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Search Results for " mitophagy "

Targets

44

Compounds

29

Natural Products

5

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T13809 P62-mediated mitophagy inducer PMI Mitophagy
P62-mediated mitophagy inducer (PMI) is a regulator of mitophagy .
T72420 Mitophagy activator 1
Mitophagy activator 1 is an activator of mitophagy . Mitophagy activator 1 is the isomer of EP-0035985 .
T1554 Iohexol Mitophagy , Autophagy
Iohexol is a contrast agent. The osmolality of iohexol ranges from 322 mOsm/kg-approximately 1.1 times that of blood plasma-to 844 mOsm/kg, almost three times that of blood.
T36682 USP30 inhibitor 18 DUB
USP30 inhibitor 18 is a selective USP30 inhibitor with an IC50 of 0.02 μM. USP30 inhibitor 18 increases protein ubiquitination and accelerates mitophagy[1]. [1]. Arthur F Kluge, et al. Novel highly selective inhibitors o...
T0876 Clioquinol Chinoform,Iodochlorhydroxyquin Mitophagy , Antibiotic , Autophagy , Antifungal
Clioquinol (Iodochlorhydroxyquin) is an orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities.
T2414 Torkinib PP 242 Apoptosis , Mitophagy , PI3K , mTOR , Autophagy
Torkinib (PP 242) (PP 242) is a selective and ATP-competitive mTOR inhibitor (IC50: 8 nM). It also inhibits mTORC1/2 (IC50s: 30/58 nM).
T0943 Carbamazepine NSC 169864 Mitophagy , Sodium Channel , Autophagy
Carbamazepine (NSC-169864) is a tricyclic compound chemically related to tricyclic antidepressants (TCA) with anticonvulsant and analgesic properties. Carbamazepine exerts its anticonvulsant activity by reducing polysyna...
T2099 ABT-737 Mitophagy , BCL , Autophagy
ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w (EC50s: 78.7/30.3/197.8 nM).
T0972 Isoniazid INH,Isonicotinic acid hydrazide,Isonicotinic hydrazide Mitophagy , Dehydrogenase , CAT , Antibacterial , Autophagy
Isoniazid (Isonicotinic hydrazide) is an antibacterial agent used primarily as a tuberculostatic.
T1907 Mdivi-1 Mitochondrial division inhibitor 1 Apoptosis , Mitophagy , Dynamin , Autophagy
Mdivi-1 (Mitochondrial division inhibitor 1) is a mitochondrial division inhibitor that inhibits DRP1 and Dynamin I (IC50=1-10 μM). Mdivi-1 inhibits mitochondrial autophagy.
T1829 Ruxolitinib INCB018424,(R)-Ruxolitinib Apoptosis , Mitophagy , Tyrosine Kinases , JAK , Autophagy
Ruxolitinib (INCB018424) is a JAK1/2 inhibitor (IC50=3.3/2.8 nM) that is potent and selective. Rixolitinib exhibits antitumor activity and induces autophagy and apoptosis.
T2240 GSK2578215A Mitophagy , LRRK2 , Autophagy
GSK2578215A is a potent and selective LRRK2 kinase inhibitor.
T1583 Vorinostat MK0683,suberoylanilide hydroxamic acid,SAHA Apoptosis , Mitophagy , Virus Protease , HDAC , Autophagy
Vorinostat (suberoylanilide hydroxamic acid) is a pan-inhibitor of Histone Deacetylase with antineoplastic activity (IC50: ~10 nM).
T8526 Metformin 1,1-Dimethylbiguanide Mitophagy , AMPK , Autophagy
Metformin (1,1-Dimethylbiguanide) is an AMPK activator with blood-brain barrier permeability. Metformin may improve glycemic control by increasing insulin sensitivity and decreasing intestinal glucose uptake, and is comm...
T1477 AICAR NSC105823,AICA Riboside,Acadesine,AICAR (Acadesine) Mitophagy , YAP , AMPK , Autophagy
AICAR (NSC105823) is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes.
T0101 Doxazosin mesylate UK 33274 mesylate Mitophagy , Adrenergic Receptor , Autophagy
Doxazosin mesylate (UK 33274 mesylate)(UK 33274) is a quinazoline-derivative. It is a selectively antagonizes postsynaptic α1-adrenergic receptors.
T3015 Olaparib AZD2281,KU0059436 Mitophagy , PARP , Autophagy
Olaparib (KU0059436) is a small molecule inhibitor of PARP1/PARP2 (IC50=5/1 nM), with weak inhibitory activity against PARP tankyrase-1 (IC50=1.5 μM), and is selective and orally active. Olaparib exhibits autophagy and m...
T0374L Sunitinib SU 11248 Apoptosis , Mitophagy , VEGFR , FLT , IRE1 , PDGFR , c-Kit , Autophagy
Sunitinib (SU 11248), a multi-targeted RTK inhibitor, is targeting PDGFRβ and VEGFR2 (Flk-1) with IC50 of 2 nM and 80 nM and also inhibits c-Kit.
T6223 U0126-EtOH U0126 Ethanol,U0126 Mitophagy , Influenza Virus , MEK , Autophagy
U0126-EtOH (U0126 Ethanol) is a non-ATP competitive specific inhibitor of MEK1/2 (IC50: 0.07/0.06 μM).
T6714 URB-597 KDS-4103,FAAH Inhibitor II Mitophagy , FAAH , Autophagy
URB-597 (FAAH Inhibitor II) is an effective, orally bioavailable FAAH inhibitor (IC50: 4.6 nM), and no effect on other cannabinoid-related targets.
T2534 Pitavastatin calcium P-872441,nisvastatin,itavastatin,Pitavastatin hemicalcium,NK-104 Apoptosis , Mitophagy , Endogenous Metabolite , HMG-CoA Reductase , Autophagy
Pitavastatin calcium (NK-104) is a potent inhibitor of HMG-CoA reductase (Ki: 1.7 nM). It lowers both total cholesterol and low-density lipoprotein cholesterol in animals and humans. Metabolism of pitavastatin by the cyt...
T1567 Olanzapine LY170053 Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , AChR
Olanzapine (LY170053) is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness.
T1602 Valproic acid sodium salt Sodium Valproate Mitophagy , Gamma-secretase , HIV Protease , GABA Receptor , HDAC , Autophagy
Valproic acid sodium salt (Sodium Valproate) is the sodium salt form of valproic acid with anti-epileptic activity. Valproic acid sodium salt is converted into its active form, valproate ion, in blood. Although the mecha...
T0005 Aspirin Acetylsalicylate,Acetylsalicylic Acid,ASA Mitophagy , Virus Protease , COX , Autophagy
Aspirin (Acetylsalicylic Acid) is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Aspirin is a histone deacetylase inhibitors to up-regulate cel...
T0942 Quinacrine dihydrochloride Mepacrine dihydrochloride,SN-390,Quinacrine 2HCl Apoptosis , Mitophagy , DNA , Phospholipase , Parasite , Autophagy , Histamine Receptor
Quinacrine dihydrochloride (Mepacrine dihydrochloride) is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities.
T0740 Metformin hydrochloride Metformin HCl,1, 1-Dimethylbiguanide hydrochloride,1,1-Dimethylbiguanide hydrochloride Mitophagy , AMPK , Autophagy
Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) , a widely used anti-diabetic drug, has a potential function as an anti-Y medicine. It inhibits the proliferation of a variety of Y cells including colon, pro...
T0374 Sunitinib Malate Sutent,SU 11248 (Malate),SU 11248,Sunitinib Apoptosis , Mitophagy , VEGFR , FLT , IRE1 , PDGFR , c-Kit , Autophagy
Sunitinib Malate (Sunitinib) is an indolinone-based tyrosine kinase inhibitor. It blocks the tyrosine kinase activities of VEGFR2, PDGFRβ (IC50: 80/2 nM), and c-kit.
T0947 Dexamethasone acetate Dexamethasone 21-acetate,Dexamethason acetate,NSC 39471 Glucocorticoid Receptor , Mitophagy , IL Receptor , Annexin A , NOS , Antibacterial , Autophagy
Dexamethasone acetate (NSC 39471) is the acetate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuclear steroid receptors, dexa...
T1076 Dexamethasone MK 125,Prednisolone F,NSC 34521,Hexadecadrol Glucocorticoid Receptor , Mitophagy , IL Receptor , SARS-CoV , Antibacterial , Antibiotic , Autophagy , Complement System
Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist and an IL receptor modulator. Dexamethasone has anti-inflammatory and immunosuppressive activity and induces autophagy. Dexamethasone inhibits LPS-induced...
T6474 Divalproex Sodium Valproate semisodium,Epival HDAC
Divalproex Sodium (Valproate semisodium) binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzyme...
T8929 BC1618 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]- Mitophagy , Others , E1/E2/E3 Enzyme , AMPK
BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) is an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling. It promotes mitochondrial fission, facilitates autophag...
T1764 Adezmapimod PB 203580,RWJ 64809,SB203580 Mitophagy , p38 MAPK , Autophagy
Adezmapimod (SB 203580) is a p38 MAPK inhibitor (IC50=0.3-0.5 μM) that is selective and ATP-competitive. Adezmapimod possesses autophagy and mitochondrial autophagy activating activity. Adezmapimod displays more than 100...
T13036 Sulfosuccinimidyl oleate Sulfo-N-succinimidyl oleate Mitophagy
Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) (Sulfo-N-succinimidyl oleate) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate is a potent and irreversible inhibit...
T12352L Oxidopamine hydrobromide 6-Hydroxydopamine hydrobromide,6-OHDA hydrobromide Mitophagy , Dopamine Receptor , Autophagy
Oxidopamine hydrobromide (6-OHDA hydrobromide) is a neurotransmitter dopamine antagonist.
T3043 Ruxolitinib phosphate INC424,INCB018424,INC 424 phosphate,Ruxolitinib (INCB-18424) phosphate,INCB018424 phosphate Mitophagy , JAK , Autophagy
Ruxolitinib phosphate (INCB018424)(INCB018424 phosphate) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3.
T12352 Oxidopamine hydrochloride 6-Hydroxydopamine hydrochloride,6-OHDA hydrochloride Mitophagy , Dopamine Receptor , Autophagy
Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is an neurotransmitter dopamine antagonist.
T21332 U0126 U 0126,U-0126 Mitophagy , MEK , Autophagy
U0126, an effective and selective non-competitive inhibitor of MAP kinase, inhibits MEK-1 and MEK-2 with IC50 values of 0.07 and 0.06 μM respectively. U0126 inhibits autophagy and mitophagy.
T73331 GSK3-IN-3 Mitophagy , GSK-3
GSK3-IN-3 is a mitochondrial autophagy (mitophagy) inducer and GSK-3 inhibitor (IC50: 3.01 μM) that induces parkin-dependent mitochondrial autophagy. GSK3-IN-3 is non-ATP and non-substrate competitive and neuroprotective...
T69365 HMS607P03
HMS607P03 is an activator of SIRT1 which induces autophagic cell death via the AMPK-mTOR-ULK complex and induces mitophagy by the SIRT1-PINK1-Parkin pathway. HMS607P03 downregulates 14-3-3γ, catalase, profilin-1, and HSP...
T62331 Autophagy-IN-1
Autophagy-IN-1 is a potent inhibitor of autophagy/mitophagy, blocking autophagosomal-lysosomal fusion in cancer cells while selectively increasing autophagic flux. Autophagy-IN-1 significantly inhibits tumour growth in t...
T21675 SB 203580 hydrochloride
Adezmapimod (SB 203580) hydrochloride is a selective and ATP-competitive p38 MAPK inhibitor with IC 50 s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. Adezmapimod hydrochloride inhibits LCK, GSK3β an...
T73324 PARL-IN-1
PARL-IN-1 is a potent PARL inhibitor with an IC 50 value of 28 nM. PARL-IN-1 inhibits PARL and leads to a robust activation of the PINK1/Parkin pathway. PARL-IN-1 promotes PINK1/Parkin-dependent mitophagy .
T37519 Diquat (bromide)
Diquat is a bipyridylium herbicide that, as a stable radical, acts as an electron acceptor in the electron transport chain and is reoxidized by molecular oxygen, producing reactive oxygen species (ROS).1Diquat administra...
T74571 TSPO Ligand-Linker Conjugates 1
TSPO Ligand-Linker Conjugates 1 contains a ligand for translocator protein ( TSPO ) and a linker, which is used for the synthesis of mitochondria-targeting autophagy-targeting chimera ( AUTAC ). AUTAC can bind the TSPO o...

Compounds

P62-mediated mitophagy inducer
T13809
Synonym: PMI
Target: Mitophagy
Mitophagy activator 1
T72420
Synonym:
Target:
Iohexol
T1554
Synonym:
Target: Mitophagy, Autophagy
USP30 inhibitor 18
T36682
Synonym:
Target: DUB
Clioquinol
T0876
Synonym: Chinoform,Iodochlorhydroxyquin
Target: Mitophagy, Antibiotic, Autophagy, Antifungal
Torkinib
T2414
Synonym: PP 242
Target: Apoptosis, Mitophagy, PI3K, mTOR, Autophagy
Carbamazepine
T0943
Synonym: NSC 169864
Target: Mitophagy, Sodium Channel, Autophagy
ABT-737
T2099
Synonym:
Target: Mitophagy, BCL, Autophagy
Isoniazid
T0972
Synonym: INH,Isonicotinic acid hydrazide,Isonicotinic hydrazide
Target: Mitophagy, Dehydrogenase, CAT, Antibacterial, Autophagy
Mdivi-1
T1907
Synonym: Mitochondrial division inhibitor 1
Target: Apoptosis, Mitophagy, Dynamin, Autophagy
Ruxolitinib
T1829
Synonym: INCB018424,(R)-Ruxolitinib
Target: Apoptosis, Mitophagy, Tyrosine Kinases, JAK, Autophagy
GSK2578215A
T2240
Synonym:
Target: Mitophagy, LRRK2, Autophagy
Vorinostat
T1583
Synonym: MK0683,suberoylanilide hydroxamic acid,SAHA
Target: Apoptosis, Mitophagy, Virus Protease, HDAC, Autophagy
Metformin
T8526
Synonym: 1,1-Dimethylbiguanide
Target: Mitophagy, AMPK, Autophagy
AICAR
T1477
Synonym: NSC105823,AICA Riboside,Acadesine,AICAR (Acadesine)
Target: Mitophagy, YAP, AMPK, Autophagy
Doxazosin mesylate
T0101
Synonym: UK 33274 mesylate
Target: Mitophagy, Adrenergic Receptor, Autophagy
Olaparib
T3015
Synonym: AZD2281,KU0059436
Target: Mitophagy, PARP, Autophagy
Sunitinib
T0374L
Synonym: SU 11248
Target: Apoptosis, Mitophagy, VEGFR, FLT, IRE1, PDGFR, c-Kit, Autophagy
U0126-EtOH
T6223
Synonym: U0126 Ethanol,U0126
Target: Mitophagy, Influenza Virus, MEK, Autophagy
URB-597
T6714
Synonym: KDS-4103,FAAH Inhibitor II
Target: Mitophagy, FAAH, Autophagy
Pitavastatin calcium
T2534
Synonym: P-872441,nisvastatin,itavastatin,Pitavastatin hemicalcium,NK-104
Target: Apoptosis, Mitophagy, Endogenous Metabolite, HMG-CoA Reductase, Autophagy
Olanzapine
T1567
Synonym: LY170053
Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, AChR
Valproic acid sodium salt
T1602
Synonym: Sodium Valproate
Target: Mitophagy, Gamma-secretase, HIV Protease, GABA Receptor, HDAC, Autophagy
Aspirin
T0005
Synonym: Acetylsalicylate,Acetylsalicylic Acid,ASA
Target: Mitophagy, Virus Protease, COX, Autophagy
Quinacrine dihydrochloride
T0942
Synonym: Mepacrine dihydrochloride,SN-390,Quinacrine 2HCl
Target: Apoptosis, Mitophagy, DNA, Phospholipase, Parasite, Autophagy, Histamine Receptor
Metformin hydrochloride
T0740
Synonym: Metformin HCl,1, 1-Dimethylbiguanide hydrochloride,1,1-Dimethylbiguanide hydrochloride
Target: Mitophagy, AMPK, Autophagy
Sunitinib Malate
T0374
Synonym: Sutent,SU 11248 (Malate),SU 11248,Sunitinib
Target: Apoptosis, Mitophagy, VEGFR, FLT, IRE1, PDGFR, c-Kit, Autophagy
Dexamethasone acetate
T0947
Synonym: Dexamethasone 21-acetate,Dexamethason acetate,NSC 39471
Target: Glucocorticoid Receptor, Mitophagy, IL Receptor, Annexin A, NOS, Antibacterial, Autophagy
Dexamethasone
T1076
Synonym: MK 125,Prednisolone F,NSC 34521,Hexadecadrol
Target: Glucocorticoid Receptor, Mitophagy, IL Receptor, SARS-CoV, Antibacterial, Antibiotic, Autophagy, Complement System
Divalproex Sodium
T6474
Synonym: Valproate semisodium,Epival
Target: HDAC
BC1618
T8929
Synonym: 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-
Target: Mitophagy, Others, E1/E2/E3 Enzyme, AMPK
Adezmapimod
T1764
Synonym: PB 203580,RWJ 64809,SB203580
Target: Mitophagy, p38 MAPK, Autophagy
Sulfosuccinimidyl oleate
T13036
Synonym: Sulfo-N-succinimidyl oleate
Target: Mitophagy
Oxidopamine hydrobromide
T12352L
Synonym: 6-Hydroxydopamine hydrobromide,6-OHDA hydrobromide
Target: Mitophagy, Dopamine Receptor, Autophagy
Ruxolitinib phosphate
T3043
Synonym: INC424,INCB018424,INC 424 phosphate,Ruxolitinib (INCB-18424) phosphate,INCB018424 phosphate
Target: Mitophagy, JAK, Autophagy
Oxidopamine hydrochloride
T12352
Synonym: 6-Hydroxydopamine hydrochloride,6-OHDA hydrochloride
Target: Mitophagy, Dopamine Receptor, Autophagy
U0126
T21332
Synonym: U 0126,U-0126
Target: Mitophagy, MEK, Autophagy
GSK3-IN-3
T73331
Synonym:
Target: Mitophagy, GSK-3
HMS607P03
T69365
Synonym:
Target:
Autophagy-IN-1
T62331
Synonym:
Target:
SB 203580 hydrochloride
T21675
Synonym:
Target:
PARL-IN-1
T73324
Synonym:
Target:
Diquat (bromide)
T37519
Synonym:
Target:
TSPO Ligand-Linker Conjugates 1
T74571
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T6468 D-glutamine Mitophagy , Ferroptosis , Endogenous Metabolite , GluR , Autophagy
D-glutamine, an D type stereoisomer of glutamine, is one of the 20 amino acids which is encoded by the standard genetic code.
T5S1099 Liensinine Apoptosis , Mitophagy , Others , Autophagy
1. Liensinine, a kind of isoquinoline alkaloid, can antagonize the ventricular arrhythmias.
T0595 Naringin Naringoside Mitophagy , P450 , Endogenous Metabolite , Autophagy
Naringin (Naringoside), a flavanone glycoside, exerts various of pharmacological effects such as blood lipid lowering, antioxidant activity, anticancer activity, and inhibition of cytochrome P450 enzymes.
T3427 Polydatin Piceid,Polydotin Peceid Apoptosis , Mitophagy , NF-κB , Autophagy
Polydatin (Piceid), the glycoside of Resveratrol, is originally isolated from the Chinese herb Polygonum cuspidatum. The compound can inhibit platelet aggregation and elevate the ratios of LDL-C/HDL-C and TC/HDL-C. In th...
T5515 Hemin Hemin chloride Mitophagy , Ferroptosis , Autophagy
Hemin (Hemin chloride) is an iron-containing porphyrin and Heme oxygenase (HO)-1 inducer.
T2140 Parthenolide (-)-Parthenolide Apoptosis , Mitophagy , NF-κB , HDAC , Autophagy
(-)-Parthenolide ((-)-Parthenolide), an inhibitor of the Nuclear Factor-κB Pathway, also promotes the ubiquitination of MDM2 and activates p53 cellular functions.
T2174 Quercetin Sophoretin Apoptosis , Mitophagy , Reactive Oxygen Species , PI3K , Autophagy
Quercetin (Sophoretin) is a natural flavonoid and is an agonist of SIRT1. Quercetin is also a PI3K inhibitor, inhibiting PI3Kγ, PI3Kδ, and PI3Kβ (IC50=2.4/3.0/5.4 μM). Quercetin can induce apoptosis and autophagy.
T3028 Tripterin Celastrol,Tripterine Apoptosis , Mitophagy , Proteasome , Autophagy
Tripterin (Celastrol) is an effective proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome(IC50=2.5 μM) with antioxidant and anti-inflammatory activity.
T0649 Salicylic acid 2-Hydroxybenzoic acid Apoptosis , Mitophagy , COX , Endogenous Metabolite , Autophagy
Salicylic acid (2-Hydroxybenzoic acid), a natural compound extracted from Willow bark, is an anti-inflammatory inhibitor of activity cyclooxygenase.
T2177 Kaempferol Kempferol,Robigenin Apoptosis , Estrogen Receptor/ERR , Mitophagy , Estrogen/progestogen Receptor , HIV Protease , Endogenous Metabolite , Parasite , Autophagy
Kaempferol (Robigenin) is a natural flavonoid which has been isolated from Delphinium, Witch-hazel, grapefruit, and other plant sources.
T4S1102 Liensinine diperchlorate Liensinine-Perchlorate Mitophagy , Others , Autophagy
Liensinine Diperchlorate is an isoquinoline alkaloid extracted from hibiscus seed embryos. Liensinine Diperchlorate inhibits late autophagy by blocking autophagosome-lysosome fusion, and has biological activities such as...
T6062 Brefeldin A BFA,Ascotoxin,Cyanein,Decumbin ATPase , Mitophagy , Antibiotic , Autophagy , HSV , CRISPR/Cas9
Brefeldin A (Cyanein) belongs to the class of macrolide antibiotics and is an ATPase inhibitor (IC50=0.2 μM). Brefeldin A can induce tumor cell differentiation and apoptosis, and also possesses autophagy inhibitory activ...
T1879 3-Methyladenine 3-MA,NSC 66389 Mitophagy , PI3K , Endogenous Metabolite , Autophagy
3-Methyladenine (3-MA) is a PI3K inhibitor that selectively inhibits class IB PI3Kγ (IC50=60 μM) and class III VPS34 (IC50=25 μM). 3-Methyladenine inhibits autophagy.
T1659 Melatonin Melatonine,N-Acetyl-5-methoxytryptamine CaMK , Apoptosis , Mitophagy , Estrogen/progestogen Receptor , Melatonin Receptor , Glutathione Peroxidase , Endogenous Metabolite , ROR , Autophagy
Melatonin (Melatonine) is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin...
T1131 Ivermectin MK-933 Mitophagy , GluCls , P2X Receptor , SARS-CoV , HIV Protease , Antibiotic , Parasite , Autophagy , HSV
Ivermectin (MK-933) is a glutamate-gated chloride channel (GluCls) activator, with antiparasitic activity.
T1558 Resveratrol trans-Resveratrol,SRT 501 Apoptosis , Mitophagy , IκB/IKK , Lipoxygenase , Sirtuin , COX , NADPH , DNA/RNA Synthesis , Nrf2 , Antibacterial , Antibiotic , Autophagy , Antifungal
Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autop...
T0687 Simvastatin MK-0733,MK 733 Apoptosis , Mitophagy , Ferroptosis , HMG-CoA Reductase , Autophagy
Simvastatin (MK 733) is a HMG-CoA Reductase Inhibitor. The mechanism of action of simvastatin is as a Hydroxymethylglutaryl-CoA Reductase Inhibitor.
T0132 Etoposide VP-16,VP-16-213 Apoptosis , Mitophagy , Topoisomerase , Antibacterial , Antibiotic , Autophagy
Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 μM). Etoposide has antitumor activity and induces apoptosis and autophagy.
T1516 Curcumin Diferuloylmethane,Natural Yellow 3,Indian Saffron,Turmeric yellow Mitophagy , Epigenetic Reader Domain , Ferroptosis , Influenza Virus , Nrf2 , Histone Acetyltransferase , HDAC , Autophagy
Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide range of pharmacological activities such as antitumor, ant...
T2830 Betulinic acid ALS-357,Lupatic acid,Betulic acid Apoptosis , Mitophagy , NF-κB , HIV Protease , Topoisomerase , Endogenous Metabolite , Aminopeptidase , Autophagy
Betulinic acid (ALS-357) is a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) which has antiretroviral, antimalarial, and anti-inflammatory propert...
T2870 Matrine Vegard,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine Mitophagy , Ferroptosis , Opioid Receptor , Autophagy
Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.
T6290 Tanespimycin 17-AAG,CP 127374,NSC 330507,KOS 953 Apoptosis , Mitophagy , HSP , Antibacterial , Antibiotic , Autophagy
Tanespimycin (KOS 953) (17-AAG) is an inhibitor of Hsp90 that selectively inhibits BT474 tumor cell Hsp90 (IC50: 5 nM).
T1020 Doxorubicin hydrochloride Adriamycin,Doxorubicin (Adriamycin) HCl,Hydroxydaunorubicin hydrochloride,NSC 123127 Apoptosis , Mitophagy , HBV , HIV Protease , Topoisomerase , Antibacterial , Antibiotic , AMPK , Autophagy
Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM). Doxorubicin hydrochloride exhibits cytotoxicity and antitum...
T2822 Ginsenoside Rb1 Gypenoside Ⅲ,Gypenoside III ATPase , Mitophagy , IRAK , NF-κB , Autophagy , HSV
Ginsenoside Rb1 (Gypenoside Ⅲ) is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors.
T1662 5-Aminolevulinic acid hydrochloride Hydrangin,5-ALA,5-Aminolevulinic acid HCl,ALA hydrochloride Apoptosis , Mitophagy , Endogenous Metabolite , Autophagy
5-Aminolevulinic acid hydrochloride (5-ALA) is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles.
T7064 Valproic Acid Sodium valproate,2-Propylpentanoic Acid,VPA,Depakine,2-Propylvaleric Acid Mitophagy , Gamma-secretase , HIV Protease , GABA Receptor , Sodium Channel , HDAC , Autophagy
Valproic Acid (2-Propylpentanoic Acid) is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels. Currently, the various molecular mechanisms of action of Val...
T1456 Doxorubicin Hydroxydaunorubicin,Adriamycin Topoisomerase , AMPK
Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.
T14149 AICAR phosphate AICA Riboside phosphate,Acadesine phosphate Mitophagy , NOS , YAP , AMPK
AICAR phosphate (Acadesine phosphate) is an AMPK activator and inhibitor of autophagy, YAP, and mitophagy, as well as an adenosine analog that regulates glucose and lipid metabolism, and inhibits the production of pro-in...
TN1362 Afzelin Kaempferol-3-O-rhamnoside PTEN , p38 MAPK , TNF , Mitochondrial Metabolism , Antibacterial , Prostaglandin Receptor , Autophagy
Afzelin (Kaempferol-3-O-rhamnoside) has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as UV-absorbing activity and may protect human skin from UVB-induced d...

Natural Products

D-glutamine
T6468
Synonym:
Target: Mitophagy, Ferroptosis, Endogenous Metabolite, GluR, Autophagy
Liensinine
T5S1099
Synonym:
Target: Apoptosis, Mitophagy, Others, Autophagy
Naringin
T0595
Synonym: Naringoside
Target: Mitophagy, P450, Endogenous Metabolite, Autophagy
Polydatin
T3427
Synonym: Piceid,Polydotin Peceid
Target: Apoptosis, Mitophagy, NF-κB, Autophagy
Hemin
T5515
Synonym: Hemin chloride
Target: Mitophagy, Ferroptosis, Autophagy
Parthenolide
T2140
Synonym: (-)-Parthenolide
Target: Apoptosis, Mitophagy, NF-κB, HDAC, Autophagy
Quercetin
T2174
Synonym: Sophoretin
Target: Apoptosis, Mitophagy, Reactive Oxygen Species, PI3K, Autophagy
Tripterin
T3028
Synonym: Celastrol,Tripterine
Target: Apoptosis, Mitophagy, Proteasome, Autophagy
Salicylic acid
T0649
Synonym: 2-Hydroxybenzoic acid
Target: Apoptosis, Mitophagy, COX, Endogenous Metabolite, Autophagy
Kaempferol
T2177
Synonym: Kempferol,Robigenin
Target: Apoptosis, Estrogen Receptor/ERR, Mitophagy, Estrogen/progestogen Receptor, HIV Protease, Endogenous Metabolite, Parasite, Autophagy
Liensinine diperchlorate
T4S1102
Synonym: Liensinine-Perchlorate
Target: Mitophagy, Others, Autophagy
Brefeldin A
T6062
Synonym: BFA,Ascotoxin,Cyanein,Decumbin
Target: ATPase, Mitophagy, Antibiotic, Autophagy, HSV, CRISPR/Cas9
3-Methyladenine
T1879
Synonym: 3-MA,NSC 66389
Target: Mitophagy, PI3K, Endogenous Metabolite, Autophagy
Melatonin
T1659
Synonym: Melatonine,N-Acetyl-5-methoxytryptamine
Target: CaMK, Apoptosis, Mitophagy, Estrogen/progestogen Receptor, Melatonin Receptor, Glutathione Peroxidase, Endogenous Metabolite, ROR, Autophagy
Ivermectin
T1131
Synonym: MK-933
Target: Mitophagy, GluCls, P2X Receptor, SARS-CoV, HIV Protease, Antibiotic, Parasite, Autophagy, HSV
Resveratrol
T1558
Synonym: trans-Resveratrol,SRT 501
Target: Apoptosis, Mitophagy, IκB/IKK, Lipoxygenase, Sirtuin, COX, NADPH, DNA/RNA Synthesis, Nrf2, Antibacterial, Antibiotic, Autophagy, Antifungal
Simvastatin
T0687
Synonym: MK-0733,MK 733
Target: Apoptosis, Mitophagy, Ferroptosis, HMG-CoA Reductase, Autophagy
Etoposide
T0132
Synonym: VP-16,VP-16-213
Target: Apoptosis, Mitophagy, Topoisomerase, Antibacterial, Antibiotic, Autophagy
Curcumin
T1516
Synonym: Diferuloylmethane,Natural Yellow 3,Indian Saffron,Turmeric yellow
Target: Mitophagy, Epigenetic Reader Domain, Ferroptosis, Influenza Virus, Nrf2, Histone Acetyltransferase, HDAC, Autophagy
Betulinic acid
T2830
Synonym: ALS-357,Lupatic acid,Betulic acid
Target: Apoptosis, Mitophagy, NF-κB, HIV Protease, Topoisomerase, Endogenous Metabolite, Aminopeptidase, Autophagy
Matrine
T2870
Synonym: Vegard,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine
Target: Mitophagy, Ferroptosis, Opioid Receptor, Autophagy
Tanespimycin
T6290
Synonym: 17-AAG,CP 127374,NSC 330507,KOS 953
Target: Apoptosis, Mitophagy, HSP, Antibacterial, Antibiotic, Autophagy
Doxorubicin hydrochloride
T1020
Synonym: Adriamycin,Doxorubicin (Adriamycin) HCl,Hydroxydaunorubicin hydrochloride,NSC 123127
Target: Apoptosis, Mitophagy, HBV, HIV Protease, Topoisomerase, Antibacterial, Antibiotic, AMPK, Autophagy
Ginsenoside Rb1
T2822
Synonym: Gypenoside Ⅲ,Gypenoside III
Target: ATPase, Mitophagy, IRAK, NF-κB, Autophagy, HSV
5-Aminolevulinic acid hydrochloride
T1662
Synonym: Hydrangin,5-ALA,5-Aminolevulinic acid HCl,ALA hydrochloride
Target: Apoptosis, Mitophagy, Endogenous Metabolite, Autophagy
Valproic Acid
T7064
Synonym: Sodium valproate,2-Propylpentanoic Acid,VPA,Depakine,2-Propylvaleric Acid
Target: Mitophagy, Gamma-secretase, HIV Protease, GABA Receptor, Sodium Channel, HDAC, Autophagy
Doxorubicin
T1456
Synonym: Hydroxydaunorubicin,Adriamycin
Target: Topoisomerase, AMPK
AICAR phosphate
T14149
Synonym: AICA Riboside phosphate,Acadesine phosphate
Target: Mitophagy, NOS, YAP, AMPK
Afzelin
TN1362
Synonym: Kaempferol-3-O-rhamnoside
Target: PTEN, p38 MAPK, TNF, Mitochondrial Metabolism, Antibacterial, Prostaglandin Receptor, Autophagy

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-02376 BNIP3L Protein, Human, Recombinant Human E. coli
The deletion of BNIP3L results in retention of mitochondria during lens fiber cell remodeling, and that deletion of BNIP3L also results in the retention of endoplasmic reticulum and Golgi apparatus. BNIP3L localizes to t...
TMPH-01147 Human coronavirus HKU1 (isolate N5) Protein I (His & Myc) HCoV-HKU1 E. coli
Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, ...
TMPH-02366 Junin mammarenavirus (JUNV) Nucleoprotein/NP Protein (His & SUMO) JUNV E. coli
Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, ...
TMPJ-00924 Decorin Protein, Mouse, Recombinant (His) Mouse Human Cells
Decorin, also known as PG40 and DCN, is a member of the class I family of small leucine-rich proteoglycans (SLRPs) that is expressed in the stroma of various forms of cancer and has been recently proposed to act as a gua...
TMPH-02555 C1QL1 Protein, Mouse, Recombinant (His) Mouse Yeast
Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regul...
TargetMol