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Search Results for " pi3k/akt/mtor信号通路 "

Targets

7

Compounds

5

Natural Products

3

Libraries

Cat No. Product Name Synonyms Targets
T1826 PI3K-IN-1 Voxtalisib Analogue,Voxtalisib (SAR245409, XL765) Analogue,XL765,SAR245409 DNA-PK , PI3K
PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.
T0365 Thioridazine hydrochloride Mellaril,Aldazine Apoptosis , Potassium Channel , Dopamine Receptor , 5-HT Receptor , Antibacterial , Adrenergic Receptor , Autophagy
Thioridazine hydrochloride (Mellaril) , an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4 selectivity.
T64219 PI3K/mTOR Inhibitor-6
PI3K/mTOR Inhibitor-6 (Compound 19c) is a potent dual PI3K/mTOR inhibitor that is more stable than gedatolisib in artificial gastric fluid. 10 μM of PI3K/mTOR Inhibitor-6 significantly inhibits the PI3K/Akt/mTOR signalli...
T79332 Antiproliferative agent-32 Apoptosis
Antiproliferative agent-32 (Compound 1c) impedes phosphorylation within the PI3K/Akt/mTOR signaling pathway, restrains proliferation of Huh7 and SK-Hep-1 cells, induces apoptosis, and inflicts mitochondrial damage, rende...
T64041 PI3K/mTOR Inhibitor-7
PI3K/mTOR Inhibitor-7 is a potent dual PI3K/mTOR inhibitor. PI3K/mTOR Inhibitor-7 is 4.7-fold more potent than gedatolisib, with IC50 values of 1.4 μM and 0.3 μM, respectively. 10 μM of PI3K/mTOR Inhibitor-7 is able to s...
T61990 Topoisomerase I/II inhibitor 3
Topoisomerase I/II inhibitor 3 (compound 7) is a potent dual inhibitor of topoisomerase I (Topo I) and II (Topo II) . By inhibiting PI3K /Akt/mTOR signaling pathway, Topoisomerase I/II inhibitor 3 can inhibit cell prolif...
T82971 ARI-1
ARI-1 is a receptor tyrosine kinase-like orphan receptor 1 (ROR1) inhibitor that binds to ROR1's extracellular Frizzled domain, effectively inhibiting aberrant ROR1 expression linked to non-small cell lung cancer (NSCLC)...
Cat No. Product Name Synonyms Targets
T5740 25(R,S)-Ruscogenin (25RS)-Ruscogenin Others , HIF
25(R,S)-Ruscogenin is a natual product.
TN1405 Arnicolide D Akt , Caspase , PI3K , STAT , mTOR
Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling path...
T4672 Brevilin A Apoptosis , Anti-infection , JAK , STAT , Autophagy
Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT si...
T5497 AMAROGENTIN Apoptosis , AMPK
Amarogentin is mainly extracted from Swertia and Gentiana roots. It plays cemopreventive/therapeutic role during liver carcinogenesis through modulation of cell cycle and apoptosis
TN2328 Zeylenone Apoptosis , ERK , MAPK , Akt , PI3K , mTOR
Zeylenone, a cyclohexene oxide from Uvaria grandiflora, has antitumour and antiproliferative activity, inhibiting cervical cancer cell proliferation and inducing apoptosis through the PI3K/AKT/mTOR and MAPK/ERK signallin...
Cat No. Product Name
L1300 PI3K-AKT-mTOR Compound Library

425 compounds
A unique collection of 425 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with PI3K/Akt/mTOR signaling;
L2193 Anti-Liver Cancer Compound Library

1816 compounds
1816 species of compounds related to liver cancer that can be used in anti-liver cancer drug development and pharmacological studies.
L2195 Anti-Prostate Cancer Compound Library

2096 compounds
2096 compounds associated with prostate cancer that can be used for high-throughput and high-content screening.
TargetMol