Home Tools
Log in
Cart

Search Result

Search Results for " ht29 "

Targets

32

Compounds

5

Natural Products

2

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T9966 GSK-1520489A Wee1
GSK-1520489A is an active PKMYT1 inhibitor.
T6255 Bromosporine Epigenetic Reader Domain , CDK
Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 μM), respectively.
T2617 SNS-314 Mesylate SNS-314 Aurora Kinase
SNS-314 Mesylate (SNS-314) is an effective and specific Aurora A/B/C inhibitor (IC50: 9/31/3 nM). It is less inhibition of Trk A/B, Fms, Flt4, c-Raf, Axl, and DDR2.
T6967 RHPS4 RHPS 4 methosulfate,NSC714187 Apoptosis , Telomerase
RHPS4 (RHPS 4 methosulfate) is a potent inhibitor of Telomerase at submicromolar.
T16961 Supinoxin RX-5902 Apoptosis , DNA/RNA Synthesis
Supinoxin (RX-5902) is an orally active inhibitor of phosphorylated-p68 RNA helicase and a potent first-in-class anti-cancer agent. Supinoxin induces cell apoptosis and inhibits the growth of TNBC cancer cell lines (IC50...
T13009 STAT3-IN-1 Apoptosis , STAT
STAT3-IN-1 selective and orally active inhibitor of STAT3(in HT29 and MDA-MB 231 cells, with IC50 values of 1.82 μM and 2.14 μM , respectively), induces tumor apoptosis.
T20882 4-Nitrobenzoic acid Kyselina p-nitrobenzoova,4Nitrobenzoic acid,Nitrodracylic acid,4 Nitrobenzoic acid
4-Nitrobenzoic acid (4Nitrobenzoic acid) is a pharmaceutical intermediate often found in the production of folic acid, DABA, PABA and dyes.
T11369 GB-110 Others
GB-110 selectively induces PAR2-mediated intracellular Ca2+ release in HT29 cells with an EC50 of 0.28 μM. GB-110 is a potent, orally active, and nonpeptidic protease activated receptor 2 (PAR2) agonist.
T2283 PX-12 IV-2,PX12 Thioredoxin
PX-12 (PX12) (1-methylpropyl 2-imidazolyl disulfide) is a small-molecule inhibitor of Trx-1 (thioredoxin-1), stimulates apoptosis, down-regulates HIF-1α and vascular endothelial growth factor (VEGF) and inhibits tumor gr...
T73854 GB-110 hydrochloride
GB-110 hydrochloride is a potent, orally active, and nonpeptidic protease activated receptor 2 (PAR2) agonist. GB-110 hydrochloride selectively induces PAR2-mediated intracellular Ca 2+ release in HT29 cells with an EC 5...
T3437 Lys05 Lys01 trihydrochloride lysosomal autophagy , Autophagy
Lys05, or Lys01 trihydrochloride, is a potent, water soluble lysosomal autophagy inhibitor. Lys05 is a previously undescribed dimeric chloroquine which more potently accumulates in the lysosome and blocks autophagy compa...
T21749 4-iodo-SAHA
4-Iodo-SAHA (1k) is an orally active class I and class II histone deacetylase (HDAC) inhibitor with EC 50 s of 1.1, 0.95, 0.12, 0.24, 0.85 and 1.3 μM for Skbr3, HT29, U937, JA16 and HL60 cell lines, respectively. 4-Iodo-...
T61532 Tubulin polymerization-IN-6
Tubulin polymerization-IN-6 (compound 5f) is a potent inhibitor of tubulin polymerization, with an IC50 of 1.09 μM. It not only inhibits cell migration and tube formation but also has anti-angiogenic properties. Addition...
T12259 NSC 601980 Others
NSC601980 exhibits antitumor activity in the yeast screening experiment, which can inhibit cell proliferation in the COLO 205 and HT29 with Log GI 50 of -6.6 and -6.9 respectively.
T41189 AY 254
AY 254 is a potent PAR2 biased agonist. Selectively activates ERK1/2 signaling (EC50= 2 nM for ERK1/2 phosphorylation versus 80 nM for Ca2+release). Reduces cytoKi ne-induced caspase 3/8 activation, promotes scratch-woun...
T11369L GB-110 hydrochloride (1252806-70-4 free base) GB-110 hydrochloride Others
GB-110 hydrochloride selectively induces PAR2-mediated intracellular Ca2+ release in HT29 cells with an EC50 of 0.28 μM. GB-110 hydrochloride is a potent, orally active, and nonpeptidic protease activated receptor 2 (PAR...
T72524 Antitumor agent-47
Antitumor agent-47 is a silibinin derivative with an antitumor activity. Antitumor agent-47 shows cytotoxic activity against NCI-H1299 and HT29 cells with IC 50 values of 8.07 µM and 6.27 µM, respectively .
T62922 Tubulin inhibitor 25
Tubulin inhibitor 25 is a potent inhibitor of tubulin (IC50: 0.98 μM) and significantly inhibits HT29 cells. tubulin inhibitor 25 inhibits cell migration and microtubule formation and contributes to anti-angiogenesis.
T72525 Antitumor agent-48
Antitumor agent-48 is a 2,3-dehydrosilybin derivative with an antitumor activity. Antitumor agent-48 shows cytotoxic activity against MCF-7, NCI-H1299, HepG2 and HT29 cells with IC 50 values of 8.06 µM, 13.1 µM, 16.51 µM...
T36704 CCT241533 dihydrochloride CCT 241533 dihydrochloride
Potent Chk2 inhibitor (IC50 = 3 nM). Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells. Blocks ionizing radi...
T79388 Anticancer agent 154 Reactive Oxygen Species
Anticancer agent 154 (Compound 8h) enhances reactive oxygen species production, causing mitochondrial damage, and promotes cell apoptosis and DNA damage. It triggers ferroptosis by depleting GSH, diminishing GPX4 express...
T78156 MC4033 Apoptosis
MC4033 exhibits inhibitory concentration 50 (IC50) values of 39.4 µM in HCT116, 52.1 µM in H1299, 41 µM in A549, and 30.1 µM in U937 [1]. Additionally, treatment with MC4033 at concentrations of 25, 50, 100, and 200 µM f...
T60793 Tubulin inhibitor 26
Tubulin inhibitor 26 (compound 3c) is an indazole derivative which is a potent tubulin inhibitor with noteworthy low nanomolar potency against HepG2, HCT116, SW620, HT29 and A549 cancer cell lines. Tubulin inhibitor 26 i...
T79353 P-gp/BCRP-IN-2
P-gp/BCRP-IN-2 (compound 15), an oxadiazole derivative, functions as a dual inhibitor targeting both the ABC transporter P-glycoprotein (IC50: 1.6 nM) and BCRP (IC50: 600 nM). Additionally, it bolsters the anti-prolifera...
T79599 Anti-inflammatory agent 53 COX
Anti-inflammatory agent 52 (compound 7c) is an orally active, selective COX-2 inhibitor with demonstrated anti-HT29 metastatic activity, causing periodic arrest in the S phase and G2/M phase. This agent exhibits moderate...
T79598 Anti-inflammatory agent 52 COX
Anti-inflammatory agent 52 (compound 7j) is an orally active, selective COX-2 inhibitor with the capability to induce G2/M phase arrest and exhibit anti-HT29 transfer activity. It demonstrates moderate anti-inflammatory ...
T78855 Anticancer agent 157 NO Synthase
Anticancer Agent 157 (compound 15) is a nitric oxide (NO) inhibitor with IC50 values of 0.62 μg/mL, exhibiting both anti-inflammatory and anticancer effects. It interacts with inducible NO synthase (iNOS) and caspase 8, ...
T71382 KRC-108
KRC-108 is a multiple kinase inhibitor. KRC-108 is a potent inhibitor of Ron, Flt3 and TrkA as well as c-Met. KRC-108 inhibited oncogenic c-Met M1250T and Y1230D more strongly than wild type c-Met. The anti-proliferative...
T36742 CDK5 inhibitor 20-223 CDK5 inhibitor 20-223
CDK5 inhibitor 20-223 is a potent CDK2 and CDK5 inhibitor with IC50s of 6.0 and 8.8 nM, respectively. CDK5 inhibitor 20-223 is an effective anti-colorectal cancer (CRC) agent[1]. CDK5 inhibitor 20-223 (10 nM-10 μM; 72 ho...
T68896 Daniquidone NSC 320846,BAY-H 2049 Topoisomerase
Daniquidone (Batracylin) is a potent dual inhibitor of DNA topoisomerase I and DNA topoisomerase II with cytotoxic and antiproliferative activity that induces DNA fragmentation for the study of neoplasms, immune disorder...
T41070 LP-184
LP-184 (Compound 6), referred to as an acylfulvene analog, demonstrates the ability to inhibit tumor growth with noteworthy anti-cancer efficacy observed across multiple cell lines, including ovarian, colon, prostate, an...
T13782 MS432 MEK
MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.

Compounds

GSK-1520489A
T9966
Synonym:
Target: Wee1
Bromosporine
T6255
Synonym:
Target: Epigenetic Reader Domain, CDK
SNS-314 Mesylate
T2617
Synonym: SNS-314
Target: Aurora Kinase
RHPS4
T6967
Synonym: RHPS 4 methosulfate,NSC714187
Target: Apoptosis, Telomerase
Supinoxin
T16961
Synonym: RX-5902
Target: Apoptosis, DNA/RNA Synthesis
STAT3-IN-1
T13009
Synonym:
Target: Apoptosis, STAT
4-Nitrobenzoic acid
T20882
Synonym: Kyselina p-nitrobenzoova,4Nitrobenzoic acid,Nitrodracylic acid,4 Nitrobenzoic acid
Target:
GB-110
T11369
Synonym:
Target: Others
PX-12
T2283
Synonym: IV-2,PX12
Target: Thioredoxin
GB-110 hydrochloride
T73854
Synonym:
Target:
Lys05
T3437
Synonym: Lys01 trihydrochloride
Target: lysosomal autophagy, Autophagy
4-iodo-SAHA
T21749
Synonym:
Target:
Tubulin polymerization-IN-6
T61532
Synonym:
Target:
NSC 601980
T12259
Synonym:
Target: Others
AY 254
T41189
Synonym:
Target:
GB-110 hydrochloride (1252806-70-4 free base)
T11369L
Synonym: GB-110 hydrochloride
Target: Others
Antitumor agent-47
T72524
Synonym:
Target:
Tubulin inhibitor 25
T62922
Synonym:
Target:
Antitumor agent-48
T72525
Synonym:
Target:
CCT241533 dihydrochloride
T36704
Synonym: CCT 241533 dihydrochloride
Target:
Anticancer agent 154
T79388
Synonym:
Target: Reactive Oxygen Species
MC4033
T78156
Synonym:
Target: Apoptosis
Tubulin inhibitor 26
T60793
Synonym:
Target:
P-gp/BCRP-IN-2
T79353
Synonym:
Target:
Anti-inflammatory agent 53
T79599
Synonym:
Target: COX
Anti-inflammatory agent 52
T79598
Synonym:
Target: COX
Anticancer agent 157
T78855
Synonym:
Target: NO Synthase
KRC-108
T71382
Synonym:
Target:
CDK5 inhibitor 20-223
T36742
Synonym: CDK5 inhibitor 20-223
Target:
Daniquidone
T68896
Synonym: NSC 320846,BAY-H 2049
Target: Topoisomerase
LP-184
T41070
Synonym:
Target:
MS432
T13782
Synonym:
Target: MEK
Cat No. Product Name Synonyms Targets
TN4132 Germanicol
Germanicol induces selective growth inhibitory effects in human colon HCT-116 and HT29 cancer cells through induction of apoptosis, cell cycle arrest and inhibition of cell migration. Germanicol may have anti-inflammator...
T13629 Cyclo(Ala-Gly) Others
Cyclo (Ala-Gly) is a mangrove endophytic fungus, a metabolite of Penicillium thomi, which is cytotoxic to A549, HepG2 and HT29 cells. The IC50 value is in the range of 9.5-18.1 μM.
TN1324 6-O-Nicotinoylscutebarbatine G Others
6-O-Nicotinoylscutebarbatine G shows cytotoxic activities against three human tumor cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and with IC50 values in th...
TN3812 Dehydrovomifoliol AChR
Dehydrovomifoliol could be a marker of Polish heather honey. Dehydrovomifoliol exhibits moderate acetylcholinesterase (AChE) inhibitory activities. Dehydrovomifoliol shows significant cytotoxic activities against three h...
TN3300 8alpha-Tigloyloxyhirsutinolide 13-O-acetate NADPH-oxidase , P450 , MAO
8alpha-Tigloyloxyhirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes. 8alpha-Tigloyloxyhirsutinolide 13-O-acetate has anti-cancer activity, it is active against both cancer cell...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-00836 IGFBP-4 Protein, Human, Recombinant (His) Human HEK293
Insulin-like growth factor-binding protein 4 (IGFBP-4) is a 24-kDa protein that binds insulin-like growth factor 1 (IGF-1) and IGF-2 with high affinity and inhibits IGF action in vitro. The Insulin-like growth factor-bin...
TMPY-03629 Syntaxin 8 Protein, Human, Recombinant (His) Human HEK293
STX8, also known as syntaxin 8, directly interacts with HECTd3. STX8 forms the SNARE complex with syntaxin 7, vti1b and endobrevin. STX8 belongs to the syntaxin family. Members of this family are key molecules implicated...
TargetMol