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Search Result

Search Results for " rok "

Targets

Neurokinin receptor ROCK

74

Compounds

14

Natural Products

8

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T2155 Thiazovivin ROCK
Thiazovivin, a ROCK inhibitor (IC50: 0.5 μM), increases the survival rate of hESC.
TQ0187 SR-3677 ROCK , Autophagy
SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).
T12747 ROCK2-IN-2 ROCK
ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).
T1870 Y-27632 ROCK , Apoptosis
Y-27632 dihydrochloride (Y-27632 2HCl) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 dihydrochloride also inhibits isolation-induced apoptosis in mouse prostate stem or progenitor cells.
T7391 SAR407899 ROCK , Rho
SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.
T15798 LX7101 ROCK , LIM Kinase , PKA
LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).
T7301 BDP5290 ROCK
BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.)
T12746 ROCK inhibitor-2 ROCK
ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2 (IC50s of 17 nM and 2 nM, respectively).
T1898 RKI-1447 RKI1447 ROCK
RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities.
T3513 GSK180736A GSK180736 ROCK , GRK , PKA
GSK180736A is an effective and selective GRK2 inhibitor (IC50: 0.77 μM) and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA (IC50: 30 μM), but highly effective against ROCK1 (IC50: 100 nM).
T2633 GSK429286A RHO-15 ROCK
GSK429286A (RHO-15) is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).
T14960 Chroman 1 ROCK
Chroman 1 is an inhibitor of ROCK2 (IC50: 1 nM).
T4095 ZINC00881524 ROCK inhibitor ROCK
ZINC00881524 (ROCK inhibitor) is an effective and specific ROCK inhibitor.
T2011 RKI1313 RKI 1313,RKI-1313 ROCK
RKI1313 (RKI-1313) was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasion.
T14989 CMPD101 ROCK , GRK , PKC
CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM). Which can be used for the study of heart failure. CMPD101 exhibits less selectively against GRK1, GRK5, ROCK-2 and PKCα with I...
T7885 Afuresertib hydrochloride ROCK , Akt , PKC
Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)
T4488 GSK-25 GSK25 ROCK , S6 Kinase , mTOR
GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested).
T13384L Y-33075 dihydrochloride CaMK , ROCK , PKC
Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).
T7648 HA-100 Myosin , PKA , PKC
HA-100 is an inhibitor of protein kinase
T2482 AT13148 ROCK , SGK , Akt , PKA , S6 Kinase
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
T1911 Afuresertib GSK2110183C,GSK2110183 ROCK , Akt , PKC
Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity.
T4276L Hydroxyfasudil Hydroxy-Fasudil,HA-1100 ROCK , PKA
Hydroxyfasudil (Hydroxy-Fasudil) is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).
T7764 CCG-222740 ROCK , Rho , Ras
CCG-222740 is an inhibitor of Rho/MRTF pathway
TQ0110 ROCK-IN-2 TC-S 7001,Azaindole 1 ROCK
ROCK-IN-2 (Azaindole 1) is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2.
TQ0319 Ripasudil K-115,Ripasudil hydrochloride dihydrate ROCK
Ripasudil (Ripasudil hydrochloride dihydrate) (K-115) hydrochloride dihydrate is a specific ROCK inhibitor (IC50s: 51/19 nM for ROCK1/ROCK2).
T3518 GSK269962A GSK269962B,GSK 269962,GSK269962A HCl ROCK , S6 Kinase
GSK269962A (GSK269962A HCl) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
T6867 Belumosudil KD025,Rezurock,ROCK inhibitor,SLx-2119 ROCK
Belumosudil (Rezurock) is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM).
T23308 SAR407899 hydrochloride ROCK
ATP-competitive ROCK inhibitor
T4276 Hydroxyfasudil Hydrochloride Hydroxyfasudil (HA-1100) HCl,HA 1100 hydrochloride ROCK
Hydroxyfasudil Hydrochloride (HA 1100 hydrochloride) is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).
T7552 H-1152 ROCK
H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).
T1606 Fasudil HA-1077,AT877 ROCK , Serine/threonin kinase , Calcium Channel , PKA , PKC , Autophagy
Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
T1725 Y-27632 dihydrochloride Y-27632 2HCl ROCK , Apoptosis
Y-27632 dihydrochloride (Y-27632 2HCl) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 dihydrochloride also inhibits isolation-induced apoptosis in mouse prostate stem or progenitor cells.
T7492 Ripasudil free base K-115 (free base) ROCK , Antibacterial
Ripasudil free base (K-115 (free base)) is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.
T3060 Fasudil hydrochloride Fasudil (HA-1077) HCl,HA-1077,Fasudil HCl,HA-1077 hydrochloride,AT-877 ROCK , Serine/threonin kinase , Calcium Channel , HIV Protease , PKA , PKC , Autophagy
Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.
TP1008 Neurokinin A α-Neurokinin,Substance K,Neuromedin L Neurokinin receptor
Neurokinin A (NKA), formerly known as Substance K, is a neurologically active peptide translated from the pre-protachykinin gene.
T10056 Neurokinin antagonist 1 Neuropeptide Y Receptor
Neurokinin antagonist 1 is a potent is a neuropeptide antagonist that can be used to study neurological disorders.
TP1363L Neurokinin B acetate(86933-75-7 free base) Neurokinin K Neurokinin receptor
Neurokinin B acetate(86933-75-7 free base) is the acetate form of Neurokinin B, which belongs to the tachykinin family. Neurokinin binds to neurokinin receptor 1 (NK1R), nk2r and NK3R, and mediates its biological effects...
TP1385 Neurokinin A(4-10) TFA(97559-35-8 free base) Neurokinin A(4-10) TFA Neurokinin receptor
Neurokinin A(4-10) TFA(97559-35-8 free base) is a tachykinin NK2 receptor agonist[1].
T22517 5,7-Dichlorokynurenic acid 5,7-dichlorokynurenic acid sodium,5,7-DCKA NMDAR
5,7-Dichlorokynurenic acid (5,7-dichlorokynurenic acid sodium) is an NMDA receptor antagonist.
T26116 Rokitamycin
Rokitamycin is a macrolide antibiotic produced from strains of Streptomyces kitasatoensis.
TP1279 Neurokinin B (TFA) Neurokinin B TFA
Neurokinin B TFA belongs to the tachykinin family.Neurokinin B binds to a series of GPCR, including neurokinin receptors 1 (NK1R), NK2R, and nk3r, to modulate their biological effects
T76426 [Lys5,MeLeu9,Nle10]Neurokinin A(4-10)
[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (LMN-NKA), a Neurokinin A analogue, serves as a selective and potent agonist for the NK2 receptor (NK2R). This compound exhibits prokinetic activity, making it a valuable tool for re...
T7559 Neurokinin A(4-10) Neurokinin A(4-10)(TFA) Neurokinin receptor
Neurokinin A(4-10)(TFA) is an agonist of tachykinin NK2 receptor .
TP2472 Leucopyrokinin Pglu-thr-ser-phe-thr-pro-arg-leu-NH2
Leucopyrokinin is a myotropic neuropeptide.
T80915 Tyr0-Neurokinin A
Tyr0-Neurokinin A, a member of the tachykinin peptide family, acts as an agonist for the Tacr2 receptor. It is utilized in research focused on insulin resistance, obesity, and diabetes [1] [2].
T76655 Prokineticin 2 Isoform 2 (human)
Prokineticin 2 Isoform 2 (human), a hypothalamic neuropeptide, regulates thermoregulation and energy metabolism while decreasing food intake in rodents. This isoform is implicated in the study of metabolic syndrome (MetS...
T70654 Ciprokiren
Ciprokiren is a renin inhibitor discovered by Roche. Ciprokinen inhibited human renin in a buffer and human plasma with an IC50 of 0.07 and 0.65 nmol/L, respectively. In animal models, acute and chronic administration of...
T82511 Ebdarokimab
Ebdarokimab (AK101), a humanized IgG1-κ antibody, is typically produced in Chinese Hamster Ovary (CHO) cells [1].
T80577 Varokibart
Varokibart (TEV-53275) is a human IgG4λ antibody that targets interleukin-5 (IL-5) [1].
T124721 7,8-Dihydrokawain-5-ol
7,8-Dihydrokawain-5-ol is a useful organic compound for research related to life sciences. The catalog number is T124721 and the CAS number is 52247-81-1.

Compounds

Thiazovivin
T2155
Synonym:
Target: ROCK
SR-3677
TQ0187
Synonym:
Target: ROCK, Autophagy
ROCK2-IN-2
T12747
Synonym:
Target: ROCK
Y-27632
T1870
Synonym:
Target: ROCK, Apoptosis
SAR407899
T7391
Synonym:
Target: ROCK, Rho
LX7101
T15798
Synonym:
Target: ROCK, LIM Kinase, PKA
BDP5290
T7301
Synonym:
Target: ROCK
ROCK inhibitor-2
T12746
Synonym:
Target: ROCK
RKI-1447
T1898
Synonym: RKI1447
Target: ROCK
GSK180736A
T3513
Synonym: GSK180736
Target: ROCK, GRK, PKA
GSK429286A
T2633
Synonym: RHO-15
Target: ROCK
Chroman 1
T14960
Synonym:
Target: ROCK
ZINC00881524
T4095
Synonym: ROCK inhibitor
Target: ROCK
RKI1313
T2011
Synonym: RKI 1313,RKI-1313
Target: ROCK
CMPD101
T14989
Synonym:
Target: ROCK, GRK, PKC
Afuresertib hydrochloride
T7885
Synonym:
Target: ROCK, Akt, PKC
GSK-25
T4488
Synonym: GSK25
Target: ROCK, S6 Kinase, mTOR
Y-33075 dihydrochloride
T13384L
Synonym:
Target: CaMK, ROCK, PKC
HA-100
T7648
Synonym:
Target: Myosin, PKA, PKC
AT13148
T2482
Synonym:
Target: ROCK, SGK, Akt, PKA, S6 Kinase
Afuresertib
T1911
Synonym: GSK2110183C,GSK2110183
Target: ROCK, Akt, PKC
Hydroxyfasudil
T4276L
Synonym: Hydroxy-Fasudil,HA-1100
Target: ROCK, PKA
CCG-222740
T7764
Synonym:
Target: ROCK, Rho, Ras
ROCK-IN-2
TQ0110
Synonym: TC-S 7001,Azaindole 1
Target: ROCK
Ripasudil
TQ0319
Synonym: K-115,Ripasudil hydrochloride dihydrate
Target: ROCK
GSK269962A
T3518
Synonym: GSK269962B,GSK 269962,GSK269962A HCl
Target: ROCK, S6 Kinase
Belumosudil
T6867
Synonym: KD025,Rezurock,ROCK inhibitor,SLx-2119
Target: ROCK
SAR407899 hydrochloride
T23308
Synonym:
Target: ROCK
Hydroxyfasudil Hydrochloride
T4276
Synonym: Hydroxyfasudil (HA-1100) HCl,HA 1100 hydrochloride
Target: ROCK
H-1152
T7552
Synonym:
Target: ROCK
Fasudil
T1606
Synonym: HA-1077,AT877
Target: ROCK, Serine/threonin kinase, Calcium Channel, PKA, PKC, Autophagy
Y-27632 dihydrochloride
T1725
Synonym: Y-27632 2HCl
Target: ROCK, Apoptosis
Ripasudil free base
T7492
Synonym: K-115 (free base)
Target: ROCK, Antibacterial
Fasudil hydrochloride
T3060
Synonym: Fasudil (HA-1077) HCl,HA-1077,Fasudil HCl,HA-1077 hydrochloride,AT-877
Target: ROCK, Serine/threonin kinase, Calcium Channel, HIV Protease, PKA, PKC, Autophagy
Neurokinin A
TP1008
Synonym: α-Neurokinin,Substance K,Neuromedin L
Target: Neurokinin receptor
Neurokinin antagonist 1
T10056
Synonym:
Target: Neuropeptide Y Receptor
Neurokinin B acetate(86933-75-7 free base)
TP1363L
Synonym: Neurokinin K
Target: Neurokinin receptor
Neurokinin A(4-10) TFA(97559-35-8 free base)
TP1385
Synonym: Neurokinin A(4-10) TFA
Target: Neurokinin receptor
5,7-Dichlorokynurenic acid
T22517
Synonym: 5,7-dichlorokynurenic acid sodium,5,7-DCKA
Target: NMDAR
Rokitamycin
T26116
Synonym:
Target:
Neurokinin B (TFA)
TP1279
Synonym: Neurokinin B TFA
Target:
[Lys5,MeLeu9,Nle10]Neurokinin A(4-10)
T76426
Synonym:
Target:
Neurokinin A(4-10)
T7559
Synonym: Neurokinin A(4-10)(TFA)
Target: Neurokinin receptor
Leucopyrokinin
TP2472
Synonym: Pglu-thr-ser-phe-thr-pro-arg-leu-NH2
Target:
Tyr0-Neurokinin A
T80915
Synonym:
Target:
Prokineticin 2 Isoform 2 (human)
T76655
Synonym:
Target:
Ciprokiren
T70654
Synonym:
Target:
Ebdarokimab
T82511
Synonym:
Target:
Varokibart
T80577
Synonym:
Target:
7,8-Dihydrokawain-5-ol
T124721
Synonym:
Target:
1 2
Cat No. Product Name Synonyms Targets
TQ0183 Narciclasine Lycoricidinol ROCK
Narciclasine (Lycoricidinol), a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.
TN2029 P-Hydroxy-5,6-dehydrokawain 4'-Hydroxydehydrokawain Others
p-Hydroxy-5,6-dehydrokawain (4'-Hydroxydehydrokawain) is isolated from Kawain.
TN1204 2,3-Dehydrokievitone Antifungal
2,3-Dehydrokievitone, an isoflavone extracted from Erythrina sacleuxii, has antimicrobial activity against methicillin-resistant Staphylococcus aureus infections by decreasing the expression of α-hemolysin.
T10191L 7-Chlorokynurenic acid 7-chloro-4-hydroxy-2-carboxyquinoline,7-CKA GluR , NMDAR
7-Chlorokynurenic acid (7-chloro-4-hydroxy-2-carboxyquinoline) is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B coagonist site. 7-Chlorokynurenic acid inhibits the reuptake...
TN1406 Dihydrokaempferol Aromadendrin Apoptosis , BCL
Dihydrokaempferol (Aromadendrin) is a natural product. It induces apoptosis and inhibits Bcl-2 and Bcl-xL expression, possesses anti-inflammatory, antioxidant, and anti-diabetic properties, it exhibits anti-inflammatory ...
T4591 Dihydrokavain Marindinin,7,8-Dihydrokavain,7,8-Dihydrokawain Others
Dihydrokavain (Marindinin), a prominent kavalactone in the kava plant, significantly contributes to the plant's anxiolytic effects, as evidenced by a study conducted on chicks.
TN2987 3Alaph-Tigloyloxypterokaurene L3 Others
3Alaph-Tigloyloxypterokaurene L3 is a natural product from Wedelia trilobata.
TN6178 Dihydrokaempferol 3-O-glucoside Aromadendrin 3-O-glucoside
Dihydrokaempferol 3-O-glucoside is a natural product for research related to life sciences. The catalog number is TN6178 and the CAS number is 31049-08-8.
TN4853 Pterokaurane R Others
Pterokaurane R is a natural product for research related to life sciences. The catalog number is TN4853 and the CAS number is 67349-43-3.
TN2920 3alpha-Angeloyloxypterokaurene L3 Others
3alpha-Angeloyloxypterokaurene L3 is a natural product from Wedelia trilobata.
TN6375 Dihydrokaempferide Aromadendrin 4'-methyl ether
Dihydrokaempferide is a natural product for research related to life sciences. The catalog number is TN6375 and the CAS number is 137225-59-3.
TN5039 Sorokinianin Antifection
Sorokinianin is a phytotoxin, it has antifungal activity, it is highly effective in suppressing spore germination of F. solani (75%) at 100 ug/ml concentration.
TN2921 3alpha-Cinnamoyloxypterokaurene L3 Others
3alpha-Cinnamoyloxypterokaurene L3 is a natural product for research related to life sciences. The catalog number is TN2921 and the CAS number is 79406-13-6.
TN4854 Pterokaurene L3 Others
Pterokaurene L3 is a natural product for research related to life sciences. The catalog number is TN4854 and the CAS number is 77658-38-9.

Natural Products

Narciclasine
TQ0183
Synonym: Lycoricidinol
Target: ROCK
p-Hydroxy-5,6-dehydrokawain
TN2029
Synonym: 4'-Hydroxydehydrokawain
Target: Others
2,3-Dehydrokievitone
TN1204
Synonym:
Target: Antifungal
7-Chlorokynurenic acid
T10191L
Synonym: 7-chloro-4-hydroxy-2-carboxyquinoline,7-CKA
Target: GluR, NMDAR
Dihydrokaempferol
TN1406
Synonym: Aromadendrin
Target: Apoptosis, BCL
Dihydrokavain
T4591
Synonym: Marindinin,7,8-Dihydrokavain,7,8-Dihydrokawain
Target: Others
3Alaph-Tigloyloxypterokaurene L3
TN2987
Synonym:
Target: Others
Dihydrokaempferol 3-O-glucoside
TN6178
Synonym: Aromadendrin 3-O-glucoside
Target:
Pterokaurane R
TN4853
Synonym:
Target: Others
3alpha-Angeloyloxypterokaurene L3
TN2920
Synonym:
Target: Others
Dihydrokaempferide
TN6375
Synonym: Aromadendrin 4'-methyl ether
Target:
Sorokinianin
TN5039
Synonym:
Target: Antifection
3alpha-Cinnamoyloxypterokaurene L3
TN2921
Synonym:
Target: Others
Pterokaurene L3
TN4854
Synonym:
Target: Others

Recombinant Proteins

Species：
Human (4)
Bovine (2)
Mouse (1)
Rat (1)
Expression System：
Baculovirus-Insect Cells (3)
HEK293 (3)
P. pastoris (1)
Yeast (1)
Tag：
His (5)
C-hFc (1)
His,GST (1)
Tag Free (1)
Cat No. Product Name Species Expression System
TMPY-00904 Urokinase/uPA Protein, Human, Recombinant (His) Human HEK293
Plasminogen activator, urokinase, also known as PLAU and uPA, is a serine protease which converts plasminogen to plasmin, a broad-spectrum protease active on extracellular matrix (ECM) components. It is involved in compl...
TMPY-02945 Prokineticin 1/EG-VEGF Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
EG-VEGF, also known as prokineticin-1, is a member of the AVIT (prokineticin) family. Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. EG-VEG...
TMPY-04626 Enterokinase/EK Protein, Bovine, Recombinant Bovine P. pastoris
Enterokinase is a member of the trypsin family of serine proteases. The precursor protein is cleaved into two chains which then forms a heterodimer linked by a disulfide bond. The heavy chain anchors enterokinase in the ...
TMPY-00519 Gastrokine 1 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
Gastrokine 1 (GKN1) belongs to the BRICHOS domain family and plays a major role in maintaining gastric mucosa integrity. GKN1 is highly expressed in gastric tissue and is secreted into the stomach but is not expressed in...
TMPK-00972 PK-1/PROK1 Protein, Mouse, Recombinant (hFc) Mouse HEK293
PK-1 (Ac10) is a baculovirus-encoded serine/threonine kinase,a pk-1 knockout AcMNPV failed to produce infectious progeny, while the pk-1 repair virus could rescue this defect.the kinase activity of PK-1 is essential in r...
TMPY-00274 Enterokinase Protein, Bovine, Recombinant (His) Bovine Yeast
TMPY-04504 Urokinase/uPA Protein, Rat, Recombinant (His) Rat HEK293
Plasminogen activator, urokinase, also known as PLAU and uPA, is a serine protease which converts plasminogen to plasmin, a broad-spectrum protease active on extracellular matrix (ECM) components. It is involved in compl...
TMPY-04559 CDC42BPB Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
CDC42BPB is a member of the serine / threonine protein kinase family that contains a Cdc42 / Rsc-binding p21 binding domain similar to that of PAK kinase. The kinase domain of this protein is related to the myotonic dyst...
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