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Search Results for " s1p "

Targets

69

Compounds

3

Natural Products

2

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T4031 S1p receptor agonist 1 S1p-receptor-agonist-1 S1P Receptor , LPL Receptor
S1p receptor agonist 1 (S1p-receptor-agonist-1) is an S1P receptor agonist.
T62517 S1p receptor agonist 2
S1p receptor agonist 2 (compound 1) is an agonist of the S1P5 receptor with a higher selectivity than S1P1 and/or S1P3 receptors.S1p receptor agonist 2 can be used in the endogenous SIP signaling system and in the mitiga...
T6923 Ozanimod RPC-1063 S1P Receptor , LPL Receptor
Ozanimod (RPC-1063) (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in trials studying the treatment of Crohn's Disease, Ulcerative Colitis, Multiple Sclerosis, and Relapsing Multiple Sclero...
T83910 S1PL-IN-31 Sphingosine-1-Phosphate Lyase Inhibitor 31,S1PL Inhibitor 31,S1P Lyase Inhibitor 31
S1PL-IN-31 is a dual-function chemical compound acting as an inhibitor of sphingosine-1-phosphate (S1P) lyase with an IC50 value of 210 nM and as an antagonist of the Smoothened (Smo) receptor with an IC50 of 440 nM. Dem...
T8461 SKI V Apoptosis , PI3K , S1P Receptor
SKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK,IC50 : 2 μM), and is a PI3K inhibitor(hPI3k,IC50 : 6 μM), induces apoptosis and has antitumor activity
T6403 Siponimod BAF-312 S1P Receptor , LPL Receptor
BAF312 (Siponimod (BAF-312)), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, respectively. The specificity of BAF312 for S1P1 and S1P5 receptors exhibi...
TQ0138 K145 hydrochloride Apoptosis , S1P Receptor
K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 µM and Ki of 6.4 µM. K145 hydrochloride can induce apoptosis and has strong antitumor activity.
T6085 PF-543 Sphingosine Kinase 1 Inhibitor II,PF 543 Apoptosis , S1P Receptor , Autophagy , LPL Receptor
PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.
T8840 PF-543 hydrochloride PF-543 Apoptosis , S1P Receptor , Autophagy , LPL Receptor
PF-543 hydrochloride (PF-543) inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.
T12821 S1PR1 modulator 1 LPL Receptor
S1PR1 modulator 1 is a selective inhibitor of S1PR1 with a pIC50 of 7.6.
T72294 S1P5 receptor agonist-1
S1P5 receptor agonist-1 (example 6) is a potent and selective agonist of S1P 5 receptor with an EC 50 value of 20 nM .
T63378 S1PR1 agonist 1
S1PR1 agonist 1 is a potent agonist of S1PR1. S1PR1 agonist 1 has potential in autoimmune diseases.
T62886 S1PR1 agonist 2
S1PR1 agonist 2 is a potent agonist of S1PR1. S1PR1 agonist 2 has potential for studies of autoimmune diseases.
T79817 S1P1 agonist 6 hemicalcium LPL Receptor
Compound I (S1P1 agonist 6 hemicalcium) is an S1P1 agonist that diminishes autoimmune activity by inhibiting lymphocyte trafficking, and serves as an immunosuppressive agent in researching a range of autoimmune diseases ...
T62732 S1P1 agonist 5
S1P1 agonist 5 is a selective, orally active S1P1 agonist. S1P1 agonist 5 inhibits the drainage of lymphocytes from lymphoid tissue into peripheral blood. S1P1 agonist 5 has potential for studies in multiple sclerosis (M...
T39798 S1P2 antagonist 1
S1P2 antagonist 1 is an orally bioavailable S1P2 antagonist against fibrotic diseases.
T28643 S1P1-IN-Ex26
S1P1-IN-Ex26 is a potent, selective antagonist of S1P1 receptor.
T79816 S1P1 agonist 6 LPL Receptor
Compound I (S1P1 agonist 6) is an S1P1 agonist that mitigates autoimmune activity by inhibiting lymphocyte trafficking and has potential as an immunosuppressive agent in autoimmune disease research [1].
T61639 S1P1 agonist 4
S1P1 agonist 4 has a better profile in both potency ( EC 50 < 0.05 mg/kg) and predicted human half-life (t1/2 ~ 5 days).
T10912 S1PR1-MO-1 Others
S1PR-MO-1 is a modulator of sphingosine-1-phosphate receptor and is used to study hyperproliferative inflammatory diseases.
T16833 S1P1 Agonist III Others
S1P1 Agonist III is an effective and orally active S1P1 agonist (EC50: 18 nM).
T12437 PF429242 dihydrochloride S1P Receptor
PF429242 dihydrochloride is a reversible and competitive inhibitor of S1P (IC50 of 175 nM).
T2539 Fingolimod hydrochloride Fingolimod (FTY720) HCl,FTY720 TRP/TRPV Channel , S1P Receptor , PAK , LPL Receptor
Fingolimod hydrochloride (FTY720) , a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).
T63047 SLP9101555 S1P Receptor , LPL Receptor
SLP9101555 is a potent and selective sphingosine kinase 2 (SphK2) inhibitor with a Ki of 90 nM.SLP9101555 has a high affinity for SphK2, which is 200-fold higher than that of SphK1.SLP9101555 dramatically reduces extrace...
T61112 SLF1081851 LPL Receptor
SLF1081851 is a Spns2 inhibitor. SLF1081851 inhibits S1P release with IC50 of 1.93 μM.
T38294 4-Deoxypyridoxine hydrochloride S1P Receptor
4-Deoxypyridoxine (4-DPD) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells. 4-DPD inhib...
T26866 BMS-960 BMS 960,BMS960 S1P Receptor
BMS-960 is an S1P agonist with potential anti-tumour activity for cancer research.
T38826 Vibozilimod Vibozilimod,SCD-044 S1P Receptor
Vibozilimod (SCD-044) is S1P receptor-1 (S1PR1) agonist .
T27864 LX-2931 LX 3305,LX2931,LX-3305,ACB20034,LX 2931,LX3305 S1P Receptor
LX-2931(LX-3305) is a sphingosine-1-phosphate cleavage enzyme (S1P) inhibitor for the treatment of rheumatoid arthritis.
T10762 Ceranib1 Others
Ceranib1 is an inhibitor of ceramidase. It inhibits the proliferation of ovarian cancer cells. Ceranib1 inhibits ceramidase activity toward an exogenous ceramide analog, induces the accumulation of multiple ceramide spec...
T15629 JTE-013 Apoptosis , S1P Receptor , LPL Receptor
JTE-013 is an effective and specific antagonist of S1P2. JTE-013 suppresses the specific binding of radiolabeled S1P to human and rat S1P2 (IC50s: 17 nM and 22 nM, respectively).
T76828 Sonepcizumab LT 1009 LPL Receptor
Sonepcizumab (LT 1009) is a fully humanized monoclonal antibody against S1P. Sonepcizumab has anti-cancer activity and can be used to study metastatic renal cell carcinoma (mRCC) to prevent eye scarring after glaucoma fi...
T22102 ML-178 CYM50179 Others
ML-178, a dichlorobenzene, is a potent and selective agonist of sphingosine-1-phosphate receptor 4 (S1PR4), with an EC50 of 46 nM, and has no effect on other S1P receptors at a concentration of 25 μM.
T10761 Ceranib-2 3-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]-4-phenyl-1H-quinolin-2-one Apoptosis , S1P Receptor
Ceranib-2 (3-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]-4-phenyl-1H-quinolin-2-one) is an inhibitor of ceramidase with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 decreases levels of sphingosine and S1P, induces cell apoptosis...
T22101 ML-031 S1P Receptor
ML-031 activated S1P2 with an EC50 value of 1 μM in an S1P reporter assay.
T28169 NIBR-0213 NIBR 0213 LPL Receptor
NIBR-0213, a potent and selective S1P(1) antagonist, has efficacy in experimental autoimmune encephalomyelitis.
T2026 CYM5442 S1P Receptor , LPL Receptor
CYM5442 is an S1P agonist, targeting to Sphingosine.
T6673 SKI II SphK-I2 Apoptosis , Wnt/beta-catenin , S1P Receptor
SKI II (SphK-I2) is a highly selective and non-ATP-competitive S1P receptor inhibitor (IC50: 0.5 μM) while exhibiting no inhibitory action on other kinases including PKCα, PI3K, and ERK2.
T22703 CYM-5520 CYM 5520 S1P Receptor , LPL Receptor
CYM-5520 is a noncompetitive allosteric agonist of S1P2
T0640 Benzyl butyl phthalate BBP,1,2-benzenedicarboxylic acid,butyl phenylmethyl ester,Butyl benzyl phthalate Others , Aryl Hydrocarbon Receptor
Benzyl butyl phthalate (1,2-benzenedicarboxylic acid) is used as a plasticizer for PVC.
T37113 Z62954982
Z62954982 (ZINC08010136) is a potent, selective and cell-permeable Rac1 (IC50=12 μM) inhibitor that is 4 times more effective than NSC23766 (IC50=50 μM). Z62954982 disrupts the Rac1/Tiam1 complex and decreases cytoplasmi...
T24822 SPM-242 racemate SPM 242 racemate,SPM242 racemate
SPM-242 racemate is an antagonist of S1P(3)-selective.
T37955 Sphingosine-1-phosphate (d16:1) Sphingosine-1-phosphate (d16:1)
C16 Sphingosine-1-phosphate (C16 S1P) is a derivative of sphingosine-1-phosphate that binds to S1P1/EDG-1, S1P3/EDG-3, and S1P2/EDG-5 receptors with affinities of 115%, 83%, and 103%, respectively, relative to S1P in CHO...
T28838 SPM-242 SPM 242
SPM-242 is an orthosteric agonist of Sphingosine 1-phosphate (S1P) and a bitopic antagonist. S1P is a lysophospholipid signaling molecule that regulates important biological functions, including vascular development and...
T70613 SLP120701 HCl
SLP120701 is a potent and selective sphingosine kinase 2 inhibitor. Sphingosine-1-phosphate (S1P) is a ubiquitous, endogenous small molecule that is synthesized by two isoforms of sphingosine kinase (SphK1 and 2). Interv...
T70614 SLR080811 HCl
SLR080811 is a SphK inhibitor. Sphingosine-1-phosphate (S1P) is a ubiquitous, endogenous small molecule that is synthesized by two isoforms of sphingosine kinase (SphK1 and 2). Intervention of the S1P signaling pathway h...
T36833 A6770
A6770 is an inhibitor of sphingosine-1-phosphate (S1P) lyase.1It induces accumulation of [3H]sphinganine-1-phosphate ([3H]dhS1P), an S1P lyase substrate, in IT-79MTNC3 cells that endogenously express high levels of S1P l...
T70900 VT-ME6
VT-ME6 is a potent and selective sphingosine kinase 2 inhibitor. VT-ME6, contained a quaternary ammonium group as a warhead and established that a positively charged moiety is necessary for engaging key amino acid residu...
T34402 RP-101075 RP101075
RP-101075 is a etabolite of Ozanimod. It exhibits a similar specificity profile as Ozanimod at the S1P receptor family in vitro, and pharmacodynamic profile in vivo.
T10387 ASP1126 Others
ASP1126 is a selective and orally active sphingosine-1-phosphate (S1P) agonist (EC50s: 7.12 nM, 517 nM for hS1P1 and hS1P3).

Compounds

S1p receptor agonist 1
T4031
Synonym: S1p-receptor-agonist-1
Target: S1P Receptor, LPL Receptor
S1p receptor agonist 2
T62517
Synonym:
Target:
Ozanimod
T6923
Synonym: RPC-1063
Target: S1P Receptor, LPL Receptor
S1PL-IN-31
T83910
Synonym: Sphingosine-1-Phosphate Lyase Inhibitor 31,S1PL Inhibitor 31,S1P Lyase Inhibitor 31
Target:
SKI V
T8461
Synonym:
Target: Apoptosis, PI3K, S1P Receptor
Siponimod
T6403
Synonym: BAF-312
Target: S1P Receptor, LPL Receptor
K145 hydrochloride
TQ0138
Synonym:
Target: Apoptosis, S1P Receptor
PF-543
T6085
Synonym: Sphingosine Kinase 1 Inhibitor II,PF 543
Target: Apoptosis, S1P Receptor, Autophagy, LPL Receptor
PF-543 hydrochloride
T8840
Synonym: PF-543
Target: Apoptosis, S1P Receptor, Autophagy, LPL Receptor
S1PR1 modulator 1
T12821
Synonym:
Target: LPL Receptor
S1P5 receptor agonist-1
T72294
Synonym:
Target:
S1PR1 agonist 1
T63378
Synonym:
Target:
S1PR1 agonist 2
T62886
Synonym:
Target:
S1P1 agonist 6 hemicalcium
T79817
Synonym:
Target: LPL Receptor
S1P1 agonist 5
T62732
Synonym:
Target:
S1P2 antagonist 1
T39798
Synonym:
Target:
S1P1-IN-Ex26
T28643
Synonym:
Target:
S1P1 agonist 6
T79816
Synonym:
Target: LPL Receptor
S1P1 agonist 4
T61639
Synonym:
Target:
S1PR1-MO-1
T10912
Synonym:
Target: Others
S1P1 Agonist III
T16833
Synonym:
Target: Others
PF429242 dihydrochloride
T12437
Synonym:
Target: S1P Receptor
Fingolimod hydrochloride
T2539
Synonym: Fingolimod (FTY720) HCl,FTY720
Target: TRP/TRPV Channel, S1P Receptor, PAK, LPL Receptor
SLP9101555
T63047
Synonym:
Target: S1P Receptor, LPL Receptor
SLF1081851
T61112
Synonym:
Target: LPL Receptor
4-Deoxypyridoxine hydrochloride
T38294
Synonym:
Target: S1P Receptor
BMS-960
T26866
Synonym: BMS 960,BMS960
Target: S1P Receptor
Vibozilimod
T38826
Synonym: Vibozilimod,SCD-044
Target: S1P Receptor
LX-2931
T27864
Synonym: LX 3305,LX2931,LX-3305,ACB20034,LX 2931,LX3305
Target: S1P Receptor
Ceranib1
T10762
Synonym:
Target: Others
JTE-013
T15629
Synonym:
Target: Apoptosis, S1P Receptor, LPL Receptor
Sonepcizumab
T76828
Synonym: LT 1009
Target: LPL Receptor
ML-178
T22102
Synonym: CYM50179
Target: Others
Ceranib-2
T10761
Synonym: 3-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]-4-phenyl-1H-quinolin-2-one
Target: Apoptosis, S1P Receptor
ML-031
T22101
Synonym:
Target: S1P Receptor
NIBR-0213
T28169
Synonym: NIBR 0213
Target: LPL Receptor
CYM5442
T2026
Synonym:
Target: S1P Receptor, LPL Receptor
SKI II
T6673
Synonym: SphK-I2
Target: Apoptosis, Wnt/beta-catenin, S1P Receptor
CYM-5520
T22703
Synonym: CYM 5520
Target: S1P Receptor, LPL Receptor
Benzyl butyl phthalate
T0640
Synonym: BBP,1,2-benzenedicarboxylic acid,butyl phenylmethyl ester,Butyl benzyl phthalate
Target: Others, Aryl Hydrocarbon Receptor
Z62954982
T37113
Synonym:
Target:
SPM-242 racemate
T24822
Synonym: SPM 242 racemate,SPM242 racemate
Target:
Sphingosine-1-phosphate (d16:1)
T37955
Synonym: Sphingosine-1-phosphate (d16:1)
Target:
SPM-242
T28838
Synonym: SPM 242
Target:
SLP120701 HCl
T70613
Synonym:
Target:
SLR080811 HCl
T70614
Synonym:
Target:
A6770
T36833
Synonym:
Target:
VT-ME6
T70900
Synonym:
Target:
RP-101075
T34402
Synonym: RP101075
Target:
ASP1126
T10387
Synonym:
Target: Others
1 2
Cat No. Product Name Synonyms Targets
T21500 Sphingosine-1-phosphate S1P Endogenous Metabolite , S1P Receptor , LPL Receptor
Sphingosine-1-phosphate (S1P) is an agonist for S1P1-5 receptors and a ligand for GPR3, GPR6, GPR12.Sphingosine-1-phosphate is an intracellular second messenger that mobilises Ca2+ as an extracellular ligand for G-protei...
T19778 2-ATHBI Others
2-ATHBI is a S1P lyase inhibitor.
T7939 Fingolimod FTY-720A,FTY-720 S1P Receptor , PAK , LPL Receptor
Fingolimod (FTY-720A) is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-04432 Sphingosine Kinase 1/SPHK1 Protein, Human, Recombinant Human Baculovirus-Insect Cells
SPHK1, also known as sphingosine Kinase 1, catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P). S1P exhibits a broad spectrum of biological activities including cell proliferation, survival...
TMPY-04431 Sphingosine Kinase 1/SPHK1 Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
SPHK1, also known as sphingosine Kinase 1, catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P). S1P exhibits a broad spectrum of biological activities including cell proliferation, survival...
TargetMol