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Search Result

Search Results for " tyk2 "

72

Compounds

38

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T39314 JAK1/TYK2-IN-1 JAK1/TYK2-IN-1
JAK1/TYK2-IN-1 is a dual inhibitor of TYK2 and JAK1 ( IC 50 = 29 and 41 nM respectively).
T13237L Ropsacitinib Tyk2-IN-8,PF-06826647 Tyrosine Kinases
Ropsacitinib (PF-06826647) is a selective TYK2 inhibitor, which binds to TYK2 catalytically active JH1 domain (IC50: 17 nM).
T13232 TyK2-IN-2 PDE
TyK2-IN-2 is a selective inhibitor of TYK2 (IC50s: 7 nM, 0.1 μM, and 0.05 μM for TYK2 JH2, IL-23, and IFNα).
T13234 Tyk2-IN-5 Others
Tyk2-IN-5 is a selective and orally active inhibitor of Tyk2 JH2 (Ki: 0.086 nM for Tyk2 JH2; IC50: 25 nM for IFNα).
T13237 Tyk2-IN-9 Others
Tyk2-IN-9 (Compound 26), a selective Tyk-2 inhibitor, exhibits IC50 values of 0.076 nM for TYK2-JH2 and 1.8 nM for JAK1-JH2, respectively. This specificity makes it suitable for research into inflammatory or autoimmune d...
T13233 Tyk2-IN-3 Tyrosine Kinases
Tyk2-IN-3 is an inhibitor of Tyk2 pseudokinase (IC50: 485 nM).
T13235 Tyk2-IN-7 Others
Tyk2-IN-7 is an inhibitor of TYK2 JH2, binds to the TYK2 JH2 domain (IC50: 0.00053 μM; Ki.app: 0.00007 μM).
T62451 TYK2-IN-12
TYK2-IN-12 (compound 30) is a selective, orally active inhibitor of TYK2 (tyrosine kinase 2) (Ki: 0.51 nM). TYK2-IN-12 inhibits IL-12-induced IFNγ in human and mouse whole blood with IC50 values of 2.7 and 7.0 μM, respec...
T61658 TYK2-IN-11
TYK2-IN-11 (Compound 5B) is a potent and selective inhibitor of Tyk-2, providing inhibition to TYK2-JH2 and JAK1-JH2 with IC50 values of 0.016 nM and 0.31 nM, respectively. This compound demonstrates potential for advanc...
T63146 JAK2/TYK2-IN-1
JAK2/TYK2-IN-2 is a potent and selective inhibitor of TYK2 (IC50: 9 nM) and JAK2 (IC50: 157 nM) with anti-inflammatory effects.
T64265 JAK1/TYK2-IN-3
JAK1/TYK2-IN-3 is a selective, potent, orally active dual inhibitor of TYK2 (IC50: 6 nM) and JAK1 (IC50: 37 nM).JAK1/TYK2-IN-3 selectively acts on both JAK2 and JAK3 with IC50 values of 140 nM and 362 nM.JAK1/TYK2 -IN-3 ...
T75026 PROTAC TYK2 degradation agent1 PROTACs
PROTAC TYK2 Degradation Agent1 is a potent, subtype-selective degrader of TYK2, exhibiting degradation activity with a DC50 of 14 nM. It is utilized in autoimmune disease research [1].
T72421 LRRK2/NUAK1/TYK2-IN-1
LRRK2/NUAK1/TYK2-IN-1 (compound 226) exhibits inhibitory activity against LRRK2 (Wt), LRRK2 (G2019), TYK2, and NUAK1, demonstrating IC50 values below 10 nM. This compound is useful for research into autoimmune diseases.
T12266 Ilginatinib NS-018 Tyrosine Kinases , JAK
Ilginatinib (NS-018) is a highly active and orally bioavailable inhibitor of JAK2.
T12266L2 Ilginatinib hydrochloride NS-018 hydrochloride Tyrosine Kinases , JAK
Ilginatinib hydrochloride (NS-018 hydrochloride) is a highly active and orally bioavailable inhibitor of JAK2.
T12266L Ilginatinib maleate NS-018 maleate Tyrosine Kinases , JAK
Ilginatinib maleate (NS-018 maleate) is a highly active and orally bioavailable inhibitor of JAK2.
T22338 2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide GDC046 Others , JAK
2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity, physicochemical properties and pharmacokinetic profile.
T22142 RO8191 RO4948191,CDM-3008 HCV Protease , HBV , JAK , IFNAR , STAT
RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.
T6104 Cerdulatinib hydrochloride Cerdulatinib,PRT2070,PRT062070 hydrochloride,PRT062070,PRT2070 hydrochloride MLK , c-Fms , Tyrosine Kinases , Hippo pathway , JAK , Syk
Cerdulatinib hydrochloride (PRT2070 hydrochloride) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively. Also inhibits 19...
T5049 NVP-BSK805 NVP-BSK805 2HCl,BSK 805 Tyrosine Kinases , JAK
NVP-BSK805 (BSK 805) is an ATP-competitive JAK2 inhibitor.
T22416 RO495 CS-2667 Tyrosine Kinases , JAK
RO495 (CS-2667), a potent inhibitor of TYK2, inhibits TYK2 with IC50 of 1.5nM as tested in cell-based pharmacological assays
T14687 Deucravacitinib BMS-986165 Tyrosine Kinases , JAK , IFNAR , Interleukin
Deucravacitinib (BMS-986165) inhibits IL-12/23 and type I IFN pathways[1][2]. BMS-986165 is a highly selective, orally bioavailable allosteric TYK2 inhibitor for the treatment of autoimmune diseases. Which selectively bi...
T4210 SAR-20347 SAR20347 Tyrosine Kinases , JAK
SAR-20347 is an inhibitor of TYK2, JAK1/2/3 (IC50: 0.6/23/26/41 nM).
T1929 Filgotinib GLPG0634 Tyrosine Kinases , JAK
Filgotinib (GLPG0634) is a selective JAK1 inhibitor. The IC50 values against JAK1, JAK2, JAK3, and TYK2 are 10 nM, 28 nM, 810 nM, and 116 nM, respectively.
T6790 BMS-911543 BMS911543 Tyrosine Kinases , Histone Methyltransferase , JAK
BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. Phase 1/2.
T3080 Pyridone 6 Janus-Associated Kinase Inhibitor I,JAK Inhibitor,CMP 6,JAK Inhibitor I Tyrosine Kinases , JAK
Pyridone 6 (JAK Inhibitor)(CMP 6) is a potent and selective inhibitor of JAK1 (IC50=15 nM, murine JAK1), JAK2 (IC50=1 nM), JAK3 (Ki=5 nM), and Tyk2 (IC50=1 nM); displaying significantly weaker affinities (130 nM to 10 mM...
T61494 JAK-IN-21 Tyrosine Kinases , JAK
JAK-IN-21 is a selective and potent JAK inhibitor that inhibits JAK1, JAK2, J2V617F and TYK2 with IC50 values of 1.73, 2.04, 109 and 62.9 nM, respectively.
TQ0010 Brepocitinib PF-06700841 Tyrosine Kinases , JAK
Brepocitinib (PF-06700841) is a potent dual JAK1/TYK2 inhibitor (IC50s: 17 nM/23 nM). Brepocitinib also inhibits JAK2/3 (IC50s: 77 nM/6.49 μM).
T62902 NDI-034858 TAK-279,NDI-03485 IL Receptor , Tyrosine Kinases
NDI-034858 (TAK-279) is a tyrosine kinase 2 (TYK2) inhibitor (Kd<200 pM) that targets the JH2 structural domain of Tyk2 for the treatment of autoimmune diseases caused by aberrant expression of IL12 and IL23.
T3076 GLPG0634 analog GLPG0634 analogue Tyrosine Kinases , JAK
GLPG0634 analog (GLPG0634 analogue) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for JAK1/2/3 and TYK2, respectively.
T17019 TCS 21311 NIBR3049 GSK-3 , JAK , PKC
TCS 21311 (NIBR3049) is an effective and highly selective inhibitor of JAK3 (IC50: 8 nM). TCS 21311 inhibits PKCα, PKCθ, and GSK3β (IC50s: 13, 68, and 3 nM, respectively). It displays >100-fold selectivity over JAK1, JAK...
T2487 Cerdulatinib PRT2070,PRT062070 Tyrosine Kinases , JAK , Syk
Cerdulatinib (PRT2070) is an novel oral dual Syk/JAK inhibitor.
T6294 NVP-BSK805 2HCl (1092499-93-8(free base)) NVP-BSK805 dihydrochloride,BSK 805,NVP-BSK805 (dihydrochloride) Tyrosine Kinases , JAK
NVP-BSK805 2HCl (1092499-93-8(free base)) (BSK 805)(IC50=0.5 nM), a specific and effective ATP-competitive JAK2 inhibitor, is more than 20-fold specificity over JAK1, JAK3 and TYK2.
T15096 Delgocitinib JTE-052,Corectim（Delgocitinib） Tyrosine Kinases , JAK
Delgocitinib (Corectim(Delgocitinib)) is a potent and specific JAK inhibitor with an IC50 value of 2.8, 2.6, 13 and 58 nM against JAK1, JAK2, JAK3 and Tyk2. Delgocitinib is involved in a variety of inflammatory and autoi...
T12427 Brepocitinib P-Tosylate PF-06700841 P-Tosylate JAK
Brepocitinib P-Tosylate (PF-06700841 P-Tosylate) is a potent dual inhibitor of Janus kinase 1 (JAK1) and TYK2 (IC50s of 17 nM and 23 nM, respectively).
T5091 FM-381 FM381 JAK
FM381 is a potent covalent reversible inhibitor of JAK3. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.
T9195 SHR0302 ARQ252 Apoptosis , JAK
SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity for JAK1 is more than 10 times for JAK2, 77 times for JAK3, 420 times for Tyk2).
T3069 AZD-1480 JAK
AZD1480 is a novel ATP-competitive JAK2 inhibitor (IC50: 0.26 nM), selectivity act against Tyk2 and JAK3, and to a smaller extent against JAK1. AZD1480 has been used in trials studying the treatment of Solid Malignancies...
TQ0037 Abrocitinib PF-04965842 JAK
Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2).
T6380 AMG 900 AMG900,AMG-900 p38 MAPK , Tyrosine Kinases , Aurora Kinase
AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM. It is >10-fold selective for Aurora kinases than p38α, Tyk2, JNK2, Met and Tie2. Phase 1.
T3998 Itacitinib INCB39110,INCB039110 JAK
Itacitinib (INCB039110) is an orally bioavailable inhibitor of Janus-associated kinase 1 (JAK1) with potential antineoplastic activity.
T2638 Gandotinib LY2784544 VEGFR , FGFR , FLT , JAK
LY2784544(Gandotinib (LY2784544)) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM). The selectivity is higher 8- and 20-fold than JAK1 and JAK3.
T2636 Decernotinib VX-509,VRT-831509 Tyrosine Kinases , JAK
Decernotinib (VRT-831509)(VX-509; VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays.
T3620 Solcitinib GLPG-0778,GSK-2586184 JAK
Solcitinib (GLPG-0778) (GSK2586184, GLPG0778) is a JAK1 inhibitor. Solcitinib may be potentially used for the treatment of psoriasis, ulcerative colitis, and systemic lupus erythematosus.
T14669 BMS-066 IκB/IKK , Tyrosine Kinases
BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor. With IC50s of 9 nM and 72 nM, respectively.
T11704 JAK-IN-3 CCR
JAK-IN-3 is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively.
T16488 PF-06263276 Others
PF-06263276 is an effective and selective inhibitor of pan-JAK. It also has IC50s of 2.2 nM, 23.1 nM, 59.9 nM and 29.7 nM for JAK1, JAK2, JAK3, and TYK2, respectively.
T70214 BMS-986202
BMS-986202 is a novel Tyk2 inhibitor, binding to Tyk2 JH2, showing efficacies for IL-23-driven acanthosis, anti-CD40-induced colitis, and spontaneous lupus.
T39858 NVP-BSK805 trihydrochloride NVP-BSK805 trihydrochloride
NVP-BSK805 trihydrochloride is a potent ATP-competitive inhibitor of JAK2, exhibiting IC50 values of 0.48 nM, 31.63 nM, 18.68 nM, and 10.76 nM against JAK2 JH1, JAK1 JH1, JAK3 JH1, and TYK2 JH1, respectively.
T78175 JAK-IN-25 JAK
JAK-IN-25 (compound 19), a potent JAK inhibitor, exhibits IC50 values of 6 nM for TYK2, 21 nM for JAK1, 8 nM for JAK2, and 1051 nM for JAK3. It also demonstrates an IC50 of 28 nM against human whole blood IL-12 (HEB IL-1...

Compounds

JAK1/TYK2-IN-1
T39314
Synonym: JAK1/TYK2-IN-1
Target:
Ropsacitinib
T13237L
Synonym: Tyk2-IN-8,PF-06826647
Target: Tyrosine Kinases
TyK2-IN-2
T13232
Synonym:
Target: PDE
Tyk2-IN-5
T13234
Synonym:
Target: Others
Tyk2-IN-9
T13237
Synonym:
Target: Others
Tyk2-IN-3
T13233
Synonym:
Target: Tyrosine Kinases
Tyk2-IN-7
T13235
Synonym:
Target: Others
TYK2-IN-12
T62451
Synonym:
Target:
TYK2-IN-11
T61658
Synonym:
Target:
JAK2/TYK2-IN-1
T63146
Synonym:
Target:
JAK1/TYK2-IN-3
T64265
Synonym:
Target:
PROTAC TYK2 degradation agent1
T75026
Synonym:
Target: PROTACs
LRRK2/NUAK1/TYK2-IN-1
T72421
Synonym:
Target:
Ilginatinib
T12266
Synonym: NS-018
Target: Tyrosine Kinases, JAK
Ilginatinib hydrochloride
T12266L2
Synonym: NS-018 hydrochloride
Target: Tyrosine Kinases, JAK
Ilginatinib maleate
T12266L
Synonym: NS-018 maleate
Target: Tyrosine Kinases, JAK
2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
T22338
Synonym: GDC046
Target: Others, JAK
RO8191
T22142
Synonym: RO4948191,CDM-3008
Target: HCV Protease, HBV, JAK, IFNAR, STAT
Cerdulatinib hydrochloride
T6104
Synonym: Cerdulatinib,PRT2070,PRT062070 hydrochloride,PRT062070,PRT2070 hydrochloride
Target: MLK, c-Fms, Tyrosine Kinases, Hippo pathway, JAK, Syk
NVP-BSK805
T5049
Synonym: NVP-BSK805 2HCl,BSK 805
Target: Tyrosine Kinases, JAK
RO495
T22416
Synonym: CS-2667
Target: Tyrosine Kinases, JAK
Deucravacitinib
T14687
Synonym: BMS-986165
Target: Tyrosine Kinases, JAK, IFNAR, Interleukin
SAR-20347
T4210
Synonym: SAR20347
Target: Tyrosine Kinases, JAK
Filgotinib
T1929
Synonym: GLPG0634
Target: Tyrosine Kinases, JAK
BMS-911543
T6790
Synonym: BMS911543
Target: Tyrosine Kinases, Histone Methyltransferase, JAK
Pyridone 6
T3080
Synonym: Janus-Associated Kinase Inhibitor I,JAK Inhibitor,CMP 6,JAK Inhibitor I
Target: Tyrosine Kinases, JAK
JAK-IN-21
T61494
Synonym:
Target: Tyrosine Kinases, JAK
Brepocitinib
TQ0010
Synonym: PF-06700841
Target: Tyrosine Kinases, JAK
NDI-034858
T62902
Synonym: TAK-279,NDI-03485
Target: IL Receptor, Tyrosine Kinases
GLPG0634 analog
T3076
Synonym: GLPG0634 analogue
Target: Tyrosine Kinases, JAK
TCS 21311
T17019
Synonym: NIBR3049
Target: GSK-3, JAK, PKC
Cerdulatinib
T2487
Synonym: PRT2070,PRT062070
Target: Tyrosine Kinases, JAK, Syk
NVP-BSK805 2HCl (1092499-93-8(free base))
T6294
Synonym: NVP-BSK805 dihydrochloride,BSK 805,NVP-BSK805 (dihydrochloride)
Target: Tyrosine Kinases, JAK
Delgocitinib
T15096
Synonym: JTE-052,Corectim（Delgocitinib）
Target: Tyrosine Kinases, JAK
Brepocitinib P-Tosylate
T12427
Synonym: PF-06700841 P-Tosylate
Target: JAK
FM-381
T5091
Synonym: FM381
Target: JAK
SHR0302
T9195
Synonym: ARQ252
Target: Apoptosis, JAK
AZD-1480
T3069
Synonym:
Target: JAK
Abrocitinib
TQ0037
Synonym: PF-04965842
Target: JAK
AMG 900
T6380
Synonym: AMG900,AMG-900
Target: p38 MAPK, Tyrosine Kinases, Aurora Kinase
Itacitinib
T3998
Synonym: INCB39110,INCB039110
Target: JAK
Gandotinib
T2638
Synonym: LY2784544
Target: VEGFR, FGFR, FLT, JAK
Decernotinib
T2636
Synonym: VX-509,VRT-831509
Target: Tyrosine Kinases, JAK
Solcitinib
T3620
Synonym: GLPG-0778,GSK-2586184
Target: JAK
BMS-066
T14669
Synonym:
Target: IκB/IKK, Tyrosine Kinases
JAK-IN-3
T11704
Synonym:
Target: CCR
PF-06263276
T16488
Synonym:
Target: Others
BMS-986202
T70214
Synonym:
Target:
NVP-BSK805 trihydrochloride
T39858
Synonym: NVP-BSK805 trihydrochloride
Target:
JAK-IN-25
T78175
Synonym:
Target: JAK
1 2

Recombinant Proteins

Species：
Human (15)
Mouse (10)
Rhesus (5)
EBV (3)
Cynomolgus (2)
HPV 16 (2)
Rat (1)
Expression System：
HEK293 (28)
E. coli (6)
Yeast (2)
Baculovirus (1)
Human Cells (1)
Tag：
His (11)
hFc (8)
N-terminal 6xHis-tagged (4)
C-His-Avi (3)
C-hFc (3)
6*His (1)
C-Fc (1)
His,AVI (1)
His,hFc (1)
N-terminal 10xHis-tagged (1)
Cat No. Product Name Species Expression System
TMPH-01778 TYK2 Protein, Human, Recombinant (His) Human Baculovirus
Non-receptor kinase involved in various processes including cell growth, development, cell migration, innate and adaptive immunity. Plays both structural and catalytic roles in numerous cytokines and interferons signalin...
TMPH-01777 TYK2 Protein, Human, Recombinant (E. coli, His) Human E. coli
Non-receptor kinase involved in various processes including cell growth, development, cell migration, innate and adaptive immunity. Plays both structural and catalytic roles in numerous cytokines and interferons signalin...
TMPY-02647 IFNAR1 Protein, Human, Recombinant (His) Human HEK293
Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus prote...
TMPY-05338 IL-10R alpha/IL-10RA Protein, Human, Recombinant (His) Human HEK293
IL10RA (Interleukin 10 Receptor Subunit Alpha, also known as CD210) is a Protein Coding gene. The protein encoded by this gene is a receptor for interleukin 10. Two transcript variants, one protein-coding, and the other,...
TMPY-05496 IL-10R alpha/IL-10RA Protein, Mouse, Recombinant (hFc) Mouse HEK293
IL10RA (Interleukin 10 Receptor Subunit Alpha, also known as CD210) is a Protein Coding gene. The protein encoded by this gene is a receptor for interleukin 10. Two transcript variants, one protein-coding, and the other,...
TMPY-04125 PTP1B Protein, Human, Recombinant (His) Human E. coli
PTP1B, also known as PTPN1, belongs to the protein-tyrosine phosphatase (PTP) family. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly c...
TMPY-01258 IL-13RA1 Protein, Human, Recombinant (His) Human HEK293
Interleukin 13 receptor, alpha 1, also known as IL13RA1/IL-13RA1 and CD213A1 (cluster of differentiation 213A1), is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha,...
TMPY-01170 IL-13RA1 Protein, Mouse, Recombinant (His) Mouse HEK293
Interleukin 13 receptor, alpha 1, also known as IL13RA1/IL-13RA1 and CD213A1 (cluster of differentiation 213A1), is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha,...
TMPJ-00398 IL-12RB2 Protein, Mouse, Recombinant (hFc) Mouse Human Cells
The IL12 receptor complex, formed by IL12RB1 and IL12RB2, mediates the type I immune responses of various types of lymphocytes. Its ligand, IL12, is a heterodimeric cytokine composed of IL-12p35 and IL-12p40 subunits tha...
TMPH-01832 Human Papilloma Virus type 16 (HPV 16) Protein E6 (E. coli, His) HPV 16 E. coli
Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host UBE3A/E6-AP ...
TMPK-00342 IFNAR1 Protein, Mouse, Recombinant (His & Avi) Mouse HEK293
IFN-alpha / beta R1, also known as IFNAR1, belongs to the class II cytokine receptor family of proteins. Class II cytokine receptors form heterodimeric receptor complexes that mediate class II cytokine signals. Subunits ...
TMPK-01105 IL-22RA1 Protein, Human, Recombinant (hFc) Human HEK293
Interleukin (IL)-22 is a member of the IL-10 family of cytokines and represents an important effector molecule of activated Th22, Th1, and Th17 cells, as well as Tc-cell subsets, gammadelta T cells, natural killer (NK), ...
TMPK-00325 IFNAR1 Protein, Human, Recombinant (His & Avi) Human HEK293
IFN-alpha / beta R1, also known as IFNAR1, belongs to the class II cytokine receptor family of proteins. Class II cytokine receptors form heterodimeric receptor complexes that mediate class II cytokine signals. Subunits ...
TMPH-01833 Human Papilloma Virus type 16 (HPV 16) Protein E6 (His) HPV 16 Yeast
Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host UBE3A/E6-AP ...
TMPK-00343 IFNAR1 Protein, Mouse, Recombinant (hFc) Mouse HEK293
IFN-alpha / beta R1, also known as IFNAR1, belongs to the class II cytokine receptor family of proteins. Class II cytokine receptors form heterodimeric receptor complexes that mediate class II cytokine signals. Subunits ...
TMPK-00326 IFNAR1, Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293
IFN-alpha / beta R1, also known as IFNAR1, belongs to the class II cytokine receptor family of proteins. Class II cytokine receptors form heterodimeric receptor complexes that mediate class II cytokine signals. Subunits ...
TMPK-01071 IL-22RA1 Protein, Mouse, Recombinant (hFc) Mouse HEK293
Interleukin (IL)-22 is a member of the IL-10 family of cytokines and represents an important effector molecule of activated Th22, Th1, and Th17 cells, as well as Tc-cell subsets, gammadelta T cells, natural killer (NK), ...
TMPY-03125 SHP-2 Protein, Mouse, Recombinant (His) Mouse HEK293
SHP2, also known as PTPN11, belongs to the protein-tyrosine phosphatase(PTP) family, non-receptor class 2 subfamily. PTPs catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric ac...
TMPU-00003 STAT2 Protein, Human, Recombinant (His) Human E. coli
Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading...
TMPY-04254 IFNAR1 Protein, Rhesus, Recombinant (His) Rhesus HEK293
Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus prote...
TMPY-02634 IFNAR1 Protein, Human, Recombinant (hFc) Human HEK293
Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus prote...
TMPY-05317 IL-10R alpha/IL-10RA Protein, Rhesus, Recombinant (His) Rhesus HEK293
IL10RA (Interleukin 10 Receptor Subunit Alpha, also known as CD210) is a Protein Coding gene. The protein encoded by this gene is a receptor for interleukin 10. Two transcript variants, one protein-coding, and the other,...
TMPH-00543 Epstein-Barr virus (strain Raji) LMP1 Protein (His & SUMO) EBV E. coli
Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several s...
TMPY-03829 IFNAR1 Protein, Rhesus, Recombinant (hFc) Rhesus HEK293
Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus prote...
TMPY-01489 IFNAR1 Protein, Mouse, Recombinant (His) Mouse HEK293
Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus prote...
TMPH-00542 Epstein-Barr virus (strain Raji) LMP1 Protein (His) EBV Yeast
Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several s...
TMPY-03927 IFNAR1 Protein, Rhesus, Recombinant Rhesus HEK293
Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus prote...
TMPY-03321 IL-10R alpha/IL-10RA Protein, Rhesus, Recombinant (hFc) Rhesus HEK293
IL10RA (Interleukin 10 Receptor Subunit Alpha, also known as CD210) is a Protein Coding gene. The protein encoded by this gene is a receptor for interleukin 10. Two transcript variants, one protein-coding, and the other,...
TMPH-00541 Epstein-Barr virus (strain AG876) LMP1 Protein (His & Myc) EBV E. coli
Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several s...
TMPY-02994 IL-13RA1 Protein, Rat, Recombinant (hFc) Rat HEK293
Interleukin 13 receptor, alpha 1, also known as IL13RA1/IL-13RA1 and CD213A1 (cluster of differentiation 213A1), is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha,...
TMPY-06590 IL-13RA1 Protein, Human, Recombinant (aa 1-343, hFc) Human HEK293
Interleukin 13 receptor, alpha 1, also known as IL13RA1/IL-13RA1 and CD213A1 (cluster of differentiation 213A1), is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha,...
TMPY-05432 IL-13RA1 Protein, Mouse, Recombinant (hFc) Mouse HEK293
Interleukin 13 receptor, alpha 1, also known as IL13RA1/IL-13RA1 and CD213A1 (cluster of differentiation 213A1), is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha,...
TMPY-05795 IL-13RA1 Protein, Mouse, Recombinant (mFc) Mouse HEK293
Interleukin 13 receptor, alpha 1, also known as IL13RA1/IL-13RA1 and CD213A1 (cluster of differentiation 213A1), is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha,...
TMPY-05123 IL-13RA1 Protein, Human, Recombinant (His), Biotinylated Human HEK293
Interleukin 13 receptor, alpha 1, also known as IL13RA1/IL-13RA1 and CD213A1 (cluster of differentiation 213A1), is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha,...
TMPY-01074 IL-13RA1 Protein, Human, Recombinant (His & hFc) Human HEK293
Interleukin 13 receptor, alpha 1, also known as IL13RA1/IL-13RA1 and CD213A1 (cluster of differentiation 213A1), is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha,...
TMPY-04816 IL-13RA1 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
Interleukin 13 receptor, alpha 1, also known as IL13RA1/IL-13RA1 and CD213A1 (cluster of differentiation 213A1), is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha,...
TMPY-06519 IL-13RA1 Protein, Cynomolgus, Recombinant (hFc) Cynomolgus HEK293
Interleukin 13 receptor, alpha 1, also known as IL13RA1/IL-13RA1 and CD213A1 (cluster of differentiation 213A1), is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha,...
TMPY-06579 IL-13RA1 Protein, Human, Recombinant(aa 1-343, His & Avi), Biotinylated Human HEK293
Interleukin 13 receptor, alpha 1, also known as IL13RA1/IL-13RA1 and CD213A1 (cluster of differentiation 213A1), is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha,...
TYK2 Protein, Human, Recombinant (His)
TMPH-01778
Species: Human
Expression System: Baculovirus
TYK2 Protein, Human, Recombinant (E. coli, His)
TMPH-01777
Species: Human
Expression System: E. coli
IFNAR1 Protein, Human, Recombinant (His)
TMPY-02647
Species: Human
Expression System: HEK293
IL-10R alpha/IL-10RA Protein, Human, Recombinant (His)
TMPY-05338
Species: Human
Expression System: HEK293
IL-10R alpha/IL-10RA Protein, Mouse, Recombinant (hFc)
TMPY-05496
Species: Mouse
Expression System: HEK293
PTP1B Protein, Human, Recombinant (His)
TMPY-04125
Species: Human
Expression System: E. coli
IL-13RA1 Protein, Human, Recombinant (His)
TMPY-01258
Species: Human
Expression System: HEK293
IL-13RA1 Protein, Mouse, Recombinant (His)
TMPY-01170
Species: Mouse
Expression System: HEK293
IL-12RB2 Protein, Mouse, Recombinant (hFc)
TMPJ-00398
Species: Mouse
Expression System: Human Cells
Human Papilloma Virus type 16 (HPV 16) Protein E6 (E. coli, His)
TMPH-01832
Species: HPV 16
Expression System: E. coli
IFNAR1 Protein, Mouse, Recombinant (His & Avi)
TMPK-00342
Species: Mouse
Expression System: HEK293
IL-22RA1 Protein, Human, Recombinant (hFc)
TMPK-01105
Species: Human
Expression System: HEK293
IFNAR1 Protein, Human, Recombinant (His & Avi)
TMPK-00325
Species: Human
Expression System: HEK293
Human Papilloma Virus type 16 (HPV 16) Protein E6 (His)
TMPH-01833
Species: HPV 16
Expression System: Yeast
IFNAR1 Protein, Mouse, Recombinant (hFc)
TMPK-00343
Species: Mouse
Expression System: HEK293
IFNAR1, Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00326
Species: Human
Expression System: HEK293
IL-22RA1 Protein, Mouse, Recombinant (hFc)
TMPK-01071
Species: Mouse
Expression System: HEK293
SHP-2 Protein, Mouse, Recombinant (His)
TMPY-03125
Species: Mouse
Expression System: HEK293
STAT2 Protein, Human, Recombinant (His)
TMPU-00003
Species: Human
Expression System: E. coli
IFNAR1 Protein, Rhesus, Recombinant (His)
TMPY-04254
Species: Rhesus
Expression System: HEK293
IFNAR1 Protein, Human, Recombinant (hFc)
TMPY-02634
Species: Human
Expression System: HEK293
IL-10R alpha/IL-10RA Protein, Rhesus, Recombinant (His)
TMPY-05317
Species: Rhesus
Expression System: HEK293
Epstein-Barr virus (strain Raji) LMP1 Protein (His & SUMO)
TMPH-00543
Species: EBV
Expression System: E. coli
IFNAR1 Protein, Rhesus, Recombinant (hFc)
TMPY-03829
Species: Rhesus
Expression System: HEK293
IFNAR1 Protein, Mouse, Recombinant (His)
TMPY-01489
Species: Mouse
Expression System: HEK293
Epstein-Barr virus (strain Raji) LMP1 Protein (His)
TMPH-00542
Species: EBV
Expression System: Yeast
IFNAR1 Protein, Rhesus, Recombinant
TMPY-03927
Species: Rhesus
Expression System: HEK293
IL-10R alpha/IL-10RA Protein, Rhesus, Recombinant (hFc)
TMPY-03321
Species: Rhesus
Expression System: HEK293
Epstein-Barr virus (strain AG876) LMP1 Protein (His & Myc)
TMPH-00541
Species: EBV
Expression System: E. coli
IL-13RA1 Protein, Rat, Recombinant (hFc)
TMPY-02994
Species: Rat
Expression System: HEK293
IL-13RA1 Protein, Human, Recombinant (aa 1-343, hFc)
TMPY-06590
Species: Human
Expression System: HEK293
IL-13RA1 Protein, Mouse, Recombinant (hFc)
TMPY-05432
Species: Mouse
Expression System: HEK293
IL-13RA1 Protein, Mouse, Recombinant (mFc)
TMPY-05795
Species: Mouse
Expression System: HEK293
IL-13RA1 Protein, Human, Recombinant (His), Biotinylated
TMPY-05123
Species: Human
Expression System: HEK293
IL-13RA1 Protein, Human, Recombinant (His & hFc)
TMPY-01074
Species: Human
Expression System: HEK293
IL-13RA1 Protein, Cynomolgus, Recombinant (His)
TMPY-04816
Species: Cynomolgus
Expression System: HEK293
IL-13RA1 Protein, Cynomolgus, Recombinant (hFc)
TMPY-06519
Species: Cynomolgus
Expression System: HEK293
IL-13RA1 Protein, Human, Recombinant(aa 1-343, His & Avi), Biotinylated
TMPY-06579
Species: Human
Expression System: HEK293
Cat No. Product Name
L3700 JAK-STAT Compound Library

256 compounds
A unique collection of 256 JAK/STAT signaling targeted compounds for high throughput and high content screening;

Libraries

JAK-STAT Compound Library
L3700
Compounds: 256
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