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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T13809 | P62-mediated mitophagy inducer | PMI | Mitophagy |
P62-mediated mitophagy inducer (PMI) is a regulator of mitophagy . | |||
T72420 | Mitophagy activator 1 | ||
Mitophagy activator 1 is an activator of mitophagy . Mitophagy activator 1 is the isomer of EP-0035985 . | |||
T1554 | Iohexol | Mitophagy , Autophagy | |
Iohexol is a contrast agent. The osmolality of iohexol ranges from 322 mOsm/kg-approximately 1.1 times that of blood plasma-to 844 mOsm/kg, almost three times that of blood. | |||
T36682 | USP30 inhibitor 18 | DUB | |
USP30 inhibitor 18 is a selective USP30 inhibitor with an IC50 of 0.02 μM. USP30 inhibitor 18 increases protein ubiquitination and accelerates mitophagy[1]. [1]. Arthur F Kluge, et al. Novel highly selective inhibitors o... | |||
T0876 | Clioquinol | Chinoform,Iodochlorhydroxyquin | Mitophagy , Antibiotic , Autophagy , Antifungal |
Clioquinol (Iodochlorhydroxyquin) is an orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities. | |||
T2414 | Torkinib | PP 242 | Apoptosis , Mitophagy , PI3K , mTOR , Autophagy |
Torkinib (PP 242) (PP 242) is a selective and ATP-competitive mTOR inhibitor (IC50: 8 nM). It also inhibits mTORC1/2 (IC50s: 30/58 nM). | |||
T0943 | Carbamazepine | NSC 169864 | Mitophagy , Sodium Channel , Autophagy |
Carbamazepine (NSC-169864) is a tricyclic compound chemically related to tricyclic antidepressants (TCA) with anticonvulsant and analgesic properties. Carbamazepine exerts its anticonvulsant activity by reducing polysyna... | |||
T2099 | ABT-737 | Mitophagy , BCL , Autophagy | |
ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w (EC50s: 78.7/30.3/197.8 nM). | |||
T0972 | Isoniazid | INH,Isonicotinic acid hydrazide,Isonicotinic hydrazide | Mitophagy , Dehydrogenase , CAT , Antibacterial , Autophagy |
Isoniazid (Isonicotinic hydrazide) is an antibacterial agent used primarily as a tuberculostatic. | |||
T1907 | Mdivi-1 | Mitochondrial division inhibitor 1 | Apoptosis , Mitophagy , Dynamin , Autophagy |
Mdivi-1 (Mitochondrial division inhibitor 1) is a mitochondrial division inhibitor that inhibits DRP1 and Dynamin I (IC50=1-10 μM). Mdivi-1 inhibits mitochondrial autophagy. | |||
T1829 | Ruxolitinib | INCB018424,(R)-Ruxolitinib | Apoptosis , Mitophagy , Tyrosine Kinases , JAK , Autophagy |
Ruxolitinib (INCB018424) is a JAK1/2 inhibitor (IC50=3.3/2.8 nM) that is potent and selective. Rixolitinib exhibits antitumor activity and induces autophagy and apoptosis. | |||
T2240 | GSK2578215A | Mitophagy , LRRK2 , Autophagy | |
GSK2578215A is a potent and selective LRRK2 kinase inhibitor. | |||
T1583 | Vorinostat | MK0683,suberoylanilide hydroxamic acid,SAHA | Apoptosis , Mitophagy , Virus Protease , HDAC , Autophagy |
Vorinostat (suberoylanilide hydroxamic acid) is a pan-inhibitor of Histone Deacetylase with antineoplastic activity (IC50: ~10 nM). | |||
T8526 | Metformin | 1,1-Dimethylbiguanide | Mitophagy , AMPK , Autophagy |
Metformin (1,1-Dimethylbiguanide) is an AMPK activator with blood-brain barrier permeability. Metformin may improve glycemic control by increasing insulin sensitivity and decreasing intestinal glucose uptake, and is comm... | |||
T1477 | AICAR | NSC105823,AICA Riboside,Acadesine,AICAR (Acadesine) | Mitophagy , YAP , AMPK , Autophagy |
AICAR (NSC105823) is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes. | |||
T0101 | Doxazosin mesylate | UK 33274 mesylate | Mitophagy , Adrenergic Receptor , Autophagy |
Doxazosin mesylate (UK 33274 mesylate)(UK 33274) is a quinazoline-derivative. It is a selectively antagonizes postsynaptic α1-adrenergic receptors. | |||
T3015 | Olaparib | AZD2281,KU0059436 | Mitophagy , PARP , Autophagy |
Olaparib (KU0059436) is a small molecule inhibitor of PARP1/PARP2 (IC50=5/1 nM), with weak inhibitory activity against PARP tankyrase-1 (IC50=1.5 μM), and is selective and orally active. Olaparib exhibits autophagy and m... | |||
T0374L | Sunitinib | SU 11248 | Apoptosis , Mitophagy , VEGFR , FLT , IRE1 , PDGFR , c-Kit , Autophagy |
Sunitinib (SU 11248), a multi-targeted RTK inhibitor, is targeting PDGFRβ and VEGFR2 (Flk-1) with IC50 of 2 nM and 80 nM and also inhibits c-Kit. | |||
T6223 | U0126-EtOH | U0126 Ethanol,U0126 | Mitophagy , Influenza Virus , MEK , Autophagy |
U0126-EtOH (U0126 Ethanol) is a non-ATP competitive specific inhibitor of MEK1/2 (IC50: 0.07/0.06 μM). | |||
T6714 | URB-597 | KDS-4103,FAAH Inhibitor II | Mitophagy , FAAH , Autophagy |
URB-597 (FAAH Inhibitor II) is an effective, orally bioavailable FAAH inhibitor (IC50: 4.6 nM), and no effect on other cannabinoid-related targets. | |||
T2534 | Pitavastatin calcium | P-872441,nisvastatin,itavastatin,Pitavastatin hemicalcium,NK-104 | Apoptosis , Mitophagy , Endogenous Metabolite , HMG-CoA Reductase , Autophagy |
Pitavastatin calcium (NK-104) is a potent inhibitor of HMG-CoA reductase (Ki: 1.7 nM). It lowers both total cholesterol and low-density lipoprotein cholesterol in animals and humans. Metabolism of pitavastatin by the cyt... | |||
T1567 | Olanzapine | LY170053 | Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , AChR |
Olanzapine (LY170053) is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness. | |||
T1602 | Valproic acid sodium salt | Sodium Valproate | Mitophagy , Gamma-secretase , HIV Protease , GABA Receptor , HDAC , Autophagy |
Valproic acid sodium salt (Sodium Valproate) is the sodium salt form of valproic acid with anti-epileptic activity. Valproic acid sodium salt is converted into its active form, valproate ion, in blood. Although the mecha... | |||
T0005 | Aspirin | Acetylsalicylate,Acetylsalicylic Acid,ASA | Mitophagy , Virus Protease , COX , Autophagy |
Aspirin (Acetylsalicylic Acid) is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Aspirin is a histone deacetylase inhibitors to up-regulate cel... | |||
T0942 | Quinacrine dihydrochloride | Mepacrine dihydrochloride,SN-390,Quinacrine 2HCl | Apoptosis , Mitophagy , DNA , Phospholipase , Parasite , Autophagy , Histamine Receptor |
Quinacrine dihydrochloride (Mepacrine dihydrochloride) is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities. | |||
T0740 | Metformin hydrochloride | Metformin HCl,1, 1-Dimethylbiguanide hydrochloride,1,1-Dimethylbiguanide hydrochloride | Mitophagy , AMPK , Autophagy |
Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) , a widely used anti-diabetic drug, has a potential function as an anti-Y medicine. It inhibits the proliferation of a variety of Y cells including colon, pro... | |||
T0374 | Sunitinib Malate | Sutent,SU 11248 (Malate),SU 11248,Sunitinib | Apoptosis , Mitophagy , VEGFR , FLT , IRE1 , PDGFR , c-Kit , Autophagy |
Sunitinib Malate (Sunitinib) is an indolinone-based tyrosine kinase inhibitor. It blocks the tyrosine kinase activities of VEGFR2, PDGFRβ (IC50: 80/2 nM), and c-kit. | |||
T0947 | Dexamethasone acetate | Dexamethasone 21-acetate,Dexamethason acetate,NSC 39471 | Glucocorticoid Receptor , Mitophagy , IL Receptor , Annexin A , NOS , Antibacterial , Autophagy |
Dexamethasone acetate (NSC 39471) is the acetate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuclear steroid receptors, dexa... | |||
T1076 | Dexamethasone | MK 125,Prednisolone F,NSC 34521,Hexadecadrol | Glucocorticoid Receptor , Mitophagy , IL Receptor , SARS-CoV , Antibacterial , Antibiotic , Autophagy , Complement System |
Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist and an IL receptor modulator. Dexamethasone has anti-inflammatory and immunosuppressive activity and induces autophagy. Dexamethasone inhibits LPS-induced... | |||
T6474 | Divalproex Sodium | Valproate semisodium,Epival | HDAC |
Divalproex Sodium (Valproate semisodium) binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzyme... | |||
T8929 | BC1618 | 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]- | Mitophagy , Others , E1/E2/E3 Enzyme , AMPK |
BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) is an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling. It promotes mitochondrial fission, facilitates autophag... | |||
T1764 | Adezmapimod | PB 203580,RWJ 64809,SB203580 | Mitophagy , p38 MAPK , Autophagy |
Adezmapimod (SB 203580) is a p38 MAPK inhibitor (IC50=0.3-0.5 μM) that is selective and ATP-competitive. Adezmapimod possesses autophagy and mitochondrial autophagy activating activity. Adezmapimod displays more than 100... | |||
T13036 | Sulfosuccinimidyl oleate | Sulfo-N-succinimidyl oleate | Mitophagy |
Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) (Sulfo-N-succinimidyl oleate) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate is a potent and irreversible inhibit... | |||
T12352L | Oxidopamine hydrobromide | 6-Hydroxydopamine hydrobromide,6-OHDA hydrobromide | Mitophagy , Dopamine Receptor , Autophagy |
Oxidopamine hydrobromide (6-OHDA hydrobromide) is a neurotransmitter dopamine antagonist. | |||
T3043 | Ruxolitinib phosphate | INC424,INCB018424,INC 424 phosphate,Ruxolitinib (INCB-18424) phosphate,INCB018424 phosphate | Mitophagy , JAK , Autophagy |
Ruxolitinib phosphate (INCB018424)(INCB018424 phosphate) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3. | |||
T12352 | Oxidopamine hydrochloride | 6-Hydroxydopamine hydrochloride,6-OHDA hydrochloride | Mitophagy , Dopamine Receptor , Autophagy |
Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is an neurotransmitter dopamine antagonist. | |||
T21332 | U0126 | U 0126,U-0126 | Mitophagy , MEK , Autophagy |
U0126, an effective and selective non-competitive inhibitor of MAP kinase, inhibits MEK-1 and MEK-2 with IC50 values of 0.07 and 0.06 μM respectively. U0126 inhibits autophagy and mitophagy. | |||
T73331 | GSK3-IN-3 | Mitophagy , GSK-3 | |
GSK3-IN-3 is a mitochondrial autophagy (mitophagy) inducer and GSK-3 inhibitor (IC50: 3.01 μM) that induces parkin-dependent mitochondrial autophagy. GSK3-IN-3 is non-ATP and non-substrate competitive and neuroprotective... | |||
T69365 | HMS607P03 | ||
HMS607P03 is an activator of SIRT1 which induces autophagic cell death via the AMPK-mTOR-ULK complex and induces mitophagy by the SIRT1-PINK1-Parkin pathway. HMS607P03 downregulates 14-3-3γ, catalase, profilin-1, and HSP... | |||
T62331 | Autophagy-IN-1 | ||
Autophagy-IN-1 is a potent inhibitor of autophagy/mitophagy, blocking autophagosomal-lysosomal fusion in cancer cells while selectively increasing autophagic flux. Autophagy-IN-1 significantly inhibits tumour growth in t... | |||
T21675 | SB 203580 hydrochloride | ||
Adezmapimod (SB 203580) hydrochloride is a selective and ATP-competitive p38 MAPK inhibitor with IC 50 s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. Adezmapimod hydrochloride inhibits LCK, GSK3β an... | |||
T73324 | PARL-IN-1 | ||
PARL-IN-1 is a potent PARL inhibitor with an IC 50 value of 28 nM. PARL-IN-1 inhibits PARL and leads to a robust activation of the PINK1/Parkin pathway. PARL-IN-1 promotes PINK1/Parkin-dependent mitophagy . | |||
T37519 | Diquat (bromide) | ||
Diquat is a bipyridylium herbicide that, as a stable radical, acts as an electron acceptor in the electron transport chain and is reoxidized by molecular oxygen, producing reactive oxygen species (ROS).1Diquat administra... | |||
T74571 | TSPO Ligand-Linker Conjugates 1 | ||
TSPO Ligand-Linker Conjugates 1 contains a ligand for translocator protein ( TSPO ) and a linker, which is used for the synthesis of mitochondria-targeting autophagy-targeting chimera ( AUTAC ). AUTAC can bind the TSPO o... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T6468 | D-glutamine | Mitophagy , Ferroptosis , Endogenous Metabolite , GluR , Autophagy | |
D-glutamine, an D type stereoisomer of glutamine, is one of the 20 amino acids which is encoded by the standard genetic code. | |||
T5S1099 | Liensinine | Apoptosis , Mitophagy , Others , Autophagy | |
1. Liensinine, a kind of isoquinoline alkaloid, can antagonize the ventricular arrhythmias. | |||
T0595 | Naringin | Naringoside | Mitophagy , P450 , Endogenous Metabolite , Autophagy |
Naringin (Naringoside), a flavanone glycoside, exerts various of pharmacological effects such as blood lipid lowering, antioxidant activity, anticancer activity, and inhibition of cytochrome P450 enzymes. | |||
T3427 | Polydatin | Piceid,Polydotin Peceid | Apoptosis , Mitophagy , NF-κB , Autophagy |
Polydatin (Piceid), the glycoside of Resveratrol, is originally isolated from the Chinese herb Polygonum cuspidatum. The compound can inhibit platelet aggregation and elevate the ratios of LDL-C/HDL-C and TC/HDL-C. In th... | |||
T5515 | Hemin | Hemin chloride | Mitophagy , Ferroptosis , Autophagy |
Hemin (Hemin chloride) is an iron-containing porphyrin and Heme oxygenase (HO)-1 inducer. | |||
T2140 | Parthenolide | (-)-Parthenolide | Apoptosis , Mitophagy , NF-κB , HDAC , Autophagy |
(-)-Parthenolide ((-)-Parthenolide), an inhibitor of the Nuclear Factor-κB Pathway, also promotes the ubiquitination of MDM2 and activates p53 cellular functions. | |||
T2174 | Quercetin | Sophoretin | Apoptosis , Mitophagy , Reactive Oxygen Species , PI3K , Autophagy |
Quercetin (Sophoretin) is a natural flavonoid and is an agonist of SIRT1. Quercetin is also a PI3K inhibitor, inhibiting PI3Kγ, PI3Kδ, and PI3Kβ (IC50=2.4/3.0/5.4 μM). Quercetin can induce apoptosis and autophagy. | |||
T3028 | Tripterin | Celastrol,Tripterine | Apoptosis , Mitophagy , Proteasome , Autophagy |
Tripterin (Celastrol) is an effective proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome(IC50=2.5 μM) with antioxidant and anti-inflammatory activity. | |||
T0649 | Salicylic acid | 2-Hydroxybenzoic acid | Apoptosis , Mitophagy , COX , Endogenous Metabolite , Autophagy |
Salicylic acid (2-Hydroxybenzoic acid), a natural compound extracted from Willow bark, is an anti-inflammatory inhibitor of activity cyclooxygenase. | |||
T2177 | Kaempferol | Kempferol,Robigenin | Apoptosis , Estrogen Receptor/ERR , Mitophagy , Estrogen/progestogen Receptor , HIV Protease , Endogenous Metabolite , Parasite , Autophagy |
Kaempferol (Robigenin) is a natural flavonoid which has been isolated from Delphinium, Witch-hazel, grapefruit, and other plant sources. | |||
T4S1102 | Liensinine diperchlorate | Liensinine-Perchlorate | Mitophagy , Others , Autophagy |
Liensinine Diperchlorate is an isoquinoline alkaloid extracted from hibiscus seed embryos. Liensinine Diperchlorate inhibits late autophagy by blocking autophagosome-lysosome fusion, and has biological activities such as... | |||
T6062 | Brefeldin A | BFA,Ascotoxin,Cyanein,Decumbin | ATPase , Mitophagy , Antibiotic , Autophagy , HSV , CRISPR/Cas9 |
Brefeldin A (Cyanein) belongs to the class of macrolide antibiotics and is an ATPase inhibitor (IC50=0.2 μM). Brefeldin A can induce tumor cell differentiation and apoptosis, and also possesses autophagy inhibitory activ... | |||
T1879 | 3-Methyladenine | 3-MA,NSC 66389 | Mitophagy , PI3K , Endogenous Metabolite , Autophagy |
3-Methyladenine (3-MA) is a PI3K inhibitor that selectively inhibits class IB PI3Kγ (IC50=60 μM) and class III VPS34 (IC50=25 μM). 3-Methyladenine inhibits autophagy. | |||
T1659 | Melatonin | Melatonine,N-Acetyl-5-methoxytryptamine | CaMK , Apoptosis , Mitophagy , Estrogen/progestogen Receptor , Melatonin Receptor , Glutathione Peroxidase , Endogenous Metabolite , ROR , Autophagy |
Melatonin (Melatonine) is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin... | |||
T1131 | Ivermectin | MK-933 | Mitophagy , GluCls , P2X Receptor , SARS-CoV , HIV Protease , Antibiotic , Parasite , Autophagy , HSV |
Ivermectin (MK-933) is a glutamate-gated chloride channel (GluCls) activator, with antiparasitic activity. | |||
T1558 | Resveratrol | trans-Resveratrol,SRT 501 | Apoptosis , Mitophagy , IκB/IKK , Lipoxygenase , Sirtuin , COX , NADPH , DNA/RNA Synthesis , Nrf2 , Antibacterial , Antibiotic , Autophagy , Antifungal |
Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autop... | |||
T0687 | Simvastatin | MK-0733,MK 733 | Apoptosis , Mitophagy , Ferroptosis , HMG-CoA Reductase , Autophagy |
Simvastatin (MK 733) is a HMG-CoA Reductase Inhibitor. The mechanism of action of simvastatin is as a Hydroxymethylglutaryl-CoA Reductase Inhibitor. | |||
T0132 | Etoposide | VP-16,VP-16-213 | Apoptosis , Mitophagy , Topoisomerase , Antibacterial , Antibiotic , Autophagy |
Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 μM). Etoposide has antitumor activity and induces apoptosis and autophagy. | |||
T1516 | Curcumin | Diferuloylmethane,Natural Yellow 3,Indian Saffron,Turmeric yellow | Mitophagy , Epigenetic Reader Domain , Ferroptosis , Influenza Virus , Nrf2 , Histone Acetyltransferase , HDAC , Autophagy |
Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide range of pharmacological activities such as antitumor, ant... | |||
T2830 | Betulinic acid | ALS-357,Lupatic acid,Betulic acid | Apoptosis , Mitophagy , NF-κB , HIV Protease , Topoisomerase , Endogenous Metabolite , Aminopeptidase , Autophagy |
Betulinic acid (ALS-357) is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has antiretroviral, antimalarial, and anti-inflammatory propert... | |||
T2870 | Matrine | Vegard,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine | Mitophagy , Ferroptosis , Opioid Receptor , Autophagy |
Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist. | |||
T6290 | Tanespimycin | 17-AAG,CP 127374,NSC 330507,KOS 953 | Apoptosis , Mitophagy , HSP , Antibacterial , Antibiotic , Autophagy |
Tanespimycin (KOS 953) (17-AAG) is an inhibitor of Hsp90 that selectively inhibits BT474 tumor cell Hsp90 (IC50: 5 nM). | |||
T1020 | Doxorubicin hydrochloride | Adriamycin,Doxorubicin (Adriamycin) HCl,Hydroxydaunorubicin hydrochloride,NSC 123127 | Apoptosis , Mitophagy , HBV , HIV Protease , Topoisomerase , Antibacterial , Antibiotic , AMPK , Autophagy |
Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM). Doxorubicin hydrochloride exhibits cytotoxicity and antitum... | |||
T2822 | Ginsenoside Rb1 | Gypenoside Ⅲ,Gypenoside III | ATPase , Mitophagy , IRAK , NF-κB , Autophagy , HSV |
Ginsenoside Rb1 (Gypenoside Ⅲ) is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors. | |||
T1662 | 5-Aminolevulinic acid hydrochloride | Hydrangin,5-ALA,5-Aminolevulinic acid HCl,ALA hydrochloride | Apoptosis , Mitophagy , Endogenous Metabolite , Autophagy |
5-Aminolevulinic acid hydrochloride (5-ALA) is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles. | |||
T7064 | Valproic Acid | Sodium valproate,2-Propylpentanoic Acid,VPA,Depakine,2-Propylvaleric Acid | Mitophagy , Gamma-secretase , HIV Protease , GABA Receptor , Sodium Channel , HDAC , Autophagy |
Valproic Acid (2-Propylpentanoic Acid) is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels. Currently, the various molecular mechanisms of action of Val... | |||
T1456 | Doxorubicin | Hydroxydaunorubicin,Adriamycin | Topoisomerase , AMPK |
Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity. | |||
T14149 | AICAR phosphate | AICA Riboside phosphate,Acadesine phosphate | Mitophagy , NOS , YAP , AMPK |
AICAR phosphate (Acadesine phosphate) is an AMPK activator and inhibitor of autophagy, YAP, and mitophagy, as well as an adenosine analog that regulates glucose and lipid metabolism, and inhibits the production of pro-in... | |||
TN1362 | Afzelin | Kaempferol-3-O-rhamnoside | PTEN , p38 MAPK , TNF , Mitochondrial Metabolism , Antibacterial , Prostaglandin Receptor , Autophagy |
Afzelin (Kaempferol-3-O-rhamnoside) has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as UV-absorbing activity and may protect human skin from UVB-induced d... |
Cat No. | Product Name | Species | Expression System |
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TMPY-02376 | BNIP3L Protein, Human, Recombinant | Human | E. coli |
The deletion of BNIP3L results in retention of mitochondria during lens fiber cell remodeling, and that deletion of BNIP3L also results in the retention of endoplasmic reticulum and Golgi apparatus. BNIP3L localizes to t... | |||
TMPH-01147 | Human coronavirus HKU1 (isolate N5) Protein I (His & Myc) | HCoV-HKU1 | E. coli |
Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, ... | |||
TMPH-02366 | Junin mammarenavirus (JUNV) Nucleoprotein/NP Protein (His & SUMO) | JUNV | E. coli |
Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, ... | |||
TMPJ-00924 | Decorin Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
Decorin, also known as PG40 and DCN, is a member of the class I family of small leucine-rich proteoglycans (SLRPs) that is expressed in the stroma of various forms of cancer and has been recently proposed to act as a gua... | |||
TMPH-02555 | C1QL1 Protein, Mouse, Recombinant (His) | Mouse | Yeast |
Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regul... |