Search Result

Search Results for " mapk信号通路 "

Targets

Compounds

Natural Products

Libraries

Cat No.	Product Name	Synonyms	Targets
T26193	SKLB-163	SKLB163	MAPK , Akt , Caspase , Rho , JNK
	SKLB-163 acts by downregulating RhoGDI, activating JNK-1 signaling pathway and caspase-3, and reducing phosphorylated Akt and p44/42 MAPK.		MAPK , Akt , Caspase , Rho , JNK
T63644	Exarafenib	RAF/KIN_2787	Raf , p38 MAPK
	Exarafenib (RAF/KIN_2787) is a potent and orally available pan-RAF inhibitor.Exarafenib has antitumor activity and acts by inhibiting downstream MAPK pathway signaling.Exarafenib is used in cancer research.		Raf , p38 MAPK
T10789	Chitosan oligosaccharide	COS	AMPK
	Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine. It has the ability to activate AMPK and simultaneously inhibit inflammatory signaling pathways, including NF-κB and MAPK.		AMPK
T6760	APS-2-79 hydrochloride	APS-2-79 HCl,APS-2-79	MEK , MAPK
	APS-2-79 hydrochloride (APS-2-79 HCl) is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing RAF heterodimerization as well as the conformational changes required for phosphorylation and activ...		MEK , MAPK
T16923	SPP-86		c-RET
	SPP-86 is an effective and selective cell-permeable inhibitor of RET tyrosine kinase with an IC50 of 8 nM.		c-RET
T39823L	Apelin-12 acetate	Apelin-12 acetate (229961-08-4 Free base)	Apelin receptor , p38 MAPK , JNK
	Apelin-12 acetate possesses a high affinity to orphan receptor APJ receptor. Apelin-12 acetate inhibits the JNK and p38 MAPK signaling pathway of the apoptosis-related MAPKs family, thus offering protection to neurons.		Apelin receptor , p38 MAPK , JNK
T12979	BI-3406		p38 MAPK , MAPK , Ras
	BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.		p38 MAPK , MAPK , Ras
T8656	CAY10404	3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T	Apoptosis , Akt , COX
	CAY10404 (3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T) is a potent and highly selective inhibitor of COX-2 and COX-1. It is also a potent inhibitor of PKB/Akt and MAPK signalling pathways and induces apoptosis in NSC-LC cel...		Apoptosis , Akt , COX
T27242	EF24	EF 24,EF-24,3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone	ERK , MEK , Caspase
	EF24 (3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone) treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK. EF24 shows potent anti-tumor activity in oral ...		ERK , MEK , Caspase
T12781	RV01		Others
	RV01 is a novel quinoline-substituted analogue of resveratrol that inhibits DNA damage, reduces ethanol-induced acetaldehyde dehydrogenase (ALDH2) mRNA expression, and has hydroxyl radical scavenging activity. rV01 reduc...		Others
T72223	Anti-inflammatory agent 7
	Anti-inflammatory Agent 7 suppresses proinflammatory cytokines by hindering the NF-κB/MAPK signaling pathway in both LPS-treated RAW 264.7 cells and mice.
T78838	Akt/NF-κB/MAPK-IN-1		p38 MAPK
	Akt/NF-κB/MAPK-IN-1 (compound 2m) serves as a potent, orally active inhibitor targeting NO with an IC50 of 7.70 μM and demonstrates low toxicity. This compound exerts anti-inflammatory effects by impeding the Akt/NF-κB a...		p38 MAPK
T64147	ERK1/2 inhibitor 6
	ERK1/2 inhibitor 6 is a potent inhibitor of ERK1/2. ERK1/2 inhibitor 6 has shown potential for the study or prevention of cancer, inflammation or other proliferative diseases.
T60754	MAPK-IN-1
	MAPK-IN-1 (Compound 2) is an inhibitor of MAPK signaling pathway with anti-neuroinflammatory and neuroprotective activity that can be used for the research of Alzheimer's disease. MAPK-IN-1 inhibits AChE with an IC 50 of...
T64155	ERK1/2 inhibitor 5
	ERK1/2 inhibitor 5 is a potent inhibitor of ERK1/2. ERK1/2 inhibitor 5 has the potential to investigate or prevent cancer, inflammation or other proliferative diseases.
T74374	ERK1/2 inhibitor 4
	ERK1/2 Inhibitor 5, a potent suppressant of the ERK1/2 pathway, is instrumental in the mitogen-activated protein kinase (MAPK) signal transduction pathway, where extracellular signal-regulated kinase (ERK) serves as a cr...
T74373	ERK1/2 inhibitor 3
	ERK1/2 Inhibitor 3, a potent inhibitor of ERK1/2, plays a crucial role in the signal transduction pathway by targeting the Mitogen-activated protein kinase (MAPK) family, specifically the extracellular signal-regulated k...
T79585	Anti-inflammatory agent 50		NF-κB
	Anti-inflammatory agent 50 (compound a1), a derivative of Fusidic acid, exerts its effects through inhibition of inflammatory mediators including NO, IL-6, and TNF-α. It mitigates acute lung injury by modulating these me...		NF-κB
T76583	H-Ile-Lys-Val-Ala-Val-OH
	H-Ile-Lys-Val-Ala-Val-OH, a significant active site within laminin-1, enhances cell adhesion, neurite outgrowth, and tumor growth. It also encourages the growth and proliferation of BMMSC populations through the activati...
T73504	MR2938
	MR2938 is a potent acetylcholinesterase (AChE) inhibitor, evidenced by an IC50 value of 5.04 μM, and significantly inhibits nitric oxide (NO) production with an IC50 of 3.29 μM. Additionally, it mitigates neuroinflammati...
T70004	APS-2-79
	APS-2-79, a KSR-dependent MEK antagonist, disrupts ATP (biotin) binding within the KSR2-MEK1 complex, achieving an inhibitory concentration (IC50) of 120 nM. This action stabilizes the KSR inactive state and antagonizes ...
T78829	JNK2-IN-1		JNK
	JNK2-IN-1 (Compound J27), a selective JNK2 inhibitor with a dissociation constant (Kd) of 79.2 µM, exhibits anti-inflammatory effects by attenuating TNF-α and IL-6 secretion via inhibition of the NF-κB/MAPK pathway. It e...		JNK
T62284	Anti-inflammatory agent 21
	Anti-inflammatory agent 21 (compound 9o) is a low cytotoxic, orally active anti-inflammatory agent that acts on NO (IC50: 0.76 μM). Anti-inflammatory agent 21 is able to accumulate ROS and block NF-κB/MAPK signaling path...

Compounds

SKLB-163

T26193

Synonym: SKLB163

Target: MAPK, Akt, Caspase, Rho, JNK

Exarafenib

T63644

Synonym: RAF/KIN_2787

Target: Raf, p38 MAPK

Chitosan oligosaccharide

T10789

Synonym: COS

Target: AMPK

APS-2-79 hydrochloride

T6760

Synonym: APS-2-79 HCl,APS-2-79

Synonym: Apelin-12 acetate (229961-08-4 Free base)

Target: Apelin receptor, p38 MAPK, JNK

BI-3406

T12979

Synonym:

Target: p38 MAPK, MAPK, Ras

CAY10404

T8656

Synonym: 3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T

Target: Apoptosis, Akt, COX

EF24

T27242

Synonym: EF 24,EF-24,3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone

Target: ERK, MEK, Caspase

Anti-inflammatory agent 7

Anti-inflammatory agent 50

T79585

Synonym:

Target: NF-κB

H-Ile-Lys-Val-Ala-Val-OH

Anti-inflammatory agent 21

T62284

Synonym:

Target:

Cat No.	Product Name	Synonyms	Targets
T2789	Scutellarin	Breviscapin,Breviscapinun,Breviscapine,Scutellarein-7-glucuronide	Akt , HIV Protease , STAT
	Scutellarin (Scutellarein-7-glucuronide), an active flavone isolated from Scutellaria baicalensis, can inhibit RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts, and down-regulate the STAT3/Girdin/Akt signal...		Akt , HIV Protease , STAT
T3847	Asperuloside	Asperulosid	Others , NO Synthase
	Asperuloside (Asperulosid) has anti-inflammatory activity.		Others , NO Synthase
TN2081	Maohuoside A		MAPK
	Maohuoside A promotes osteogenesis of rat mesenchymal stem cells via BMP and MAPK signaling pathways.		MAPK
T2885	Esculin	Aesculin	Antiviral , p38 MAPK , Antibacterial
	Esculin (Aesculin) is a glucoside found in horse chestnuts.		Antiviral , p38 MAPK , Antibacterial
T5729	L-quebrachitol		Wnt/beta-catenin
	L-quebrachitol is a natural product.L-quebrachitol may promote osteoblastogenesis by triggering the BMP-2-response as well as the Runx2, MAPK, and Wnt/β-catenin signaling pathway.		Wnt/beta-catenin
T16324	Nimbolide		Apoptosis , NF-κB , CDK
	Nimbolide suppresses CDK4/CDK6 kinase activity. Nimbolide inhibits the NF-κB, Wnt, PI3K-Akt, MAPK, and JAK-STAT signaling pathways. Nimbolide causes apoptosis through the inactivation of NF-κB. Nimbolide is a triterpene ...		Apoptosis , NF-κB , CDK
T5755	Aloesin		Tyrosinase
	Aloesin is a C-glycosylated chromone compound found in aloe (Liliaceae) that inhibits tyrosinase (IC50 = 0.9 mM), an enzyme responsible for catalyzing the first step of the conversion of tyrosine to melanin.		Tyrosinase
TN1410	Asperulosidic acid	ASPA	ERK , NF-κB
	Asperulosidic acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities. ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the NF-κB and mitogen-a...		ERK , NF-κB
T3836	Eudesmin		MAPK , S6 Kinase
	Eudesmin shows antiinflammatory, neuritogenic, anticonvulsant and sedative effects, the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65 expressions, and anti-apoptosis of neuron the in brain.50 m...		MAPK , S6 Kinase
T5S0761	Nitidine chloride		Apoptosis , ERK , FAK , p38 MAPK , NF-κB , Topoisomerase , STAT , Parasite
	1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721 cells in vitro in a time- and dose-dependent manner and id...
T5716	4'-Methoxyresveratrol	4'-O-Methylresveratrol	advanced glycation end products
	4'-Methoxyresveratrol (4'-O-Methylresveratrol) is a natural product form the roots of Rheum palmatum L,has significant hypoglycemic, anti-inflammatory, and antioxidant effects.4'-Methoxyresveratrol alleviates AGE-induced...		advanced glycation end products
T3669	Curcumenol	(+)-Curcumenol	P450
	Curcumenol ((+)-Curcumenol), one of the major components of Zedoary turmeric oil, is an antibiotic drug which has anti-Y, anti-inflammation activity. Curcumenol may be safely used without inducing metabolic drug-drug int...		P450
T3S1416	Decursin	Decursinol angelate,(+)-Decursin	Apoptosis , PKC
	1. Decursin (Decursinol angelate) is able to attenuate kainic acid-induced seizures and could have potential as an antiepileptic drug. 2. Decursin exhibits hepatoprotective effects , potentially by inhibiting the TGF-β1 ...		Apoptosis , PKC
T4S2326	Cornuside	7-Galloylsecologanol,7-O-Galloylsecologanol,Comuside	ERK , p38 MAPK , NF-κB , JNK
	1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardi...		ERK , p38 MAPK , NF-κB , JNK
T74191	Tanshinol borneol ester
	Tanshinol borneol ester, an angiogenesis stimulator, enhances several critical phases of angiogenesis via the Akt and MAPK signaling pathways. This compound also exhibits anti-ischemic and anti-atherosclerosis properties...
TN2328	Zeylenone		Apoptosis , ERK , MAPK , Akt , PI3K , mTOR
	Zeylenone, a cyclohexene oxide from Uvaria grandiflora, has antitumour and antiproliferative activity, inhibiting cervical cancer cell proliferation and inducing apoptosis through the PI3K/AKT/mTOR and MAPK/ERK signallin...		Apoptosis , ERK , MAPK , Akt , PI3K , mTOR
T80631	Esculin sesquihydrate		p38 MAPK
	Esculin sesquihydrate, a coumarin glucoside with fluorescent properties and a constituent of ash bark, improves cognitive deficits associated with experimental diabetic nephropathy (DN). It also offers anti-oxidative and...		p38 MAPK
T72803	Norartocarpetin
	Norartocarpetin is a potent tyrosinase inhibitor exhibiting significant antibrowning properties useful for food system research, with an IC50 of 0.47 μM. Furthermore, it demonstrates substantial anticancer activity speci...

Natural Products

Scutellarin

T2789

Synonym: Breviscapin,Breviscapinun,Breviscapine,Scutellarein-7-glucuronide

Target: Akt, HIV Protease, STAT

Asperuloside

T3847

Synonym: Asperulosid

Target: Others, NO Synthase

Target: Antiviral, p38 MAPK, Antibacterial

L-quebrachitol

T5729

Synonym:

Target: Wnt/beta-catenin

Nimbolide

T16324

Synonym:

Target: Apoptosis, NF-κB, CDK

Target: MAPK, S6 Kinase

Nitidine chloride

T5S0761

Synonym:

Target: Apoptosis, ERK, FAK, p38 MAPK, NF-κB, Topoisomerase, STAT, Parasite

4'-Methoxyresveratrol

T5716

Synonym: 4'-O-Methylresveratrol

Target: advanced glycation end products

Curcumenol

T3669

Synonym: (+)-Curcumenol

Target: P450

Decursin

T3S1416

Synonym: Decursinol angelate,(+)-Decursin

Target: Apoptosis, PKC

Cornuside

T4S2326

Synonym: 7-Galloylsecologanol,7-O-Galloylsecologanol,Comuside

Target: ERK, p38 MAPK, NF-κB, JNK

Tanshinol borneol ester

Target: Apoptosis, ERK, MAPK, Akt, PI3K, mTOR

Esculin sesquihydrate

Cat No.	Product Name
L1400	MAPK Inhibitor Library	367 compounds
	A unique collection of 367 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;
L7900	Osteogenesis Compound Library	320 compounds
	A unique collection of 320 osteogenesis related compounds for high throughput and high content screening;
L7700	Neural Regeneration Compound Library	529 compounds
	A unique collection of 149 neuroregeneration related compounds for high throughput and high content screening;
L8500	HIF-1 Signaling Pathway Compound Library	1352 compounds
	A unique collection of 1352 HIF-1 related small chemicals can be used for drug discovery in ischemic disease and cancer and related mechanism studies；
L1310	Cytoskeletal Signaling Pathway Compound Library	773 compounds
	A unique collection of 773 cytoskeleton-related compounds, can be used for HTS and HCS；

Libraries

MAPK Inhibitor Library

L1400

Compounds: 367

Osteogenesis Compound Library

L7900

Compounds: 320

Neural Regeneration Compound Library

L7700

Compounds: 529

HIF-1 Signaling Pathway Compound Library

L8500

Compounds: 1352

Cytoskeletal Signaling Pathway Compound Library

L1310

Compounds: 773