Expression System: HEK293

Cat No.	Product Name
L8500	HIF-1 Signaling Pathway Compound Library	1352 compounds
	A unique collection of 1352 HIF-1 related small chemicals can be used for drug discovery in ischemic disease and cancer and related mechanism studies；
L2130	Anti-Cancer Metabolism Compound Library	1280 compounds
	A unique collection of 1280 cancer cellular metabolism related compounds for cancer research and high throughput screening (HTS) and high content screening (HCS);

Libraries

HIF-1 Signaling Pathway Compound Library

L8500

Compounds: 1352

Anti-Cancer Metabolism Compound Library

L2130

Compounds: 1280