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Search Results for " phosphorylase "

Targets

53

Compounds

10

Natural Products

7

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T37577 Glycogen Phosphorylase Inhibitor
Glycogen phosphorylase in the liver, muscle, and brain initiate glycogenolysis by releasing glucose-1-phosphate from glycogen. Glycogen phosphorylase inhibitor is a cell-permeable acyl urea first identified as an inhibit...
TP1056 Phosphorylase Kinase β-Subunit Fragment (420-436) Phosphorylase Kinase β-Subunit(420-436),Phosphorylase Kinase β-Subunit Fragment 420-436
Phosphorylase Kinase β-Subunit Fragment (420-436) is a peptide fragment (430-436) derived from the β-Subunit of phosphorylase kinase. Phosphorylase kinase, a serine/threonine-specific protein kinase, plays a crucial role...
T76100 Maltose phosphorylase
Maltose phosphorylase, a dimerase belonging to family 65 of the glycoside hydrolases [1], catalyzes the conversion of maltose and inorganic phosphate into β-D-glucose-1-phosphate and glucose.
T76103 Sucrose phosphorylase
Sucrose phosphorylase, a bacterial transglucosidase, catalyzes the conversion of sucrose and phosphate into α-D-glucose-1-phosphate and D-fructose. This enzyme can also hydrolyze glucosylated sucrose into α-D-glucose or ...
T76096 Purine nucleoside phosphorylase
Purine Nucleoside Phosphorylase, an essential enzyme in purine metabolism, plays a critical role in the purine salvage pathway. Its deficiency impairs T cell function. With inorganic orthophosphate as a co-substrate, thi...
T75401 D-galactosyl-β1-3-N-acetyl-D-hexosamine phosphorylase (BiGalHexNAcP)
D-galactosyl-β1-3-N-acetyl-D-hexosamine phosphorylase (BiGalHexNAcP), belonging to the CAZy glycoside hydrolase family GH112, plays a pivotal role in biochemical research. This enzyme catalyzes the phosphorolysis of lact...
T9727 2'-Fluoro-2'-Deoxyadenosine Nucleoside Antimetabolite/Analog
2'-Fluoro-2'-Deoxyadenosine is efficiently cleaved to the toxic 2-fluoroadenine (FAde) by Escherichia coli purine nucleoside phosphorylase (PNP). 2'-Fluoro-2'-Deoxyadenosine showed good in vivo activity against tumors ex...
T12399 Peldesine BCX 34 Nucleoside Antimetabolite/Analog , HIV Protease
Peldesine (BCX 34) is an effective, competitive, reversible, and orally active inhibitor of purine nucleoside phosphorylase. Peldesine inhibits T-cell proliferation with an IC50 of 800 nM. Peldesine can be used in resear...
T14141 AGI-24512 Others , Methionine Adenosyltransferase (MAT)
AGI-24512 is a inhibitor of methionine adenosyltransferase 2A (MATA2 ).It is useful for treatment of cancer and blocks growth of MTAP-deleted cancer cells in vitro.
T75398 UDP-sugar pyrophosphorylase (BlUSP)
UDP-sugar pyrophosphorylase (BlUSP) is an enzyme that activates glucose-1-phosphate (Glc-1-P) to UDP-glucose (UDP-Glc) and catalyzes the reversible transfer of the uridyl group from UTP to sugar-1-phosphate, resulting in...
T8493 Ingliforib GPi 296,CP 368296 Phosphorylase
Ingliforib (CP 368296) is a novel glycogen phosphorylase inhibitor,has antihyperglycemic and cardioprotective properties.
T0745 Disodium monofluorophosphate Sodium Monofluorophosphate,NSC248 Phosphatase , PKM , Phosphorylase
Disodium monofluorophosphate (NSC248) is a competitive inhibitor of pyruvate kinase and alkaline phosphatase, which also irreversibly inhibits phosphorylase phosphatase.
T7782 3'-Deoxyguanosine Others
3'-Deoxyguanosine is a ligand that can be complexed with enzymes, such as purine nucleoside phosphorylase, and receptors.
T15337 Forodesine BCX-1777,Immucillin-H Others
Forodesine is a potent human lymphocyte proliferation inhibitor. Forodesine is an orally active inhibitor of purine nucleoside phosphorylase (IC50s: 0.48 to 1.57 nM for human, mouse, rat, monkey, and dog PNP). It could i...
TQ0008 MT-DADMe-ImmA Methylthio-DADMe-Immucillin A,MTDIA Others
MT-DADMe-ImmA (MTDIA) is an inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP, Ki: 90 pM).
T10421 AVE5688 Phosphorylase
AVE5688 is an inhibitor of glycogen phosphorylase (GP, IC50s: 430 nM and 915 nM; Kds: 170 nM and 530 nM for rmGPb and rmGPa). It can be used for the research of type 2 diabetes.
T22683 CP-316819 CP 316819,GPi 819 Others
CP-316819 (GPi 819) is a potent inhibitor of glycogen phosphorylase (GPase) with hypoglycemic effects, inhibits huSMGPa and huLGPa, maintains neuronal activity during hypoglycemia, and can be used in the study of hypergl...
T2366 Tipiracil hydrochloride MA-1 hydrochloride Nucleoside Antimetabolite/Analog
Tipiracil hydrochloride (MA-1 hydrochloride) is a thymidine phosphorylase inhibitor (TPI). Tipiracil hydrochloride is one of the active components in TAS-102, which is an anticancer drug candidate currently in clinical t...
T67822L Ulodesine BCX4208 Endogenous Metabolite
Ulodesine (BCX4208) is a purine nucleoside phosphorylase (PNP) inhibitor that inhibits PNP with an IC50 value of 2.293 nM/L. Ulodesine may be used to study hyperuricaemia.
T6455 CP-91149 Phosphorylase
CP-91149 is a selective glycogen phosphorylase (GP) inhibitor with IC50 of 0.13 μM in the presence of glucose, 5- to 10-fold less potent in the absence of glucose.
T6745 5-Iodotubercidin 5-ITu,NSC 113939 Adenosine Receptor
5-Iodotubercidin (NSC-113939) is a potent adenosine kinase inhibitor with IC50 of 26 nM. It inhibits nucleoside transporter, CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC.
TNU0091 3'-Deoxy-3'-fluoroguanosine Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis
3'-Deoxy-3'-fluoroguanosine is a nucleoside phosphorylase inhibitor that inhibits RNA replication by binding replons. 3 '-Deoxy-3' -fluoroguanosine is used to treat viral hepatitis, cancer and other diseases.
T12908 SIBA 5'-Deoxy-5'-isobutylthioadenosine,5'-Isobutylthioadenosine Nucleoside Antimetabolite/Analog , HSV
SIBA (5'-Deoxy-5'-isobutylthioadenosine) is a synthetic analogue of SAH, acts as an inhibitor of S-adenosylmethionine-mediated transmethylation. SIBA can interfere with a variety of enzymatic activities in vitro, such as...
T1600 Doxifluridine Ro 21-9738,AMC 0101,5'-DFUR,5-Fluoro-5'-deoxyuridine Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis
Doxifluridine (AMC 0101) is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid degradation of 5-FU by...
T1349 5-Fluorouridine Others , DNA/RNA Synthesis
5-fluorouridine is also known as FUrd, 5-Fluorouracil 1-beta-D-ribofuranoside, 5-Fur, or 5-Fluoro-uridine. 5-fluorouridine is a solid. This compound belongs to the pyrimidine nucleosides and analogues. These are compound...
T22803 GPi 688 Others
glycogen phosphorylase inhibitor
T14964 CI 972 anhydrous CI 972 (anhydrous) Others
CI 972 anhydrous is an inhibitor of purine nucleoside phosphorylase (PNP) (Ki: 0.83 μM) used as a T cell-selective immunosuppressive agent.
T70939 8-Aminoinosine
8-Aminoinosine is an endogenous 8-aminopurine that induces diuresis, natriuresis, and glucosuria by inhibiting purine nucleoside phosphorylase (PNPase).
T68524 AVE 9423
AVE 9423 is an allosteric glycogen phosphorylase inhibitor.
T60343 Tipiracil
Tipiracil is an inhibitor of thymidine phosphorylase(TPase).
T70768 MDL-74428
MDL-74428 is an inhibitor of purine nucleoside phosphorylase.
T40410 Maltoheptaose hydrate
Maltoheptaose hydrate, a maltooligosaccharide composed of seven glucose units, serves as an activator of phosphorylase B for the preparation of heptulose-2-phosphate.
T62931 Antiangiogenic agent 2
Antiangiogenic agent 2 (compound 3b) is a potent inhibitor of thymidine phosphorylase (IC50: 39.71 μM) and exhibits anti-angiogenic effects.
T31048 CP-320626 CP 320626
CP-320626 is an effective inhibitor of glycogen phosphorylase A (LGPA) in the human liver and GPA in the human muscle. Can act synergistically with glucose. It is a possible target for the treatment of type 2 diabetes.
T31672 Erythrofuranosyladenine 9-β-D-Erythrofuranosyladenine,ETA
Erythrofuranosyladenine(9-beta-D-Erythrofuranosyladenine, ETA) is a nontoxic MTAP substrate. Erythrofuranosyladenine is an effective salvage agent for methylthioadenosine phosphorylase–selective therapy of T-cell acute l...
T19148 5-Aza-7-deazaguanine Others
5-Aza-7-deazaguanine is a substrate for E. coli purine nucleoside phosphorylase (wild-type/Ser90Ala mutant) in the synthesis of base-modified nucleosides.
TNU1023 7-Deaza-2’-deoxyadenosine
Nucleoside Derivatives –7-Deaza-purine nucleosides; Drugs and Inhibitors; Purine nucleoside phosphorylase inhibitor
T40932 Benzylacyclouridine 5-Benzylacyclouridine,BAU
Benzylacyclouridine (BAU) is a powerful and selective inhibitor of uridine phosphorylase, the initial enzyme involved in uridine catabolism. Additionally, it can regulate the cytotoxic adverse effects of 5-fluorouracil (...
T12162 N6-Methyladenosine 5'-monophosphate disodium salt Others
N6-Methyladenosine 5'-monophosphate disodium salt is a glycogen phosphorylase b activator(Ka of 22 µM).
T11313 Forodesine hydrochloride BCX-1777 hydrochloride,Immucillin-H hydrochloride Others
Forodesine hydrochloride (BCX-1777 hydrochloride), a potent inhibitor of human lymphocyte proliferation, effectively induces apoptosis in leukemic cells by elevating dGTP levels. This compound is an orally active, highly...
T78379 9-Deazaguanine Others
9-Deazaguanine is a nucleoside analog that exhibits potent inhibitory activity against purine nucleoside phosphorylase (PNP) [1].
T35416 α-D-Glucose-1-phosphate (sodium salt hydrate)
α-D-Glucose-1-phosphate is an intermediate in glycogen metabolism.1,2It is a precursor in the biosynthesis of UDP-glucose, the glucose donor in glycogen biosynthesis.2α-D-Glucose-1-phosphate can be formed during glycogen...
T74046 D-Ribofuranose1-dihydrogenphosphate dicyclohexanamine
D-Ribofuranose 1-dihydrogen phosphate dicyclohexanamine, commonly referred to as ribose 1-phosphate, serves as a precursor in the synthesis of 5-fluorouracil (FUra) via uridine phosphorylase [1].
T83684 Myelin Basic Protein Peptide (mouse, bovine) TFA Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu,MBP Peptide
Myelin basic protein (MBP) peptide, a selective substrate for protein kinase C (PKC) over protein kinase A (PKA), casein kinase 1 (CK1), CK2, phosphorylase kinase, and calcium/calmodulin-dependent protein kinase (CaMKII)...
T35777 Nodularin
The cyanobacterium Nodularia spumigena often contaminates the drinking water of rural communities in developing countries and accumulates in mussels, flounder, and cod from the northern Baltic Sea. Nodularin is a hepatot...
T76304 Adipokinetic hormone II (Locusta migratoria)
Adipokinetic hormone II (Locusta migratoria) (Lom-AKH-II), an insect adipokinetic hormone (AKH), elevates fat body cAMP levels in vitro. These hormones (AKHs) regulate the mobilization of carbohydrates and lipids from fa...
T35423 7-oxo Staurosporine
7-oxo Staurosporine is an antibiotic originally isolated from S. platensis with diverse biological activites. It inhibits PKC, PKA, phosphorylase kinase, EGFR, and c-Src in vitro (IC50s = 9, 26, 5, 200, and 800 nM, respe...
T83805 Rp-Adenosine-5'-O-(1-thiodiphosphate) sodium Rp-ADP-α-S
Rp-Adenosine-5'-O-(1-thiodiphosphate) (Rp-ADP-α-S), a sulfur-containing isomer of the nucleotide derivative ADP-α-S, acts as an inhibitor of phosphorylase kinase with an inhibition constant (Ki) of 0.53 µM. This compound...
T83806 Sp-Adenosine-5'-O-(1-thiodiphosphate) sodium Sp-ADP-α-S
Sp-Adenosine-5’-O-(1-thiodiphosphate) (Sp-ADP-α-S), an isomer of the sulfur-containing nucleotide derivative ADP-α-S, functions as an inhibitor of phosphorylase kinase with an inhibition constant (Ki) of 0.53 µM. This co...
T76306 Adipokinetic hormone I (Locusta migratoria)
Adipokinetic hormone I (Locusta migratoria) (Lom-AKH-I), an insect adipokinetic hormone (AKH), increases fat body cAMP levels in vitro. AKHs regulate the mobilization of carbohydrates and lipids from fat body stores for ...

Compounds

Glycogen Phosphorylase Inhibitor
T37577
Synonym:
Target:
Phosphorylase Kinase β-Subunit Fragment (420-436)
TP1056
Synonym: Phosphorylase Kinase β-Subunit(420-436),Phosphorylase Kinase β-Subunit Fragment 420-436
Target:
Maltose phosphorylase
T76100
Synonym:
Target:
Sucrose phosphorylase
T76103
Synonym:
Target:
Purine nucleoside phosphorylase
T76096
Synonym:
Target:
D-galactosyl-β1-3-N-acetyl-D-hexosamine phosphorylase (BiGalHexNAcP)
T75401
Synonym:
Target:
2'-Fluoro-2'-Deoxyadenosine
T9727
Synonym:
Target: Nucleoside Antimetabolite/Analog
Peldesine
T12399
Synonym: BCX 34
Target: Nucleoside Antimetabolite/Analog, HIV Protease
AGI-24512
T14141
Synonym:
Target: Others, Methionine Adenosyltransferase (MAT)
UDP-sugar pyrophosphorylase (BlUSP)
T75398
Synonym:
Target:
Ingliforib
T8493
Synonym: GPi 296,CP 368296
Target: Phosphorylase
Disodium monofluorophosphate
T0745
Synonym: Sodium Monofluorophosphate,NSC248
Target: Phosphatase, PKM, Phosphorylase
3'-Deoxyguanosine
T7782
Synonym:
Target: Others
Forodesine
T15337
Synonym: BCX-1777,Immucillin-H
Target: Others
MT-DADMe-ImmA
TQ0008
Synonym: Methylthio-DADMe-Immucillin A,MTDIA
Target: Others
AVE5688
T10421
Synonym:
Target: Phosphorylase
CP-316819
T22683
Synonym: CP 316819,GPi 819
Target: Others
Tipiracil hydrochloride
T2366
Synonym: MA-1 hydrochloride
Target: Nucleoside Antimetabolite/Analog
Ulodesine
T67822L
Synonym: BCX4208
Target: Endogenous Metabolite
CP-91149
T6455
Synonym:
Target: Phosphorylase
5-Iodotubercidin
T6745
Synonym: 5-ITu,NSC 113939
Target: Adenosine Receptor
3'-Deoxy-3'-fluoroguanosine
TNU0091
Synonym:
Target: Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis
SIBA
T12908
Synonym: 5'-Deoxy-5'-isobutylthioadenosine,5'-Isobutylthioadenosine
Target: Nucleoside Antimetabolite/Analog, HSV
Doxifluridine
T1600
Synonym: Ro 21-9738,AMC 0101,5'-DFUR,5-Fluoro-5'-deoxyuridine
Target: Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis
5-Fluorouridine
T1349
Synonym:
Target: Others, DNA/RNA Synthesis
GPi 688
T22803
Synonym:
Target: Others
CI 972 anhydrous
T14964
Synonym: CI 972 (anhydrous)
Target: Others
8-Aminoinosine
T70939
Synonym:
Target:
AVE 9423
T68524
Synonym:
Target:
Tipiracil
T60343
Synonym:
Target:
MDL-74428
T70768
Synonym:
Target:
Maltoheptaose hydrate
T40410
Synonym:
Target:
Antiangiogenic agent 2
T62931
Synonym:
Target:
CP-320626
T31048
Synonym: CP 320626
Target:
Erythrofuranosyladenine
T31672
Synonym: 9-β-D-Erythrofuranosyladenine,ETA
Target:
5-Aza-7-deazaguanine
T19148
Synonym:
Target: Others
7-Deaza-2’-deoxyadenosine
TNU1023
Synonym:
Target:
Benzylacyclouridine
T40932
Synonym: 5-Benzylacyclouridine,BAU
Target:
N6-Methyladenosine 5'-monophosphate disodium salt
T12162
Synonym:
Target: Others
Forodesine hydrochloride
T11313
Synonym: BCX-1777 hydrochloride,Immucillin-H hydrochloride
Target: Others
9-Deazaguanine
T78379
Synonym:
Target: Others
α-D-Glucose-1-phosphate (sodium salt hydrate)
T35416
Synonym:
Target:
D-Ribofuranose1-dihydrogenphosphate dicyclohexanamine
T74046
Synonym:
Target:
Myelin Basic Protein Peptide (mouse, bovine) TFA
T83684
Synonym: Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu,MBP Peptide
Target:
Nodularin
T35777
Synonym:
Target:
Adipokinetic hormone II (Locusta migratoria)
T76304
Synonym:
Target:
7-oxo Staurosporine
T35423
Synonym:
Target:
Rp-Adenosine-5'-O-(1-thiodiphosphate) sodium
T83805
Synonym: Rp-ADP-α-S
Target:
Sp-Adenosine-5'-O-(1-thiodiphosphate) sodium
T83806
Synonym: Sp-ADP-α-S
Target:
Adipokinetic hormone I (Locusta migratoria)
T76306
Synonym:
Target:
1 2
Cat No. Product Name Synonyms Targets
T8155 Maltoheptaose Phospholipase
Maltoheptaose is an activator of phosphorylase B for the preparation of heptulose-2-phosphate.
T3S1850 Bayogenin Others
Bayogenin is an alfalfa saponin, Bayogenin shows moderate potency of glycogen phosphorylase inhibition.
T1709 2'-Deoxyinosine Guanine deoxyriboside,Deoxyinosine Others , Endogenous Metabolite
2'-Deoxyinosine (Guanine deoxyriboside) inhibits the growth of human colon-carcinoma cell lines and is associated with purine nucleoside phosphorylase (PNP) deficiency.
T6680 Staurosporine Antibiotic AM-2282,AM-2282,CGP 41251 Apoptosis , PKA , Antibacterial , Antibiotic , Src , PKC , Antifungal
Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-Fgr, phosphorylase kinase and TAOK2. Staurosporine also induces...
TWP2911 Thymidine 5-Methyldeoxyuridine,Deoxyribothymidine,DThyd,NSC 21548,Thymidin Others , DNA/RNA Synthesis , Endogenous Metabolite
1. Thymidine (DThyd) overload due to Thymidine phosphorylase deficiency, and mitochondrial toxicity caused by antiviral Thymidine analogues.
T4720 6-Hydroxypyridin-2(1H)-one hydrochloride 2,6-Dihydroxypyridine hydrochloride Others , Endogenous Metabolite
6-Hydroxypyridin-2(1H)-one hydrochloride (2,6-Dihydroxypyridine hydrochloride) is used as a reagent to synthesize uridine phosphorylase inhibitors that increase Uridine (Urd) (U829910) levels. Uridine is a promising bioc...
T13539 Allopurinol riboside Others , Endogenous Metabolite , Parasite , Drug Metabolite
Allopurinol riboside is a metabolite of allopurinol with potency against parasites. Allopurinol riboside competitively inhibits the action of purine nucleoside phosphorylase on inosine with a Ki of 277 μM.
TN4188 Hederagonic acid Others
Hederagonic acid ,arjunolic acid, bayogenin, and 4-epi-hederagonic acid show moderate potency of glycogen phosphorylase inhibition with IC50 of 53-103 uM.
T15636 K-252a Antibiotic K 252a,Antibiotic SF 2370,SF2370 Others
K-252a is a staurosporine analog isolated from Nocardiopsis sp. soil fungi. K-252a inhibits protein kinase (IC50: 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphoryla...
TN4584 Morolic acid IL Receptor , COX , HIV Protease
Morolic acid and moronic acid have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an insulin sensitization with consequent changes of glucose, cholesterol and triglycerides, in part mediat...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-02279 Nucleoside phosphorylase/PNP Protein, Human, Recombinant (His) Human E. coli
Purine nucleoside phosphorylase (PNP) is a purine-metabolizing enzyme that catalyzes the reversible phosphorolysis of 6-oxypurine (deoxy)nucleosides to their respective bases and (deoxy)ribose-1-phosphate. It is a key en...
TMPY-04557 PHKG1 Protein, Human, Recombinant (GST) Human Baculovirus-Insect Cells
Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform, also known as Phosphorylase kinase subunit gamma-1 and PHKG1, is a member of the protein kinase superfamily and CAMK Ser/Thr protein kinase family. P...
TMPJ-01207 UPP1 Protein, Human, Recombinant (His) Human E. coli
Uridinephosphorylase 1 (UPP1) is a member of the family of pentosyltransferase. UPP1 catalyses the reversible phosphorolysis of uridine to uracil. The expression levels and the enzymatic activity of UPP1 are higher in h...
TMPY-03384 CALM2 Protein, Human, Recombinant (His) Human E. coli
Calmodulin 2, also known as CALM2, is a calmodulin. Calmodulin 2 mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). It is involved in a genetic pathway that regulates the centro...
TMPY-04573 CAMKIV Protein, Mouse, Recombinant (His & GST) Mouse Baculovirus-Insect Cells
Ca2+/ calmodulin-dependent protein kinase 4 (CAMKⅣ) belongs to the serine/threonine protein kinase family, and to the Ca2+/calmodulin-dependent protein kinase subfamily which is widely recognized as an essential enzyme i...
TMPY-04543 CAMKIV Protein, Human, Recombinant (GST) Human Baculovirus-Insect Cells
Ca2+/ calmodulin-dependent protein kinase 4 (CAMKⅣ) belongs to the serine/threonine protein kinase family, and to the Ca2+/calmodulin-dependent protein kinase subfamily which is widely recognized as an essential enzyme i...
TMPY-04759 CAMKIV Protein, Mouse, Recombinant Mouse Baculovirus-Insect Cells
Ca2+/ calmodulin-dependent protein kinase 4 (CAMKⅣ) belongs to the serine/threonine protein kinase family, and to the Ca2+/calmodulin-dependent protein kinase subfamily which is widely recognized as an essential enzyme i...
TargetMol