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Cat No. | Product Name | Synonyms | Targets |
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T36682 | USP30 inhibitor 18 | DUB | |
USP30 inhibitor 18 is a selective USP30 inhibitor with an IC50 of 0.02 μM. USP30 inhibitor 18 increases protein ubiquitination and accelerates mitophagy[1]. [1]. Arthur F Kluge, et al. Novel highly selective inhibitors o... | |||
T73331 | GSK3-IN-3 | Mitophagy , GSK-3 | |
GSK3-IN-3 is a mitochondrial autophagy (mitophagy) inducer and GSK-3 inhibitor (IC50: 3.01 μM) that induces parkin-dependent mitochondrial autophagy. GSK3-IN-3 is non-ATP and non-substrate competitive and neuroprotective... | |||
T13809 | P62-mediated mitophagy inducer | PMI | Mitophagy |
P62-mediated mitophagy inducer (PMI) is a regulator of mitophagy . | |||
T73324 | PARL-IN-1 | ||
PARL-IN-1, a potent PARL inhibitor, exhibits an IC50 value of 28 nM. It effectively inhibits PARL, consequently robustly activating the PINK1/Parkin pathway and promoting PINK1/Parkin-dependent mitophagy. | |||
T69642 | FT385 | ||
FT385 is a novel USP30 inhibitor, recapitulating genetic loss of USP30 and setting the trigger for PINK1-PARKIN amplification of mitochondrial ubiquitylation. | |||
T61512 | FT3967385 | ||
FT3967385 is a newly developed compound that functions as a USP30 inhibitor, emulating the genetic deficiency of USP30. This inhibition serves as a catalyst for the amplification of mitochondrial ubiquitylation through t... | |||
T40959 | T0467 | T0467 | |
T0467 is a chemical compound that activates the translocation of parkin to the mitochondria in a PINK1-dependent manner in vitro. However, T0467 does not induce the accumulation of PINK1 in the mitochondria of dopaminerg... | |||
T69365 | HMS607P03 | ||
HMS607P03 is an activator of SIRT1 which induces autophagic cell death via the AMPK-mTOR-ULK complex and induces mitophagy by the SIRT1-PINK1-Parkin pathway. HMS607P03 downregulates 14-3-3γ, catalase, profilin-1, and HSP... |
Cat No. | Product Name | Synonyms | Targets |
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TP1072 | Valinomycin | NSC 122023 | Apoptosis , PTEN , Antibacterial , Antibiotic , Autophagy |
Valinomycin (NSC-122023) is a cyclic depsipeptide antibiotic and a potassium-specific ionophore.Valinomycin induces PINK1 activation and promotes Parkin phosphorylation at Ser65. | |||
TN1362 | Afzelin | Kaempferol-3-O-rhamnoside | PTEN , p38 MAPK , TNF , Mitochondrial Metabolism , Antibacterial , Prostaglandin Receptor , Autophagy |
Afzelin (Kaempferol-3-O-rhamnoside) has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as UV-absorbing activity and may protect human skin from UVB-induced d... | |||
T2717 | Salidroside | Rhodioloside | Apoptosis , mTOR |
Salidroside (Rhodioloside) is a bioactive phenolic glycoside compound isolated from Rhodiola crenulata. It is a prolyl endopeptidase Inhibitor. |
Cat No. | Product Name | ||
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L9830 | Anti-Parkinson's Disease Compound Library | 908 compounds | |
A unique collection of 908 compounds with anti-PD activities or acting on main drug targets of PD can be used for HTS and HCS. |