Search Result

Search Results for " tmem173 "

Targets

Compounds

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T13015	STING agonist-4		STING
	STING agonist-4 is an agonist of stimulator of Interferon Genes (STING) receptor(IC50 of 20 nM).		STING
T13613	ChX710		STING
	ChX710 activates the type I interferon response to cytosolic DNA by priming specific Interferon-Stimulated Genes (ISGs), inducing the ISRE promoter sequence, and facilitating the phosphorylation of Interferon Regulatory ...		STING
T7329	C-178		STING
	C-178 is a covalent inhibitor of STING, binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells.		STING
T9853	STING activator Compound 53		STING
	STING activator Compound 53 based on an oxindole core structure demonstrated robust on-target functional activation of STING (human EC50 185 nM) in immortalised and primary cells and a cytokine induction fingerprint cons...		STING
T6919	Omaveloxolone	RTA-408	Apoptosis , Others , Nrf2 , STING
	Omaveloxolone (RTA-408) (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.		Apoptosis , Others , Nrf2 , STING
T9554	SN-008		STING
	SN-008 is a less active analog SN-011 which is a STING antagonist. SN-008 can be used as a negative control.		STING
T5674	H-151		STING
	H-151 is a highly potent and selective STING antagonist. H-151 covalently binds to Cys91 of STING and inhibits palmitoylation of Cys91, thereby inhibiting STING activity. H-151 can be used in the study of autoinflammator...		STING
T8655	SR-717		STING
	SR-717 is a cGAMP analog, a non-nucleoside STING agonist that induces a "closed" activation conformation of STING. SR-717 has antitumor activity and promotes activation of immune cells and cross-presentation of antigens.		STING
T8798	MSA-2		STING
	MSA-2 is a potent and orally available non-nucleotide STING agonist.		STING
T9029	STING-IN-3	C-171	STING
	STING-IN-3 (C-171) is an inhibitor of stimulator of interferon genes (STING). It binds to STING, inhibits its palmitoylation, and prevents the recruitment and phosphorylation of TBK1.		STING
T5154	C-176	C176,STING inhibitor 1	STING
	C-176 (STING inhibitor 1) is a strong, covalent mouse STING inhibitor		STING
T5516	DiABZI STING agonist-1 trihydrochloride		STING
	diABZI STING agonist-1 (trihydrochloride) is stimulator of interferon genes (STING) receptor agonist.		STING
T8328	STING agonist-1	G10	Virus Protease , STING
	STING agonist-1 (G10) is a human-specific STING agonist,elicits antiviral activity against emerging Alphaviruses.		Virus Protease , STING
T9028	STING-IN-2	C-170	STING
	STING-IN-2 (C-170) is a potent and covalent inhibitor of STING. C-170 efficiently inhibits both mouse STING (mmSTING) and human STING (hsSTING). It can be used for autoinflammatory disease research.		STING
T7081	CCCP	Carbonyl Cyanide m-Chlorophenylhydrazone,Carbonyl cyanide 3-chlorophenylhydrazone	Apoptosis , IκB/IKK , COX , Mitochondrial Metabolism , STING , IFNAR , Antibacterial
	CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. CCCP inhibits the activation of STING and its downstream signaling molecules ...
T9137	SN-011	[1,1'-Biphenyl]-4-carboxamide, N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl]-,GUN35901	STING
	SN-011 (GUN35901) is a STING inhibitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease. It is a demethyl analogue of DUN99845.		STING
T10252L2	ADU-S100 ammonium salt	ML RR-S2 CDA ammonium salt,MIW815 ammonium salt	STING
	ADU-S100 ammonium salt (ML RR-S2 CDA ammonium salt) is an activator of stimulator of interferon genes (STING). ADU-S100 ammonium salt leads to potent and systemic tumor regression and immunity.		STING
T6273	Vadimezan	DMXAA,5,6-Dimethylxanthenone-4-acetic Acid,NSC 640488,ASA-404	Influenza Virus , VDA , STING , IFNAR
	Vadimezan (DMXAA) is a vascular disrupting agent, a murine STING agonist, and an inducer of cytokines such as type I IFN. Vadimezan has antitumor activity and induces a rapid cessation of blood flow in tumors without aff...		Influenza Virus , VDA , STING , IFNAR
T39829	BPK-25
	BPK-25 is an active acrylamide compound that enhances the degradation of proteins in the nucleosome remodeling and deacetylation (NuRD) complex through a post-translational mechanism involving covalent protein interactio...

Compounds

STING activator Compound 53

Target: Apoptosis, Others, Nrf2, STING

Synonym: C176,STING inhibitor 1

Target: STING

diABZI STING agonist-1 trihydrochloride

Target: Virus Protease, STING

Synonym: Carbonyl Cyanide m-Chlorophenylhydrazone,Carbonyl cyanide 3-chlorophenylhydrazone

Target: Apoptosis, IκB/IKK, COX, Mitochondrial Metabolism, STING, IFNAR, Antibacterial

SN-011

T9137

Synonym: [1,1'-Biphenyl]-4-carboxamide, N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl]-,GUN35901

Target: STING

ADU-S100 ammonium salt

T10252L2

Synonym: ML RR-S2 CDA ammonium salt,MIW815 ammonium salt

Target: STING

Vadimezan

T6273

Synonym: DMXAA,5,6-Dimethylxanthenone-4-acetic Acid,NSC 640488,ASA-404

Target: Influenza Virus, VDA, STING, IFNAR

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-01206	Sting Protein, Human, Recombinant (Sumo & His)	Human	E. coli
	Stimulator of Interferon Gene(Sting,TMEM173) belongs to the TMEM173 family. STING is 379 amino acids (aa) in length. It contains an N-terminal cytoplasmic region (aa 1-20), four transmembrane segments (aa 21-173), and a ...
TMPH-01827	Human Papilloma Virus type 11 (HPV 11) Protein E7 (His & Myc)	HPV 11	E. coli
	Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery t...
TMPH-01836	Human Papilloma Virus type 18 (HPV 18) Protein E7 (E. coli, His)	HPV 18	E. coli
	Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery t...
TMPH-01838	Human Papilloma Virus type 52 (HPV 52) Protein E7 (His & SUMO)	HPV 52	E. coli
	Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery t...
TMPH-01837	Human Papilloma Virus type 18 (HPV 18) Protein E7 (His)	HPV 18	Yeast
	Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery t...
TMPH-01834	Human Papilloma Virus type 16 (HPV 16) Protein E7 (His)	HPV 16	E. coli
	Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery t...
TMPH-00900	Human adenovirus C serotype 5 Early E1A protein (His & SUMO)	HAdV-5	E. coli
	Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery t...