pah — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12268	NTP42		Prostaglandin Receptor , PPAR
	NTP42 is an antagonist of thromboxane A2 (TXA2) receptor(IC50 of 3.278 nM)		Prostaglandin Receptor , PPAR
T8900	Seralutinib	GB002	PDGFR
	Seralutinib (GB002) is an inhibitor of inhaled PDGFRα and PDGFRβ. It is used in the study for pulmonary arterial hypertension.		PDGFR
T14782	Brilaroxazine	RP5063	Dopamine Receptor , 5-HT Receptor
	Brilaroxazine (RP5063) is a potent multimodal dopamine/5-HT modulator. Brilaroxazine is a partial agonist of dopamine D2, D3, and D4 receptors, 5-HT1A (Ki =1.5 nM) and 5-HT2A (Ki = 2.5 nM), and has antagonist activity 5-...		Dopamine Receptor , 5-HT Receptor
T6085	PF-543	Sphingosine Kinase 1 Inhibitor II,PF 543	Apoptosis , S1P Receptor , Autophagy , LPL Receptor
	PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.		Apoptosis , S1P Receptor , Autophagy , LPL Receptor
T8840	PF-543 hydrochloride	PF-543	Apoptosis , S1P Receptor , Autophagy , LPL Receptor
	PF-543 hydrochloride (PF-543) inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.		Apoptosis , S1P Receptor , Autophagy , LPL Receptor
T34746	Sulfo-SANPAH Crosslinker	Sulfo-SANPAH Cross-linker,Sulfo-SANPAH Cross linker	Others
	Sulfo-SANPAH Crosslinker (Sulfo-SANPAH Cross linker) is a water-soluble isobisfunctional protein crosslinker.		Others
T36588	9(R)-PAHSA
	9(R)-PAHSA is a stereoisomer of 9-PAHSA , an endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs).
T23178	PPAHV		Others
	vanilloid TRPV1 (VR1) receptor agonist		Others
T125133	Pahutoxin
	Pahutoxin is a useful organic compound for research related to life sciences and the catalog number is T125133.
T35446	10(R)-PAHSA
	10(R)-PAHSA is a stereoisomer of 10-PAHSA , an endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs).
T35447	10(S)-PAHSA
	10(S)-PAHSA is a stereoisomer of 10-PAHSA , an endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs).
T36142	10-PAHSA
	10-PAHSA is a newly identified endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs). It is a FAHFA in which palmitic acid is esterified to 10-hydroxy stearic acid. A...
T73841	9-PAHPA
	9-PAHPA, a fatty acid ester of hydroxy fatty acid (FAHFA), belongs to a recently identified family of endogenous lipids known for their antidiabetic and anti-inflammatory properties [1].
T126416	Homopahutoxin
	Homopahutoxin is a useful organic compound for research related to life sciences and the catalog number is T126416.
T36590	9-PAHSA
	Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are newly identified endogenous lipids regulated by fasting and high-fat feeding and associated with insulin sensitivity. Structurally, these esters are comprise...
T36586	12-PAHSA
	Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are newly identified endogenous lipids regulated by fasting and high-fat feeding and associated with insulin sensitivity. Structurally, these esters are comprise...
T2561	Macitentan	ACT-064992	Apoptosis , Endothelin Receptor
	Macitentan (ACT-064992) is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH).		Apoptosis , Endothelin Receptor
T3216	Selexipag	NS-304,ACT-293987,Uptravi	Others , Prostaglandin Receptor
	Selexipag (ACT-293987)(NS-304) is prostacyclin receptor agonist that causes vasodilation in pulmonary vasculature and is used in the therapy of pulmonary arterial hypertension (PAH).		Others , Prostaglandin Receptor
T1655	Ambrisentan	BSF-208075,BSF 208075,LU 208075	Endothelin Receptor
	Ambrisentan (BSF 208075) is an endothelin receptor antagonist used in the therapy of pulmonary arterial hypertension (PAH). Ambrisentan has been associated with a low rate of serum enzyme elevations during therapy but ha...		Endothelin Receptor
T0352	Dibenzothiophene	Imino semicarbazide,Diphenylene sulfide	Others
	Dibenzothiophene (Imino semicarbazide), a component of petroleum oils, is a sulfur-containing polycyclic aromatic hydrocarbon (PAH) derivate consisting of 3 fused rings with keratolytic activity.		Others
T78835	Phosphatase-IN-1		Antifungal
	Phosphatase-IN-1 (compound II-8), a propranolol derivative, acts as an inhibitor of phosphatidate phosphatase (Pah). It binds to MoPah1 with an affinity constant of 19.8 μM, demonstrating growth inhibition of plant patho...		Antifungal
T13193	TPN171		PDE
	TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonary arterial hypertension (PAH). TPN171 was proven to exert a longer l...		PDE
TP1016L	Aviptadil Acetate	Vasoactive Intestinal Peptide acetate salt	RAAS , SARS-CoV
	Aviptadil Acetate (Vasoactive Intestinal Peptide acetate salt) induces pulmonary vasodilation and inhibits the proliferation of vascular SMCs and platelet aggregation. Avitadil acetate can be used for research on pulmona...		RAAS , SARS-CoV
T36696	DMBA
	7,12-Dimethylbenz[a]anthracene (DMBA) is a polycyclic aromatic hydrocarbon (PAH) that has been found in tobacco smoke and diesel exhaust and has carcinogenic activity.1,2It undergoes metabolic activation by numerous enzy...
T79573	ET receptor antagonist 1		Estrogen Receptor/ERR
	ET Receptor Antagonist 1 (compound 16h), with an IC50 value of 0.18 nM, is an orally active agent that can be utilized for pulmonary arterial hypertension (PAH) research. It has demonstrated efficacy in mitigating monocr...		Estrogen Receptor/ERR
T79575	ET receptor antagonist 3		Estrogen Receptor/ERR
	"ET receptor antagonist 3 (compound 17d) is an orally active ET receptor antagonist with an IC50 of 0.26 nM, utilized for pulmonary arterial hypertension (PAH) research. This compound demonstrates efficacy in mitigating ...		Estrogen Receptor/ERR
T79574	ET receptor antagonist 2		Estrogen Receptor/ERR
	ET Receptor Antagonist 2 (Compound 16j) is an orally active ET receptor antagonist with an IC50 of 0.22 nM, suitable for pulmonary arterial hypertension (PAH) research. It has been shown to mitigate monocrotaline-induced...		Estrogen Receptor/ERR
T71847	Terguride
	Terguride is 5-HT receptor antagonist. Terguride is a drug used to treat hyperprolactinemia that antagonizes 5-HT2A and 5-HT2B and activates dopamine receptors. It has also been extensively studied for the treatment of P...
T16779	Rodatristat ethyl	RVT-014,KAR5585,RVT-1201	5-HT Receptor , Hydroxylase
	Rodatristat ethyl (KAR5585) is a first-of-its-kind orally active and potent tryptophan hydroxylase 1 (TPH1) inhibitor that significantly reduces 5-hydroxytryptamine (5-HT) levels and decreases pulmonary arterial hyperten...		5-HT Receptor , Hydroxylase
T11935	Macitentan (n-butyl analogue)		Others
	Macitentan n-butyl analogue, a derivative of Macitentan, functions as an orally active dual antagonist targeting both endothelin ETA and ETB receptors. This compound shows promise for treating idiopathic pulmonary fibros...		Others
T78076	PBR28		Others
	PBR28, a TSPO modulator, holds potential for preventative research in Pulmonary Arterial Hypertension (PAH) and is instrumental in brain positron emission tomography (PET) imaging studies through its capacity for radioac...		Others
TP2096	ELA-21 (human)
	High affinity apelin receptor agonist. Binds apelin receptors in left ventricle from normal and pulmonary arterial hypertensive (PAH) hearts (pKi values are 9.31 and 9.46, respectively). Bioactive fragment of ELA-32. Inh...
T65598	Cefminox sodium
	Cefminox (Sodium) is a new cephamycin antibiotic possessing a D-amino acid moiety derived from D-cysteine at the C-7B side chain. Cefminox is active against a wide range of bacteria, especially Gram-negative and anaerobi...

Compounds

NTP42

T12268

Synonym:

Target: Prostaglandin Receptor, PPAR

Target: Dopamine Receptor, 5-HT Receptor

PF-543

T6085

Synonym: Sphingosine Kinase 1 Inhibitor II,PF 543

Target: Apoptosis, S1P Receptor, Autophagy, LPL Receptor

PF-543 hydrochloride

T8840

Synonym: PF-543

Target: Apoptosis, S1P Receptor, Autophagy, LPL Receptor

Sulfo-SANPAH Crosslinker

T34746

Synonym: Sulfo-SANPAH Cross-linker,Sulfo-SANPAH Cross linker

Target: Apoptosis, Endothelin Receptor

Selexipag

T3216

Synonym: NS-304,ACT-293987,Uptravi

Target: Others, Prostaglandin Receptor

Ambrisentan

T1655

Synonym: BSF-208075,BSF 208075,LU 208075

Target: Endothelin Receptor

Dibenzothiophene

T0352

Synonym: Imino semicarbazide,Diphenylene sulfide

Synonym: Vasoactive Intestinal Peptide acetate salt

Target: RAAS, SARS-CoV

ET receptor antagonist 1

T79573

Synonym:

Target: Estrogen Receptor/ERR

ET receptor antagonist 3

T79575

Synonym:

Target: Estrogen Receptor/ERR

ET receptor antagonist 2

T79574

Synonym:

Target: Estrogen Receptor/ERR

Synonym: RVT-014,KAR5585,RVT-1201

Target: 5-HT Receptor, Hydroxylase

Macitentan (n-butyl analogue)

Cat No.	Product Name	Synonyms	Targets
TN5358	Eupahualin C
	Eupahualin C shows significant activities against cell lines of human chronic myelogenous leukemia (K562) and human bone cancer (U2OS).
T7914	Acenaphthylene		Others
	Acenaphthylene is environmental polycyclic aromatic hydrocarbon (PAH)pollutants		Others
T14961	Chrysene	䓛	Others
	Chrysene is a high molecular weight (HMW), polycyclic aromatic hydrocarbon (PAH).		Others
T5290	(S)-2-Hydroxy-3-phenylpropanoic acid	L-(−)-3-Phenyllactic acid	Others , Endogenous Metabolite
	(S)-2-Hydroxy-3-phenylpropanoic acid (L-(−)-3-Phenyllactic acid) is a chiral aromatic compound involved in phenylalanine metabolism. It is likely produced from phenylpyruvate via the action of lactate dehydrogenase. The ...		Others , Endogenous Metabolite
T82897	Benzo[e]pyrene
	Benzo[e]pyrene, a highly toxic polyaromatic hydrocarbon (PAH), is found in fossil fuels [1].

Cat No.	Product Name	Species	Expression System
TMPY-02707	PAH Protein, Human, Recombinant (415 Asn/Asp, His)	Human	Baculovirus-Insect Cells
	PAH (phenylalanine hydroxylase), also known as PH, belongs to the biopterin-dependent aromatic amino acid hydroxylase family. It contains 1 ACT domain, N-terminal region of PAH is thought to contain allosteric binding si...
TMPH-03508	IpaH9.8 Protein, Shigella flexneri, Recombinant (His)	Shigella flexneri	Yeast
	Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway and modulates the acute i...

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