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Search Results for " pai-1 "

Targets

15

Compounds

2

Natural Products

1741

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T2030 Tiplaxtinin PAI-039,Tiplasinin PAI-1 , Apoptosis
Tiplaxtinin (Tiplasinin)(PAI-039) is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 2.7 uM.
T4254 TM5441 PAI-1 , Apoptosis
TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor 1 (PAI-1).
T3442 UK-371804 UK371804 PAI-1 , Serine Protease
UK-371804 is an effective and specific uPA inhibitor. It was selected as a candidate for further preClinicalal evaluation for the treatment of chronic dermal ulcers.
T8962 TM5007 PAI-1
TM5007 is a poent inhibitor of plasminogen activator inhibitor-1 (PAI-1; IC50 of 29 uM).
T13257 Upamostat PAI-1 , Serine/threonin kinase , Serine Protease
Upamostat is an inhibitor of a serine protease and is a urokinase plasminogen activator (uPA) inhibitor.
T4255 TM5275 sodium TM5275 sodium salt PAI-1
TM5275 sodium (TM5275 sodium salt) is an inhibitor of plasminogen activator inhibitor 1 (PAI-1).
T29856 Aleplasinin PAZ 417,PAZ417,PAZ-417 PAI-1
Aleplasinin (PAZ 417) is a selective and orally active inhibitor of Plasminogen activator inhibitor-1(PAI-1) and a key negative regulator of the fibrinolytic system. Aleplasinin can be used in Alzheimer's disease studies...
T13408 ZK824190 Others , Serine Protease
ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA) as a potential treatment for multiple sclerosis(IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively).
T28788 SK-216 SK216.Plasminogen activator inhibitor-1 (PAI-1) inhibitor
SK-216 is a specific PAI-1 inhibitor. SK-216 reduced the extent of angiogenesis in the tumors and inhibited VEGF-induced migration and tube formation by human umbilical vein endothelial cells in vitro. SK-216 reduced the...
T23764 AZ3976 AZ 3976,AZ-3976 PAI-1
AZ3976 is an inhibitor of PAI-1 with an IC50 of 16 μM in a plasma clot lysis assay. AZ3976 displays profibrinolytic activities.
T68572 IMD-1622
IMD-1622 is a plasminogen activator inhibitor-1 (PAI-1) inhibitor.
T25915 Diaplasinin PAI-749,PAI749,PAI 749
PAI-749 is a selective and effective antagonist agent of plasminogen activator inhibitor 1 (PAI-1).
T25217 CDE-096
CDE-096 is a plasminogenactivator inhibitor-1 (PAI-1) inactivator.
T70810 THR-18
THR-18 is an 18-mer peptide derived from the sequence of human plasminogen activator inhibitor 1 (PAI-1), having the ability to bind to a site of tissue plasminogen activator (tPA) distal to its catalytic site and uncoup...
T35520 Aflatoxin G1-13C17 Aflatoxin G1-13C17
Aflatoxin G1-13C17is intended for use as an internal standard for the quantification of aflatoxin G1by GC- or LC-MS. Aflatoxin G1is a mycotoxin that has been found inA. terricola.1In vivo, aflatoxin G1is lethal to duckli...
Cat No. Product Name Synonyms Targets
T4S0592 Toddalolactone (+)-Toddalolactone PAI-1
Toddalolactone ((+)-Toddalolactone) is an anti-inflammatory and analgesic.
T3876 Loureirin B PAI-1 , ERK , Potassium Channel , JNK
Loureirin B can downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppress TGF-β1-induced fibrosis, during which TGF-β1/Smad2/3 pathw...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-01474 PAI-1 Protein, Human, Recombinant (His) Human HEK293
Plasminogen activator inhibitor 1, also known as PAI-1, Endothelial plasminogen activator inhibitor, SerpinE1 and PLANH1, is a secreted glycoprotein that belongs to the serpin family. SerpinE1 is the primary physiologica...
TMPH-00833 PAI-1 Protein, Horse, Recombinant Horse Yeast
TMPH-00356 PAI-1 Protein, Feline, Recombinant Feline E. coli
TMPY-00629 PAI-1 Protein, Rat, Recombinant (hFc) Rat HEK293
Plasminogen activator inhibitor 1, also known as PAI-1, Endothelial plasminogen activator inhibitor, SerpinE1 and PLANH1, is a secreted glycoprotein that belongs to the serpin family. SerpinE1 is the primary physiologica...
TMPH-02833 PAI-1 Protein, Mouse, Recombinant (His) Mouse Yeast
Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-reg...
TMPY-02559 PAI-1 Protein, Rat, Recombinant (His) Rat HEK293
Plasminogen activator inhibitor 1, also known as PAI-1, Endothelial plasminogen activator inhibitor, SerpinE1 and PLANH1, is a secreted glycoprotein that belongs to the serpin family. SerpinE1 is the primary physiologica...
TMPH-00832 PAI-1 Protein, Horse, Recombinant (E. coli) Horse E. coli
TMPH-02834 PAI-1 Protein, Mouse, Recombinant (His & SUMO) Mouse E. coli
Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-reg...
TMPH-01869 PAI-2 Protein, Human, Recombinant (His) Human HEK293
Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1.
TMPH-02848 CYR61/CCN1 Protein, Mouse, Recombinant (His) Mouse E. coli
Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflam...
TMPH-01068 CYR61/CCN1 Protein, Human, Recombinant (His & SUMO) Human E. coli
Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflam...
TMPY-01711 Serpin B2 Protein, Human, Recombinant (GST) Human Baculovirus-Insect Cells
Serpins are the largest and most diverse family of serine protease inhibitors which are involved in some fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, infl...
TMPH-00324 SVTLE Protein, Calloselasma rhodostoma, Recombinant (His) Calloselasma rhodostoma Yeast
Thrombin-like snake venom serine protease that acts as an anticoagulant. It cleaves fibrinogen (FGA) to split off the A-fibrinopeptides (A, AY and AP), but not the B-fibrinopeptide. The resulting fibrin polymers are impe...
TMPY-04451 AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
TMPY-02501 CD3D & CD3E Heterodimer Protein, Human, Recombinant Human HEK293
TMPY-03745 CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His) Human HEK293
TMPY-03878 Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His) Human HEK293
Integrin alpha-5, also known as ITGA5, is a single-pass type I membrane protein which belongs to the integrin alpha chain family. ITGA5 contains 7 FG-GAP repeats. Alpha chain 5 undergoes post-translational cleavage in th...
TMPY-00699 CD155/PVR Protein, Human, Recombinant (hFc) Human HEK293
CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the nectins and nectin-like (Necl) subfamily. CD155 was originall...
TMPY-00664 ANGPT2/Angiopoietin-2 Protein, Human, Recombinant (hFc) Human HEK293
Angiopoietin-2 (ANG 2, or ANGPT2), is a member of the ANG family, which plays an important role in angiogenesis during the development and growth of human cancers. Both ANGPT-1 and ANGPT-2 appear to bind to the tyrosine ...
TMPY-00399 HER3/ERBB3 Protein, Human, Recombinant Human HEK293
ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin bindin...
TMPY-05239 HER2/ERBB2 Protein, Human, Recombinant , Biotinylated Human HEK293
Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth fa...
TMPY-01226 CD4 Protein, Mouse, Recombinant (His) Mouse HEK293
T-cell surface glycoprotein CD4, is a single-pass type I membrane protein. CD4 contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. CD4 is a glycoprotein expre...
TMPY-01023 CD38 Protein, Human, Recombinant (His) Human HEK293
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-05364 CD8 alpha Protein, Human, Recombinant (hFc) Human HEK293
T-cell surface glycoprotein CD8 alpha chain, also known as CD8a, is a single-pass type I membrane protein. The CD8 glycoprotein is expressed by thymocytes, mature T cells and natural killer (NK) cells and has been imp...
TMPY-02031 B7-H3 Protein, Human, Recombinant (His) Human HEK293
B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an important role in adaptive immune responses, and was shown to ei...
TMPY-01050 Cadherin 6/CDH6 Protein, Human, Recombinant (His) Human HEK293
Cadherins are a family of calcium-dependent, cell-cell adhesion molecules that play an important morpho regulatory role in a wide variety of tissues. Alterations in cadherin function have been implicated in tumor progres...
TMPY-01608 Decorin Protein, Human, Recombinant (His) Human HEK293
Decorin is a ubiquitous small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a core p...
TMPY-02019 CD59 Protein, Human, Recombinant (His) Human HEK293
CD59 glycoprotein, also known as 2 kDa homologous restriction factor, HRF2, MAC-inhibitory protein, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, MIC11, MIRL and CD59, is a cell membran...
TMPY-02099 CD63 Protein, Human, Recombinant (His) Human HEK293
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with th...
TMPY-05319 BCMA/TNFRSF17 Protein, Human, Recombinant (His) Human HEK293
Tumor necrosis factor receptor superfamily, member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA) or CD269 antigen, is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in...
TMPY-02034 Siglec-2/CD22 Protein, Human, Recombinant (His) Human HEK293
CD22 is a member of the immunoglobulin superfamily, SIGLEC family of lectins. It is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. CD22 serves as an adhesi...
TMPY-05435 ANGPT1/Angiopoietin-1 Protein, Human, Recombinant (hFc) Human HEK293
The angiopoietin (ANGPT)-TIE2/TEK signaling pathway is essential for blood and lymphatic vascular homeostasis. ANGPT1 is a potent TIE2 activator, whereas ANGPT2 functions as a context-dependent agonist/antagonist. In dis...
TMPY-04348 CTLA-4 Protein, Human, Recombinant (His) Human HEK293
Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands o...
TMPY-02361 VEGFR2/KDR Protein, Human, Recombinant (His) Human HEK293
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ...
TMPY-05208 PD-L1 Protein, Human, Recombinant Human HEK293
Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune res...
TMPY-01853 SIRP gamma Protein, Human, Recombinant (His) Human HEK293
Signal-regulatory protein gamma (SIRPG/SIRP gamma) also known as CD172 antigen-like family member B, CD172g, and CD172g antigen, is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunog...
TMPY-01912 Cadherin 17/CDH17 Protein, Human, Recombinant (His) Human HEK293
Cadherin-17 or LI-cadherin is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Cadherin-17/LI-cadherin is a cadherin-like protein consisting of an extracellular r...
TMPY-04970 TIGIT Protein, Human, Recombinant (hFc) Human HEK293
TIGIT, also known as V-set and transmembrane domain-containing protein 3 (VSTM3) or V-set and immunoglobulin domain-containing protein 9 (VSIG9) is a new surface protein containing an immunoglobulin variable domain, a tr...
TMPY-01827 CD30/TNFRSF8 Protein, Human, Recombinant (His) Human HEK293
CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor (TNFR) superfamily. CD30 protein is expressed by activated, but not resting, T and B cells. CD30 can regulate proliferation of...
TMPY-01283 Glypican 3/GPC3 Protein, Human, Recombinant (His) Human HEK293
Glypican-3, also known as Intestinal protein OCI-5, GPC3, and OCI5, is a member of the glypican family. It belongs to the glypican family and is highly expressed in the lung, liver, and kidney. It is a heparan sulfate pr...
TMPY-01851 CD73 Protein, Human, Recombinant (His) Human HEK293
5'-nucleotidase, also known as NT5E, NTE, and CD73, is a cell membrane protein that belongs to the 5'-nucleotidase family. CD73 is a glycosylphosphatidylinositol (GPI) anchored purine salvage enzyme expressed on the surf...
TMPY-01462 IL-11R alpha/IL-11RA Protein, Human, Recombinant (His) Human HEK293
Interleukin 11 receptor, alpha subunit (IL11RA/IL-11RA) is a subunit of the interleukin 11 receptor which is a member of the hematopoietic cytokine receptor family. IL11RA/IL-11RA is expressed in some cell lines, includi...
TMPY-01938 CD98 Protein, Human, Recombinant (His) Human HEK293
4F2 cell-surface antigen heavy chain, also known as 4F2 heavy chain antigen, Lymphocyte activation antigen 4F2 large subunit, CD98, SLC3A2 and MDU1, is a single-pass type I I membrane protein that belongs to the SLC3A tr...
TMPY-04799 IFNAR2 Protein, Human, Recombinant (His), Biotinylated Human HEK293
Interferon-alpha/beta receptor beta chain (IFNAR2) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus protei...
TMPY-00991 LIFR Protein, Human, Recombinant (His) Human HEK293
LIFR (leukemia inhibitory factor receptor) belongs to the family of cytokine receptors. LIFR forms a high-affinity receptor complex with gp130, which mediates the activity of LIF (leukemia inhibitory factor) and thus aff...
TMPY-04949 PD-L1 Protein, Human, Recombinant (His), Biotinylated Human HEK293
Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune res...
TMPY-04698 HER2/ERBB2 Protein, Human, Recombinant (aa 489-630, His) Human HEK293
Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth fa...
TMPY-01305 OSMR Protein, Human, Recombinant (His) Human HEK293
Oncostatin-M specific receptor subunit beta also known as the oncostatin M receptor (OSMR) and Interleukin-31 receptor subunit beta (IL-31RB), is one of the receptor proteins for oncostatin M. OSMR is a member of the typ...
TMPY-04826 LILRB5/CD85c Protein, Human, Recombinant (His) Human HEK293
A genetic variant in LILRB5 (leukocyte immunoglobulin-like receptor subfamily-B) (rs12975366: T > C: Asp247Gly) has been reported to be associated with lower creatine phosphokinase (CK) and lactate dehydrogenase (LDH) le...
TMPY-03958 TGF alpha Protein, Human, Recombinant Human E. coli
The miR-137 served as a tumor suppressor in non-small cell lung cancer (NSCLC) and its suppressive effect is mediated by repressing TGFA expression. TGFA gene expression was significantly higher in tumor tissues compared...
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PAI-1 Protein, Human, Recombinant (His)
TMPY-01474
Species: Human
Expression System: HEK293
PAI-1 Protein, Horse, Recombinant
TMPH-00833
Species: Horse
Expression System: Yeast
PAI-1 Protein, Feline, Recombinant
TMPH-00356
Species: Feline
Expression System: E. coli
PAI-1 Protein, Rat, Recombinant (hFc)
TMPY-00629
Species: Rat
Expression System: HEK293
PAI-1 Protein, Mouse, Recombinant (His)
TMPH-02833
Species: Mouse
Expression System: Yeast
PAI-1 Protein, Rat, Recombinant (His)
TMPY-02559
Species: Rat
Expression System: HEK293
PAI-1 Protein, Horse, Recombinant (E. coli)
TMPH-00832
Species: Horse
Expression System: E. coli
PAI-1 Protein, Mouse, Recombinant (His & SUMO)
TMPH-02834
Species: Mouse
Expression System: E. coli
PAI-2 Protein, Human, Recombinant (His)
TMPH-01869
Species: Human
Expression System: HEK293
CYR61/CCN1 Protein, Mouse, Recombinant (His)
TMPH-02848
Species: Mouse
Expression System: E. coli
CYR61/CCN1 Protein, Human, Recombinant (His & SUMO)
TMPH-01068
Species: Human
Expression System: E. coli
Serpin B2 Protein, Human, Recombinant (GST)
TMPY-01711
Species: Human
Expression System: Baculovirus-Insect Cells
SVTLE Protein, Calloselasma rhodostoma, Recombinant (His)
TMPH-00324
Species: Calloselasma rhodostoma
Expression System: Yeast
AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST)
TMPY-04451
Species: Human
Expression System: Baculovirus-Insect Cells
CD3D & CD3E Heterodimer Protein, Human, Recombinant
TMPY-02501
Species: Human
Expression System: HEK293
CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His)
TMPY-03745
Species: Human
Expression System: HEK293
Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His)
TMPY-03878
Species: Human
Expression System: HEK293
CD155/PVR Protein, Human, Recombinant (hFc)
TMPY-00699
Species: Human
Expression System: HEK293
ANGPT2/Angiopoietin-2 Protein, Human, Recombinant (hFc)
TMPY-00664
Species: Human
Expression System: HEK293
HER3/ERBB3 Protein, Human, Recombinant
TMPY-00399
Species: Human
Expression System: HEK293
HER2/ERBB2 Protein, Human, Recombinant , Biotinylated
TMPY-05239
Species: Human
Expression System: HEK293
CD4 Protein, Mouse, Recombinant (His)
TMPY-01226
Species: Mouse
Expression System: HEK293
CD38 Protein, Human, Recombinant (His)
TMPY-01023
Species: Human
Expression System: HEK293
CD8 alpha Protein, Human, Recombinant (hFc)
TMPY-05364
Species: Human
Expression System: HEK293
B7-H3 Protein, Human, Recombinant (His)
TMPY-02031
Species: Human
Expression System: HEK293
Cadherin 6/CDH6 Protein, Human, Recombinant (His)
TMPY-01050
Species: Human
Expression System: HEK293
Decorin Protein, Human, Recombinant (His)
TMPY-01608
Species: Human
Expression System: HEK293
CD59 Protein, Human, Recombinant (His)
TMPY-02019
Species: Human
Expression System: HEK293
CD63 Protein, Human, Recombinant (His)
TMPY-02099
Species: Human
Expression System: HEK293
BCMA/TNFRSF17 Protein, Human, Recombinant (His)
TMPY-05319
Species: Human
Expression System: HEK293
Siglec-2/CD22 Protein, Human, Recombinant (His)
TMPY-02034
Species: Human
Expression System: HEK293
ANGPT1/Angiopoietin-1 Protein, Human, Recombinant (hFc)
TMPY-05435
Species: Human
Expression System: HEK293
CTLA-4 Protein, Human, Recombinant (His)
TMPY-04348
Species: Human
Expression System: HEK293
VEGFR2/KDR Protein, Human, Recombinant (His)
TMPY-02361
Species: Human
Expression System: HEK293
PD-L1 Protein, Human, Recombinant
TMPY-05208
Species: Human
Expression System: HEK293
SIRP gamma Protein, Human, Recombinant (His)
TMPY-01853
Species: Human
Expression System: HEK293
Cadherin 17/CDH17 Protein, Human, Recombinant (His)
TMPY-01912
Species: Human
Expression System: HEK293
TIGIT Protein, Human, Recombinant (hFc)
TMPY-04970
Species: Human
Expression System: HEK293
CD30/TNFRSF8 Protein, Human, Recombinant (His)
TMPY-01827
Species: Human
Expression System: HEK293
Glypican 3/GPC3 Protein, Human, Recombinant (His)
TMPY-01283
Species: Human
Expression System: HEK293
CD73 Protein, Human, Recombinant (His)
TMPY-01851
Species: Human
Expression System: HEK293
IL-11R alpha/IL-11RA Protein, Human, Recombinant (His)
TMPY-01462
Species: Human
Expression System: HEK293
CD98 Protein, Human, Recombinant (His)
TMPY-01938
Species: Human
Expression System: HEK293
IFNAR2 Protein, Human, Recombinant (His), Biotinylated
TMPY-04799
Species: Human
Expression System: HEK293
LIFR Protein, Human, Recombinant (His)
TMPY-00991
Species: Human
Expression System: HEK293
PD-L1 Protein, Human, Recombinant (His), Biotinylated
TMPY-04949
Species: Human
Expression System: HEK293
HER2/ERBB2 Protein, Human, Recombinant (aa 489-630, His)
TMPY-04698
Species: Human
Expression System: HEK293
OSMR Protein, Human, Recombinant (His)
TMPY-01305
Species: Human
Expression System: HEK293
LILRB5/CD85c Protein, Human, Recombinant (His)
TMPY-04826
Species: Human
Expression System: HEK293
TGF alpha Protein, Human, Recombinant
TMPY-03958
Species: Human
Expression System: E. coli
TargetMol