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Search Result

Search Results for " pten "

Targets

PTEN PTEN Autophagy

36

Compounds

15

Natural Products

13

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T7012 VO-Ohpic trihydrate VO-Ohpic PTEN , Autophagy
VO-Ohpic trihydrate (VO-Ohpic) is a potent inhibitor of PTEN (phosphatase and tensin homolog) with IC50 of 35 nM.
T7953 BpV(HOpic) bpV (HOpic) PTEN
BpV(HOpic) (bpV (HOpic)) is a potent inhibitor of PTEN (IC50 of 14 nM).
T6303 CCT128930 Akt , PKA , S6 Kinase , Autophagy
CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM, 28-fold greater selectivity for Akt2 than the closely related PKA kinase.
T6667 SF1670 PTP CD45 Inhibitor,PTPase CD45 Inhibitor Phosphatase , PTEN , Autophagy
SF1670 (PTPase CD45 Inhibitor) is a specific PTEN inhibitor with IC50 of 2 μM.
T1952 MK-2206 dihydrochloride MK-2206 2HCl Apoptosis , Akt , Autophagy
MK-2206 dihydrochloride (MK-2206 2HCl) is a variant Akt inhibitor that inhibits Akt1, Akt2, and Akt3 (IC50=8/12/65 nM) with orally active, highly potent and selective potency. MK-2206 dihydrochloride exhibits antitumor a...
T14511 BAY1082439 Apoptosis , PI3K
BAY1082439, an orally bioavailable, selective inhibitor of PI3Kα/β/δ, demonstrates high efficacy in inhibiting the growth of Pten-null prostate cancer [1][2]. Additionally, BAY1082439 is effective against mutated forms o...
T6303L CCT128930 hydrochloride CCT128930 hydrochloride(885499-61-6 Free base) Apoptosis , Akt , PKA , mTOR , Autophagy
CCT128930 hydrochloride (CCT128930 hydrochloride) is a potent and selective inhibitor of AKT with IC50 of 6 nM. CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophagy. CCT128930 hydrochloride has 28...
T77548 (6Z)-7-Phenyl-7-(3-Pyridinyl)-6-Heptenoic Acid
(6Z)-7-Phenyl-7-(3-Pyridinyl)-6-Heptenoic Acid is a derivative of 7-Phenyl-7-(3-Pyridyl) -6-Heptenoic Acid that can be used in biological research.
T64309 Isometheptene mucate
Isometheptene mucate is a sympathomimetic agent, an indirectly acting adrenergic receptor agonist, which can be used in the study of migraine.
T81790 Miptenalimab BI-754111
Miptenalimab (BI-754111) is an anti-human LAG-3 antibody with a dissociation constant (K D) of 88.6 nM for h LAG-3, effectively blocking the interaction between LAG-3 and its ligand MHC-II [1].
T32062 Heptenophos BRN 1978448,BRN1978448,BRN-1978448
Heptenophos is a biochemical.
T66069 T-Butyl (3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-isopropylidenedioxy-6-heptenoate
t-Butyl (3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-isopropylidenedioxy-6-heptenoate is a useful organic compound for research related to life sciences. The catalog number is T66069 and the CAS number i...
T33197 M-Anisidine, 4-(3-heptenyloxy)-
m-Anisidine, 4-(3-heptenyloxy)- is a bioactive chemical.
T130740 7-(4-Hydroxy-3-methoxyphenyl)-1-phenyl-4-hepten-3-
7-(4-Hydroxy-3-methoxyphenyl)-1-phenyl-4-hepten-3- is a useful organic compound for research related to life sciences and the catalog number is T130740.
T27155 Dexisometheptene TNX 201,TNX-201,(R)-Isometheptene,TNX201
Dexisometheptene is an antimigraine drug candidate. Dexisometheptene significantly increases the pain threshold of acute pain response, and potently and selectively binds to receptors in the central nervous system known ...
T125501 Trans-2-Heptenal
trans-2-Heptenal is a useful organic compound for research related to life sciences. The catalog number is T125501 and the CAS number is 18829-55-5.
T83658 SQLE-IN-1 Antifungal
SQLE-IN-1 is a squalene epoxidase (SQLE) inhibitor with anti-tumor activity. It can inhibit the proliferation and migration of liver cancer cell line Huh7, inhibit the production of cellular cholesterol, and increase the...
T13376 YS-49 RAAS , Akt , PI3K , Adrenergic Receptor
YS-49 is an activator of PI3K/Akt (a downstream target of RhoA).
T10594 BpV(phen) PTEN
bpV(phen) is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor (IC50s: 343 nM, 920 nM, and 38 nM for PTP-β, PTP-1B, and PTEN).
T71739 PTPMT1-IN-1
PTPMT1-IN-1 is a PTEN-like mitochondrial phosphatase PTPMT1 inhibitor.
T39929 MS21
MS21 is a unique AKT degrader that selectively hampers the proliferation of cancers with mutations in the PI3K/PTEN pathway, alongside wild-type KRAS and BRAF.
T26775 Bepafant WEB-2170,WEB2170,STY 2108,STY-2108,WEB 2170
Bepafant is a platelet activating factor (PAF) antagonist. Bepafant may produce significant anti-inflammatory effects. Bepafant triggered apoptosis in NB4, KG1, and NB4-MR4 cells where PTEN was expressed, but not in THP1...
T71757 SC-10914
SC10914 is a highly potent PARP inhibitor (PARP1 IC50 = 7.87 nM) with potent anti-proliferative activity against human BRCA deficient tumor cells (MDA-MB-436, BRCA1 deficient, IC50 = 4.03 nM, Capan-1 BRCA2 deficient, IC5...
T60776 Anticancer agent 68
Compound 12, also known as Anticancer agent 68, functions as an anti-cancer agent by arresting cells at the G2/M phase and inducing programmed cell death. Moreover, it promotes tumor suppression by activating p53 and PTE...
T81784 MK-2206 free base Akt
MK-2206 free base is an allosteric Akt inhibitor that is both potent and selective, administered orally, exhibiting IC50 values of 8, 12, and 65 nM for Akt1, Akt2, and Akt3, respectively. It demonstrates sensitivity in ...
T61344 VO-OHPic
VO-OHPic is a reversible, noncompetitive, and selective inhibitor of PTEN with an IC50 of 46 nM. It effectively attenuates apoptosis, adverse cardiac remodeling, and the presence of pro-inflammatory M1 macrophages in mod...
T71147 PBS-1086
PBS-1086 is a novel dual inhibitor of the canonical and noncanonical NF-κB pathways, increasing the magnitude and duration of initial EGFR inhibitor response in multiple NSCLC models, decreasing PDHK1 expression, and sup...
T62609 MK-2206
MK-2206 is an orally active, highly selective, metabotropic Akt inhibitor that acts on Akt1 (IC50: 8 nM), Akt2 (IC50: 12 nM) and Akt3 (IC50: 65 nM). Many breast cancer cell lines, PIK3CA mutants and PTEN-losing cell line...
T35491 3,5-dimethyl PIT-1
PtdIns-(3,4,5)-P3 (PIP3) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as phosphatidylinositol 3-kinase (PI3K) or PTEN. Protein binding to PIP3 is impor...
T63879 MicroRNA-21-IN-1
MicroRNA-21-IN-1 (compound 7A) is an effective inhibitor of microRNA with antiproliferative effects on Hela and HCT-116 cells, showing IC50 values of 5.5 μM and 2.8 μM, respectively. It also induces apoptosis in Hela cel...
T75238 YS-49 monohydrate
YS-49 (monohydrate) is an isoquinoline compound alkaloid that functions as a PI3K/Akt activator, specifically targeting a downstream effect of RhoA, to mitigate the activation of RhoA/PTEN in 3-methylcholanthrene-treated...
T38847 Vevorisertib Vevorisertib,ARQ 751
Vevorisertib (ARQ 751) is a highly effective oral compound that selectively inhibits pan-AKT serine/threonine kinases such as AKT1 (with an IC50 value of 0.55 nM), AKT2 (with an IC50 value of 0.81 nM), and AKT3 (with an ...
T27621 Ipatasertib HCl GDC0068,RG 7440,GDC 0068,RG-7440,GDC-0068,RG7440
Ipatasertib is an orally active, potent and selective Akt inhibitor with antitumor activity. Inhibition of Akt activity by Ipatasertib resulted in blockade of cell-cycle progression and reduced viability of cancer cell l...
T37029 PtdIns-(3,4,5)-P3-biotin (sodium salt) PtdIns-(3,4,5)-P3-biotin (sodium salt)
The PtdIn phosphates play an important role in the generation and transduction of intracellular signals. PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the ...
T70552 Ipatasertib tosylate
Ipatasertib, also known as GDC0068, is an orally active, potent and selective Akt inhibitor. GDC-0068 blocked Akt signaling both in cultured human cancer cell lines and in tumor xenograft models. Inhibition of Akt acti...
T65598 Cefminox sodium
Cefminox (Sodium) is a new cephamycin antibiotic possessing a D-amino acid moiety derived from D-cysteine at the C-7B side chain. Cefminox is active against a wide range of bacteria, especially Gram-negative and anaerobi...

Compounds

VO-Ohpic trihydrate
T7012
Synonym: VO-Ohpic
Target: PTEN, Autophagy
BpV(HOpic)
T7953
Synonym: bpV (HOpic)
Target: PTEN
CCT128930
T6303
Synonym:
Target: Akt, PKA, S6 Kinase, Autophagy
SF1670
T6667
Synonym: PTP CD45 Inhibitor,PTPase CD45 Inhibitor
Target: Phosphatase, PTEN, Autophagy
MK-2206 dihydrochloride
T1952
Synonym: MK-2206 2HCl
Target: Apoptosis, Akt, Autophagy
BAY1082439
T14511
Synonym:
Target: Apoptosis, PI3K
CCT128930 hydrochloride
T6303L
Synonym: CCT128930 hydrochloride(885499-61-6 Free base)
Target: Apoptosis, Akt, PKA, mTOR, Autophagy
(6Z)-7-Phenyl-7-(3-Pyridinyl)-6-Heptenoic Acid
T77548
Synonym:
Target:
Isometheptene mucate
T64309
Synonym:
Target:
Miptenalimab
T81790
Synonym: BI-754111
Target:
Heptenophos
T32062
Synonym: BRN 1978448,BRN1978448,BRN-1978448
Target:
t-Butyl (3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-isopropylidenedioxy-6-heptenoate
T66069
Synonym:
Target:
m-Anisidine, 4-(3-heptenyloxy)-
T33197
Synonym:
Target:
7-(4-Hydroxy-3-methoxyphenyl)-1-phenyl-4-hepten-3-
T130740
Synonym:
Target:
Dexisometheptene
T27155
Synonym: TNX 201,TNX-201,(R)-Isometheptene,TNX201
Target:
trans-2-Heptenal
T125501
Synonym:
Target:
SQLE-IN-1
T83658
Synonym:
Target: Antifungal
YS-49
T13376
Synonym:
Target: RAAS, Akt, PI3K, Adrenergic Receptor
bpV(phen)
T10594
Synonym:
Target: PTEN
PTPMT1-IN-1
T71739
Synonym:
Target:
MS21
T39929
Synonym:
Target:
Bepafant
T26775
Synonym: WEB-2170,WEB2170,STY 2108,STY-2108,WEB 2170
Target:
SC-10914
T71757
Synonym:
Target:
Anticancer agent 68
T60776
Synonym:
Target:
MK-2206 free base
T81784
Synonym:
Target: Akt
VO-OHPic
T61344
Synonym:
Target:
PBS-1086
T71147
Synonym:
Target:
MK-2206
T62609
Synonym:
Target:
3,5-dimethyl PIT-1
T35491
Synonym:
Target:
microRNA-21-IN-1
T63879
Synonym:
Target:
YS-49 monohydrate
T75238
Synonym:
Target:
Vevorisertib
T38847
Synonym: Vevorisertib,ARQ 751
Target:
Ipatasertib HCl
T27621
Synonym: GDC0068,RG 7440,GDC 0068,RG-7440,GDC-0068,RG7440
Target:
PtdIns-(3,4,5)-P3-biotin (sodium salt)
T37029
Synonym: PtdIns-(3,4,5)-P3-biotin (sodium salt)
Target:
Ipatasertib tosylate
T70552
Synonym:
Target:
Cefminox sodium
T65598
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T3780 Oroxin B Hypocretin-2 Apoptosis , PTEN , Antioxidant , PI3K , Autophagy
Oroxin B (Hypocretin-2) has antioxidant activity.
TN1362 Afzelin Kaempferol-3-O-rhamnoside PTEN , p38 MAPK , TNF , Mitochondrial Metabolism , Antibacterial , Prostaglandin Receptor , Autophagy
Afzelin (Kaempferol-3-O-rhamnoside) has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as UV-absorbing activity and may protect human skin from UVB-induced d...
T6S2116 Ginkgolic acid C17:1 Phosphatase , PTEN
1. Ginkgolic acid C17:1 can significantly inhibit enterohemorrhagic Escherichia coli O157:H7(EHEC) biofilm formation on the surfaces of polystyrene and glass, and on nylon membranes.
T4115 Auraptene 7-geranyloxycoumarin MMP , BACE
Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its C-7. It has anti-inflammatory, anti-carcinogenic, anti-bacterial, neuroprotective, and hepatoprotective activities. It inhibits le...
T2852 Citropten Limettin,Citroptene,Limetin,5, 7-Dimethoxycoumarin,5,7-Dimethoxycoumarin Others
Citropten (Limetin) is a natural organic compound and is found in the essential oils of citrus such as lime, lemon, and bergamot.
T2S1702 (5R,6E)-5-Hydroxy-1,7-diphenyl-6-hepten-3-one (5R)-trans-1,7-diphenyl-5-hydroxy-6-hept,5-Hydroxy-1,7-diphenyl-6-hepten-3-one Antioxidant
(5R,6E)-5-Hydroxy-1,7-diphenyl-6-hepten-3-one ((5R)-trans-1,7-diphenyl-5-hydroxy-6-hept) has antioxidant activity.
T2143 Bergapten 5-Methoxypsoralen P450 , Autophagy
Bergapten (5-Methoxypsoralen), a psoralen, inhibits cell replication.
T5747 ISOBERGAPTEN Others
ISOBERGAPTEN is a plant growth regulating substance, it is the principal constituents responsible for the antimycobacterial activity of the roots of Heracleum maximum; it may form an important class of natural defensive ...
TN1345 8-Hydroxybergapten Others
8-Hydroxybergapten may have anti-wrinkle activity.
TN5075 Subelliptenone G Others
Subelliptenone G is a natural product from Garcinia hanburyi Hook.f.
TN2523 1,7-Diphenyl-5-hydroxy-4,6-hepten-3-one Others
1,7-Diphenyl-5-hydroxy-4,6-hepten-3-one is a natural product of Alpinia, Zingiberaceae. The catalog number is TN2523 and the CAS number is 87095-77-0. 1,7-Diphenyl-5-hydroxy-4,6-hepten-3-one can be used as a reference st...
TN2522 1,7-Diphenyl-4-hepten-3-one Others
1,7-Diphenyl-4-hepten-3-one has feeding deterrent activities against Tribolium castaneum.
TN3218 7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one Beta Amyloid , PI3K , mTOR
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may provide new insights on drug discovery of Alzheimer's dise...
TN1415 Auraptenol 5-HT Receptor
Auraptenol possesses robust antidepressant-like efficacy in mice.
T3404 Cucurbitacin B Cuc B,DATISCACIN,Amarine Apoptosis , PTEN , Integrin , Endogenous Metabolite , HIF , STAT , Autophagy
Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inh...

Natural Products

Oroxin B
T3780
Synonym: Hypocretin-2
Target: Apoptosis, PTEN, Antioxidant, PI3K, Autophagy
Afzelin
TN1362
Synonym: Kaempferol-3-O-rhamnoside
Target: PTEN, p38 MAPK, TNF, Mitochondrial Metabolism, Antibacterial, Prostaglandin Receptor, Autophagy
Ginkgolic acid C17:1
T6S2116
Synonym:
Target: Phosphatase, PTEN
Auraptene
T4115
Synonym: 7-geranyloxycoumarin
Target: MMP, BACE
Citropten
T2852
Synonym: Limettin,Citroptene,Limetin,5, 7-Dimethoxycoumarin,5,7-Dimethoxycoumarin
Target: Others
(5R,6E)-5-Hydroxy-1,7-diphenyl-6-hepten-3-one
T2S1702
Synonym: (5R)-trans-1,7-diphenyl-5-hydroxy-6-hept,5-Hydroxy-1,7-diphenyl-6-hepten-3-one
Target: Antioxidant
Bergapten
T2143
Synonym: 5-Methoxypsoralen
Target: P450, Autophagy
ISOBERGAPTEN
T5747
Synonym:
Target: Others
8-Hydroxybergapten
TN1345
Synonym:
Target: Others
Subelliptenone G
TN5075
Synonym:
Target: Others
1,7-Diphenyl-5-hydroxy-4,6-hepten-3-one
TN2523
Synonym:
Target: Others
1,7-Diphenyl-4-hepten-3-one
TN2522
Synonym:
Target: Others
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one
TN3218
Synonym:
Target: Beta Amyloid, PI3K, mTOR
Auraptenol
TN1415
Synonym:
Target: 5-HT Receptor
Cucurbitacin B
T3404
Synonym: Cuc B,DATISCACIN,Amarine
Target: Apoptosis, PTEN, Integrin, Endogenous Metabolite, HIF, STAT, Autophagy

Recombinant Proteins

Species：
Mouse (7)
Human (6)
Expression System：
Baculovirus-Insect Cells (8)
HEK293 (3)
E. coli (2)
Tag：
His (5)
GST (2)
His,GST (2)
Tag Free (2)
N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged (1)
hFc (1)
Cat No. Product Name Species Expression System
TMPY-02758 ENTPD5 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
Ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5), also known as CD39 antigen-like 4, ER-UDPase, Guanosine-diphosphatase ENTPD5, Nucleoside diphosphatase Uridine-diphosphatase ENTPD5. This hydrolase is expressed ...
TMPY-04276 ENTPD5 Protein, Mouse, Recombinant (His) Mouse Baculovirus-Insect Cells
Ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5), also known as CD39 antigen-like 4, ER-UDPase, Guanosine-diphosphatase ENTPD5, Nucleoside diphosphatase Uridine-diphosphatase ENTPD5. This hydrolase is expressed ...
TMPY-03111 PIK3IP1 Protein, Human, Recombinant (hFc) Human HEK293
PIK3IP1 contains 1 kringle domain and is a negative regulator of phosphatidylinositol-3-kinase (PI3K), suppresses the development of hepatocellular carcinoma. PI3K is a well-known regulator of cell division, motility, me...
TMPY-04933 PIK3IP1 Protein, Mouse, Recombinant (His) Mouse HEK293
PIK3IP1 contains 1 kringle domain and is a negative regulator of phosphatidylinositol-3-kinase (PI3K), suppresses the development of hepatocellular carcinoma. PI3K is a well-known regulator of cell division, motility, me...
TMPY-04446 AKT3 Protein, Mouse, Recombinant (aa 106-479) Mouse Baculovirus-Insect Cells
v-akt murine thymoma viral oncogene homolog 3 (AKT3), also known as PKB-GAMMA, with AKT1/PKBalpha, AKT2/PKBbeta, are the memerbers of Akt kinase family, share extensive structural similarity and perform common as well as...
TMPH-02286 USP7 Protein, Human, Recombinant (His & Myc & SUMO) Human E. coli
Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of M...
TMPY-04574 AKT3 Protein, Mouse, Recombinant (aa 106-479, His & GST) Mouse Baculovirus-Insect Cells
v-akt murine thymoma viral oncogene homolog 3 (AKT3), also known as PKB-GAMMA, with AKT1/PKBalpha, AKT2/PKBbeta, are the memerbers of Akt kinase family, share extensive structural similarity and perform common as well as...
TMPY-04553 AKT3 Protein, Human, Recombinant (GST) Human Baculovirus-Insect Cells
v-akt murine thymoma viral oncogene homolog 3 (AKT3), also known as PKB-GAMMA, with AKT1/PKBalpha, AKT2/PKBbeta, are the memerbers of Akt kinase family, share extensive structural similarity and perform common as well as...
TMPY-04372 CK2 alpha/CSNK2A1 Protein, Human, Recombinant (GST) Human Baculovirus-Insect Cells
Casein kinase II subunit alpha, also known as CK II alpha, CSNK2A1 and CK2A1, is a member of the protein kinase superfamily, Ser / Thr protein kinase family and CK2 subfamily. Casein kinase II (CSNK2A1) is a serine / thr...
TMPY-04758 CK2 alpha/CSNK2A1 Protein, Mouse, Recombinant Mouse Baculovirus-Insect Cells
Casein kinase II subunit alpha, also known as CK II alpha, CSNK2A1 and CK2A1, is a member of the protein kinase superfamily, Ser / Thr protein kinase family and CK2 subfamily. Casein kinase II (CSNK2A1) is a serine / thr...
TMPY-01482 FABP4 Protein, Mouse, Recombinant (His) Mouse HEK293
Fatty acid-binding protein, adipocyte, also known as Adipocyte-type fatty acid-binding protein, Fatty acid-binding protein 4, Adipocyte lipid-binding protein, and FABP4, is a cytoplasm protein which belongs to thecalyc...
TMPY-02103 FABP4 Protein, Human, Recombinant (29 Ala/Thr, His) Human E. coli
Fatty acid-binding protein, adipocyte, also known as Adipocyte-type fatty acid-binding protein, Fatty acid-binding protein 4, Adipocyte lipid-binding protein, and FABP4, is a cytoplasm protein which belongs to thecalyc...
TMPY-04441 CK2 alpha/CSNK2A1 Protein, Mouse, Recombinant (His & GST) Mouse Baculovirus-Insect Cells
Casein kinase II subunit alpha, also known as CK II alpha, CSNK2A1 and CK2A1, is a member of the protein kinase superfamily, Ser / Thr protein kinase family and CK2 subfamily. Casein kinase II (CSNK2A1) is a serine / thr...
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