Search Result

Search Results for " nrf2 "

Targets

111

Compounds

Natural Products

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T39719	Nrf2 activator-1	Nrf2 activator-1	Nrf2
	Nrf2 activator-1 is a potent activator of NF-E2-related factor 2 (Nrf2).Nrf2 activator-1 can be used to study COPD and other respiratory diseases including asthma, acute lung injury (ALI), acute respiratory distress synd...		Nrf2
T12253	Nrf2-IN-1		Others , Nrf2
	Nrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor. Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).		Others , Nrf2
T24546	Nrf2-Activator-12G	Nrf2 Activator IV,Nrf2 Activator-IV
	Nrf2-Activator-12G is a potent Nrf-2 activator.
T78650	Nrf2 activator-3		Antioxidant , Nrf2
	Nrf2 activator-3 is a potent Nrf2 activator with potential anti-inflammatory, antioxidant and anti-tumor activity, which can be used to study neurological and immune-related diseases.		Antioxidant , Nrf2
T39514	Keap1-Nrf2-IN-3	Keap1-Nrf2-IN-3
	Keap1-Nrf2-IN-3 is a KEAP1:NRF2 protein protein interaction inhibitor, and with a K d value of 2.5 nM for KEAP1 protein.
T11752	Keap1-Nrf2-IN-1	Keap1–Nrf2-IN-1	Src
	Keap1–Nrf2 IN-1 activates Nrf2-regulated cytoprotective response and antagonizes acetaminophen-induced liver injury both in cellular and in vivo models. Keap1–Nrf2 IN-1 is a Kelch-like ECH-associated protein 1-nuclear fa...		Src
T63016	Nrf2 activator-4		Reactive Oxygen Species , Nrf2
	Nrf2 activator-4 is an Nrf2 activator that inhibits the production of reactive oxygen species in microglia for the treatment of fatty liver disease associated with metabolic dysfunction in humans.		Reactive Oxygen Species , Nrf2
T72697	Nrf2 activator-6
	Nrf2 Activator-6, a tetrahydroisoquinoline compound, functions as an Nrf2 activator, demonstrating potency with an IC50 value of 5 nM in inhibiting the Kelch domain-Nrf2 interaction.
T79702	Nrf2 activator-9
	Nrf2 activator-9 (compound D-36) is an agent that mitigates oxidative stress by inhibiting the apoptosis of HUVEC cells induced by oxidized low-density lipoprotein (oxLDL) and high glucose (HG). It also protects vascular...
T80522	Keap1-Nrf2 probe
	Keap1-Nrf2 probe [1] is a fluorescent molecule designed to target the interaction between the Kelch-like ECH-associated protein 1 (Keap1) and nuclear factor erythroid 2-related factor 2 (Nrf2).
T79484	Nrf2 activator-8
	Nrf2 Activator-8 (Compound 10e), with an EC50 of 37.9 nM, is a potent Nrf2 activator that demonstrates significant antioxidant and anti-inflammatory properties in BV-2 microglial cells. Furthermore, this compound notably...
T72760	Keap1-Nrf2-IN-6
	Keap1-Nrf2-IN-6 is a potent, selective inhibitor of the Keap1-Nrf2 protein−protein interaction (PPI), demonstrating an inhibitory concentration (IC50) of 41 nM and a dissociation constant (Kd) of 68 nM.
T78697	Keap1-Nrf2-IN-15
	Keap1-Nrf2-IN-15 (Compound 24a) is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, displaying IC50 values of 77 nM in a fluorescence polarization (FP) assay and 2.5 nM in a time-resolved fluorescence re...
T78696	Nrf2 activator-7
	Nrf2 Activator-7 (Compound 12b) effectively enhances the Nrf2 signaling pathway as a potent Nrf2 activator.
T61688	Nrf2 activator-2
	Nrf2 activator-2 (referred to as compound O15), an Osthole derivative, is a highly potent Nrf2 agonist exhibiting an EC 50 of 2.9 μM in 293 T cells. By effectively disrupting the binding between Keap1 and Nrf2, Nrf2 acti...
T78841	Nrf2-IN-3
	Nrf2-IN-3 (Compound R16), a Nrf2 inhibitor, binds to KEAP1 mutants (G333C mKEAP1) thereby restoring the impaired KEAP1/NRF2 interactions. This restoration sensitizes KEAP1-mutant cancer cells to chemotherapeutic agents, ...
T63364	Nrf2 activator-5
	Nrf2 activator-5 is a potent activator of Nrf2 that attenuates H2O2-induced oxidative stress and LPS-stimulated inflammation in BV-2 microglia, exhibiting antioxidant and anti-inflammatory activity.
T72417	AChE/Nrf2 modulator 1
	AChE/Nrf2 modulator 1, an orally active compound, serves as a modulator of acetylcholinesterase (AChE) and nuclear factor erythroid 2-related factor 2 (Nrf2). It exhibits Nrf2 inductive activity alongside inhibitory effe...
T74600	Keap1-Nrf2-IN-9
	Keap1-Nrf2-IN-9 (compound 11) is a potent inhibitor of the Keap1-Nrf2 protein−protein interaction (PPI) with an IC50 value of 0.575 µM. It enhances the expression of Nrf2 target genes, including heme oxygenase 1 (Hmox1),...
T72706	Keap1-Nrf2-IN-13
	Keap1-Nrf2-IN-13 is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction (PPI), exhibiting an IC50 value of 0.15 μM, indicative of its high efficacy. It binds strongly to the Keap1 protein by forming hydrogen...
T81984	Keap1-Nrf2-IN-10
	Keap1-Nrf2-IN-10 (compound 15) is a potent inducer of NQO1 and efficaciously mitigates oxidative stress in gamma-irradiated mice by reducing MDA and ROS levels, as well as NQO1 in the liver, which enhances the survival r...
T64218	Keap1-Nrf2-IN-1 TFA
	Keap1-Nrf2-IN-1 TFA (compound35) is a Keap1-Nrf2 protein-protein interaction inhibitor (IC50: 43 nM) that activates Nrf2-regulated cytoprotective responses. Keap1-Nrf2-IN-1 TFA antagonizes acetaminophen-induced liver inj...
T63294	Keap1-Nrf2-IN-5
	Keap1-Nrf2-IN-5 is a potent inhibitor of Keap1-Nrf2 PPI (Keap1-Nrf2 protein-protein interaction) (IC50: 4.1 μM, Kd: 3.7 μM).
T63987	Keap1-Nrf2-IN-14
	Keap1-Nrf2-IN-14 is a KEAP1-NRF2 inhibitor that effectively disrupts the KEAP1-NRF2 interaction (IC50: 75 nM) with a Kd=24 nM for KEAP1. Keap1-Nrf2-IN-14 induces the expression of NRF2 target genes and is able to enhance...
T64190	Keap1-Nrf2-IN-12
	eap1-Nrf2-IN-12 is a potent inhibitor of Keap1-Nrf2 (IC50: 2.30 μM). eap1-Nrf2-IN-12 is metabolically stable in human liver microsomes.
T72687	Keap1-Nrf2-IN-11
	Keap1-Nrf2-IN-11 (Compound 6k), a potent Keap1-Nrf2 inhibitor, exhibits a dissociation constant (KD) of 0.21 nM. It hampers the production of reactive oxygen species (ROS) and nitric oxide (NO), as well as the expression...
T80260	Keap1-Nrf2-IN-16
	Keap1-Nrf2-IN-16 is a biologically active peptide with KEAP1 binding activity.
T61773	Keap1-Nrf2-IN-4
	Keap1-Nrf2-IN-4, a powerful neddylation inhibitor, demonstrates significant anti-proliferation activity against MGC-803 cells (IC50 = 2.55 μM), effectively impeding their migration and inducing apoptosis. Additionally, i...
T61522	Nrf2/HO-1 activator 2
	Nrf2/HO-1 activator 2 (compound 13m), a difluoro-substituted derivative, is a highly potent activator of Nrf2/HO-1. It exhibits substantial neuroprotective and antioxidant properties by activating the Nrf2/HO-1 pathway t...
T72827	Nrf2/HO-1-IN-1
	Nrf2/HO-1-IN-1 is a potent Nrf2/HO-1 pathway inhibitor, with an IC 50 value of 0.38 μM for NO . Nrf2/HO-1-IN-1 can significantly reduce the level of ROS in cells. Nrf2/HO-1-IN-1 can be used for researching anti-inflammat...
T61205	Nrf2/HO-1 activator 1
	Nrf2/HO-1 activator 1 (Compound 24) is a potent neuroprotective agent with significant antioxidant activities, specifically targeting Nrf2/HO-1. It is particularly useful in Parkinson's disease (PD) research, illustratin...
TP2109	TAT 14		Nrf2
	Nrf2 activator; inhibits Nrf2/Keap1 interaction. Induces upregulation of Nrf2 pathway downstream gene expression including heme-oxygenase 1. Suppresses LPS-induced TNF-α expression in THP-1 cells.		Nrf2
T60395	Nrf2-ARE/hMAO-B/QR2 modulator 1
	Nrf2-ARE/hMAO-B/QR2 modulator 1 is a new resveratrol-based multitarget-directed ligands (MTDLs) that showed a well-balanced MTDL profile: cellular activation of the NRF2-ARE pathway (CD = 9.83 μM), selective inhibition o...
T8979	AEM1		Nrf2
	AEM1 is an inhibitor of deregulated NRF2 transcriptional activity in cancer. AEM1 acts by broadly decreasing the expression of NRF2 controlled genes, sensitizing A549 cells to various chemotherapeutic agents, and inhibit...		Nrf2
T16331	NK-252		Others , Nrf2
	NK-252 is a potential activator of Nrf2. It has great Nrf2-activating potential.		Others , Nrf2
T4360	ML385		Others , Ferroptosis , Nrf2
	ML385 is an NRF2 inhibitor (IC50=1.9 μM) with novelty and specificity. ML385 has anti-inflammatory activity by modulating anti-oxidative stress through the inhibition of NRF2. ML385 also exhibits anti-tumor activity.		Others , Ferroptosis , Nrf2
T8970	ML162		Ferroptosis , GPX , Glutathione Peroxidase
	ML162 is an inhibitor of GPX4 that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively)		Ferroptosis , GPX , Glutathione Peroxidase
T1593	Ezetimibe	SCH 58235	Others , Nrf2 , NPC1L1 , Autophagy
	Ezetimibe (SCH 58235) is a Dietary Cholesterol Absorption Inhibitor. The physiologic effect of ezetimibe is by means of Decreased Cholesterol Absorption.		Others , Nrf2 , NPC1L1 , Autophagy
T14080	AA147	ATF6-activator-147	Others
	AA147 (ATF6-activator-147) is a small molecule endoplasmic reticulum (ER) proteostasis regulator. The selectively activates ATF6 arm of the unfolded protein response (UPR) .It acts as a prodrug that preferentially trigge...		Others
T13604	CDDO-dhTFEA		Others , NF-κB , Nrf2
	CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor. It restores mean arterial pressure (MAP), elevates Nrf2 levels and the expressi...		Others , NF-κB , Nrf2
T5364	TBHQ	tert-Butylhydroquinone	Apoptosis , ERK , Others , Ferroptosis , Nrf2 , Autophagy
	TBHQ (tert-Butylhydroquinone) is an antioxidant that induces an antioxidant response through the redox-sensitive transcription factor Nrf2.		Apoptosis , ERK , Others , Ferroptosis , Nrf2 , Autophagy
T6919	Omaveloxolone	RTA-408	Apoptosis , Others , Nrf2 , STING
	Omaveloxolone (RTA-408) (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.		Apoptosis , Others , Nrf2 , STING
T14042	4-P-PDOT	4-phenyl-2- propionamidotetralin	Melatonin Receptor , MT Receptor
	4-P-PDOT (4-phenyl-2- propionamidotetralin) is a potent, selective and affinity Melatonin receptor (MT2) antagonist.		Melatonin Receptor , MT Receptor
T11139	(E/Z)-BCI	NSC 150117	Apoptosis , Phosphatase
	(E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROS production in macrophage cells by activating the Nrf2 signa...		Apoptosis , Phosphatase
T0153	Oltipraz	NSC 347901,RP 35972	HIF/HIF Prolyl-Hydroxylase , HIV Protease , Reverse Transcriptase , Nrf2 , HIF
	Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as glutathione S transferase (GST) and NAD(P)H: quin...
TQ0120	CDDO-Im	RTA-403,CDDO-Imidazolide,TP-235	Others , Ferroptosis , Nrf2 , PPAR
	CDDO-Im (TP-235) is an activator of Nrf2 and PPAR (Kis: 232/344 nM for PPARα/PPARγ).		Others , Ferroptosis , Nrf2 , PPAR
T6165	Bardoxolone Methyl	RTA 402,CDDO Methyl ester,TP-155,NSC 713200	Apoptosis , IκB/IKK , Ferroptosis , Nrf2 , Autophagy
	Bardoxolone Methyl (TP-155) is a synthetic triterpenoid that acts as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway with potential anti-tumor and anti-inflammatory activities.		Apoptosis , IκB/IKK , Ferroptosis , Nrf2 , Autophagy
T1487	Fluvastatin sodium	XU 62320 sodium,XU-62-320,Fluvastatin sodium salt	Ferroptosis , HMG-CoA Reductase , Autophagy
	Fluvastatin sodium (Fluvastatin sodium salt), a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterol lowering agent.		Ferroptosis , HMG-CoA Reductase , Autophagy
T21233	Dihydrolipoic acid	Reduced thioctic acid,Reduced lipoic acid,DHLA,USAF XR-12,6,8-Dihydrothioctic acid	Antioxidant
	Dihydrolipoic acid (USAF XR-12), a dithiol-containing carboxylic acid, acts as a general antioxidant that is highly reactive against a variety of reactive oxygen species, including peroxynitirite, hydroxyl radicals, hydr...		Antioxidant
TP2109L	AT 14 acetate		Nrf2
	TAT 14 acetate, a 14-mer peptide, is an Nrf2 activator with anti-inflammatory properties. TAT 14 acetate increases Nrf2 protein levels due to targeting the Nrf2 binding site on Keap1, but has no effect on Nrf2 mRNA expre...		Nrf2

Compounds

Nrf2 activator-1

T39719

Synonym: Nrf2 activator-1

Target: Others, Nrf2

Nrf2-Activator-12G

T24546

Synonym: Nrf2 Activator IV,Nrf2 Activator-IV

Target: Antioxidant, Nrf2

Keap1-Nrf2-IN-3

T39514

Synonym: Keap1-Nrf2-IN-3

Target:

Keap1-Nrf2-IN-1

T11752

Synonym: Keap1–Nrf2-IN-1

Target: Reactive Oxygen Species, Nrf2

AChE/Nrf2 modulator 1

Keap1-Nrf2-IN-1 TFA

Nrf2/HO-1 activator 2

Nrf2/HO-1 activator 1

Nrf2-ARE/hMAO-B/QR2 modulator 1

Target: Others, Nrf2

ML385

T4360

Synonym:

Target: Others, Ferroptosis, Nrf2

ML162

T8970

Synonym:

Target: Ferroptosis, GPX, Glutathione Peroxidase

Ezetimibe

T1593

Synonym: SCH 58235

Target: Others, Nrf2, NPC1L1, Autophagy

AA147

T14080

Synonym: ATF6-activator-147

Target: Others, NF-κB, Nrf2

TBHQ

T5364

Synonym: tert-Butylhydroquinone

Target: Apoptosis, ERK, Others, Ferroptosis, Nrf2, Autophagy

Omaveloxolone

T6919

Synonym: RTA-408

Target: Apoptosis, Others, Nrf2, STING

4-P-PDOT

T14042

Synonym: 4-phenyl-2- propionamidotetralin

Target: Melatonin Receptor, MT Receptor

(E/Z)-BCI

T11139

Synonym: NSC 150117

Target: Apoptosis, Phosphatase

Oltipraz

T0153

Synonym: NSC 347901,RP 35972

Target: HIF/HIF Prolyl-Hydroxylase, HIV Protease, Reverse Transcriptase, Nrf2, HIF

CDDO-Im

TQ0120

Synonym: RTA-403,CDDO-Imidazolide,TP-235

Target: Others, Ferroptosis, Nrf2, PPAR

Bardoxolone Methyl

T6165

Synonym: RTA 402,CDDO Methyl ester,TP-155,NSC 713200

Target: Apoptosis, IκB/IKK, Ferroptosis, Nrf2, Autophagy

Fluvastatin sodium

T1487

Synonym: XU 62320 sodium,XU-62-320,Fluvastatin sodium salt

Target: Ferroptosis, HMG-CoA Reductase, Autophagy

Dihydrolipoic acid

T21233

Synonym: Reduced thioctic acid,Reduced lipoic acid,DHLA,USAF XR-12,6,8-Dihydrothioctic acid

Cat No.	Product Name	Synonyms	Targets
T21065	Artemisitene		Others
	Artemisitene is the oxidized form of Artemisinin and is an antimalarial agent. Artemisinin precursors are the important basic substances for biosynthesis of Artemisinin, including Artemisinin B, Artemisitene, Artemisini...		Others
TN1621	Eriodictyol-7-O-glucoside		Nrf2
	Eriodictyol-7-O-glucoside is an Nrf2 activator conferring protection against Cisplatin-induced toxicity. Eriodictyol-7-O-glucoside is a flavonoid and a free radical scavenger with antioxidant activity in pistachio skin.		Nrf2
T3849	Kinsenoside	(+)-Kinsenoside	Apoptosis , Nrf2
	Kinsenoside ((+)-Kinsenoside) shows significant antihepatotoxic, and anti-inflammatory activities. Kinsenoside could be useful for repairing beta cells in pancreatic islet injury as well as improving its function, it cou...		Apoptosis , Nrf2
T6S1302	Carnosol		Nrf2 , Endogenous Metabolite , S6 Kinase
	Carnosol is an Nrf2 activator, increasing Nrf2 levels and promoting heme oxygenase 1 (HMOX1) expression. It is a ribosomal S6 kinase (RSK2) inhibitor and can be used in gastric cancer-related research with an IC50 value ...		Nrf2 , Endogenous Metabolite , S6 Kinase
TQ0207	Sulforaphane		Apoptosis , Nrf2 , HDAC
	Sulforaphane is derived from the consumption of cruciferous vegetables, such as broccoli. It has shown anticancer and cardioprotective activities.		Apoptosis , Nrf2 , HDAC
T6S2356	Corynoline	(+)-Corynoline	Nrf2 , AChE
	1. Corynoline ((+)-Corynoline) is an acetylcholinesterase inhibitor.		Nrf2 , AChE
TN1674	Garcinone D		Reactive Oxygen Species , Nrf2 , STAT
	Garcinone D shows significant cytotoxicity against the CEM-SS cell line, with IC(50) value of 3.2 microg/ml; it exhibits dose-dependent enzyme-based microsomal aromatase inhibitory activity. Garcinone D inhibits p65 acti...		Reactive Oxygen Species , Nrf2 , STAT
T6S0232	Eriodictyol	Huazhongilexone	Influenza Virus , DNA/RNA Synthesis , Nrf2 , Endogenous Metabolite
	1. Eriodictyol (Huazhongilexone) is a flavonoid with anti-inflammatory and antioxidant activities. 2. Eriodictyol may possess antidiabetic properties through increasing glucose uptake and improving insulin resistance. 3....
TN6339	(R)-5-Hydroxy-1,7-diphenylheptan-3-one	(5R)-Dihydroyashabushiketol	Others
	(R)-5-Hydroxy-1,7-diphenylheptan-3-one ((5R)-Dihydroyashabushiketol) is extracted from the rhizomes of Alpinia officinarum, a Chinese medicinal herb. (R)-5-Hydroxy-1,7-diphenylheptan-3-one inhibits melanogenesis in theop...		Others
TQ0211	Brusatol	(+)-Brusatol,NSC 172924	Others , Ferroptosis , Nrf2
	Brusatol (NSC-172924) is a natural product isolated from the Brucea javanica plant. It inhibits Nrf2.		Others , Ferroptosis , Nrf2
T3012	Mangiferin	Alpizarin,Chinomin,Hedysarid	Apoptosis , Others , NF-κB , Nrf2
	Mangiferin (Hedysarid) is used for antidiabetes. Extracted from Mangifera indica L.		Apoptosis , Others , NF-κB , Nrf2
T1027	Luteolin	Luteolol,Flacitran,Digitoflavone,Luteoline	Apoptosis , Nrf2 , Endogenous Metabolite , PDE , Autophagy
	Luteolin (Luteolol) belongs to the flavonoid group of natural products and is a Nrf2 inhibitor, PDE inhibitor. Luteolin has a wide range of biological activities including antitumor, antioxidant, anti-inflammatory, antim...
T2915	Bardoxolone	RTA 401,CDDO	Others , Nrf2
	Bardoxolone (CDDO) is a synthetic oleanane triterpenoid that blocks the cellular synthesis of inducible nitric oxide synthase and inducible COX-2 in INF-γ-activated mouse macrophages with an IC50 value of 0.4 nM. By supp...		Others , Nrf2
T0973	Pyridoxine	Pyridoxol,Vitamin B6,Gravidox	PLK , Nrf2 , Endogenous Metabolite
	Pyridoxine (Vitamin B6) is the 4-methanol form of vitamin B6 and is converted to pyridoxal 5-phosphate in the body. Although pyridoxine and vitamin B6 are still frequently used as synonyms, especially by medical research...		PLK , Nrf2 , Endogenous Metabolite
T2S0731	Trilobatin	P-Phlorizin	Amylase
	Trilobatin (P-Phlorizin) has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially inhibits the lipopolysaccharide (LPS)-induced inflammatory respon...		Amylase
T3227	Danshensu	Salvianic acid A,Dan shen suan A	Apoptosis , Nrf2 , Autophagy
	Danshensu (Dan shen suan A) is an active ingredient of Salvia miltiorrhiza with wide cardiovascular benefit.		Apoptosis , Nrf2 , Autophagy
T0492	Dimethyl fumarate	DMF	Reactive Oxygen Species , HIV Protease , Nrf2 , Endogenous Metabolite , Autophagy
	Dimethyl fumarate (DMF), a fumarate derivative, is used as antiinflammatory and immunomodulatory agent.
TN6711	Toralactone		Others , Nrf2
	Toralactone is a natural product isolated from Cassia obtusifolia, mediates hepatoprotection via an Nrf2-dependent anti-oxidative mechanism		Others , Nrf2
T3743	4-hydroxyphenylacetic acid	p-Hydroxyphenylacetic acid,parahydroxy phenylacetate	Antioxidant , Nrf2 , Endogenous Metabolite
	4-hydroxyphenylacetic acid (parahydroxy phenylacetate) is a major microbiota-derived metabolite of polyphenols. 4-hydroxyphenylacetic acid(p-Hydroxyphenylacetic acid) is involved in the antioxidative action. 4-hydroxyphe...		Antioxidant , Nrf2 , Endogenous Metabolite
T1558	Resveratrol	trans-Resveratrol,SRT 501	Apoptosis , Mitophagy , IκB/IKK , Lipoxygenase , Sirtuin , COX , NADPH , DNA/RNA Synthesis , Nrf2 , Antibacterial , Antibiotic , Autophagy , Antifungal
	Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autop...
T1516	Curcumin	Diferuloylmethane,Natural Yellow 3,Indian Saffron,Turmeric yellow	Mitophagy , Epigenetic Reader Domain , Ferroptosis , Influenza Virus , Nrf2 , Histone Acetyltransferase , HDAC , Autophagy
	Curcumin (Natural Yellow 3) is a phenolic natural product, an inhibitor of histone acetyltransferase p300/CREB (IC50=25 μM) with specificity. Curcumin has a wide range of pharmacological activities such as antitumor, ant...
T2794	Astilbin	Neoastilbin,Taxifolin 3-O-rhamnoside,Isoastilbin,Taxifolin 3-rhamnoside,Neoisoastilbin	TNF , NF-κB , Nrf2
	Astilbin (Neoastilbin) is actions Flavonoid phytochemical found in St. John′s wort and Traditional Chinese Medicine herbal preparations.		TNF , NF-κB , Nrf2
T0973L	Pyridoxine hydrochloride	Pyridoxine HCl,Pyridoxol (hydrochloride),Vitamin B6 (hydrochloride),Vitamin B6	Nrf2 , Endogenous Metabolite
	Pyridoxine hydrochloride (Vitamin B6) is the 4-methanol form of vitaminB6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingo...		Nrf2 , Endogenous Metabolite
T1368	Methyl 3,4-dihydroxybenzoate	3,4-Dihydroxybenzoic acid methyl ester,Methyl protocatechuate,Protocatechuic acid methyl ester	Apoptosis , Antioxidant , Nrf2
	Methyl 3,4-dihydroxybenzoate (Protocatechuic acid methyl ester) is a major metabolite of antioxidant polyphenols found in green tea. Antioxidant and anti-inflammatory effect.		Apoptosis , Antioxidant , Nrf2
T8281	(R)-Sulforaphane	L-Sulforaphane	Nrf2
	(R)-Sulforaphane (L-Sulforaphane) is a potent inducer of the Keap1/Nrf2/ARE pathway.		Nrf2
T8704	4-hydroxyphenyl acetate		Nrf2
	4-Acetoxyphenol Prevents RPE Oxidative Stress-Induced Necrosis by Functioning as an NRF2 Stabilizer		Nrf2
T5S1805	5,7-Dihydroxychromone	5,7-Dihydroxy-4H-Chromen-4-One	Others , Virus Protease , PARP , Caspase , Nrf2
	1. 5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. 2. 5,7-Dihydroxychromone exerts neuroprotective effect agai...		Others , Virus Protease , PARP , Caspase , Nrf2
T5S1569	AKBA	3-O-Acetyl-11-keto-β-boswellic acid,3-O-Acetyl-11-keto-beta-boswellic acid,Acetyl-11-keto-β-boswellic acid	Others , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , Endogenous Metabolite
	AKBA (3-O-Acetyl-11-keto-beta-boswellic acid), a natural component from frankincense, is a novel activator of Nrf2.
TMA1570	Sappanone A		NF-κB , Nrf2
	Sappanone A is a high isoflavanone that exhibits anti-inflammatory effects by modulating Nrf2.Sappanone A attenuates allergic airway inflammation in ovalbumin-induced asthma.		NF-κB , Nrf2
T8181	Poricoic acid A	Poricoic acid A(F)	Others
	Poricoic acid A (Poricoic acid A(F)) is a natural product with antitumor activity. It also enhances melatonin inhibition of AKI-to-CKD transition by regulating the Gas6/AxlNFκB/Nrf2 axis.		Others
T2A2486	3',4',5',5,7-Pentamethoxyflavone	5,7,3',4',5'-Pentamethoxyflavone	Nrf2
	3',4',5',5,7-Pentamethoxyflavone is a naturally occurring brassinosteroid compound from the Rutaceae family that exhibits resistance to cancer cells by inhibiting the Nrf2 pathway to overcome chemotherapeutically active ...		Nrf2
T2212	Geniposide		Beta Amyloid , Influenza Virus
	Geniposide is an iridoid glycoside with a variety of biological activities including neuroprotective, anti-diabetic, antiproliferative, and antioxidative activity. Geniposide has been shown to regulate Nrf2 translocation...		Beta Amyloid , Influenza Virus
TN6750	2-tert-Butyl-1,4-benzoquinone		Nrf2
	2-tert-Butyl-1,4-benzoquinone (TBQ), an electrophilic metabolite of butylated hydroxyanisole (BHA), causes activation of Nrf2 together with S-arylation of its negative regulator Keap1 in RAW264.7 cells.		Nrf2
TN1058	Pelargonidin chloride		NOS , Reactive Oxygen Species , Nrf2 , NO Synthase
	Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels through Keap1/Nrf2 signaling pathway.		NOS , Reactive Oxygen Species , Nrf2 , NO Synthase
T6S1587	Notoginsenoside R2	20(S)-Notoginsenoside R2,Ginsenoside Ng-R2	Others , Nrf2
	Notoginsenoside R2 (20(S)-Notoginsenoside R2) has neuroprotection against 6-OHDA-induced neurotoxicity, is associated with Notoginsenoside R2-mediated P90RSK and Nrf2 activation through MEK1/2-ERK1/2 pathways.		Others , Nrf2
T2887	Trigonelline	Trigenolline	Apoptosis , Others , Ferroptosis , Endogenous Metabolite
	Trigonelline (Trigenolline), an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.		Apoptosis , Others , Ferroptosis , Endogenous Metabolite
T3385	Gypenoside XVII	GP-17,Gynosaponin S	Estrogen Receptor/ERR , GSK-3 , Endogenous Metabolite
	Gypenoside XVII (Gynosaponin S) confers protection against Aβ25-35-induced neurotoxicity through estrogen receptor-dependent activation of PI3K/Akt pathways, activation of Nrf2/ARE/HO-1 and inactivation of GSK-3β pathway...		Estrogen Receptor/ERR , GSK-3 , Endogenous Metabolite
TN5171	Tricetin		Apoptosis , Others , Nrf2
	Tricetin is a flavonoid isolated from pomegranate.Tricetin is a potent competitive inhibitor of Keap1-Nrf2 protein-protein interaction (PPI) and protects Parkinson's disease patients from 6-OHDA-induced neurotoxicity by ...		Apoptosis , Others , Nrf2
T3S1701	Dihydrocurcumin		PPAR , Fatty Acid Synthase
	Dihydrocurcumin is the main metabolite of curcumin, which can reduce fat accumulation and oxidative stress response. Dihydrocurcumin can regulate the mRNA and protein expression levels of SREBP-1C, PNPLA3 and PPARα, incr...		PPAR , Fatty Acid Synthase
TN1461	(-)-Butin	Butin	Akt , PI3K , Nrf2
	(-)-Butin (Butin) has antioxidant activity, can protect cells against H2O2-induced apoptosis, oxidative DNA damage and oxidative mitochondrial dysfunction; it attenuates oxidative stress by activating Nrf2-mediated Mn SO...		Akt , PI3K , Nrf2
TN5770	Gingerenone A		Nrf2
	Gingerenone A is an effective Nrf2-Gpx4 activator. It is a small molecule compound isolated from ginger. It has anti-cancer activity, can prolong the cell cycle of cancer cells, and can inhibit dextran sodium sulfate (DS...		Nrf2
TN2272	Tigloylgomisin H		Nrf2
	Tigloylgomisin H represents a potential liver cancer prevention agent, it can significantly induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells, it functions as a novel monofunctional inducer ...		Nrf2
TN1182	11-Keto-beta-boswellic acid	11-Keto-beta-boswellic acid	Leukotriene Receptor , NF-κB , Lipoxygenase
	11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor; it exerts dose dependent cardioprotective effect manifested by dose-dependent reduction in serum lactate dehydrogenas...		Leukotriene Receptor , NF-κB , Lipoxygenase
TN2063	Physalin B	NSC-287088	Apoptosis , NF-κB , Akt , PI3K , Nrf2 , NOD
	Physalin B is one of the major active compounds from the Solanaceae family of plants and has a wide range of biological activities for the treatment of inflammatory eczema and herpes, among other diseases.Physalin B amel...		Apoptosis , NF-κB , Akt , PI3K , Nrf2 , NOD
TN2347	Methylsticin	Methysticin	Others
	Methysticin is a kavalactone isolated from the kava roots. Methylsticin (Methysticin) exhibit osteoclast formation inhibitory activity. It inhibits activation of NF-χB in lung adenocarcinoma tissue, activates Nrf2 in neu...		Others
TN2244	Sulfuretin		NF-κB , Autophagy
	Sulfuretin is a potent anti-oxidant, has protective effect against t-BHP-induced oxidative damage in human liver-derived HepG2 cells is attributable to its ability to scavenge ROS and up-regulate the activity of HO-1 thr...		NF-κB , Autophagy
T3752	4-Hydroxybenzyl alcohol	4-Methylolphenol,P-Methylolphenol	Apoptosis , Endogenous Metabolite
	4-Hydroxybenzyl alcohol (P-Methylolphenol) exhibits beneficial effects in cerebral ischemic injury, has neuroprotective effect through upregulation of Nrf2, Prdx6, and PDI expression via the PI3K/Akt pathway. 4-Hydroxybe...		Apoptosis , Endogenous Metabolite
TQ0212	Glucoraphanin		Antioxidant , Reactive Oxygen Species
	Glucoraphanin, the precursor of the widely extolled chemopreventive agent sulforaphane found in broccoli, has antioxidant activity.		Antioxidant , Reactive Oxygen Species
T2909	Fraxetin	7,8-dihydroxy-6-methoxy coumarin	Apoptosis , Others
	Fraxetin (7,8-dihydroxy-6-methoxy coumarin) has dual-antioxidative ,hepatoprotective and antihyperglycemic functions, it shows potent protective effects against CCl4 induced oxidative stress and hepatic fibrosis, has a m...		Apoptosis , Others
T3S1068	Oxyresveratrol	trans-Oxyresveratrol,2,3',4,5'-tetrahydroxystilbene,Tetrahydroxystilbene	Tyrosinase , Autophagy , HSV
	1. Oxyresveratro can inhibit tyrosinase activity. 2. Oxyresveratro is useful to trauma models, as toxicity to glia could be beneficial by inhibiting reactive gliosis. 3. Oxyresveratrol (trans-Oxyresveratrol) has antioxid...		Tyrosinase , Autophagy , HSV
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Natural Products

Eriodictyol-7-O-glucoside

Synonym: (+)-Kinsenoside

Target: Apoptosis, Nrf2

Carnosol

T6S1302

Synonym:

Target: Nrf2, Endogenous Metabolite, S6 Kinase

Sulforaphane

TQ0207

Synonym:

Target: Apoptosis, Nrf2, HDAC

Corynoline

T6S2356

Synonym: (+)-Corynoline

Target: Reactive Oxygen Species, Nrf2, STAT

Eriodictyol

T6S0232

Synonym: Huazhongilexone

Target: Influenza Virus, DNA/RNA Synthesis, Nrf2, Endogenous Metabolite

(R)-5-Hydroxy-1,7-diphenylheptan-3-one

TN6339

Synonym: (5R)-Dihydroyashabushiketol

Target: Others

Brusatol

TQ0211

Synonym: (+)-Brusatol,NSC 172924

Target: Others, Ferroptosis, Nrf2

Mangiferin

T3012

Synonym: Alpizarin,Chinomin,Hedysarid

Target: Apoptosis, Others, NF-κB, Nrf2

Luteolin

T1027

Synonym: Luteolol,Flacitran,Digitoflavone,Luteoline

Target: Apoptosis, Nrf2, Endogenous Metabolite, PDE, Autophagy

Bardoxolone

T2915

Synonym: RTA 401,CDDO

Target: Others, Nrf2

Pyridoxine

T0973

Synonym: Pyridoxol,Vitamin B6,Gravidox

Target: PLK, Nrf2, Endogenous Metabolite

Synonym: Salvianic acid A,Dan shen suan A

Target: Apoptosis, Nrf2, Autophagy

Dimethyl fumarate

T0492

Synonym: DMF

Target: Reactive Oxygen Species, HIV Protease, Nrf2, Endogenous Metabolite, Autophagy

toralactone

TN6711

Synonym:

Target: Others, Nrf2

4-hydroxyphenylacetic acid

T3743

Synonym: p-Hydroxyphenylacetic acid,parahydroxy phenylacetate

Target: Antioxidant, Nrf2, Endogenous Metabolite

Resveratrol

T1558

Synonym: trans-Resveratrol,SRT 501

Target: Apoptosis, Mitophagy, IκB/IKK, Lipoxygenase, Sirtuin, COX, NADPH, DNA/RNA Synthesis, Nrf2, Antibacterial, Antibiotic, Autophagy, Antifungal

Curcumin

T1516

Synonym: Diferuloylmethane,Natural Yellow 3,Indian Saffron,Turmeric yellow

Target: Mitophagy, Epigenetic Reader Domain, Ferroptosis, Influenza Virus, Nrf2, Histone Acetyltransferase, HDAC, Autophagy

Astilbin

T2794

Synonym: Neoastilbin,Taxifolin 3-O-rhamnoside,Isoastilbin,Taxifolin 3-rhamnoside,Neoisoastilbin

Target: TNF, NF-κB, Nrf2

Pyridoxine hydrochloride

T0973L

Synonym: Pyridoxine HCl,Pyridoxol (hydrochloride),Vitamin B6 (hydrochloride),Vitamin B6

Target: Nrf2, Endogenous Metabolite

Methyl 3,4-dihydroxybenzoate

T1368

Synonym: 3,4-Dihydroxybenzoic acid methyl ester,Methyl protocatechuate,Protocatechuic acid methyl ester

Target: Apoptosis, Antioxidant, Nrf2

(R)-Sulforaphane

T8281

Synonym: L-Sulforaphane

Target: Nrf2

4-hydroxyphenyl acetate

T8704

Synonym:

Target: Nrf2

5,7-Dihydroxychromone

T5S1805

Synonym: 5,7-Dihydroxy-4H-Chromen-4-One

Target: Others, Virus Protease, PARP, Caspase, Nrf2

AKBA

T5S1569

Synonym: 3-O-Acetyl-11-keto-β-boswellic acid,3-O-Acetyl-11-keto-beta-boswellic acid,Acetyl-11-keto-β-boswellic acid

Target: Others, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, Endogenous Metabolite

Sappanone A

TMA1570

Synonym:

Target: NF-κB, Nrf2

Poricoic acid A

T8181

Synonym: Poricoic acid A(F)

Target: Others

3',4',5',5,7-Pentamethoxyflavone

T2A2486

Synonym: 5,7,3',4',5'-Pentamethoxyflavone

Target: Beta Amyloid, Influenza Virus

2-tert-Butyl-1,4-benzoquinone

TN6750

Synonym:

Target: Nrf2

Pelargonidin chloride

TN1058

Synonym:

Target: NOS, Reactive Oxygen Species, Nrf2, NO Synthase

Notoginsenoside R2

T6S1587

Synonym: 20(S)-Notoginsenoside R2,Ginsenoside Ng-R2

Target: Others, Nrf2

Trigonelline

T2887

Synonym: Trigenolline

Target: Apoptosis, Others, Ferroptosis, Endogenous Metabolite

Gypenoside XVII

T3385

Synonym: GP-17,Gynosaponin S

Target: Estrogen Receptor/ERR, GSK-3, Endogenous Metabolite

Tricetin

TN5171

Synonym:

Target: Apoptosis, Others, Nrf2

Dihydrocurcumin

T3S1701

Synonym:

Target: PPAR, Fatty Acid Synthase

(-)-Butin

TN1461

Synonym: Butin

Target: Akt, PI3K, Nrf2

11-Keto-beta-boswellic acid

TN1182

Synonym: 11-Keto-beta-boswellic acid

Target: Leukotriene Receptor, NF-κB, Lipoxygenase

Physalin B

TN2063

Synonym: NSC-287088

Target: Apoptosis, NF-κB, Akt, PI3K, Nrf2, NOD

Target: NF-κB, Autophagy

4-Hydroxybenzyl alcohol

T3752

Synonym: 4-Methylolphenol,P-Methylolphenol

Target: Apoptosis, Endogenous Metabolite

Glucoraphanin

TQ0212

Synonym:

Target: Antioxidant, Reactive Oxygen Species

Fraxetin

T2909

Synonym: 7,8-dihydroxy-6-methoxy coumarin

Target: Apoptosis, Others

Oxyresveratrol

T3S1068

Synonym: trans-Oxyresveratrol,2,3',4,5'-tetrahydroxystilbene,Tetrahydroxystilbene

Target: Tyrosinase, Autophagy, HSV

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Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-03888	KEAP1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	Kelch-like ECH-associated protein 1, also known as a cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, and INRF2, is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB ...
TMPY-02101	KEAP1 Protein, Human, Recombinant (His & GST & Avi)	Human	Baculovirus-Insect Cells
	Kelch-like ECH-associated protein 1, also known as a cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, and INRF2, is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB ...
TMPY-03432	KEAP1 Protein, Human, Recombinant	Human	Baculovirus-Insect Cells
	Kelch-like ECH-associated protein 1, also known as a cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, and INRF2, is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB ...
TMPH-02940	MAFK Protein, Mouse, Recombinant (His & Myc)	Mouse	HEK293
	Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they act as transcriptional activators by dimerizing with other (usuall...
TMPH-02941	MAFK Protein, Mouse, Recombinant (His & Myc & SUMO)	Mouse	E. coli
	Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they act as transcriptional activators by dimerizing with other (usuall...
TMPH-01788	NFE2L2 Protein, Human, Recombinant (His)	Human	E. coli
	Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzyme...

KEAP1 Protein, Human, Recombinant (His & GST)

TMPY-03888

Species: Human

Expression System: Baculovirus-Insect Cells

KEAP1 Protein, Human, Recombinant (His & GST & Avi)

TMPY-02101

Species: Human

Expression System: Baculovirus-Insect Cells

KEAP1 Protein, Human, Recombinant

TMPY-03432

Species: Human

Expression System: Baculovirus-Insect Cells

MAFK Protein, Mouse, Recombinant (His & Myc)

TMPH-02940

Species: Mouse

Expression System: HEK293

MAFK Protein, Mouse, Recombinant (His & Myc & SUMO)

TMPH-02941

Species: Mouse

Expression System: E. coli

NFE2L2 Protein, Human, Recombinant (His)

TMPH-01788

Species: Human

Expression System: E. coli

Cat No.	Product Name
L8700	Ferroptosis Compound Library		800 compounds
	A unique collection of 800 ferroptosis signaling pathway related compounds, a powerful tool for new target identification, drug discovery, and mechanism study；

Libraries

Ferroptosis Compound Library

L8700

Compounds: 800