ulk1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T63343	ULK1-IN-2		Apoptosis , Autophagy
	ULK1-IN-2 is a potent ULK1 inhibitor with potential anticancer activity, inducing apoptosis while blocking autophagy.ULK1-IN-2 has high cytotoxicity against cancer cells, with an IC50 value of 1.94 μM against A549 cells....		Apoptosis , Autophagy
T8850	Sbp-7455		Autophagy
	SBP-7455 potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the viability of TNBC cells and had oral bioavailability in mice.		Autophagy
T0097	MRT67307	MRT67307 HCl	IκB/IKK , Autophagy
	Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy. MRT67307 prevents the phosphorylation of IRF3 and the production of IFN-β and increases toll-like receptor-induced IL-10 and IL-1ra secretion in macrophage...		IκB/IKK , Autophagy
T8808L	LYN-1604 dihydrochloride	LYN-1604 2HCl（2216753-86-3 free base)	Apoptosis , Autophagy
	LYN-1604 is a novel ULK1 activator.It inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.		Apoptosis , Autophagy
T4123	LYN-1604	LYN1604	Apoptosis , Autophagy
	LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.		Apoptosis , Autophagy
T5403	ULK-101		Autophagy
	ULK-101 is a potent and selective ULK1 inhibitor ( IC50s: 8.3/30 nM for ULK1/ULK2). It can suppress autophagy.		Autophagy
T60604	XST-14		Apoptosis , Autophagy
	XST-14 is a competitive and specific inhibitor of ULK1 (IC50: 26.6 nM).XST-14 blocks autophagy by inhibiting the phosphorylation of ULK1 downstream substrates.XST-14 induces apoptosis and inhibits the growth of HCC cells...		Apoptosis , Autophagy
T2128	SBI-0206965	SBI0206965	Apoptosis , Autophagy
	SBI-0206965 is a potent, selective and cell-permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for ULK2.		Apoptosis , Autophagy
T5356	MRT68921 HCl		Autophagy
	MRT68921 hydrochloride is a potent inhibitor of both ULK1 and ULK2 (IC50s: 2.9 and 1.1 nM, respectively).		Autophagy
T6899	MRT68921	MRT68921 HCl	Autophagy
	MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively.		Autophagy
T9142	MRT68921 dihydrochloride		Autophagy
	MRT68921 dihydrochloride is a potent ULK1 and ULK2 inhibitor (IC50 of 2.9 nM and 1.1 nM, respectively).		Autophagy
T9207L	GW406108X(Z/E)		Kinesin , Autophagy
	GW406108X(Z/E) is a mixture of different configurations of GW406108X, which is an inhibitor of Kinesin-12 and ULK1 .		Kinesin , Autophagy
T8322	BL-918		Autophagy
	BL-918 is a potent activator of UNC-51-like kinase 1 (ULK1) with an EC50 of 24.14 nM.		Autophagy
T36994	MRT 67307 dihydrochloride		SIK
	MRT 67307 dihydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively. MRT67307 dihydrochloride also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 dihyd...		SIK
T6285	GSK-690693	GSK690693	Serine Protease , Akt , PKC , AMPK , Autophagy
	GSK-690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.		Serine Protease , Akt , PKC , AMPK , Autophagy
T39687	LYN-1604 hydrochloride
	LYN-1604 hydrochloride, a powerful activator of UNC-51-like kinase 1 (ULK1) with an EC50 value of 18.94 nM, has significant implications in the study of triple-negative breast cancer (TNBC).
T28847	SR-17398
	SR-17398 is an inhibitor of Unc-51-Like Kinase 1 (ULK1) (IC50 = 22.4 uM).
T9207	GW406108X	GW108X	Kinesin , Autophagy
	GW406108X (GW108X) is a Kif15 inhibitor with an IC50 of 0.82 uM in ATPase assays. GW406108X is also an ULK1 kinase inhibitor with pIC50 values of 6.37 (427 nM) and block autophagic flux.		Kinesin , Autophagy
T12662	(Rac)-BL-918		Others
	(Rac)-BL-918 is the racemate of BL-918. BL-918 is a potent activator of UNC-51-like kinase 1 (ULK1) with an EC50 of 24.14 nM, inducing cytoprotective autophagy for Parkinson’s disease treatment [1].		Others
T82385	FMF-06-098-1		PROTACs
	FMF-06-098-1 is a multitargeted depressant capable of promoting the degradation of a wide array of kinases, including AAK1, ABL2, AURKA, AURKB, BUB1B, CDC7, CDK1, CDK12, CDK13, CDK2, CDK4, CDK6, CDK7, CDK9, CHEK1, CSNK1D...		PROTACs
T74644	DB0614
	DB0614 (Example 21) is a bifunctional compound designed for the targeted degradation of kinases, effectively breaking down a wide array of kinases including AAK1, AURKA, BMP2K, CAMKK1, CDK16, CML, CDK6, EIF2AK2, FER, GAK...
T74642	DB1113
	DB1113 (Example 24) is a bifunctional compound designed for the targeted degradation of various kinases. It effectively degrades a range of kinases, including ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, M...

Compounds

ULK1-IN-2

T63343

Synonym:

Target: Apoptosis, Autophagy

Synonym: MRT67307 HCl

Target: IκB/IKK, Autophagy

LYN-1604 dihydrochloride

T8808L

Synonym: LYN-1604 2HCl（2216753-86-3 free base)

Target: Apoptosis, Autophagy

LYN-1604

T4123

Synonym: LYN1604

Target: Apoptosis, Autophagy

Target: Apoptosis, Autophagy

SBI-0206965

T2128

Synonym: SBI0206965

Target: Apoptosis, Autophagy

Synonym: MRT68921 HCl

Target: Autophagy

MRT68921 dihydrochloride

Target: Kinesin, Autophagy

MRT 67307 dihydrochloride

Target: Serine Protease, Akt, PKC, AMPK, Autophagy

LYN-1604 hydrochloride

Target: Kinesin, Autophagy

Cat No.	Product Name	Synonyms	Targets
T8200	Ginkgolide K		AMPK , Autophagy
	Ginkgolide K induces protective autophagy through the AMPK/mTOR/ULK1 signalling pathway. It possesses neuroprotective activity.

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-02478	PRKAA1 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus
	Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activat...
TMPH-02479	PRKAA1 Protein, Mouse, Recombinant (E. coli, His)	Mouse	E. coli
	Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activat...
TMPH-02632	TRIM21 Protein, Mouse, Recombinant (E. coli, His)	Mouse	E. coli
	E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of...
TMPH-02633	TRIM21 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus
	E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of...

PRKAA1 Protein, Mouse, Recombinant (His)

TMPH-02478

Species: Mouse

Expression System: Baculovirus

PRKAA1 Protein, Mouse, Recombinant (E. coli, His)

TMPH-02479

Species: Mouse

Expression System: E. coli

TRIM21 Protein, Mouse, Recombinant (E. coli, His)

TMPH-02632

Species: Mouse

Expression System: E. coli

TRIM21 Protein, Mouse, Recombinant (His)

TMPH-02633

Species: Mouse

Expression System: Baculovirus

Cat No.	Product Name
L2550	Glutamine Metabolism Compound Library		580 compounds
	A unique collection of 580 glutamine metabolism related compounds can be used for high throughput screening (HTS) and high content screening (HCS), and also is an effective tool for research in glutamine metabolism and ...

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