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Search Result

Search Results for " sphk "

Targets

Apoptosis Wnt/beta-catenin S1P Receptor

19

Compounds

1

Natural Products

2

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T6673 SKI II SphK-I2 Apoptosis , Wnt/beta-catenin , S1P Receptor
SKI II (SphK-I2) is a highly selective and non-ATP-competitive S1P receptor inhibitor (IC50: 0.5 μM) while exhibiting no inhibitory action on other kinases including PKCα, PI3K, and ERK2.
T16128 MP-A08 S1P Receptor
MP-A08 is a highly selective ATP competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 (Ki: 6.9 ± 0.8 μM and 27 ± 3 μM, respectively).
T4658 MHP Methyl caprooyl tyrosinate S1P Receptor
MHP (Methyl caprooyl tyrosinate) is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein production in KC.
T6750 Opaganib ABC294640 S1P Receptor
Opaganib (ABC294640) is an orally active and specific sphingosine kinase-2 (SphK2) inhibitor (IC50: 60 μM).
T8461 SKI V Apoptosis , PI3K , S1P Receptor
SKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK,IC50 : 2 μM), and is a PI3K inhibitor(hPI3k,IC50 : 6 μM), induces apoptosis and has antitumor activity
T9014 SKI-178 Apoptosis , S1P Receptor
SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during ...
TQ0064 Peretinoin NIK333 HCV Protease , Retinoid Receptor , S1P Receptor , Autophagy
Peretinoin (NIK333) is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR.
TQ0138 K145 hydrochloride Apoptosis , S1P Receptor
K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 µM and Ki of 6.4 µM. K145 hydrochloride can induce apoptosis and has strong antitumor activity.
T6085 PF-543 Sphingosine Kinase 1 Inhibitor II,PF 543 Apoptosis , S1P Receptor , Autophagy , LPL Receptor
PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.
T8840 PF-543 hydrochloride PF-543 Apoptosis , S1P Receptor , Autophagy , LPL Receptor
PF-543 hydrochloride (PF-543) inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.
T9992 SphK1&2-IN-1 S1P Receptor
SphK1&2-IN-1 is a sphingosine kinase inhibitor with anti-inflammatory, antitumor and hemostatic effects.
T63835 SphK1-IN-2
SphK1-IN-2 is a potent and selective SphK1 inhibitor that acts on both SphK1 (IC50: 19.81 nM) and SphK2 (IC50>10 nM). sphK1-IN-2 induces cell cycle arrest and apoptosis, exhibits anti-proliferative effects, and can be us...
T63618 SphK2-IN-1
SphK2-IN-1 is an SphK2 inhibitor with an IC50 value of 0.359 μM. SphK2-IN-1 can be used to study cancer, inflammation, neurological and cardiovascular diseases.
T63017 SphK2-IN-2
SphK2-IN-2 (21g) is a potent and selective inhibitor of SphK2 (IC50: 0.23 μM).
T61965 SphK1-IN-1
SphK1-IN-1 is an inhibitor of SphK1 with anti-tumor activity. SphK1-IN-1 inhibits the ATPase of SphK1, IC50=2.48 μM. SphK1-IN-1 has the value of cancer research.
T23045 N,N-Dimethylsphingosine Others
sphingosine kinase (SphK) inhibitor
T28504 RB-042 HCl RB 042,RB042,RB-042 hydrochloride,RB-042
RB-042 is SphK inhibitor.
T63132 Amgen-23
Amgen-23 (compound 23) is a potent inhibitor of sphingosine kinase (SPHK), acting on SPHK1 (IC50: 20 μM) and SPHK2 (IC50: 1.6 μM). amgen-23 can be used in anticancer studies.
T70614 SLR080811 HCl
SLR080811 is a SphK inhibitor. Sphingosine-1-phosphate (S1P) is a ubiquitous, endogenous small molecule that is synthesized by two isoforms of sphingosine kinase (SphK1 and 2). Intervention of the S1P signaling pathway h...
Cat No. Product Name Synonyms Targets
TQ0198 Phorbol 12-myristate 13-acetate PMA NF-κB , S1P Receptor , PKC
Phorbol 12-myristate 13-acetate (PMA) belongs to the phorbol ester group of natural products and is an activator of PKC, SphK, and NF-κB. Phorbol 12-myristate 13-acetate induces THP1 cell differentiation.

Natural Products

Phorbol 12-myristate 13-acetate
TQ0198
Synonym: PMA
Target: NF-κB, S1P Receptor, PKC

Recombinant Proteins

Species：
Human (2)
Expression System：
Baculovirus-Insect Cells (2)
Tag：
His,GST (1)
Tag Free (1)
Cat No. Product Name Species Expression System
TMPY-04432 Sphingosine Kinase 1/SPHK1 Protein, Human, Recombinant Human Baculovirus-Insect Cells
SPHK1, also known as sphingosine Kinase 1, catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P). S1P exhibits a broad spectrum of biological activities including cell proliferation, survival...
TMPY-04431 Sphingosine Kinase 1/SPHK1 Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
SPHK1, also known as sphingosine Kinase 1, catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P). S1P exhibits a broad spectrum of biological activities including cell proliferation, survival...
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