Search Result

Search Results for " parkinson’s "

Targets

Compounds

Natural Products

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T9722	YTX-465		Stearoyl-CoA Desaturase (SCD)
	YTX-465 is an inhibitor of both stearoyl-CoA desaturase(IC50s = 39 nM) and Ole1 (IC50s = 30.4 μM).		Stearoyl-CoA Desaturase (SCD)
T4081	MPTP hydrochloride	MPTP-hydrochloride	Apoptosis , Dopamine Receptor
	MPTP hydrochloride is a precursor of MPP+, a dopamine neurotoxin with blood-brain barrier permeability. MPTP hydrochloride is toxic to dopaminergic neurons, which can lead to Parkinson's disease, and is widely used in th...		Apoptosis , Dopamine Receptor
T16115	MLi-2		LRRK2
	MLi-2 is a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro (IC50 = 0.76 nM), a ce...		LRRK2
T10492	BD-AcAc 2	Ketone Ester	Reactive Oxygen Species
	BD-AcAc 2 (Ketone Ester) is a ketone monoester and can be used as a source of oral nutritional ketones. BD-AcAc 2 can elevate plasma levels of acetoacetate and β-hydroxybutyrate, blood Na+, blood glucose levels and blood...		Reactive Oxygen Species
T8322	BL-918		Autophagy
	BL-918 is a potent activator of UNC-51-like kinase 1 (ULK1) with an EC50 of 24.14 nM.		Autophagy
T2344	LY 344864	LY344864	5-HT Receptor
	LY 344864, a specifc receptor agonist, is an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor.		5-HT Receptor
T7155	JH-II-127		LRRK2
	JH-II-127 is an orally inhibitor of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, G2019S LRRK2 and A2016T LRRK2 (IC50s = 6.6, 2.2, and 47.7 nM, respectively),		LRRK2
T22830	GYY4137	GYY 4137 morpholine salt	Others
	GYY4137 (GYY 4137 morpholine salt) is a novel water-soluble and slow releasing H2S donor with vasodilator and antihypertensive activity. GYY4137 also exhibits anti-inflammatory and anticancer activity.		Others
T0059	Diphenylpyraline hydrochloride	4-Diphenylmethoxy-1-methylpiperidine hydrochloride	Histamine Receptor
	Diphenylpyraline hydrochloride (4-Diphenylmethoxy-1-methylpiperidine hydrochloride) is used in the treatment of Parkinsonism.It is a first-generation antihistamine with anticholinergic effects, functions as a dopamine re...		Histamine Receptor
T8702	SKF-83566		Dopamine Receptor , 5-HT Receptor , AChR
	SKF-83566 is a blood-brain permeable and orally active antagonist of D1-like dopamine receptor and a weaker competitive 5-HT2 receptor antagonist with Ki of 11 nM		Dopamine Receptor , 5-HT Receptor , AChR
T0267	Zonisamide	AD 810,CI 912	Calcium Channel , Sodium Channel , Carbonic Anhydrase
	Zonisamide (AD 810), a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydrase although this is not one of the main mechanisms...		Calcium Channel , Sodium Channel , Carbonic Anhydrase
T0378	Oxybuprocaine hydrochloride	Risedronic Acid,Oxybuprocaine HCl	Sodium Channel
	Oxybuprocaine hydrochloride (Oxybuprocaine HCl), a local anesthetic, is used especially in otolaryngology and ophthalmology.		Sodium Channel
T12352	Oxidopamine hydrochloride	6-Hydroxydopamine hydrochloride,6-OHDA hydrochloride	Mitophagy , Dopamine Receptor , Autophagy
	Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is an neurotransmitter dopamine antagonist.		Mitophagy , Dopamine Receptor , Autophagy
T22595	B2	Linazolamide intermediate B impurity 2,CPNQ,5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline	Others , Sirtuin
	B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease		Others , Sirtuin
T7196	HG-10-102-01		LRRK2
	HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).		LRRK2
T12352L	Oxidopamine hydrobromide	6-Hydroxydopamine hydrobromide,6-OHDA hydrobromide	Mitophagy , Dopamine Receptor , Autophagy
	Oxidopamine hydrobromide (6-OHDA hydrobromide) is a neurotransmitter dopamine antagonist.		Mitophagy , Dopamine Receptor , Autophagy
T4659	ELN484228		Others
	ELN484228 is a α-synuclein blocker. α-synuclein is a key protein in Parkinson’s disease.		Others
T28861	ST-1535		Adenosine Receptor
	ST 1535 is a potent and orally active antagonist of A2A adenosine receptor with antiparkinsonian activity and antitremorigenic effects. ST 1535 exhibits the potential for the research of Parkinson’s disease.		Adenosine Receptor
T13048	SynuClean-D	SC-D	Others
	SynuClean-D (SC-D) is an α-synuclein aggregation inhibitor preventing fibril propagation, disrupting mature amyloid fibrils, and abolishing the degeneration of dopaminergic neurons in an animal model of Parkinson’s disea...		Others
T22103	ML-193	CID 1261822	Cannabinoid Receptor
	ML-193 (CID 1261822) is a potent and selective GPR55 antagonist( IC50 : 221 nM). It shows more than 27-fold selectivity for GPR55 over GPR35, CB1 and CB2, and can improve the motor and the sensorimotor deficits of Parkin...		Cannabinoid Receptor
T11599	Ibiglustat (L-Malic acid)	Ibiglustat L-Malic acid,GZ402671 (L-Malic acid),Venglustat (L-Malic acid),SAR402671 (L-Malic acid)	Transferase
	Ibiglustat (L-Malic acid) (Ibiglustat L-Malic acid) is a selective, brain-penetrant, and allosteric inhibitor of glucosylceramide synthase. Ibiglustat (L-Malic acid) can be used in studies about PD Parkinson’s disease, S...		Transferase
T35028	Valiglurax	VU2957,VU 0652957,VU 2957,VU-0652957,VU0652957,VU-2957	GluR
	Valiglurax (VU2957), also known as VU0652957 and VU2957, is a potent, selective, CNS penetrant, and orally bioavailable mGlu4 PAM. VU2957 possessed attractive in vitro and in vivo pharmacological and DMPK properties acro...		GluR
T67729	UCM-1306		Dopamine Receptor
	UCM-1306 is a potent and orally active allosteric modulator (PAM) of human dopamine D1 receptor. UCM-1306 could increase the maximal effect of endogenous dopamine (DA) both in human and mouse D1 receptors. UCM-1306 could...		Dopamine Receptor
T26684	Auten-99 HBr	Auten-99,Auten-99 hydrochloride. Auten-99 HBr,Auten99,Auten 99	Phosphatase
	Auten-99 HBr (Auten-99) is a myotubularin phosphatase Jumpy inhibitor exerting potent neuroprotective effects. AUTEN-99 activates autophagy in cell cultures and animal models. AUTEN-99 appears to effectively penetrate th...		Phosphatase
T13049	Synucleozid	NSC 377363	Others
	Synucleozid is a potent the SNCA mRNA inhibitor that encodes α-synuclein protein (IC50=1.5 μM), has the potential for the investigation of Parkinson’s disease.		Others
T29133	VU0410150	VU-0410150,VU 0410150
	VU0410150, a pyrrylarylsulfone containing compound, has been found to be a mGluR4-positive allosteric modulator and has been evaluated as a potential drug for the treatment of Parkinson’s disease.
T13049L	Synucleozid hydrochloride (502139-01-7 free base)	Synucleozid hydrochloride,NSC 377363 hydrochloride	Others
	Synucleozid hydrochloride is a potent the SNCA mRNA inhibitor that encodes α-synuclein protein (IC50=1.5 μM), has the potential for the investigation of Parkinson’s disease.		Others
T11448	GOAT-IN-1		Others
	GOAT-IN-1 is an inhibitor of ghrelin O-acyltransferase (GOAT), which could be useful for the prophylaxis or treatment of diabetes, hyperlipidemia, non-alcoholic fatty liver, Alzheimer’s disease, Parkinson’s disease, cere...		Others
T61347	D4R antagonist-1
	D4R Antagonist-1, characterized by its potent and selective antagonistic action against D4 receptors with an IC50 value of 6.87 μM, holds potential for Parkinson’s disease research [1].
T75876	α-Conotoxin PIA TFA
	α-Conotoxin PIA TFA, targeting nicotinic acetylcholine receptor (nAChR) subtypes with α6 and α3 subunits, acts as an antagonist. This compound shows promise for research into Parkinson’s disease and schizophrenia [1].
T60573	MAO-B-IN-15
	MAO-B-IN-15 is a selective inhibitor of MAO-B that forms π-π interaction with Tyr 326 residue (IC 50 = 13.5 μM) which can be used in Parkinson’s disease research[1].
T40999	NMDA receptor antagonist 2
	NMDA receptor antagonist 2 is a highly potent and orally active NR2B subtype-selective antagonist of the N-methyl-D-aspartate (NMDA) receptor. It exhibits remarkable binding affinities, with an IC50 of 1.0 nM and a Ki va...
T78671	Glucocerebrosidase-IN-1 hydrochloride		Glucosidase
	Glucocerebrosidase-IN-1 (compound 11a) hydrochloride is a potent, selective GCase (glucocerebrosidase) inhibitor with IC50 and Ki values of 29.3 μM and 18.5 μM, respectively. It is utilized in the research of Gaucher dis...		Glucosidase
T60650	MAO-B-IN-13
	MAO-B-IN-13 (compound 12a) is a highly potent, reversible and blood-brain barrier (BBB) penetrant MAO-B inhibitor (IC50 = 10 nM). MAO-B-IN-13 shows neuroprotective and antioxidant activity which can be used in Parkinson’...
T12662	(Rac)-BL-918		Others
	(Rac)-BL-918 is the racemate of BL-918. BL-918 is a potent activator of UNC-51-like kinase 1 (ULK1) with an EC50 of 24.14 nM, inducing cytoprotective autophagy for Parkinson’s disease treatment [1].		Others
T80151	α-Synuclein 4554W
	α-Synuclein 4554W, previously identified through intracellular library screening, is an inhibitor of α-Synuclein (aSyn) aggregation and its associated toxicity. This compound, comprising GIVNGVKA sequences, effectively r...
T62054	D4R antagonis-2
	D4R antagonist-2 is a potent and selective D4R antagonist (IC50= 6.52 μM). D4R antagonist-2 displays favorable in vitro PK parameters and exhibits good brain penetration. D4R antagonist-2 has the research potential in Pa...
T73530	2-PAT
	2-PAT, analogous to Rasagiline and Selegiline, functions as a reversible MAO-A inhibitor, exhibiting an IC50 of 0.721 µM, and acts as an inactivator of MAO-B with an IC50 value of 14.6 µM. This compound shows promise for...
T83328	4A7C-301
	4A7C-301, a Nurr1 agonist, exhibits potent neuroprotective effects in vitro and markedly mitigates neuropathological abnormalities while enhancing motor and olfactory functions in male mouse models with AAV2-mediated α-s...
T72452	AChE/BChE/MAO-B-IN-2
	AChE/BChE/MAO-B-IN-2 is a potent inhibitor of the enzymes AChE, BChE, and MAO-B, with IC50 values of 48.2 nM, 83.9 nM, and 31.2 nM, respectively. It exhibits significant antioxidant activity and is applicable in Parkinso...
T60656	Monoamine Oxidase B inhibitor 1
	Monoamine Oxidase B inhibitor 1 is a potent, reversible, orally active and selective monoamine oxidase B (MAO-B) inhibitor (IC50 = 0.02 nM) that can across the blood-brain barrier (BBB). Monoamine Oxidase B inhibitor 1 s...
T37533	DOPAL
	DOPAL is an aldehyde product of the oxidative deamination of dopamine by monoamine oxidase.[1] It can be further oxidized to 3,4-dihydroxyphenylacetic acid (DOPAC) by aldehyde dehydrogenase (ALDH) and, to a lesser extent...
T60806	Monoamine Oxidase B inhibitor 2
	Monoamine Oxidase B inhibitor 2 is a potent, reversible, orally active and selective inhibitor of monoamine oxidase B (MAO-B) (IC50 = 1.33 nM) which can across the blood-brain barrier (BBB). Monoamine Oxidase B inhibitor...
T60658	HMAO-B/MB-COMT-IN-2
	hMAO-B/MB-COMT-IN-2 is a dual inhibitor of MAO-B/MB-COMT with IC 50s of 4.27 μΜ and 2.69 μΜ for hMAO-B and MB-COMT, respectively. hMAO-B/MB-COMT-IN-2 protects cells from oxidative damage that can be used in the neurodege...
T60489	HMAO-B/MB-COMT-IN-1
	hMAO-B/MB-COMT-IN-1 is a dual MAO-B/MB-COMT inhibitor with IC50s of 2.5 μΜ for hMAO-B and 3.84 μΜ for MB-COMT. hMAO-B/MB-COMT-IN-1 protects cells from oxidative damage that can be used in neurodegeneration disease resear...
T60353	Glucocerebrosidase-IN-1
	Glucocerebrosidase-IN-1 (compound 11a) is a potent and selective GCase (glucocerebrosidase) inhibitor, with an IC 50 of 29.3 μM and a K i of 18.5 μM. Due to GCase involvement in pathological disorders consequent to enzym...
T72314	α-Synuclein inhibitor 8
	α-Synuclein inhibitor 8 effectively impedes α-Synuclein aggregation and disaggregation with an IC50 of 2.5 µM, demonstrating substantial reduction in neuronal inclusion formation, which contributes to reparative effects ...
T60824	Dyrk1A-IN-3
	Dyrk1A-IN-3 (Compound 8b) is a highly selective inhibitor of dual-specificity tyrosine-regulated kinase 1A (DYRK1A). Dyrk1A-IN-3 has high binding affinity of DYRK1A with an IC 50 of 76 nM. Dyrk1A-IN-3 can be used in neur...
T74638	XL01126
	XL01126, a potent degrader of LRRK2, exhibits DC50 values of 14 nM (G2019S LRRK2) and 32 nM (WT LRRK2), respectively. It has the ability to cross the blood-brain barrier, making it a viable degrader probe for Parkinson’s...
T72280	PBT434 methanesulfonate
	PBT434 methanesulfonate is an orally active, potent α-synuclein aggregation inhibitor with the ability to cross the blood-brain barrier. Acting as an iron chelator, it modulates transcellular iron trafficking, inhibits i...

Compounds

YTX-465

T9722

Synonym:

Target: Stearoyl-CoA Desaturase (SCD)

MPTP hydrochloride

T4081

Synonym: MPTP-hydrochloride

Target: Apoptosis, Dopamine Receptor

Synonym: Ketone Ester

Target: Reactive Oxygen Species

Target: 5-HT Receptor

Synonym: GYY 4137 morpholine salt

Target: Others

Diphenylpyraline hydrochloride

T0059

Synonym: 4-Diphenylmethoxy-1-methylpiperidine hydrochloride

Target: Histamine Receptor

SKF-83566

T8702

Synonym:

Target: Dopamine Receptor, 5-HT Receptor, AChR

Zonisamide

T0267

Synonym: AD 810,CI 912

Target: Calcium Channel, Sodium Channel, Carbonic Anhydrase

Oxybuprocaine hydrochloride

T0378

Synonym: Risedronic Acid,Oxybuprocaine HCl

Target: Sodium Channel

Oxidopamine hydrochloride

T12352

Synonym: 6-Hydroxydopamine hydrochloride,6-OHDA hydrochloride

Target: Mitophagy, Dopamine Receptor, Autophagy

T22595

Synonym: Linazolamide intermediate B impurity 2,CPNQ,5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline

Target: Others, Sirtuin

Oxidopamine hydrobromide

T12352L

Synonym: 6-Hydroxydopamine hydrobromide,6-OHDA hydrobromide

Target: Mitophagy, Dopamine Receptor, Autophagy

Target: Adenosine Receptor

Target: Cannabinoid Receptor

Ibiglustat (L-Malic acid)

T11599

Synonym: Ibiglustat L-Malic acid,GZ402671 (L-Malic acid),Venglustat (L-Malic acid),SAR402671 (L-Malic acid)

Target: Transferase

Valiglurax

T35028

Synonym: VU2957,VU 0652957,VU 2957,VU-0652957,VU0652957,VU-2957

Target: Dopamine Receptor

Auten-99 HBr

T26684

Synonym: Auten-99,Auten-99 hydrochloride. Auten-99 HBr,Auten99,Auten 99

Synonym: VU-0410150,VU 0410150

Target:

Synucleozid hydrochloride (502139-01-7 free base)

T13049L

Synonym: Synucleozid hydrochloride,NSC 377363 hydrochloride

NMDA receptor antagonist 2

T40999

Synonym:

Target:

Glucocerebrosidase-IN-1 hydrochloride

Monoamine Oxidase B inhibitor 1

Monoamine Oxidase B inhibitor 2

Glucocerebrosidase-IN-1

T60353

Synonym:

Target:

α-Synuclein inhibitor 8

PBT434 methanesulfonate

T72280

Synonym:

Target:

Cat No.	Product Name	Synonyms	Targets
TN2423	Safranal		Antioxidant
	Safranal is the special volatile aroma compound of saffron		Antioxidant
T2S1200	Sinapine		Antioxidant , P-gp , AChE
	1. Sinapine, an alkaloid from seeds of the cruciferous species, can be used as an effective natural compound for chemo-resistance. 2. Sinapine has antioxidant and radio-protective activities.		Antioxidant , P-gp , AChE
T3392	Sinapine thiocyanate		P-gp , AChE
	Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds. It is the choline ester of Sinapic Acid (S486800). It is also a phenolic-chloine conjugates, acting as anti-o...		P-gp , AChE
TN6924	Anhydrosafflor yellow B	(2S,3S)-6,7-dihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2-[(1S,2R,3R)-1,2,3,4-tetrahydroxybutyl]-3-{2,3,4-trihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-oxo-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]cyclohexa-1,4-dien-1,AHSYB	Others
	Anhydrosafflor yellow B ((2S,3S)-6,7-dihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2-[(1S,2R,3R)-1,2,3,4-tetrahydroxybutyl]-3-{2,3,4-trihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-oxo-3-[(2R,3R,4S,5S,6R)-3,4,...		Others
T83281	6-(1-Hydroxyethyl)-5,6-dihydrochelerythrine
	6-(1-Hydroxyethyl)-5,6-dihydrochelerythrine, an alkaloid, markedly alters the characteristics of cellular organelles—specifically, early endosomes, mitochondria, and autophagosomes—in Parkinson’s Disease patient-derived ...
T75469	Neoechinulin C
	Neoechinulin C, an alkaloid in the echinulin class of indolediketopiperazine, shields neuronal cells from paraquat-induced damage in a Parkinson’s disease model [1].
T38606	Sinapine hydroxide
	Sinapine hydroxide, an alkaloid derived from the seeds of cruciferous plants, demonstrates a variety of beneficial properties including anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic, and radio-protective e...

Natural Products

Target: Antioxidant, P-gp, AChE

Anhydrosafflor yellow B

TN6924

Synonym: (2S,3S)-6,7-dihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2-[(1S,2R,3R)-1,2,3,4-tetrahydroxybutyl]-3-{2,3,4-trihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-oxo-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]cyclohexa-1,4-dien-1,AHSYB

Target: Others

6-(1-Hydroxyethyl)-5,6-dihydrochelerythrine

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-01051	Pleiotrophin/PTN Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	Pleiotrophin (PTN) is a secreted, strongly heparinbinding, developmentally regulated cytokine. PTN is a highly conserved protein，Human, mouse, rat, canine, porcine, equine and bovine PTN share 98% aa sequence identity or...

Pleiotrophin/PTN Protein, Mouse, Recombinant (His)

TMPJ-01051

Species: Mouse

Expression System: Human Cells

Cat No.	Product Name
L2620	Anti-Neurodegenerative Disease Compound Library	2150 compounds
	A unique collection of 2150 compounds related to neurodegenerative diseases can be used for HTS or HCS；
L9830	Anti-Parkinson's Disease Compound Library	908 compounds
	A unique collection of 908 compounds with anti-PD activities or acting on main drug targets of PD can be used for HTS and HCS.

Libraries

Anti-Neurodegenerative Disease Compound Library

L2620

Compounds: 2150

Anti-Parkinson's Disease Compound Library

L9830

Compounds: 908