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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9181 | Autophagy-IN-A9 | Others | |
Autophagy-IN-A9 is a bioactive chemical. | |||
T38977 | Autophagy-IN-C1 | Autophagy-IN-C1 | |
Autophagy-IN-C1 is a cinchona alkaloid derivative containing urea. Autophagy-IN-C1 not only induces apoptosis but also blocks autophagy in hepatocellular carcinoma (HCC) cells. | |||
T63744 | Autophagy inducer 4 | ||
Autophagy inducer 4 is a Mannich base derivative based on Magnolol and can be used as an anticancer agent. autophagy inducer 4 induces autophagy and thus inhibits cancer cells. autophagy inducer 4 is 76 times more toxic ... | |||
T60749 | Autophagy-IN-2 | ||
Autophagy-IN-2 (Compound 7h) is an inhibitor of autophagic flux which induces cancer cell apoptosis and can be used for the research of triple-negative breast cancer [1]. | |||
T61580 | Autophagy inducer 3 | ||
Autophagy Inducer 3 is a chemical compound that exhibits autophagy-induced activity, specifically inducing robust autophagic cell death in various cancer cells while sparing normal cells. This compound induces lethal aut... | |||
T62331 | Autophagy-IN-1 | ||
Autophagy-IN-1 is a potent inhibitor of autophagy/mitophagy, blocking autophagosomal-lysosomal fusion in cancer cells while selectively increasing autophagic flux. Autophagy-IN-1 significantly inhibits tumour growth in t... | |||
T28001 | MDK-6983 | MDK-6983,Compound 6k,Autophagy inhibitor 6k,MDK6983 | Autophagy |
MDK-6983 (MDK-6983) is an inhibitor of autophagy and disrupts the dynamics of actin cytoskeleton in human melanoma cells. | |||
T26683 | AUTEN-67 | Autophagy enhancer 67,MTMR14 inhibitor,AUTEN67 | |
AUTEN-67 is a specific inhibitor of MTMR14 and autophagy enhancer with potent antiaging and neuroprotective effects. AUTEN-67 also delays the onset and decreases the severity of Huntington's disease. | |||
T14346 | Aumitin | Others , Autophagy | |
Aumitin is a diaminopyrimidine-based autophagy inhibitor. Aumitin inhibits starvation- and rapamycin induced autophagy dose dependently with IC50s of 0.12 μM and 0.24 μM, respectively[1], and it inhibits mitochondrial re... | |||
T11142 | EACC | Autophagy | |
EACC, a reversible autophagy inhibitor, selectively impedes Stx17, an autophagosome-specific SNARE, from translocating, hence obstructing the fusion between autophagosomes and lysosomes. This compound effectively halts a... | |||
T1554 | Iohexol | Mitophagy , Autophagy | |
Iohexol is a contrast agent. The osmolality of iohexol ranges from 322 mOsm/kg-approximately 1.1 times that of blood plasma-to 844 mOsm/kg, almost three times that of blood. | |||
T5211 | NSC 185058 | NSC185058 | Cysteine Protease , Autophagy |
NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. It also can attenuate the autophagic activity. | |||
T2015 | Fexaramine | FXR , Autophagy | |
Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds. | |||
T15303 | FMK 9a | Cysteine Protease , Autophagy | |
FMK 9a is an irreversible inhibitor of ATG4B with IC50 values of 80 and 73 nM in the TR-FRET and cellular-based LRA assays. | |||
T0876 | Clioquinol | Chinoform,Iodochlorhydroxyquin | Mitophagy , Antibiotic , Autophagy , Antifungal |
Clioquinol (Iodochlorhydroxyquin) is an orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities. | |||
T1825 | Reversine | Aurora Kinase , Adenosine Receptor , Autophagy | |
Reversine, a small synthetic purine analogue (2, 6-disubstituted purine), is a potent inhibitior of Aurora A/B/C(IC50s=150-500 nM). | |||
T7311 | Oxyphenisatin acetate | Autophagy | |
Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468. | |||
T6056 | Thiamet G | TMG | Others , Autophagy |
Thiamet G is a potent, selective O-GlcNAcase inhibitor with Kiof 21 nM, while exhibiting 37, 000-fold selectivity over human lysosomal –hexosaminidase. | |||
T4219 | Autophinib | PI3K , Autophagy | |
Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and rapamycin induced autophagy assay. | |||
T10413 | Autogramin-1 | mTOR , Autophagy | |
Autogramin-1 potently inhibits autophagy induced by either mTORC1 inhibition (Rapamycin; IC50: 0.44 μM) or starvation (IC50: 0.17 μM). | |||
T2414 | Torkinib | PP 242 | Apoptosis , Mitophagy , PI3K , mTOR , Autophagy |
Torkinib (PP 242) (PP 242) is a selective and ATP-competitive mTOR inhibitor (IC50: 8 nM). It also inhibits mTORC1/2 (IC50s: 30/58 nM). | |||
T5181 | CA-5f | Apoptosis , Autophagy | |
CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion. | |||
T1742 | 4E1rcat | PERK , Autophagy | |
4E1RCat is a dual inhibitor of eIF4E:eIF4 g and eIF4E:4E-BP1 interaction. And it inhibits the binding of eIF4 g to eIF4E with IC50 of 3.2 μM. | |||
T3045 | Salubrinal | Apoptosis , Phosphatase , PERK , Autophagy , HSV | |
Salubrinal, a phosphatases (PP1) inhibitor(IC50=1.7 μM), exhibits function on the eukaryotic translation initiation factor 2 subunit (eIF2α). | |||
T14033 | 3BDO | Apoptosis , mTOR , Autophagy | |
3BDO is an activator of mTOR. It can also inhibit autophagy.. | |||
T11375 | GCN2iB | Others , Autophagy | |
GCN2iB is an ATP-competitive inhibitor of a serine/threonine-protein kinase general control nonderepressible 2 (GCN2), with an IC50 of 2.4 nM. | |||
T7886 | Nidufexor | FXR , Autophagy | |
Nidufexor is an agonist for the farnesoid X receptor (FXR). | |||
T3155 | SMER28 | Autophagy | |
SMER28 is a small-molecule enhancer (SMER) of autophagy, inducing autophagy independently of rapamycin in mammalian cells via an mTOR-independent mechanism and prevented the accumulation of amyloid beta peptide. | |||
T26684 | Auten-99 HBr | Auten-99,Auten-99 hydrochloride. Auten-99 HBr,Auten99,Auten 99 | Phosphatase |
Auten-99 HBr (Auten-99) is a myotubularin phosphatase Jumpy inhibitor exerting potent neuroprotective effects. AUTEN-99 activates autophagy in cell cultures and animal models. AUTEN-99 appears to effectively penetrate th... | |||
T0943 | Carbamazepine | NSC 169864 | Mitophagy , Sodium Channel , Autophagy |
Carbamazepine (NSC-169864) is a tricyclic compound chemically related to tricyclic antidepressants (TCA) with anticonvulsant and analgesic properties. Carbamazepine exerts its anticonvulsant activity by reducing polysyna... | |||
T3952 | TPEN | TPEDA | Apoptosis , Reactive Oxygen Species , Autophagy |
TPEN (TPEDA) is a specific cell-permeable heavy metal chelator. | |||
T14365 | AZ PFKFB3 26 | Glucokinase | |
AZ PFKFB3 26 is an effective and selective PFKFB3 inhibitor with an IC50 of 23 nM. The IC50s for PFKFB1 and PFKFB2 are 2.06 and 0.384 μM, respectively. | |||
T2099 | ABT-737 | Mitophagy , BCL , Autophagy | |
ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w (EC50s: 78.7/30.3/197.8 nM). | |||
T6762 | AS1842856 | Autophagy , FOXO1 | |
AS1842856, a cell-permeable inhibitor, can block the transcription activity of Foxo1 (IC50: 33 nM). It can directly bind to the active Foxo1, but not the Ser256-phosphorylated form. | |||
T11741 | KAN0438757 | Glucokinase , Autophagy | |
KAN0438757 is a selective and potent inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM. | |||
T9062 | CA77.1 | Autophagy | |
CA77.1(CA) is a novel chaperon-mediated autophagy (CMA) activator for the treatment of Alzheimer's disease (AD). | |||
T1907 | Mdivi-1 | Mitochondrial division inhibitor 1 | Apoptosis , Mitophagy , Dynamin , Autophagy |
Mdivi-1 (Mitochondrial division inhibitor 1) is a mitochondrial division inhibitor that inhibits DRP1 and Dynamin I (IC50=1-10 μM). Mdivi-1 inhibits mitochondrial autophagy. | |||
T0972 | Isoniazid | INH,Isonicotinic acid hydrazide,Isonicotinic hydrazide | Mitophagy , Dehydrogenase , CAT , Antibacterial , Autophagy |
Isoniazid (Isonicotinic hydrazide) is an antibacterial agent used primarily as a tuberculostatic. | |||
T3686 | 10074-G5 | c-Myc , Autophagy | |
10074-G5 is an inhibitor of c-Myc-Max dimerization. | |||
T14044 | 4E2RCat | PERK | |
4E2RCat is an eIF4E-eIF4G interaction inhibitor (IC50: 13.5 μM). | |||
T7679 | UBCS039 | Sirtuin , Autophagy | |
UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM) | |||
T6532 | Hesperadin | Influenza Virus , Parasite , Aurora Kinase , Autophagy | |
Hesperadin(IC50=250 nM) effectively inhibits Aurora B. It potently reduces the activity of AMPK, MAPKAP-K1, MKK1, Lck, CHK1 and PHK, but it could not inhibit MKK1 activity in vivo. | |||
T1582 | Naproxen | (S)-Naproxen | COX , Autophagy |
Naproxen ((S)-Naproxen) is a propionic acid derivative and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities. | |||
T5538 | DC661 | Apoptosis , Autophagy | |
DC661 is a palmitoyl-protein thioesterase 1 (PPT1) inhibitor that acts as an anti-lysosomal agent by inhibiting autophagy, demonstrating anti-cancer activity. | |||
T11191 | EN6 | Proton pump , Autophagy | |
EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative ... | |||
T1829 | Ruxolitinib | INCB018424,(R)-Ruxolitinib | Apoptosis , Mitophagy , Tyrosine Kinases , JAK , Autophagy |
Ruxolitinib (INCB018424) is a JAK1/2 inhibitor (IC50=3.3/2.8 nM) that is potent and selective. Rixolitinib exhibits antitumor activity and induces autophagy and apoptosis. | |||
T15806 | LY2562175 | FXR , Autophagy | |
LY2562175 is an effective and selective FXR agonist (EC50: 193 nM). | |||
T2513 | VX-702 | p38 MAPK , Autophagy | |
VX-702 is a highly specific p38α MAPK inhibitor, 14-fold higher selectivity for the p38α than p38β. VX-702 is a small molecule investigational oral anti-cytokine therapy for treatment of inflammatory diseases, specifical... | |||
T22223 | 3PO | Glucokinase , Autophagy | |
3PO is a small-molecule inhibitor of PFKFB3 (IC50: 22.9 μM), inhibiting the proliferation of several human malignant hematopoietic and adenocarcinoma cell lines (IC50: 1.4-24 μM). It suppresses glucose uptake, and decrea... | |||
T1927 | CCT007093 | Apoptosis , Phosphatase , Autophagy | |
CCT007093 is an effective PPM1D (WIP1) inhibitor (IC50: 8.4 μM). |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5763 | Sedanolide | Others , Autophagy | |
Sedanolide is a natural phthalide first isolated from seed oil of the Umbelliferae family, including celery. | |||
T6468 | D-glutamine | Mitophagy , Ferroptosis , Endogenous Metabolite , GluR , Autophagy | |
D-glutamine, an D type stereoisomer of glutamine, is one of the 20 amino acids which is encoded by the standard genetic code. | |||
T5S1287 | Ligustilide | Apoptosis , Autophagy | |
3-Butylidene-4,5-dihydrophthalide is an effective constituent extracted from Angelica sinensis. | |||
T5793 | Britannin | Apoptosis , AMPK , Autophagy | |
Britannin, a sesquiterpene lactone, inhibits proliferation and induces apoptosis through the mitochondrial signaling pathway in human breast cancer cells. | |||
T5S1099 | Liensinine | Apoptosis , Mitophagy , Others , Autophagy | |
1. Liensinine, a kind of isoquinoline alkaloid, can antagonize the ventricular arrhythmias. | |||
T0595 | Naringin | Naringoside | Mitophagy , P450 , Endogenous Metabolite , Autophagy |
Naringin (Naringoside), a flavanone glycoside, exerts various of pharmacological effects such as blood lipid lowering, antioxidant activity, anticancer activity, and inhibition of cytochrome P450 enzymes. | |||
TN1140 | Onjisaponin B | AMPK , mTOR , Autophagy | |
Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±-synuclein, it may have potential therapeutic effects on Parki... | |||
T3400 | Bakuchiol | p38 MAPK , DNA/RNA Synthesis , Autophagy | |
Bakuchiol possesses anti-tumor,and anti-helmenthic properties. It has cytotoxic activity, mainly due to its DNA polymerase1 inhibiting activity. Bakuchiol has anti-bacterial activity against oral pathogens, has great pot... | |||
T8641 | Vancomycin | Antibacterial , Antibiotic , Autophagy | |
Vancomycin is a glycopeptide antibiotic that exerts its antimicrobial activity by altering the permeability of cell membranes and selectively inhibiting ribonucleic acid synthesis. Vancomycin can be used for the treatmen... | |||
T3427 | Polydatin | Piceid,Polydotin Peceid | Apoptosis , Mitophagy , NF-κB , Autophagy |
Polydatin (Piceid), the glycoside of Resveratrol, is originally isolated from the Chinese herb Polygonum cuspidatum. The compound can inhibit platelet aggregation and elevate the ratios of LDL-C/HDL-C and TC/HDL-C. In th... | |||
TN1563 | Dehydropachymic acid | Autophagy , Immunology/Inflammation related | |
Dehydropachymic acid shows antiinflammatory activity. | |||
T5515 | Hemin | Hemin chloride | Mitophagy , Ferroptosis , Autophagy |
Hemin (Hemin chloride) is a chlorinated iron-containing porphyrin, a heme oxygenase (HO)-1 inducer. Hemin has therapeutic activity in porphyrias by reducing heme deficiency in patients, thereby inhibiting δ-aminolevulini... | |||
T2174 | Quercetin | Sophoretin | Apoptosis , Mitophagy , Reactive Oxygen Species , PI3K , Autophagy |
Quercetin (Sophoretin) is a natural flavonoid and is an agonist of SIRT1. Quercetin is also a PI3K inhibitor, inhibiting PI3Kγ, PI3Kδ, and PI3Kβ (IC50=2.4/3.0/5.4 μM). Quercetin can induce apoptosis and autophagy. | |||
TN1507 | Clematichinenoside AR | TNF , Autophagy | |
Clematichinenoside AR exerts anti-inflammatory and immunosuppressive properties, it has anti-arthritic effects on PI3K/Akt signaling pathway and TNF-α± associated with collagen-induced arthritis. | |||
T3600 | Licochalcone A | Caspase , UGT , Autophagy | |
Licochalcone A is a flavonoid isolated from the famous Chinese medicinal herb Glycyrrhiza uralensis Fisch with obvious anti-cancer effects. | |||
T2140 | Parthenolide | (-)-Parthenolide | Apoptosis , Mitophagy , NF-κB , HDAC , Autophagy |
(-)-Parthenolide ((-)-Parthenolide), an inhibitor of the Nuclear Factor-κB Pathway, also promotes the ubiquitination of MDM2 and activates p53 cellular functions. | |||
T3028 | Tripterin | Celastrol,Tripterine | Apoptosis , Mitophagy , Proteasome , Autophagy |
Tripterin (Celastrol) is a natural product, a proteasome inhibitor that inhibits the pancreatic rennet-like activity of the 20S proteasome (IC50=2.5 μM). Tripterin has anti-inflammatory, anti-infectious, and immunomodula... | |||
S00015 | Tea polyphenol | Apoptosis , Others , Autophagy | |
Tea polyphenol, also called green tea extract, are a mixture of chemical compounds, such as flavanoids and tannins, found naturally in tea. Polyphenols are powerful antioxidants, which can reduce the risk of developing c... | |||
TN1702 | Glycycoumarin | P450 , JNK , AMPK , Autophagy | |
Glycycoumarin is an estrogen agonist, it shows moderate inhibitory effects against CYP1A2 and CYP2B6. | |||
TMS1743 | Salvigenin | MAO , Autophagy , ROS Kinase | |
Salvigenin is a potent hMAO-A inhibitor, has neuroprotective, antitumor and immunomodulatory effects. | |||
T2565 | Hesperetin | Apoptosis , p38 MAPK , 5-HT Receptor , Autophagy , TGF-beta/Smad | |
Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside hesperidin, is the predominant flavonoid in lemons and oranges. | |||
T0649 | Salicylic acid | 2-Hydroxybenzoic acid | Apoptosis , Mitophagy , COX , Endogenous Metabolite , Autophagy |
Salicylic acid (2-Hydroxybenzoic acid), a natural compound extracted from Willow bark, is an anti-inflammatory inhibitor of activity cyclooxygenase. | |||
T4672 | Brevilin A | Apoptosis , Anti-infection , JAK , STAT , Autophagy | |
Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT si... | |||
T6377 | Aloperine | Apoptosis , Virus Protease , HIV Protease , Antibiotic , Autophagy | |
Aloperine exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties. | |||
T2888 | Pterostilbene | Autophagy | |
Pterostilbene is extracted from Pterocarpus indicus. | |||
T2177 | Kaempferol | Kempferol,Robigenin | Apoptosis , Estrogen Receptor/ERR , Mitophagy , Estrogen/progestogen Receptor , HIV Protease , Endogenous Metabolite , Parasite , Autophagy |
Kaempferol (Robigenin) is a natural flavonoid and an inverse agonist of ERRα and ERRγ. Kaempferol has a wide range of antitumor, anti-inflammatory, antioxidant, antibacterial and antiviral activities. | |||
T7190 | Actein | Apoptosis , Akt , JNK , Autophagy | |
Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblasts in osteoporotic patients. Actein's ability to pathways in... | |||
T3S0807 | Berbamine | CaMK , NF-κB , Autophagy | |
Berbamine is a natural product extracted from Phellodendron amurense. It acts as a calcium channel blocker and possesses anti-tumor, immunomodulatory, and cardiovascular effects. | |||
T4S1102 | Liensinine diperchlorate | Liensinine-Perchlorate | Mitophagy , Others , Autophagy |
Liensinine Diperchlorate is an isoquinoline alkaloid extracted from the embryonic seeds of the sacred lotus. It inhibits late autophagy by blocking autophagosome-lysosome fusion and exhibits biological activities such as... | |||
T3814 | Isorhapontigenin | Isorhapotogenin | Others , Autophagy |
Isorhapontigenin (Isorhapotogenin) is a tetrahydroxylated stilbenoid with a methoxy group. It is an isomer of rhapontigenin and an analog of resveratrol. It is found in the Chinese herb Gnetum cleistostachyum, in Gnetum ... | |||
T2900 | Paeonol | Peonol | MAO , Autophagy , Monoamine Oxidase |
Paeonol (Peonol) is an active extraction from Paeonia suffruticosa. Paeonol inhibits MAO-A and MAO-B with IC50 of 54.6 μM and 42.5 μM, respectively. | |||
T0579 | Myricetin | Cannabiscetin | Apoptosis , PI3K , Endogenous Metabolite , Autophagy |
Myricetin (Cannabiscetin) is a naturally-occurring flavonoid found in many grapes, berries, fruits, vegetables, herbs, as well as other plants. Walnuts are a rich dietary source. It has been shown that myricetin has anti... | |||
T6062 | Brefeldin A | BFA,Ascotoxin,Cyanein,Decumbin | ATPase , Mitophagy , Antibiotic , Autophagy , HSV , CRISPR/Cas9 |
Brefeldin A (Cyanein) belongs to the class of macrolide antibiotics and is an ATPase inhibitor (IC50=0.2 μM). Brefeldin A can induce tumor cell differentiation and apoptosis, and also possesses autophagy inhibitory activ... | |||
T5S1467 | Cucurbitacin E | CDK , Autophagy | |
Cucurbitacin E is a natural product isolated from the climbing stem of Cucumic melo L. It significantly suppresses the activity of the cyclin B1/CDC2 complex.Cucurbitacin E has prevention of neurodegeneration, it has pot... | |||
TQ0089 | Juglanin | Apoptosis , JNK , Autophagy | |
Juglanin is a JNK activator. Juglanin with inflammation and anti-tumor activities. It can induce apoptosis and autophagy on human breast cancer cells. | |||
TMA0507 | Tomatidine | NF-κB , JNK , Autophagy | |
Tomatidine serves as an anti-inflammatory agent by inhibiting NF-κB and JNK signaling pathways. Additionally, it induces autophagy in both mammalian cells and C. elegans. | |||
T1659 | Melatonin | Melatonine,N-Acetyl-5-methoxytryptamine | CaMK , Apoptosis , Mitophagy , Estrogen/progestogen Receptor , Melatonin Receptor , Glutathione Peroxidase , Endogenous Metabolite , ROR , Autophagy |
Melatonin (Melatonine) is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin... | |||
T1879 | 3-Methyladenine | 3-MA,NSC 66389 | Mitophagy , PI3K , Endogenous Metabolite , Autophagy |
3-Methyladenine (3-MA) is a PI3K inhibitor that selectively inhibits class IB PI3Kγ (IC50=60 μM) and class III VPS34 (IC50=25 μM). 3-Methyladenine inhibits autophagy. | |||
T3800 | Typhaneoside | Aervitrin | Others , Autophagy |
Typhaneoside (Aervitrin) is a flavonoid glycoside plant extract with potential ability to treat primary dysmenorrhea through the Shaofu Zhuyu decoction. | |||
T2781 | Sanguinarine | Sanguinarin,Pseudochelerythrine | Apoptosis , Antioxidant , Autophagy |
Sanguinarine (Pseudochelerythrine) is a specific inhibitor of Rac1b with anti-microbial, anti-oxidant and anti-inflammatory properties. | |||
TQ0309 | Glaucocalyxin B | Autophagy | |
Glaucocalyxin B is a diterpenoid isolated from Rabdosia japonica with anticancer and antitumor activity. It decreases the growth of HL-60 cells (IC50: 5.86 μM). | |||
T8200 | Ginkgolide K | AMPK , Autophagy | |
Ginkgolide K induces protective autophagy through the AMPK/mTOR/ULK1 signalling pathway. It possesses neuroprotective activity. | |||
TN6735 | Bigelovin | Apoptosis , Reactive Oxygen Species , Retinoid Receptor , Autophagy , RAR/RXR | |
Bigelovin is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation.It is also known as a pote... | |||
T1314 | Triclosan | Irgasan,Cloxifenolum | NADPH , Antibacterial , Antibiotic , Autophagy , Antifungal |
Triclosan (Irgasan) is an antibacterial and antifungal agent. | |||
T4519 | Alisol A | Alisol-A | Autophagy |
Alisol A (Alisol-A) may be an autophagic inducer, it has anti-cancer activity, it presents inhibitory effects on cancer cell lines tested(HepG2, MDA-MB-231, and MCF-7 cells). | |||
T1131 | Ivermectin | MK-933 | Mitophagy , GluCls , P2X Receptor , SARS-CoV , HIV Protease , Antibiotic , Parasite , Autophagy , HSV |
Ivermectin (MK-933) is a glutamate-gated chloride channel (GluCls) activator, with antiparasitic activity. | |||
T6677 | Sophocarpine | ERK , p38 MAPK , NF-κB , TLR , COX , HER , JNK , STAT | |
Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects. | |||
TN2225 | Soyasapogenol B | Apoptosis , Autophagy | |
Soyasapogenol B has anti-cancer, hypocholesterolemic, anticomplementary, hepatoprotective effects, it inhibits proliferation of cultured Hep-G2. | |||
T1558 | Resveratrol | trans-Resveratrol,SRT 501 | Apoptosis , Mitophagy , IκB/IKK , Lipoxygenase , Sirtuin , COX , NADPH , DNA/RNA Synthesis , Nrf2 , Antibacterial , Antibiotic , Autophagy , Antifungal |
Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autop... | |||
T2933 | Wogonin | Vogonin | Apoptosis , Wnt/beta-catenin , CDK , Autophagy |
Wogonin (Vogonin) is a cell-permeable and orally available flavonoid that displays anti-inflammatory and anticancer properties. | |||
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Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-01003 | ATG14 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidyletha... | |||
TMPJ-01192 | ELAPOR1 Protein, Human, Recombinant (His) | Human | Human Cells |
Endosome/lysosome-associated apoptosis and autophagy regulator (ELAPOR1), also known as EIG121 protein, is a type I transmembrane protein induced by estrogen. The estrogen-induced gene 121 (EIG121) has been associated wi... | |||
TMPH-00340 | ATG1 Protein, Candida glabrata, Recombinant (His) | Candida glabrata | E. coli |
Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein ... | |||
TMPJ-01329 | ATG5 Protein, Human, Recombinant | Human | E. coli |
ATG5 is an E2 ubiquitin ligase which is necessary for autophagy. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity, dramatically highly expressed in apoptotic ce... | |||
TMPJ-01250 | ATG4A Protein, Human, Recombinant (His) | Human | E. coli |
Cysteine Protease ATG4A (ATG4A) is a cytoplasmic protein that belongs to the peptidase C54 family. ATG4A is widely expressed in many tissues at a low level, but the highest expression is observed in skeletal muscle and b... | |||
TMPJ-01327 | ATG10 Protein, Human, Recombinant (His, T7) | Human | E. coli |
Ubiquitin-Like-Conjugating Enzyme ATG10 (ATG10) is a ubiquitous 28kDa member of the ATG10 family protein. ATG10 acts as an E2-like enzyme, catalyzes the transfer of ATG12 to ATG5 during in the initial stages of autophage... | |||
TMPJ-01354 | ATG3 Protein, Human, Recombinant | Human | E. coli |
Ubiquitin-like-conjugating enzyme ATG3 (ATG3), also known as Apg3L and Apg3p, functions as a regulatory component of autophagosome biogenesis necessary for autophagy. ATG3 exhibits 98% aa sequence identity with both its ... | |||
TMPJ-01321 | MAP1LC3B Protein, Human, Recombinant | Human | E. coli |
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) is a member of the highly conserved ATG8 protein family. ATG8 proteins are present in all known eukaryotic organisms. MAP1LC3B is one of the four genes in t... | |||
TMPY-06842 | BMP-4 Protein, Human, Recombinant (E399D) | Human | E. coli |
BMP4 (bone morphogenetic protein-4)-directed differentiation of human embryonic stem cells (ESCd). Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP... | |||
TMPY-02431 | BCL-XL Protein, Human, Recombinant (His) | Human | E. coli |
B-cell lymphoma-extra large (Bcl-xl) is a transmembrane molecule in the mitochondria. Bcl-xL (BCL2L1), belongs to the Bcl-2 family. Members of the bcl-2 family encode proteins that function either to promote or to inhibi... | |||
TMPY-00431 | BMP-4 Protein, Mouse, Recombinant (rFc) | Mouse | HEK293 |
BMP4 (bone morphogenetic protein-4)-directed differentiation of human embryonic stem cells (ESCd). Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP... | |||
TMPY-03268 | GABARAPL1 Protein, Human, Recombinant (His) | Human | E. coli |
ATG8, also known as GABARAPL1, is a ubiquitin-like protein that has a crystal structure. ATG8 consists of a 5-stranded β-sheet, which is enclosed by two α-helices at one side and one α-helix at the other side and exhibit... | |||
TMPY-00473 | NRBF2 Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
NRBF2 (Nuclear Receptor Binding Factor 2) is a Protein Coding gene. The encoded protein may modulate transcriptional activation by target nuclear receptors. It is widely expressed in the appendix, placenta, and other tis... | |||
TMPH-01287 | TUFM Protein, Human, Recombinant (His) | Human | E. coli |
Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays also a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochon... | |||
TMPH-02247 | TRIM5 Protein, Human, Recombinant (B2M & His) | Human | E. coli |
Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting a... | |||
TMPH-01363 | Galectin-8/LGALS8 Protein, Human, Recombinant (GST) | Human | E. coli |
Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy. Detects membrane rupture by binding bet... | |||
TMPH-03245 | BCL2 Protein, Rat, Recombinant (His) | Rat | in vitro E. coli expression system |
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a fee... | |||
TMPH-01684 | MAP1LC3C Protein, Human, Recombinant (His) | Human | E. coli |
Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits all ATG8 family members to infecting bacteria such as S.Typhimurium. May also p... | |||
TMPH-02520 | BCL2 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a fee... | |||
TMPH-00847 | 2-5A-dependent Rnase Protein, Human, Recombinant (Myc) | Human | E. coli |
Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stran... | |||
TMPY-05160 | PFKP Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
PFKP plays a critical role in cell proliferation in breast cancer cells. PFKP is necessary for starvation-mediated autophagy, glycolysis, and EMT, thereby promoting the malignant progression of OSCC. The Snail-PFKP axis ... | |||
TMPY-02564 | BCL-XL Protein, Mouse, Recombinant (aa 1-212, His) | Mouse | E. coli |
B-cell lymphoma-extra large (Bcl-xl) is a transmembrane molecule in the mitochondria. Bcl-xL (BCL2L1), belongs to the Bcl-2 family. Members of the bcl-2 family encode proteins that function either to promote or to inhibi... | |||
TMPY-00587 | GABARAP Protein, Human, Recombinant (His & MBP) | Human | E. coli |
The Atg8/LC3/GABARAP family of proteins, a group that has structural homology with ubiquitin, connects with a large set of binding partners to function in macroautophagy (hereafter autophagy). GABARAP in tumorigenesis in... | |||
TMPH-02334 | RAB12 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bou... | |||
TMPY-02572 | TXNDC17 Protein, Human, Recombinant | Human | E. coli |
Thioredoxin-related protein of 14 kDa (TRP14, also called TXNDC17 for thioredoxin domain containing 17, or TXNL5 for thioredoxin-like 5) is an evolutionarily well-conserved member of the thioredoxin (Trx)-fold protein fa... | |||
TMPH-03499 | IL-4 Protein, Sheep, Recombinant (His) | Sheep | Yeast |
Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both... | |||
TMPH-01814 | Optineurin Protein, Human, Recombinant (His) | Human | Baculovirus |
Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role i... | |||
TMPH-01657 | MAGEA3 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a as repressor of autophagy. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubi... | |||
TMPH-03498 | IL-4 Protein, Sheep, Recombinant (B2M & His & Myc) | Sheep | E. coli |
Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both... | |||
TMPY-03416 | TNFAIP8 Protein, Human, Recombinant (His) | Human | E. coli |
Tumor necrosis factor (TNF)-alpha-induced protein 8 (TNFAIP8) family is a newly identified protein with vital roles in maintaining immune homeostasis. Tumor necrosis factor-alpha-inducible protein 8 (TNFAIP8) is a TNF-al... | |||
TMPH-03296 | Galectin-3/LGALS3 Protein, Rat, Recombinant (His) | Rat | E. coli |
Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute infl... | |||
TMPH-02633 | TRIM21 Protein, Mouse, Recombinant (His) | Mouse | Baculovirus |
E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of... | |||
TMPH-02387 | IL-4 Protein, Lama glama, Recombinant (His) | Lama glama | Yeast |
Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both... | |||
TMPH-02457 | IL-4 Protein, Mesocricetus auratus, Recombinant (His) | Mesocricetus auratus | Yeast |
Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both... | |||
TMPH-01815 | Optineurin Protein, Human, Recombinant (E. coli, His) | Human | E. coli |
Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role i... | |||
TMPH-02632 | TRIM21 Protein, Mouse, Recombinant (E. coli, His) | Mouse | E. coli |
E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of... | |||
TMPJ-00924 | Decorin Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
Decorin, also known as PG40 and DCN, is a member of the class I family of small leucine-rich proteoglycans (SLRPs) that is expressed in the stroma of various forms of cancer and has been recently proposed to act as a gua... | |||
TMPH-01710 | Mucolipin-1/MCOLN1 Protein, Human, Recombinant (His) | Human | in vitro E. coli expression system |
Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to t... | |||
TMPY-03749 | LC3B Protein, Human, Recombinant (His) | Human | E. coli |
MAP1LC3B (Microtubule Associated Protein 1 Light Chain 3 beta, also known as LC3B) is a Protein Coding gene. The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are in... | |||
TMPH-00289 | NOD2 Protein, Bovine, Recombinant (His & KSI) | Bovine | E. coli |
Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, ... | |||
TMPJ-00016 | GABARAP Protein, Human, Recombinant (GST) | Human | E. coli |
Gamma-Aminobutyric Acid Receptor-Associated Protein (GABARAP) is a ligand-gated chloride channel protein that mediates inhibitory neurotransmission and belongs to the MAP1 LC3 family. GABARAP is highly positively charged... | |||
TMPH-02538 | Beclin-1 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways... | |||
TMPH-01328 | FBXL2 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target... | |||
TMPH-01004 | Beclin-1 Protein, Human, Recombinant (His) | Human | E. coli |
Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane traffickin... | |||
TMPH-02282 | Ubiquilin-1 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pa... | |||
TMPJ-00015 | GABARAP Protein, Human, Recombinant (His & hFc) | Human | E. coli |
Gamma-Aminobutyric Acid Receptor-Associated Protein (GABARAP) is a ligand-gated chloride channel protein that mediates inhibitory neurotransmission and belongs to the MAP1 LC3 family. GABARAP is highly positively charged... | |||
TMPH-01631 | DCP2 Protein, Human, Recombinant (His) | Human | E. coli |
Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the ... | |||
TMPH-02526 | Arginase-2/ARG2 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synth... | |||
TMPH-01788 | NFE2L2 Protein, Human, Recombinant (His) | Human | E. coli |
Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzyme... | |||
TMPH-02478 | PRKAA1 Protein, Mouse, Recombinant (His) | Mouse | Baculovirus |
Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activat... | |||
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Cat No. | Product Name | ||
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L3200 | Autophagy Compound Library | 1248 compounds | |
A unique collection of 1248 compounds with defined autophagy-inducing or -inhibitory activity for research in autophagy, high throughput screening (HTS) and high content screening (HCS) for new drugs; | |||
L1120 | AMPK-Targeted Compound Library | 80 compounds | |
80 well-chosen unique AMPK-targeted small molecules; | |||
L6810 | Traditional Chinese Medicine Monomer Library | 2771 compounds | |
A unique collection of 2771 compounds (TCM monomers) sourcing from traditional Chinese Medicines, is a powerful tool for drug discovery and research in mechanism; | |||
L6800 | Chinese Pharmacopoeia Natural Product Library | 2070 compounds | |
A unique collection of 2070 natural products included in Chinese Pharmacopoeia (CP), a powerful tool for drug development and pharmacological study; | |||
L2550 | Glutamine Metabolism Compound Library | 580 compounds | |
A unique collection of 580 glutamine metabolism related compounds can be used for high throughput screening (HTS) and high content screening (HCS), and also is an effective tool for research in glutamine metabolism and ... |