Search Result

Search Results for " pka "

Targets

147

Compounds

Natural Products

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T39217	PKA-IN-1		PKA
	PKA-IN-1 is a selective and potent cyclic AMP-dependent protein kinase (PKA) catalytic subunit (cAK) inhibitor (IC50: 0.03 μM).PKA-IN-1 can be used to study diseases of the immune system.		PKA
T21674L	PKA inhibitor fragment (6-22) amide Acetate	PKA inhibitor fragment (6-22) amide Acetate(121932-06-7 Free base)	PKA
	PKA inhibitor fragment (6-22) amide Acetate is a synthetic peptide which selectively inhibits PKA activity by binding to its substrate site (IC50 < 2 nM).		PKA
T75888	PKA Inhibitor Fragment (6-22) amide TFA	PKI-(6-22)-amide TFA,PKA Inhibitor Fragment (6-22) amide TFA(121932-06-7 Free base)	PKA
	PKA Inhibitor Fragment (6-22) amide TFA (PKA Inhibitor Fragment (6-22) amide TFA) is an inhibitor of the highly potent cAMP-dependent protein kinase A (PKA) inhibitor (Ki: 2.8 nM).PKA Inhibitor Fragment (6-22) amide TFA ...		PKA
T36019	PKA Inhibitor (5-24) (trifluoroacetate salt)
	PKI PKA Inhibitor (5-24) is a synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase) (Ki= 2.3 nM) derived from the active site of the skeletal muscle inhibitor protein.1It mimics the protein substrate by bind...
T72885	Akt1&PKA-IN-1
	Akt1&PKA-IN-1 is a potent dual inhibitor targeting Akt and PKA, exhibiting IC50 values of 0.11 μM for Akt, 0.03 μM for PKAα, and 9.8 μM for CDK2. Notably, it demonstrates selectivity for cyclin-dependent kinase 2 (CDK2).
T72886	Akt1&PKA-IN-2
	Akt1&PKA-IN-2 ((R)-29), a compound with specificity towards PKB/AKT and notable selectivity for cyclin-dependent kinase 2 (CDK2), effectively inhibits AKT1, PKAa, and CDK2a with IC50 values of 0.007 µM, 0.01 µM, and 0.69...
T76381	H1-7 (histone H1 phosphorylation site), PKA Substrate
	H1-7 (histone H1 phosphorylation site), a synthetic polypeptide serving as a PKA substrate, demonstrates utility in PKA substrate applications [1] [2].
T3498	CCG215022		GRK , PKA
	CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 μM, 0.38±0.06 μM and 3.9±1 μM for GRK2, 5 and 1, respectively.		GRK , PKA
T6304	AT7867		Akt , PKA , S6 Kinase
	AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively; little activity outside the AGC kinase family.		Akt , PKA , S6 Kinase
T3269	Metadoxine	pyridoxine-pyrrolidone carboxylat,Metasin,Metadoxil	5-HT Receptor , PKA
	Metadoxine (Metadoxil) is a neurotransmitter stimulant.		5-HT Receptor , PKA
T12103	MR-L2		PDE
	MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).		PDE
T2482	AT13148		ROCK , SGK , Akt , PKA , S6 Kinase
	AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.		ROCK , SGK , Akt , PKA , S6 Kinase
T7648	HA-100		Myosin , PKA , PKC
	HA-100 is an inhibitor of protein kinase		Myosin , PKA , PKC
T14069	A-3 hydrochloride		CaMK , Casein Kinase , PKA , PKC
	A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 µM and 80 µM, respectiv...		CaMK , Casein Kinase , PKA , PKC
TP1351	Kemptide		PKA
	Kemptide is a synthetic heptapeptide, acting as a substrate for cAMP-dependent protein kinase (PK).		PKA
T6747	8-Bromo-cAMP sodium salt	8-Br-Camp sodium salt,8-Bromo-cAMP(sodium salt),8-Bromo-cAMP	PKA
	8-Bromo-cAMP sodium salt (8-Br-Camp sodium salt) is a long-acting derivative of cyclic AMP. It is an activator of cyclic AMP-dependent protein kinase（PKA）, but resistant to degradation by cyclic AMP phosphodiesterase.		PKA
T6250	H-89 dihydrochloride	Protein kinase inhibitor H-89 dihydrochloride,H 89 2HCl,5-Isoquinolinesulfonamide	PKA , S6 Kinase , Autophagy
	H-89 dihydrochloride (5-Isoquinolinesulfonamide) is a potent inhibitor of protein kinase A (PKA; IC50: 0.14 μM, Ki: 48 nM).		PKA , S6 Kinase , Autophagy
T1418	Bucladesine sodium	dbcAMP,Dibutyryl-cAMP sodium salt,Dibutyryl-cAMP,DC2797,Sodium dibutyryl cAMP,Bucladesine,Bucladesine sodium salt	PKA , PDE
	Bucladesine sodium (DC2797) is a cAMP analog with cell-permeable properties. Bucladesine sodium is also a cAMP-dependent protein kinase (PKA) activator and a phosphodiester (PDE) inhibitor. Bucladesine sodium has anti-in...		PKA , PDE
T1606	Fasudil	HA-1077,AT877	ROCK , Serine/threonin kinase , Calcium Channel , PKA , PKC , Autophagy
	Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
T3060	Fasudil hydrochloride	Fasudil (HA-1077) HCl,HA-1077,Fasudil HCl,HA-1077 hydrochloride,AT-877	ROCK , Serine/threonin kinase , Calcium Channel , HIV Protease , PKA , PKC , Autophagy
	Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.
TP1957L	PKI (5-24) Acetate(99534-03-9 free base)		PKA
	PKI (5-24) Acetate is a high affinity PKA inhibitor (Ki = 2.3 nM).		PKA
T11020	DHODH-IN-11		Dehydrogenase , DNA/RNA Synthesis
	DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.		Dehydrogenase , DNA/RNA Synthesis
T15798	LX7101		ROCK , LIM Kinase , PKA
	LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).		ROCK , LIM Kinase , PKA
TP1789L	Malantide acetate(86555-35-3 free base)		PKA , PKC
	Malantide acetate is a dodecapeptide phosphorylated by cyclic AMP-dependent protein kinase (PKA), and increases PKA activity.Malantide is a synthetic peptide that is phosphorylated by PKA and is used to measure PKA activ...		PKA , PKC
T6139L	A-674563 2HCl(552325-73-2(fb-2hcl))		ERK , Akt , PKA , CDK , PKC
	A-674563 2HCl is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.		ERK , Akt , PKA , CDK , PKC
T27525	HA-1004		Serine/threonin kinase , PKA , PKC
	HA-1004 is a inhibitor of PKG, PKA, PKC and MLC.		Serine/threonin kinase , PKA , PKC
T6303L	CCT128930 hydrochloride	CCT128930 hydrochloride(885499-61-6 Free base)	Apoptosis , Akt , PKA , mTOR , Autophagy
	CCT128930 hydrochloride (CCT128930 hydrochloride) is a potent and selective inhibitor of AKT with IC50 of 6 nM. CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophagy. CCT128930 hydrochloride has 28...		Apoptosis , Akt , PKA , mTOR , Autophagy
T3050	ML-7 hydrochloride	ML-7 HCl	Serine/threonin kinase , Myosin , YAP , PKA , PKC
	ML-7 hydrochloride (ML-7 HCl) is a cell-permeable, reversible, effective, ATP-competitive, and specific inhibitor of myosin light chain kinase (Ki: 300 nM); also inhibits smooth-muscle myosin light chain kinase, PKA, and...		Serine/threonin kinase , Myosin , YAP , PKA , PKC
T8681	HA-1004 dihydrochloride		Calcium Channel , PKA , PKC
	HA-1004 dihydrochloride is an inhibitor of PKA, PKC, cGKI, MYLK, and calcium channel protein		Calcium Channel , PKA , PKC
T9530	W 36017		Others
	W36017 is an impurity of lidocaine with a PKA of 7.4 for blocking neurologic activity.		Others
T17043	TES		Others
	TES is used to make buffer solutions in the pH range 6.8-8.2. TES has a pKa value of 7.550 (at 25°C).		Others
T11021	DHODH-IN-12		Dehydrogenase
	DHODH-IN-12 is a leflunomide derivative and a weak dihydrorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07.		Dehydrogenase
T6303	CCT128930		Akt , PKA , S6 Kinase , Autophagy
	CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM, 28-fold greater selectivity for Akt2 than the closely related PKA kinase.		Akt , PKA , S6 Kinase , Autophagy
T8632	Anthracene-9-carboxylic acid		Others
	Anthracene-9-carboxylic acid is an inhibitor of chloride transport with a moderate to strong inhibitory action on PKA activated cardiac IcI.		Others
T21983L	PKI 14-22 amide, myristoylated Acetate	PKI 14-22 amide, myristoylated Acetate(201422-03-9 Free base)	PKA
	PKI 14-22 amide, myristoylated Acetate inhibit cAMP-dependent protein kinase (PKA) and blocks hyperalgesia produced by spinal administration of 8-bromo-cAMP.		PKA
T11234	ESI-08		cAMP
	ESI-08 is an effective antagonist of EPAC2 with an IC50 of 8.4 μM. ESI-08 selectively blocks cAMP-induced EPAC activation but not cAMP-mediated PKA activation.		cAMP
T32401	KL044	KL 044,KL-044	Others
	KL044 is a cryptochrome 1 (CRY1) activator that prolongs circadian rhythms and inhibits PER2 activity. KL044 inhibits melanogenesis by inhibiting the cAMP/PKA/CREB pathway.		Others
TP1876L	CREBtide acetate(149155-45-3 free base)		PKA
	CREBtide acetate is a synthetic substrate for PKA (Km=3.9 μM), which is based on the phosphorylation sequence in d-CREB (cAMP response element binding protein).		PKA
T6139	A-674563	A674563	ERK , GSK-3 , Akt , PKA , CDK
	A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.		ERK , GSK-3 , Akt , PKA , CDK
T65641	TAPS		Others
	TAPS, a biochemical buffer, safeguards the integrity of lysozyme structures against thermal denaturation at high temperatures. At a pKa of 8.1, TAPS achieves half-maximal activity of conjugated protein channels.		Others
T6187	TDZD-8	GSK-3β Inhibitor I,NP 01139	GSK-3
	TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.		GSK-3
T6266	PP2	AGL 1879,AG 1879,AGL 1879	EGFR , Tyrosine Kinases , JAK , Src
	PP2 (AG 1879,AGL 1879) is a effective inhibitor of Lck/Fyn (IC50:4/5 nM) , ~100-fold less potent to EGFR, inactive for ZAP-70, PKA and JAK2.		EGFR , Tyrosine Kinases , JAK , Src
T35328	H-1152 dihydrochloride	H-1152 2HCl,H-1152 dihydrochloride	ROCK
	H-1152 dihydrochloride (H-1152 2HCl) is a specific inhibitor of Rho-associated protein kinase (ROCK) with an IC50 of 12 nM and a Ki of 1.6 nM. H-1152 dihydrochloride inhibits PKA, PKC, PKG, Aurora A and CaMKII with IC50 ...		ROCK
T4444	A-674563 HCl (552325-73-2(free base))		ERK , Akt , PKA , CDK , PKC
	A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2 (IC50: 16/46 nM) but is 10- to >1, 800-fold selective for A...		ERK , Akt , PKA , CDK , PKC
T3438	S107		Others
	S107 is a RyR-selective 1, 4-benzothiazepine derivative that stabilizes RyR2 channels by enhancing the binding affinity of calstabin2 to mutant and/or PKA-phosphorylated channels.		Others
T5508	PF-AKT400	AKT protein kinase inhibitor	Akt
	PF-AKT400 (AKT protein kinase inhibitor) is a broadly selective and ATP-competitive inhibitor of Akt.		Akt
T14507	Bay 60-7550	BAY 607550	PDE
	Bay 60-7550 is a selective and potent PDE2 inhibitor (Ki: 3.8 nM) that exerts positive inotropic effects on rat heart by increasing PKA-mediated phosphorylation and can be used to ameliorate cognitive impairments and mem...		PDE
TP1890L1	MLCK inhibitor peptide 18 acetate	MLCK inhibitor peptide 18 acetate(224579-74-2 free base)	Serine/threonin kinase
	MLCK inhibitor peptide 18 acetate is a selective competitive inhibitor of myosin light chain kinase (IC50 = 50 nM). Displays 4000-fold selectivity over CaM kinase II and does not inhibit PKA. Cell permeable.		Serine/threonin kinase
T6837	Flavopiridol	L868275,Alvocidib,NSC 649890 HCl,HMR-1275	Apoptosis , HIV Protease , CDK , Autophagy
	Flavopiridol (Alvocidib) (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1, 2, 4, 6 versus CDK7. Flavopiridol is initially foun...		Apoptosis , HIV Protease , CDK , Autophagy
T11662L	INT-777	S-EMCA	GPCR19
	INT-777 (S-EMCA) is a potent TGR5 agonist with an EC50 of 0.82 μM. INT-777 (S-EMCA) inhibits NLRP5-ASC inflammasome-mediated neuroinflammation via the TGR3/cAMP/PKA signaling pathway after subarachnoid hemorrhage in rats...		GPCR19

Compounds

PKA inhibitor fragment (6-22) amide Acetate

T21674L

Synonym: PKA inhibitor fragment (6-22) amide Acetate(121932-06-7 Free base)

Target: PKA

PKA Inhibitor Fragment (6-22) amide TFA

T75888

Synonym: PKI-(6-22)-amide TFA,PKA Inhibitor Fragment (6-22) amide TFA(121932-06-7 Free base)

Target: PKA

PKA Inhibitor (5-24) (trifluoroacetate salt)

H1-7 (histone H1 phosphorylation site), PKA Substrate

Target: Akt, PKA, S6 Kinase

Metadoxine

T3269

Synonym: pyridoxine-pyrrolidone carboxylat,Metasin,Metadoxil

Target: 5-HT Receptor, PKA

Target: ROCK, SGK, Akt, PKA, S6 Kinase

HA-100

T7648

Synonym:

Target: Myosin, PKA, PKC

A-3 hydrochloride

T14069

Synonym:

Target: CaMK, Casein Kinase, PKA, PKC

8-Bromo-cAMP sodium salt

T6747

Synonym: 8-Br-Camp sodium salt,8-Bromo-cAMP(sodium salt),8-Bromo-cAMP

Target: PKA

H-89 dihydrochloride

T6250

Synonym: Protein kinase inhibitor H-89 dihydrochloride,H 89 2HCl,5-Isoquinolinesulfonamide

Target: PKA, S6 Kinase, Autophagy

Bucladesine sodium

T1418

Synonym: dbcAMP,Dibutyryl-cAMP sodium salt,Dibutyryl-cAMP,DC2797,Sodium dibutyryl cAMP,Bucladesine,Bucladesine sodium salt

Target: PKA, PDE

Fasudil

T1606

Synonym: HA-1077,AT877

Target: ROCK, Serine/threonin kinase, Calcium Channel, PKA, PKC, Autophagy

Fasudil hydrochloride

T3060

Synonym: Fasudil (HA-1077) HCl,HA-1077,Fasudil HCl,HA-1077 hydrochloride,AT-877

Target: ROCK, Serine/threonin kinase, Calcium Channel, HIV Protease, PKA, PKC, Autophagy

PKI (5-24) Acetate(99534-03-9 free base)

Target: Dehydrogenase, DNA/RNA Synthesis

LX7101

T15798

Synonym:

Target: ROCK, LIM Kinase, PKA

Malantide acetate(86555-35-3 free base)

TP1789L

Synonym:

Target: PKA, PKC

A-674563 2HCl(552325-73-2(fb-2hcl))

T6139L

Synonym:

Target: ERK, Akt, PKA, CDK, PKC

HA-1004

T27525

Synonym:

Target: Serine/threonin kinase, PKA, PKC

CCT128930 hydrochloride

T6303L

Synonym: CCT128930 hydrochloride(885499-61-6 Free base)

Target: Apoptosis, Akt, PKA, mTOR, Autophagy

ML-7 hydrochloride

T3050

Synonym: ML-7 HCl

Target: Serine/threonin kinase, Myosin, YAP, PKA, PKC

HA-1004 dihydrochloride

T8681

Synonym:

Target: Calcium Channel, PKA, PKC

Target: Dehydrogenase

CCT128930

T6303

Synonym:

Target: Akt, PKA, S6 Kinase, Autophagy

Anthracene-9-carboxylic acid

T8632

Synonym:

Target: Others

PKI 14-22 amide, myristoylated Acetate

T21983L

Synonym: PKI 14-22 amide, myristoylated Acetate(201422-03-9 Free base)

Synonym: KL 044,KL-044

Target: Others

CREBtide acetate(149155-45-3 free base)

Target: ERK, GSK-3, Akt, PKA, CDK

Synonym: GSK-3β Inhibitor I,NP 01139

Target: GSK-3

PP2

T6266

Synonym: AGL 1879,AG 1879,AGL 1879

Target: EGFR, Tyrosine Kinases, JAK, Src

H-1152 dihydrochloride

T35328

Synonym: H-1152 2HCl,H-1152 dihydrochloride

Target: ROCK

A-674563 HCl (552325-73-2(free base))

T4444

Synonym:

Target: ERK, Akt, PKA, CDK, PKC

Synonym: AKT protein kinase inhibitor

MLCK inhibitor peptide 18 acetate

TP1890L1

Synonym: MLCK inhibitor peptide 18 acetate(224579-74-2 free base)

Target: Serine/threonin kinase

Flavopiridol

T6837

Synonym: L868275,Alvocidib,NSC 649890 HCl,HMR-1275

Target: Apoptosis, HIV Protease, CDK, Autophagy

Cat No.	Product Name	Synonyms	Targets
T4S2128	Bilobetin		PKA , PPAR
	Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.		PKA , PPAR
T6680	Staurosporine	Antibiotic AM-2282,AM-2282,CGP 41251	Apoptosis , PKA , Antibacterial , Antibiotic , Src , PKC , Antifungal
	Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-Fgr, phosphorylase kinase and TAOK2. Staurosporine also induces...
TN1694	Gliotoxin		Apoptosis , NF-κB , Wnt/beta-catenin , COX , PKA , Antibacterial , Antifection
	Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway.
T2851	Daphnetin	7,8-Dihydroxycoumarin,Daphnetol	EGFR , PKA , PKC , Parasite , Autophagy
	Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μM), also exhibit anti-oxidant and anti-...		EGFR , PKA , PKC , Parasite , Autophagy
T9135	Epirosmanol		Others
	Epirosmanol is a diterpenoid containing a lactone moiety. Epirosmanol is a very weakly basic (essentially neutral) compound (based on its pKa).		Others
TN4114	Gardenin A		ERK , LDL , MAPK , PKA , PKC
	Gardenin A shows neurotrophic effects via activating MAPK/ERK, PKC, and PKA. Gardenin A exhibits antidepressant, anticonvulsant and anxiolytic effects.		ERK , LDL , MAPK , PKA , PKC
T2S0531	Pinoresinol dimethyl ether	(+)-Eudesmin	Others , PKC
	Pinoresinol dimethyl ether, a non-phenolic furan lignan isolated from the bark of Magnolia kobus, exhibits neuroactivity. It stimulates upstream MAPK, PKC, and PKA pathways, inducing neurite outgrowth in PC12 cells.		Others , PKC
T13481	2-Methoxyestrone		Endogenous Metabolite
	2-Methoxyestrone is a methoxylated catechol estrogen and metabolite of estrone (pKa: 10.81).		Endogenous Metabolite
T5S2178	Fargesin	(+/-)-Fargesin	Adrenergic Receptor
	1. Fargesin ((+/-)-Fargesin) as a potential β1AR antagonist through cAMP/PKA pathway could protect against myocardial ischemia/reperfusion injury in rats. 2. Fargesin improves dyslipidemia and hyperglycemia by activating...		Adrenergic Receptor
T4784	(S)-(-)-Phenylethanol	(S)-(-)-1-Phenylethanol,(-)-Methyl phenyl carbinol,(S)-(-)-sec-Phenylethyl alcohol	Others , Endogenous Metabolite
	(S)-(-)-Phenylethanol ((-)-Methyl phenyl carbinol) exists as a solid, soluble (in water), and a very weakly acidic compound (based on its pKa). (S)-(-)-Phenylethanol has been detected in multiple biofluids, such as feces...		Others , Endogenous Metabolite
T5082	Calcium 2-hydroxy-4-(methylthio)butanoate	calcium hydroxymethionine,2-Hydroxy-4-(methylthio)butyric acid calcium salt	Others , Endogenous Metabolite
	Calcium 2-hydroxy-4-(methylthio)butanoate (Calcium 2-hydroxy-4-(calcium hydroxymethionine)) is a nutrition enhancer. It exists as a solid, soluble (in water), and a weakly acidic compound (based on its pKa). 2-Hydroxy-4-...		Others , Endogenous Metabolite
T2834	Nobiletin	Hexamethoxyflavone	Apoptosis , MMP , Reactive Oxygen Species , ROR , Autophagy
	Nobiletin (Hexamethoxyflavone) is a natural polymethoxylated flavone isolated from citrus peels with anti-inflammatory and anti-tumor activities. Nobiletin is practically insoluble (in water) and an extremely weak acidic...		Apoptosis , MMP , Reactive Oxygen Species , ROR , Autophagy
T3739	2,6-Dimethoxyquinone	2,6-Dimethoxy-1,4-benzoquinone,2,6-Dimethoxy-p-benzoquinone,2,6-Dimethoxybenzoquinone	Others
	2,6-Dimethoxyquinone (2,6-Dimethoxy-p-benzoquinone) is a member of the class of compounds known as P-benzoquinones. 2,6-Dimethoxyquinone is slightly soluble (in water) and an extremely weak basic (essentially neutral) co...		Others
T3836	Eudesmin		MAPK , S6 Kinase
	Eudesmin shows antiinflammatory, neuritogenic, anticonvulsant and sedative effects, the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65 expressions, and anti-apoptosis of neuron the in brain.50 m...		MAPK , S6 Kinase
T4973	Paraxanthine	1,7-DIMETHYLXANTHINE	Endogenous Metabolite
	Paraxanthine (1,7-dimethylxanthine) is a metabolite of caffeine (sc-202514) which functions as an adenosine receptor ligand and a PARP-1 inhibitor in pulmonary epithelial cells. Studies suggest that Paraxanthine is struc...		Endogenous Metabolite
Fr13883	3-Methoxyphenylacetic acid		Others
	3-Methoxyphenylacetic acid belongs to the class of organic compounds known as anisoles. 3-Methoxyphenylacetic acid is slightly soluble (in water) and a weakly acidic compound (based on its pKa).3-Methoxyphenylacetic acid...		Others
T4773	3-Ethoxy-3-oxopropanoic acid	Monoethyl malonic acid,Ethyl hydrogen malonate	Others , Endogenous Metabolite
	3-Ethoxy-3-oxopropanoic acid (Monoethyl malonic acid) belongs to the class of organic compounds known as dicarboxylic acids and derivatives. These are organic compounds containing exactly two carboxylic acid groups. 3-Et...		Others , Endogenous Metabolite
T4768	Diethyl oxalpropionate	HYL 2-METHYL-3-OXOSUCCINATE	Others , Endogenous Metabolite
	Diethyl oxalpropionate (HYL 2-METHYL-3-OXOSUCCINATE), also known as methyloxalacetic acid diethyl ester or diethyl methyloxalacetate, is a member of the class of compounds known as beta-keto acids and derivatives. These ...		Others , Endogenous Metabolite
T4798	N-Acetyl-L-leucine		Others , Endogenous Metabolite
	N-Acetylleucine belongs to the class of organic compounds known as leucine and derivatives. Leucine and derivatives are compounds containing leucine or a derivative thereof resulting from reaction of leucine at the amino...		Others , Endogenous Metabolite
T8105	Indole-3-carboxaldehyde	3-Formylindole	Endogenous Metabolite
	1H-Indole-3-carboxaldehyde (3-Formylindole), also known as 3-formylindole or 3-indolealdehyde, belongs to the class of organic compounds known as indoles. Indoles are compounds containing an indole moiety, which consists...		Endogenous Metabolite
T6S1684	8-Gingerol		Antioxidant , Antibacterial , TRP/TRPV Channel
	1. 8-Gingerol has antioxidant activity. 2. 8-Gingerol has antimycobacterial activity. 3. 8-Gingerol could be used as an effective skin-whitening agent. 4. 8-Gingerol shows antipyretic and anti-inflammation characteristic...		Antioxidant , Antibacterial , TRP/TRPV Channel
T4837	Itaconic acid	methylene-butanedioicaci	Others , Endogenous Metabolite
	Itaconic acid (methylene-butanedioicaci), also known as itaconate, belongs to the class of organic compounds known as branched fatty acids. These are fatty acids containing a branched chain. Itaconic acid exists as a sol...		Others , Endogenous Metabolite
T6S1740	Nardosinone		Others
	1. Nardosinone has inhibitory effect on Ang II-induced hypertrophy in H9c2 cells, might be mediated by targeting PI3K/Akt and MEK/ERK signaling pathways. 2. Nardosinone could protect against the neuronal injury exposed t...		Others
T8274	3-Methyl-L-histidine		Endogenous Metabolite
	3-Methylhistidine belongs to the class of organic compounds known as histidine and derivatives. Histidine and derivatives are compounds containing cysteine or a derivative thereof resulting from reaction of cysteine at t...		Endogenous Metabolite
T4826	L-Histidine monohydrochloride monohydrat		Others , Endogenous Metabolite
	Histidine (abbreviated as His or H) is an alpha-amino acid. The L-isomer is one of the 22 proteinogenic amino acids, i.e., the building blocks of proteins. It is classified as a charged, polar because of the hydrophilic ...		Others , Endogenous Metabolite
T8053	N-Acetyl-L-arginine	Ac-Arg-OH	Endogenous Metabolite
	N-Acetyl-L-arginine (Ac-Arg-OH) belongs to the class of organic compounds known as n-acyl-l-alpha-amino acids. These are n-acylated alpha amino acids which have the L-configuration of the alpha-carbon atom. N-a-Acetyl-L-...		Endogenous Metabolite
T17198	UCN-02	7-epi-Hydroxystaurosporine	Others
	UCN-02 is a selective protein kinase C inhibitor produced by Streptomyces strain N-12 (IC50s: 62 nM and 250 nM for PKC and protein kinase A (PKA), respectively).		Others
T15636	K-252a	Antibiotic K 252a,Antibiotic SF 2370,SF2370	Others
	K-252a is a staurosporine analog isolated from Nocardiopsis sp. soil fungi. K-252a inhibits protein kinase (IC50: 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphoryla...		Others
T30784	Cedrene	AI3-51328,AI3 51328,AI351328
	Cedrene can regulate hepatic steatosis via the cAMP-PKA pathway.
T29462	5-OH-HxMF
	5-OH-HxMF is an inducer of neurite growth in PC12 cells through the camp / PKA / CREB pathway.
TN4317	Isopedicin		NADPH-oxidase , cAMP , p38 MAPK , PKA , JNK , PDE
	Isopedicin has anti-inflammatory functions, it inhibits the O(2)()(-) production in human neutrophils by an elevation of cellular cAMP and activation of PKA* through its inhibition of cAMP-specific PDE.		NADPH-oxidase , cAMP , p38 MAPK , PKA , JNK , PDE
T32329	Juzirine
	Juzirine is a member of the class of benzylisoquinolines. Benzylisoquinolines are organic compounds containing an isoquinoline to which a benzyl group is attached. Juzirine, practically insoluble (in water), is a very we...
T16791	Rottlerin	Mallotoxin,NSC 56346,NSC 94525	CaMK , Apoptosis , Others , HIV Protease , PKA , PKC , Autophagy
	Rottlerin (NSC-56346) is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM). Rottlerin causes apoptosis via caspase...

Natural Products

Synonym: Antibiotic AM-2282,AM-2282,CGP 41251

Target: Apoptosis, PKA, Antibacterial, Antibiotic, Src, PKC, Antifungal

Gliotoxin

TN1694

Synonym:

Target: Apoptosis, NF-κB, Wnt/beta-catenin, COX, PKA, Antibacterial, Antifection

Daphnetin

T2851

Synonym: 7,8-Dihydroxycoumarin,Daphnetol

Target: EGFR, PKA, PKC, Parasite, Autophagy

Target: ERK, LDL, MAPK, PKA, PKC

Pinoresinol dimethyl ether

T2S0531

Synonym: (+)-Eudesmin

Target: Endogenous Metabolite

Fargesin

T5S2178

Synonym: (+/-)-Fargesin

Target: Adrenergic Receptor

(S)-(-)-Phenylethanol

T4784

Synonym: (S)-(-)-1-Phenylethanol,(-)-Methyl phenyl carbinol,(S)-(-)-sec-Phenylethyl alcohol

Target: Others, Endogenous Metabolite

Calcium 2-hydroxy-4-(methylthio)butanoate

T5082

Synonym: calcium hydroxymethionine,2-Hydroxy-4-(methylthio)butyric acid calcium salt

Target: Others, Endogenous Metabolite

Nobiletin

T2834

Synonym: Hexamethoxyflavone

Target: Apoptosis, MMP, Reactive Oxygen Species, ROR, Autophagy

2,6-Dimethoxyquinone

T3739

Synonym: 2,6-Dimethoxy-1,4-benzoquinone,2,6-Dimethoxy-p-benzoquinone,2,6-Dimethoxybenzoquinone

Target: MAPK, S6 Kinase

Paraxanthine

T4973

Synonym: 1,7-DIMETHYLXANTHINE

Target: Endogenous Metabolite

3-Methoxyphenylacetic acid

Fr13883

Synonym:

Target: Others

3-Ethoxy-3-oxopropanoic acid

T4773

Synonym: Monoethyl malonic acid,Ethyl hydrogen malonate

Target: Others, Endogenous Metabolite

Diethyl oxalpropionate

T4768

Synonym: HYL 2-METHYL-3-OXOSUCCINATE

Target: Others, Endogenous Metabolite

N-Acetyl-L-leucine

T4798

Synonym:

Target: Others, Endogenous Metabolite

Indole-3-carboxaldehyde

T8105

Synonym: 3-Formylindole

Target: Endogenous Metabolite

8-Gingerol

T6S1684

Synonym:

Target: Antioxidant, Antibacterial, TRP/TRPV Channel

Itaconic acid

T4837

Synonym: methylene-butanedioicaci

Target: Others, Endogenous Metabolite

Target: Endogenous Metabolite

L-Histidine monohydrochloride monohydrat

T4826

Synonym:

Target: Others, Endogenous Metabolite

N-Acetyl-L-arginine

T8053

Synonym: Ac-Arg-OH

Target: Endogenous Metabolite

UCN-02

T17198

Synonym: 7-epi-Hydroxystaurosporine

Target: Others

K-252a

T15636

Synonym: Antibiotic K 252a,Antibiotic SF 2370,SF2370

Target: Others

Cedrene

T30784

Synonym: AI3-51328,AI3 51328,AI351328

Target: NADPH-oxidase, cAMP, p38 MAPK, PKA, JNK, PDE

Synonym: Mallotoxin,NSC 56346,NSC 94525

Target: CaMK, Apoptosis, Others, HIV Protease, PKA, PKC, Autophagy

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPK-00677	PKA/PRKACA Protein, Canine, Recombinant (His)	Canine	E. coli
	The cAMP-dependent protein kinase PKA is a well-characterized member of the serine-threonine protein AGC kinase family and is the effector kinase of cAMP signaling. As such, PKA is involved in the control of a wide varie...
TMPK-01474	HLA-A*24:02&B2M&MAGE-A3 (IMPKAGLLI) Monomer Protein, Human, MHC (His & Avi)	Human	HEK293
	Melanoma antigen gene A3 (MAGE-A3) is one of the most immunogenic cancer testis antigens and is common in various types of cancers. MAGE-A3 can be considered as a predictor for poor prognosis and an option for vaccine im...
TMPK-00696	PRAK/MAPKAPK5 Protein, Human, Recombinant (Strep-II)	Human	Baculovirus-Insect Cells
	The p38 mitogen-activated protein kinase (MAPK) pathway plays an important role in cellular responses to inflammatory stimuli and environmental stress. p38 regulated/activated protein kinase (PRAK, also known as mitogen-...
TMPK-01472	HLA-A*24:02&B2M&MAGE-A3 (IMPKAGLLI) Tetramer Protein, Human, MHC (His & Avi)	Human	HEK293
	Melanoma antigen gene A3 (MAGE-A3) is one of the most immunogenic cancer testis antigens and is common in various types of cancers. MAGE-A3 can be considered as a predictor for poor prognosis and an option for vaccine im...
TMPK-01473	HLA-A*24:02&B2M&MAGE-A3 (IMPKAGLLI) Monomer Protein, Human, MHC (His & Avi), Biotinylated	Human	HEK293
	Melanoma antigen gene A3 (MAGE-A3) is one of the most immunogenic cancer testis antigens and is common in various types of cancers. MAGE-A3 can be considered as a predictor for poor prognosis and an option for vaccine im...
TMPY-04425	PRAK/MAPKAPK5 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	MAPKAPK5 contains 1 protein kinase domain and belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family. MAPKAPK5 has significant sequence homology to mitogen-activated protein kinase (MAPK)-activated...
TMPY-04378	MAPKAPK3 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	The MAPKAP kinases are a group of MAP kinase substrates that are themselves kinases. In response to activation, the MAP kinases phosphorylate downstream components on a consensus Pro-X-Ser/Thr-Pro motif. Several kinases ...
TMPY-05207	PRKAR1A Protein, Mouse, Recombinant (His)	Mouse	Baculovirus-Insect Cells
	PRKAR1A, also known as PRKAR1 and PKR1, is one of the regulatory subunits of cAMP-dependent protein kinase A (PKA). PKA can be activated by cAMP. cAMP is a signaling molecule important for a variety of cellular functions...
TMPY-03656	PRKAR1A Protein, Human, Recombinant (His)	Human	HEK293
	PRKAR1A, also known as PRKAR1 and PKR1, is one of the regulatory subunits of cAMP-dependent protein kinase A (PKA). PKA can be activated by cAMP. cAMP is a signaling molecule important for a variety of cellular functions...
TMPJ-01309	PKI-Beta Protein, Human, Recombinant (His)	Human	E. coli
	cAMP-Dependent Protein Kinase Inhibitor β (PKI-β) is a member of the PKI family. As a member of the cAMP-dependent protein kinase inhibitor family,It has been shown that PKI-β is an extremely potent competitive inhibitor...
TMPH-00269	GPR52 Protein, Bovine, Recombinant (His & KSI)	Bovine	E. coli
	G- protein coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization. May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA...
TMPJ-00528	PPP1R1A Protein, Human, Recombinant (His)	Human	E. coli
	Protein Phosphatase 1 Regulatory Subunit 1A (PPP1R1A) is an inhibitor of protein-phosphatase 1. PPP1R1A is a cellular regulator of eIF2 alpha phosphorylation. In hormonal control of glycogen metabolism, IPP-1 protein pla...
TMPY-01117	MRAP Protein, Human, Recombinant (hFc)	Human	HEK293
	MRAP (Melanocortin 2 Receptor Accessory Protein) is a Protein Coding gene. This gene encodes a melanocortin receptor-interacting protein. It belongs to the MRAP family. MRAP, which contains a single transmembrane domain,...
TMPH-00028	Adeno-associated virus 2 (isolate Srivastava/1982) Rep78 Protein (His & MBP)	AAV-2	E. coli
	Plays an essential role in the initiation of viral DNA synthesis. Binds specifically to an inverted terminal repeat element (ITR) on the 3' and 5' ends of the viral DNA, where it cleaves a site specifically to generate a...
TMPH-01092	CHGA Protein, Human, Recombinant (His)	Human	Yeast
	Strongly inhibits glucose induced insulin release from the pancreas.; Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Displa...
TMPJ-00886	ATF1 Protein, Human, Recombinant (His)	Human	E. coli
	Cyclic AMP-dependent transcription factor ATF-1(ATF1) which contains 1 bZIP (basic-leucine zipper) domain and 1 KID (kinase-inducible) domain, belongs to the bZIP family. It influences cellular physiologic processes by r...
TMPH-02910	Somatostatin Protein, Mouse, Recombinant (His & KSI)	Mouse	E. coli
	Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhib...
TMPH-01857	PIK3CG Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-contai...
TMPH-03256	CNR1 Protein, Rat, Recombinant (His)	Rat	in vitro E. coli expression system
	G-protein coupled receptor for cannabinoids, including endocannabinoids (eCBs), such as N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effe...
TMPH-01035	CNR1 Protein-VLP, Human, Recombinant (His)	Human	HEK293
	G-protein coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such as delta(9)-tetrah...

PKA/PRKACA Protein, Canine, Recombinant (His)

TMPK-00677

Species: Canine

Expression System: E. coli

HLA-A*24:02&B2M&MAGE-A3 (IMPKAGLLI) Monomer Protein, Human, MHC (His & Avi)

TMPK-01474

Species: Human

Expression System: HEK293

PRAK/MAPKAPK5 Protein, Human, Recombinant (Strep-II)

TMPK-00696

Species: Human

Expression System: Baculovirus-Insect Cells

HLA-A*24:02&B2M&MAGE-A3 (IMPKAGLLI) Tetramer Protein, Human, MHC (His & Avi)

TMPK-01472

Species: Human

Expression System: HEK293

HLA-A*24:02&B2M&MAGE-A3 (IMPKAGLLI) Monomer Protein, Human, MHC (His & Avi), Biotinylated

TMPK-01473

Species: Human

Expression System: HEK293

PRAK/MAPKAPK5 Protein, Human, Recombinant (His & GST)

TMPY-04425

Species: Human

Expression System: Baculovirus-Insect Cells

MAPKAPK3 Protein, Human, Recombinant (GST)

TMPY-04378

Species: Human

Expression System: Baculovirus-Insect Cells

PRKAR1A Protein, Mouse, Recombinant (His)

TMPY-05207

Species: Mouse

Expression System: Baculovirus-Insect Cells

PRKAR1A Protein, Human, Recombinant (His)

TMPY-03656

Species: Human

Expression System: HEK293

PKI-Beta Protein, Human, Recombinant (His)

TMPJ-01309

Species: Human

Expression System: E. coli

GPR52 Protein, Bovine, Recombinant (His & KSI)

TMPH-00269

Species: Bovine

Expression System: E. coli

PPP1R1A Protein, Human, Recombinant (His)

TMPJ-00528

Species: Human

Expression System: E. coli

MRAP Protein, Human, Recombinant (hFc)

TMPY-01117

Species: Human

Expression System: HEK293

Adeno-associated virus 2 (isolate Srivastava/1982) Rep78 Protein (His & MBP)

TMPH-00028

Species: AAV-2

Expression System: E. coli

CHGA Protein, Human, Recombinant (His)

TMPH-01092

Species: Human

Expression System: Yeast

ATF1 Protein, Human, Recombinant (His)

TMPJ-00886

Species: Human

Expression System: E. coli

Somatostatin Protein, Mouse, Recombinant (His & KSI)

TMPH-02910

Species: Mouse

Expression System: E. coli

PIK3CG Protein, Human, Recombinant (His & Myc)

TMPH-01857

Species: Human

Expression System: E. coli

CNR1 Protein, Rat, Recombinant (His)

TMPH-03256

Species: Rat

Expression System: in vitro E. coli expression system

CNR1 Protein-VLP, Human, Recombinant (His)

TMPH-01035

Species: Human

Expression System: HEK293

Cat No.	Product Name
L1610	FDA-Approved Kinase Inhibitor Library	266 compounds
	A unique collection of 266 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.
L1600	Kinase Inhibitor Library	2720 compounds
	A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;
L7700	Neural Regeneration Compound Library	529 compounds
	A unique collection of 149 neuroregeneration related compounds for high throughput and high content screening;
L5100	Fluorochemical Library	583 compounds
	A unique collection of 583 fluorochemicals that can be used for high through-put screening (HTS) and high content screening (HCS);

Libraries

FDA-Approved Kinase Inhibitor Library

L1610

Compounds: 266

Kinase Inhibitor Library

L1600

Compounds: 2720

Neural Regeneration Compound Library

L7700

Compounds: 529

Fluorochemical Library

L5100

Compounds: 583