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Cat No. | Product Name | Synonyms | Targets |
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T11035 | DiABZI STING agonist-1 (Tautomerism) | diABZI STING agonist (Compound 3) | STING |
diABZI STING agonist-1 (Tautomerism) (diABZI STING agonist (Compound 3)) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. | |||
T13015 | STING agonist-4 | STING | |
STING agonist-4 is an agonist of stimulator of Interferon Genes (STING) receptor(IC50 of 20 nM). | |||
T9853 | STING activator Compound 53 | STING | |
STING activator Compound 53 based on an oxindole core structure demonstrated robust on-target functional activation of STING (human EC50 185 nM) in immortalised and primary cells and a cytokine induction fingerprint cons... | |||
T8328 | STING agonist-1 | G10 | Virus Protease , STING |
STING agonist-1 (G10) is a human-specific STING agonist,elicits antiviral activity against emerging Alphaviruses. | |||
T9028 | STING-IN-2 | C-170 | STING |
STING-IN-2 (C-170) is a potent and covalent inhibitor of STING. C-170 efficiently inhibits both mouse STING (mmSTING) and human STING (hsSTING). It can be used for autoinflammatory disease research. | |||
T9029 | STING-IN-3 | C-171 | STING |
STING-IN-3 (C-171) is an inhibitor of stimulator of interferon genes (STING). It binds to STING, inhibits its palmitoylation, and prevents the recruitment and phosphorylation of TBK1. | |||
T5516 | DiABZI STING agonist-1 trihydrochloride | STING | |
diABZI STING agonist-1 (trihydrochloride) is stimulator of interferon genes (STING) receptor agonist. | |||
T60000 | STING (WT/R232) activity regulator 126 | STING | |
STING (WT/R232) activity regulator 126 is a STING modulator with antibacterial and antiviral effects. | |||
T38161 | STING Agonist C11 | STING Agonist C11 | |
STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.1 It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 μM. STING agonist C11 induces phosphory... | |||
T74809 | STING agonist-30 | STING | |
STING agonist-30 is a potent activator of the STING-dependent immune response, demonstrating significant inhibitory effects on a range of viruses such as herpes simplex virus (HSV), rotavirus, and severe acute respirator... | |||
T5154 | C-176 | C176,STING inhibitor 1 | STING |
C-176 (STING inhibitor 1) is a strong, covalent mouse STING inhibitor | |||
T13014L | STING agonist-3 trihydrochloride | STING agonist-3 trihydrochloride (2138299-29-1 free base) | Others |
STING agonist-3 trihydrochloride is a selective and non-nucleotide agonist of small-molecule STING(pEC50 and pEC50 of 7.5 and 9.5, respectively), has durable anti-tumor effect and tremendous potential to improve treatme... | |||
T38159 | STING Agonist 12b | ||
STING agonist 12b is an agonist of stimulator of interferon genes (STING).1It binds to STING (Kd= 26.4 μM) and induces interferon reporter gene expression in cells expressing human or mouse STING (EC50s = 7.45 and 10.23 ... | |||
T38160 | STING Agonist 1a | ||
STING agonist 1a is an agonist of stimulator of interferon genes (STING).1It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC50= 16.77 μM). STING agonist 1a (12.5-100 μM) induces expres... | |||
T13906 | STING ligand-1 | Others | |
STING ligand-1 is a lead STING ligand(IC50 of 68 nM for HAQ STING). | |||
T13014 | STING agonist-3 | Others | |
STING agonist-3 is a selective and non-nucleotide small-molecule STING agonist(pEC50 and pIC50 of 7.5 and 9.5, respectively), has durable anti-tumor effect and tremendous potential to improve treatment of cancer. | |||
T75161 | STING agonist-31 | ||
STING agonist-31 is a STING agonist, with EC 50 values of 0.24 and 39.51 μM for h-STING and m-STING. STING agonist-31 has antitumor efficiency [1] . | |||
T74621 | STING agonist-9 | ||
STING agonist-9 (Compound 45) is a potent STING agonist with an EC 50 of 1.2 nM and 32.82 μM against h-STING and m-STING, respectively. STING agonist-9 shows antitumor activity [1] . | |||
T63458 | STING agonist-11 | ||
STING agonist-11 is a potent activator of the small molecule cyclic urea class of STING (EC50: 18 nM).STING activation is a highly promising immunotherapy. | |||
T72688 | STING agonist-20 | ||
STING agonist-20 is a potent STING agonist used in the synthesis of XMT-2056. STING agonist-20 can be used as a vaccine adjuvant in the study of cancer and other inflammatory, immune diseases . | |||
T81084 | STING agonist-18 | ||
STING Agonist-18 (Compound 1a) is a precursor for the synthesis of antibody-drug conjugates (ADCs), including Trastuzumab conjugates [1]. | |||
T75097 | STING agonist-29 | ||
STING agonist-29 (CF511) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING , exhibits activity against SARS-CoV series strains [1] . | |||
T75095 | STING agonist-27 | ||
STING agonist-27 (CF509) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING , exhibits activity against SARS-CoV series strains [1] . | |||
T75091 | STING agonist-23 | ||
STING agonist-23 (CF502) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING , increases phosphorylation of STING , TBK1 and IRF3 . STING agonist-23 promotes the levels of IFN-β , IL-6 , CX... | |||
T75093 | STING agonist-25 | ||
STING agonist-25 (CF505) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING , increases phosphorylation of STING , TBK1 and IRF3 . STING agonist-23 promotes the levels of IFN-β , IL-6 , CX... | |||
T75096 | STING agonist-28 | ||
STING agonist-28 (CF510) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING , increases phosphorylation of STING , TBK1 and IRF3 . STING agonist-23 promotes the levels of IFN-β , IL-6 , CX... | |||
T75092 | STING agonist-24 | ||
STING agonist-24 (CF504) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING , increases phosphorylation of STING , TBK1 and IRF3 . STING agonist-23 promotes the levels of IFN-β , IL-6 , CX... | |||
T63457 | STING agonist-10 | ||
STING agonist-10 is a potent activator of the STING small molecule cyclic urea class (EC50: 2600 nM).STING activation is a highly promising immunotherapy. | |||
T72614 | STING modulator-3 | ||
STING modulator-3 is a STING inhibitor. STING modulator-3 inhibits R232 STING with an K i value of 43.1 nM in scintillation proximity assay. STING modulator-3 has no effect on IRF-3 activation or TNF-β induction in THP-1... | |||
T81082 | STING-IN-7 | STING | |
STING-IN-7 (compound 21) serves as a potent inhibitor of the stimulator of interferon genes (STING) pathway, demonstrating an inhibitory concentration (IC50) of 11.5 nM. It effectively hampers the phosphorylation of both... | |||
T74267 | STING agonist-17 | ||
STING agonist-17 (compound 4a) is a potent STING agonist with an IC 50 value of 0.062 nM. STING agonist-17 has anti-cancer activity for tumor immunization [1] . | |||
T75090 | STING agonist-22 | ||
STING agonist-22 (CF501) is a potent non-nucleotide STING agonist. STING agonist-22 is a adjuvant by activating STING to induce the type I interferon (IFN-I) response and proinflammatory cytokine production. STING agonis... | |||
T83775 | STING Agonist 12L | Stimulator of Interferon Genes Agonist 12L | |
STING agonist 12L is a stimulator of interferon genes (STING) agonist that exhibits binding affinity for both wild-type STING and its variants R232, AQ, and Q with half-maximal inhibitory concentrations (IC50s) of 1.15 µ... | |||
T74896 | PROTAC STING Degrader-1 | ||
PROTAC STING Degrader-1 (Compound SP23) is a STING PROTAC degrader with a DC 50 of 3.2 μM. PROTAC STING Degrader-1 shwos anti-inflammatory activity [1] . | |||
T61043 | STING agonist-7 | ||
STING agonist-7 is an agonist of non-nucleotide STING that binds selectively to mouse STING but not human STING [1]. | |||
T75094 | STING agonist-26 | ||
STING agonist-26 (CF508) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING , increases phosphorylation of STING , TBK1 and IRF3 . STING agonist-23 promotes the levels of IFN-β , IL-6 , CX... | |||
T74719 | STING-IN-6 | ||
STING-IN-6 (compound 50) is a potent STING inhibitor with a pIC 50 of 8.9. STING-IN-6 has the potential for immunity research [1] . | |||
T74268 | STING agonist-13 | ||
STING agonist-13 is a stimulator of interferon genes ( STING ) agonist, for cancer immunity via STING-mediated immune activation. STING agonist-13 can stimulate STING downstream signaling and promoting type I interferon ... | |||
T72615 | STING modulator-4 | ||
STING modulator-4 is a competitive STING modulator with a K i of 0.0933 μM for R232H STING . STING modulator-4 has an EC 50 of >10 μM for p-IRF3 in THP-1 cell . | |||
T74718 | STING modulator-5 | ||
STING modulator-5 (compound 38) is a STING modulator with a pIC 50 value of 9.5. STING modulator-5 antagonizes peripheral blood mononuclear cells (PBMC) with a pIC 50 value of 8.1. STING modulator-5 is a antagonist of TH... | |||
T75011 | STING-IN-5 | STING | |
STING-IN-5, a potent inhibitor of the Stimulator of Interferon Genes (STING) pathway, significantly suppresses lipopolysaccharide (LPS)-induced nitric oxide (NO) synthesis in macrophages, exhibiting an IC50 of 1.15 μM. T... | |||
T81083 | STING agonist-19 | ||
STING agonist-19 serves as a precursor for the synthesis of immune-stimulating antibody conjugates (ISACs). | |||
T83841 | STING Agonist D61 | D61,Stimulator of Interferon Genes Agonist D61 | |
STING agonist D61 is a compound that activates the stimulator of interferon genes (STING), leading to the induction of IFN3-inducible secreted alkaline phosphatase (SEAP) and IFN-β-inducible reporter genes in cellular as... | |||
T74328 | STING agonist-8 dihydrochloride | ||
STING agonist-8 dihydrochloride (compound 5-AB) is a potent STING agonist with an EC 50 of 27 nM in THP1-Dual KI-hSTING-R232 cells [1] . | |||
T73746 | DiABZI STING agonist-1 | ||
diABZI STING agonist-1 is a selective stimulator of interferon genes (STING) receptor agonist, with EC 50 s of 130, 186 nM for human and mouse, respectively. | |||
T74676 | STING agonist-20-Ala-amide-PEG2-C2-NH2 | ||
STING agonist-20-Ala-amide-PEG2-C2-NH2 is an active scaffold comprising a stimulator of interferon genes (STING). STING agonist-20-Ala-amide-PEG2-C2-NH2 can be used to synthesize immune-stimulating antibody conjugate (IS... | |||
T74677 | STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA | ||
STING agonist-20-Ala-amide-PEG2-C2-NH2 (Compound 30b) TFA is an active scaffold comprising a stimulator of interferon genes ( STING ). STING agonist-20-Ala-amide-PEG2-C2-NH2 TFA can be used to synthesize immune-stimulati... | |||
T9119 | SU0268 | Others | |
SU0268 is a potent and specific 8-Oxoguanine DNA glycosylase 1 (OGG1) inhibitor. SU0268 regulates inflammatory responses during Pseudomonas aeruginosa infection. | |||
T7329 | C-178 | STING | |
C-178 is a covalent inhibitor of STING, binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells. | |||
T13613 | ChX710 | STING | |
ChX710 could prime the type I interferon response to cytosolic DNA, which specific cellular Interferon-Stimulated Genes (ISGs), induces the ISRE promoter sequence, and the phosphorylation of Interferon Regulatory Factor ... |
Cat No. | Product Name | Synonyms | Targets |
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T10909 | Cyclic-di-GMP | c-di-GMP,cyclic diguanylate,5GP-5GP | Others |
Cyclic-di-GMP is a STING agonist and ubiquitous second messenger, which regulates the formation, motility and virulence of biofilms in various bacterial species. | |||
T72243 | Cyclic-di-GMP diammonium | 5GP-5GP diammonium,c-di-GMP diammonium ; cyclic diguanylate diammonium ; 5GP-5GP diammonium,c-di-GMP diammonium,cyclic diguanylate diammonium | |
Cyclic di-GMP (c-di-GMP) diammonium is a STING activator and a global bacterial second messenger, which regulates biofilm formation, motility, and virulence in diverse bacterial species . | |||
T64248 | Cyclic-di-GMP sodium | ||
Cyclic di-GMP sodium (c-di-GMP sodium) is a STING activator and a ubiquitous second messenger that regulates biofilm formation, motility and virulence of various bacteria. | |||
T73717 | CGAMP diammonium | ||
cGAMP (Cyclic GMP-AMPP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STIN... | |||
T13606L | CGAMP disodium | ||
cGAMP disodium is a cyclic dinucleotide (CDN) found in bacteria that acts as an endogenous second messenger affecting interferon production in response to cytoplasmic DNA. cGAMP disodium cascades signals from type I inte... |
Cat No. | Product Name | Species | Expression System |
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TMPJ-01206 | Sting Protein, Human, Recombinant (Sumo & His) | Human | E. coli |
Stimulator of Interferon Gene(Sting,TMEM173) belongs to the TMEM173 family. STING is 379 amino acids (aa) in length. It contains an N-terminal cytoplasmic region (aa 1-20), four transmembrane segments (aa 21-173), and a ... | |||
TMPH-01645 | MGP Protein, Human, Recombinant (His) | Human | E. coli |
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery t... | |||
TMPH-01653 | MLANA Protein, Human, Recombinant (His) | Human | Yeast |
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery t... | |||
TMPH-01652 | MLANA Protein, Human, Recombinant (B2M & His) | Human | E. coli |
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery t... | |||
TMPH-02079 | SPTLC2 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a... | |||
TMPH-02078 | Semenogelin-1/SEMG1 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a... |