Search Result

Search Results for " autophagy "

757

Compounds

315

Natural Products

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T9181	Autophagy-IN-A9		Others
	Autophagy-IN-A9 is a bioactive chemical.		Others
T38977	Autophagy-IN-C1	Autophagy-IN-C1
	Autophagy-IN-C1 is a cinchona alkaloid derivative containing urea. Autophagy-IN-C1 not only induces apoptosis but also blocks autophagy in hepatocellular carcinoma (HCC) cells.
T63744	Autophagy inducer 4
	Autophagy inducer 4 is a Mannich base derivative based on Magnolol and can be used as an anticancer agent. autophagy inducer 4 induces autophagy and thus inhibits cancer cells. autophagy inducer 4 is 76 times more toxic ...
T60749	Autophagy-IN-2
	Autophagy-IN-2 (Compound 7h) is an inhibitor of autophagic flux which induces cancer cell apoptosis and can be used for the research of triple-negative breast cancer [1].
T61580	Autophagy inducer 3
	Autophagy Inducer 3 is a chemical compound that exhibits autophagy-induced activity, specifically inducing robust autophagic cell death in various cancer cells while sparing normal cells. This compound induces lethal aut...
T62331	Autophagy-IN-1
	Autophagy-IN-1 is a potent inhibitor of autophagy/mitophagy, blocking autophagosomal-lysosomal fusion in cancer cells while selectively increasing autophagic flux. Autophagy-IN-1 significantly inhibits tumour growth in t...
T28001	MDK-6983	MDK-6983,Compound 6k,Autophagy inhibitor 6k,MDK6983	Autophagy
	MDK-6983 (MDK-6983) is an inhibitor of autophagy and disrupts the dynamics of actin cytoskeleton in human melanoma cells.		Autophagy
T26683	AUTEN-67	Autophagy enhancer 67,MTMR14 inhibitor,AUTEN67
	AUTEN-67 is a specific inhibitor of MTMR14 and autophagy enhancer with potent antiaging and neuroprotective effects. AUTEN-67 also delays the onset and decreases the severity of Huntington's disease.
T14346	Aumitin		Others , Autophagy
	Aumitin is a diaminopyrimidine-based autophagy inhibitor. Aumitin inhibits starvation- and rapamycin induced autophagy dose dependently with IC50s of 0.12 μM and 0.24 μM, respectively[1], and it inhibits mitochondrial re...		Others , Autophagy
T11142	EACC		Autophagy
	EACC, a reversible autophagy inhibitor, selectively impedes Stx17, an autophagosome-specific SNARE, from translocating, hence obstructing the fusion between autophagosomes and lysosomes. This compound effectively halts a...		Autophagy
T1554	Iohexol		Mitophagy , Autophagy
	Iohexol is a contrast agent. The osmolality of iohexol ranges from 322 mOsm/kg-approximately 1.1 times that of blood plasma-to 844 mOsm/kg, almost three times that of blood.		Mitophagy , Autophagy
T5211	NSC 185058	NSC185058	Cysteine Protease , Autophagy
	NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. It also can attenuate the autophagic activity.		Cysteine Protease , Autophagy
T2015	Fexaramine		FXR , Autophagy
	Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds.		FXR , Autophagy
T15303	FMK 9a		Cysteine Protease , Autophagy
	FMK 9a is an irreversible inhibitor of ATG4B with IC50 values of 80 and 73 nM in the TR-FRET and cellular-based LRA assays.		Cysteine Protease , Autophagy
T0876	Clioquinol	Chinoform,Iodochlorhydroxyquin	Mitophagy , Antibiotic , Autophagy , Antifungal
	Clioquinol (Iodochlorhydroxyquin) is an orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities.		Mitophagy , Antibiotic , Autophagy , Antifungal
T1825	Reversine		Aurora Kinase , Adenosine Receptor , Autophagy
	Reversine, a small synthetic purine analogue (2, 6-disubstituted purine), is a potent inhibitior of Aurora A/B/C(IC50s=150-500 nM).		Aurora Kinase , Adenosine Receptor , Autophagy
T7311	Oxyphenisatin acetate		Autophagy
	Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468.		Autophagy
T6056	Thiamet G	TMG	Others , Autophagy
	Thiamet G is a potent, selective O-GlcNAcase inhibitor with Kiof 21 nM, while exhibiting 37, 000-fold selectivity over human lysosomal –hexosaminidase.		Others , Autophagy
T4219	Autophinib		PI3K , Autophagy
	Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and rapamycin induced autophagy assay.		PI3K , Autophagy
T10413	Autogramin-1		mTOR , Autophagy
	Autogramin-1 potently inhibits autophagy induced by either mTORC1 inhibition (Rapamycin; IC50: 0.44 μM) or starvation (IC50: 0.17 μM).		mTOR , Autophagy
T2414	Torkinib	PP 242	Apoptosis , Mitophagy , PI3K , mTOR , Autophagy
	Torkinib (PP 242) (PP 242) is a selective and ATP-competitive mTOR inhibitor (IC50: 8 nM). It also inhibits mTORC1/2 (IC50s: 30/58 nM).		Apoptosis , Mitophagy , PI3K , mTOR , Autophagy
T5181	CA-5f		Apoptosis , Autophagy
	CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion.		Apoptosis , Autophagy
T1742	4E1rcat		PERK , Autophagy
	4E1RCat is a dual inhibitor of eIF4E:eIF4 g and eIF4E:4E-BP1 interaction. And it inhibits the binding of eIF4 g to eIF4E with IC50 of 3.2 μM.		PERK , Autophagy
T3045	Salubrinal		Apoptosis , Phosphatase , PERK , Autophagy , HSV
	Salubrinal, a phosphatases (PP1) inhibitor(IC50=1.7 μM), exhibits function on the eukaryotic translation initiation factor 2 subunit (eIF2α).		Apoptosis , Phosphatase , PERK , Autophagy , HSV
T14033	3BDO		Apoptosis , mTOR , Autophagy
	3BDO is an activator of mTOR. It can also inhibit autophagy..		Apoptosis , mTOR , Autophagy
T11375	GCN2iB		Others , Autophagy
	GCN2iB is an ATP-competitive inhibitor of a serine/threonine-protein kinase general control nonderepressible 2 (GCN2), with an IC50 of 2.4 nM.		Others , Autophagy
T7886	Nidufexor		FXR , Autophagy
	Nidufexor is an agonist for the farnesoid X receptor (FXR).		FXR , Autophagy
T3155	SMER28		Autophagy
	SMER28 is a small-molecule enhancer (SMER) of autophagy, inducing autophagy independently of rapamycin in mammalian cells via an mTOR-independent mechanism and prevented the accumulation of amyloid beta peptide.		Autophagy
T26684	Auten-99 HBr	Auten-99,Auten-99 hydrochloride. Auten-99 HBr,Auten99,Auten 99	Phosphatase
	Auten-99 HBr (Auten-99) is a myotubularin phosphatase Jumpy inhibitor exerting potent neuroprotective effects. AUTEN-99 activates autophagy in cell cultures and animal models. AUTEN-99 appears to effectively penetrate th...		Phosphatase
T0943	Carbamazepine	NSC 169864	Mitophagy , Sodium Channel , Autophagy
	Carbamazepine (NSC-169864) is a tricyclic compound chemically related to tricyclic antidepressants (TCA) with anticonvulsant and analgesic properties. Carbamazepine exerts its anticonvulsant activity by reducing polysyna...		Mitophagy , Sodium Channel , Autophagy
T3952	TPEN	TPEDA	Apoptosis , Reactive Oxygen Species , Autophagy
	TPEN (TPEDA) is a specific cell-permeable heavy metal chelator.		Apoptosis , Reactive Oxygen Species , Autophagy
T14365	AZ PFKFB3 26		Glucokinase
	AZ PFKFB3 26 is an effective and selective PFKFB3 inhibitor with an IC50 of 23 nM. The IC50s for PFKFB1 and PFKFB2 are 2.06 and 0.384 μM, respectively.		Glucokinase
T2099	ABT-737		Mitophagy , BCL , Autophagy
	ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w (EC50s: 78.7/30.3/197.8 nM).		Mitophagy , BCL , Autophagy
T6762	AS1842856		Autophagy , FOXO1
	AS1842856, a cell-permeable inhibitor, can block the transcription activity of Foxo1 (IC50: 33 nM). It can directly bind to the active Foxo1, but not the Ser256-phosphorylated form.		Autophagy , FOXO1
T11741	KAN0438757		Glucokinase , Autophagy
	KAN0438757 is a selective and potent inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM.		Glucokinase , Autophagy
T9062	CA77.1		Autophagy
	CA77.1(CA) is a novel chaperon-mediated autophagy (CMA) activator for the treatment of Alzheimer's disease (AD).		Autophagy
T1907	Mdivi-1	Mitochondrial division inhibitor 1	Apoptosis , Mitophagy , Dynamin , Autophagy
	Mdivi-1 (Mitochondrial division inhibitor 1) is a mitochondrial division inhibitor that inhibits DRP1 and Dynamin I (IC50=1-10 μM). Mdivi-1 inhibits mitochondrial autophagy.		Apoptosis , Mitophagy , Dynamin , Autophagy
T0972	Isoniazid	INH,Isonicotinic acid hydrazide,Isonicotinic hydrazide	Mitophagy , Dehydrogenase , CAT , Antibacterial , Autophagy
	Isoniazid (Isonicotinic hydrazide) is an antibacterial agent used primarily as a tuberculostatic.
T3686	10074-G5		c-Myc , Autophagy
	10074-G5 is an inhibitor of c-Myc-Max dimerization.		c-Myc , Autophagy
T14044	4E2RCat		PERK
	4E2RCat is an eIF4E-eIF4G interaction inhibitor (IC50: 13.5 μM).		PERK
T7679	UBCS039		Sirtuin , Autophagy
	UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)		Sirtuin , Autophagy
T6532	Hesperadin		Influenza Virus , Parasite , Aurora Kinase , Autophagy
	Hesperadin(IC50=250 nM) effectively inhibits Aurora B. It potently reduces the activity of AMPK, MAPKAP-K1, MKK1, Lck, CHK1 and PHK, but it could not inhibit MKK1 activity in vivo.		Influenza Virus , Parasite , Aurora Kinase , Autophagy
T1582	Naproxen	(S)-Naproxen	COX , Autophagy
	Naproxen ((S)-Naproxen) is a propionic acid derivative and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities.		COX , Autophagy
T5538	DC661		Apoptosis , Autophagy
	DC661 is a palmitoyl-protein thioesterase 1 (PPT1) inhibitor that acts as an anti-lysosomal agent by inhibiting autophagy, demonstrating anti-cancer activity.		Apoptosis , Autophagy
T11191	EN6		Proton pump , Autophagy
	EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative ...		Proton pump , Autophagy
T1829	Ruxolitinib	INCB018424,(R)-Ruxolitinib	Apoptosis , Mitophagy , Tyrosine Kinases , JAK , Autophagy
	Ruxolitinib (INCB018424) is a JAK1/2 inhibitor (IC50=3.3/2.8 nM) that is potent and selective. Rixolitinib exhibits antitumor activity and induces autophagy and apoptosis.
T15806	LY2562175		FXR , Autophagy
	LY2562175 is an effective and selective FXR agonist (EC50: 193 nM).		FXR , Autophagy
T2513	VX-702		p38 MAPK , Autophagy
	VX-702 is a highly specific p38α MAPK inhibitor, 14-fold higher selectivity for the p38α than p38β. VX-702 is a small molecule investigational oral anti-cytokine therapy for treatment of inflammatory diseases, specifical...		p38 MAPK , Autophagy
T22223	3PO		Glucokinase , Autophagy
	3PO is a small-molecule inhibitor of PFKFB3 (IC50: 22.9 μM), inhibiting the proliferation of several human malignant hematopoietic and adenocarcinoma cell lines (IC50: 1.4-24 μM). It suppresses glucose uptake, and decrea...		Glucokinase , Autophagy
T1927	CCT007093		Apoptosis , Phosphatase , Autophagy
	CCT007093 is an effective PPM1D (WIP1) inhibitor (IC50: 8.4 μM).		Apoptosis , Phosphatase , Autophagy

Compounds

Synonym: Autophagy-IN-C1

Target:

Autophagy inducer 4

Autophagy inducer 3

Synonym: MDK-6983,Compound 6k,Autophagy inhibitor 6k,MDK6983

Target: Autophagy

AUTEN-67

T26683

Synonym: Autophagy enhancer 67,MTMR14 inhibitor,AUTEN67

Target: Others, Autophagy

Target: Mitophagy, Autophagy

NSC 185058

T5211

Synonym: NSC185058

Target: Cysteine Protease, Autophagy

Fexaramine

T2015

Synonym:

Target: FXR, Autophagy

FMK 9a

T15303

Synonym:

Target: Cysteine Protease, Autophagy

Clioquinol

T0876

Synonym: Chinoform,Iodochlorhydroxyquin

Target: Mitophagy, Antibiotic, Autophagy, Antifungal

Reversine

T1825

Synonym:

Target: Aurora Kinase, Adenosine Receptor, Autophagy

Oxyphenisatin acetate

Target: Others, Autophagy

Autophinib

T4219

Synonym:

Target: PI3K, Autophagy

Autogramin-1

T10413

Synonym:

Target: mTOR, Autophagy

Torkinib

T2414

Synonym: PP 242

Target: Apoptosis, Mitophagy, PI3K, mTOR, Autophagy

CA-5f

T5181

Synonym:

Target: Apoptosis, Autophagy

4E1rcat

T1742

Synonym:

Target: PERK, Autophagy

Salubrinal

T3045

Synonym:

Target: Apoptosis, Phosphatase, PERK, Autophagy, HSV

3BDO

T14033

Synonym:

Target: Apoptosis, mTOR, Autophagy

GCN2iB

T11375

Synonym:

Target: Others, Autophagy

Nidufexor

T7886

Synonym:

Target: FXR, Autophagy

Synonym: Auten-99,Auten-99 hydrochloride. Auten-99 HBr,Auten99,Auten 99

Target: Mitophagy, Sodium Channel, Autophagy

TPEN

T3952

Synonym: TPEDA

Target: Apoptosis, Reactive Oxygen Species, Autophagy

Target: Mitophagy, BCL, Autophagy

AS1842856

T6762

Synonym:

Target: Autophagy, FOXO1

KAN0438757

T11741

Synonym:

Target: Glucokinase, Autophagy

Synonym: Mitochondrial division inhibitor 1

Target: Apoptosis, Mitophagy, Dynamin, Autophagy

Isoniazid

T0972

Synonym: INH,Isonicotinic acid hydrazide,Isonicotinic hydrazide

Target: Mitophagy, Dehydrogenase, CAT, Antibacterial, Autophagy

10074-G5

T3686

Synonym:

Target: c-Myc, Autophagy

Target: Sirtuin, Autophagy

Hesperadin

T6532

Synonym:

Target: Influenza Virus, Parasite, Aurora Kinase, Autophagy

Naproxen

T1582

Synonym: (S)-Naproxen

Target: COX, Autophagy

DC661

T5538

Synonym:

Target: Apoptosis, Autophagy

EN6

T11191

Synonym:

Target: Proton pump, Autophagy

Ruxolitinib

T1829

Synonym: INCB018424,(R)-Ruxolitinib

Target: Apoptosis, Mitophagy, Tyrosine Kinases, JAK, Autophagy

LY2562175

T15806

Synonym:

Target: FXR, Autophagy

VX-702

T2513

Synonym:

Target: p38 MAPK, Autophagy

3PO

T22223

Synonym:

Target: Glucokinase, Autophagy

CCT007093

T1927

Synonym:

Target: Apoptosis, Phosphatase, Autophagy

Cat No.	Product Name	Synonyms	Targets
T5763	Sedanolide		Others , Autophagy
	Sedanolide is a natural phthalide first isolated from seed oil of the Umbelliferae family, including celery.		Others , Autophagy
T6468	D-glutamine		Mitophagy , Ferroptosis , Endogenous Metabolite , GluR , Autophagy
	D-glutamine, an D type stereoisomer of glutamine, is one of the 20 amino acids which is encoded by the standard genetic code.
T5S1287	Ligustilide		Apoptosis , Autophagy
	3-Butylidene-4,5-dihydrophthalide is an effective constituent extracted from Angelica sinensis.		Apoptosis , Autophagy
T5793	Britannin		Apoptosis , AMPK , Autophagy
	Britannin, a sesquiterpene lactone, inhibits proliferation and induces apoptosis through the mitochondrial signaling pathway in human breast cancer cells.		Apoptosis , AMPK , Autophagy
T5S1099	Liensinine		Apoptosis , Mitophagy , Others , Autophagy
	1. Liensinine, a kind of isoquinoline alkaloid, can antagonize the ventricular arrhythmias.		Apoptosis , Mitophagy , Others , Autophagy
T0595	Naringin	Naringoside	Mitophagy , P450 , Endogenous Metabolite , Autophagy
	Naringin (Naringoside), a flavanone glycoside, exerts various of pharmacological effects such as blood lipid lowering, antioxidant activity, anticancer activity, and inhibition of cytochrome P450 enzymes.		Mitophagy , P450 , Endogenous Metabolite , Autophagy
TN1140	Onjisaponin B		AMPK , mTOR , Autophagy
	Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±-synuclein, it may have potential therapeutic effects on Parki...		AMPK , mTOR , Autophagy
T3400	Bakuchiol		p38 MAPK , DNA/RNA Synthesis , Autophagy
	Bakuchiol possesses anti-tumor,and anti-helmenthic properties. It has cytotoxic activity, mainly due to its DNA polymerase1 inhibiting activity. Bakuchiol has anti-bacterial activity against oral pathogens, has great pot...		p38 MAPK , DNA/RNA Synthesis , Autophagy
T8641	Vancomycin		Antibacterial , Antibiotic , Autophagy
	Vancomycin is a glycopeptide antibiotic that exerts its antimicrobial activity by altering the permeability of cell membranes and selectively inhibiting ribonucleic acid synthesis. Vancomycin can be used for the treatmen...		Antibacterial , Antibiotic , Autophagy
T3427	Polydatin	Piceid,Polydotin Peceid	Apoptosis , Mitophagy , NF-κB , Autophagy
	Polydatin (Piceid), the glycoside of Resveratrol, is originally isolated from the Chinese herb Polygonum cuspidatum. The compound can inhibit platelet aggregation and elevate the ratios of LDL-C/HDL-C and TC/HDL-C. In th...		Apoptosis , Mitophagy , NF-κB , Autophagy
TN1563	Dehydropachymic acid		Autophagy , Immunology/Inflammation related
	Dehydropachymic acid shows antiinflammatory activity.		Autophagy , Immunology/Inflammation related
T5515	Hemin	Hemin chloride	Mitophagy , Ferroptosis , Autophagy
	Hemin (Hemin chloride) is a chlorinated iron-containing porphyrin, a heme oxygenase (HO)-1 inducer. Hemin has therapeutic activity in porphyrias by reducing heme deficiency in patients, thereby inhibiting δ-aminolevulini...		Mitophagy , Ferroptosis , Autophagy
T2174	Quercetin	Sophoretin	Apoptosis , Mitophagy , Reactive Oxygen Species , PI3K , Autophagy
	Quercetin (Sophoretin) is a natural flavonoid and is an agonist of SIRT1. Quercetin is also a PI3K inhibitor, inhibiting PI3Kγ, PI3Kδ, and PI3Kβ (IC50=2.4/3.0/5.4 μM). Quercetin can induce apoptosis and autophagy.
TN1507	Clematichinenoside AR		TNF , Autophagy
	Clematichinenoside AR exerts anti-inflammatory and immunosuppressive properties, it has anti-arthritic effects on PI3K/Akt signaling pathway and TNF-α± associated with collagen-induced arthritis.		TNF , Autophagy
T3600	Licochalcone A		Caspase , UGT , Autophagy
	Licochalcone A is a flavonoid isolated from the famous Chinese medicinal herb Glycyrrhiza uralensis Fisch with obvious anti-cancer effects.		Caspase , UGT , Autophagy
T2140	Parthenolide	(-)-Parthenolide	Apoptosis , Mitophagy , NF-κB , HDAC , Autophagy
	(-)-Parthenolide ((-)-Parthenolide), an inhibitor of the Nuclear Factor-κB Pathway, also promotes the ubiquitination of MDM2 and activates p53 cellular functions.		Apoptosis , Mitophagy , NF-κB , HDAC , Autophagy
T3028	Tripterin	Celastrol,Tripterine	Apoptosis , Mitophagy , Proteasome , Autophagy
	Tripterin (Celastrol) is a natural product, a proteasome inhibitor that inhibits the pancreatic rennet-like activity of the 20S proteasome (IC50=2.5 μM). Tripterin has anti-inflammatory, anti-infectious, and immunomodula...		Apoptosis , Mitophagy , Proteasome , Autophagy
S00015	Tea polyphenol		Apoptosis , Others , Autophagy
	Tea polyphenol, also called green tea extract, are a mixture of chemical compounds, such as flavanoids and tannins, found naturally in tea. Polyphenols are powerful antioxidants, which can reduce the risk of developing c...		Apoptosis , Others , Autophagy
TN1702	Glycycoumarin		P450 , JNK , AMPK , Autophagy
	Glycycoumarin is an estrogen agonist, it shows moderate inhibitory effects against CYP1A2 and CYP2B6.		P450 , JNK , AMPK , Autophagy
TMS1743	Salvigenin		MAO , Autophagy , ROS Kinase
	Salvigenin is a potent hMAO-A inhibitor, has neuroprotective, antitumor and immunomodulatory effects.		MAO , Autophagy , ROS Kinase
T2565	Hesperetin		Apoptosis , p38 MAPK , 5-HT Receptor , Autophagy , TGF-beta/Smad
	Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside hesperidin, is the predominant flavonoid in lemons and oranges.
T0649	Salicylic acid	2-Hydroxybenzoic acid	Apoptosis , Mitophagy , COX , Endogenous Metabolite , Autophagy
	Salicylic acid (2-Hydroxybenzoic acid), a natural compound extracted from Willow bark, is an anti-inflammatory inhibitor of activity cyclooxygenase.
T4672	Brevilin A		Apoptosis , Anti-infection , JAK , STAT , Autophagy
	Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT si...		Apoptosis , Anti-infection , JAK , STAT , Autophagy
T6377	Aloperine		Apoptosis , Virus Protease , HIV Protease , Antibiotic , Autophagy
	Aloperine exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties.
T2888	Pterostilbene		Autophagy
	Pterostilbene is extracted from Pterocarpus indicus.		Autophagy
T2177	Kaempferol	Kempferol,Robigenin	Apoptosis , Estrogen Receptor/ERR , Mitophagy , Estrogen/progestogen Receptor , HIV Protease , Endogenous Metabolite , Parasite , Autophagy
	Kaempferol (Robigenin) is a natural flavonoid and an inverse agonist of ERRα and ERRγ. Kaempferol has a wide range of antitumor, anti-inflammatory, antioxidant, antibacterial and antiviral activities.
T7190	Actein		Apoptosis , Akt , JNK , Autophagy
	Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblasts in osteoporotic patients. Actein's ability to pathways in...		Apoptosis , Akt , JNK , Autophagy
T3S0807	Berbamine		CaMK , NF-κB , Autophagy
	Berbamine is a natural product extracted from Phellodendron amurense. It acts as a calcium channel blocker and possesses anti-tumor, immunomodulatory, and cardiovascular effects.		CaMK , NF-κB , Autophagy
T4S1102	Liensinine diperchlorate	Liensinine-Perchlorate	Mitophagy , Others , Autophagy
	Liensinine Diperchlorate is an isoquinoline alkaloid extracted from the embryonic seeds of the sacred lotus. It inhibits late autophagy by blocking autophagosome-lysosome fusion and exhibits biological activities such as...		Mitophagy , Others , Autophagy
T3814	Isorhapontigenin	Isorhapotogenin	Others , Autophagy
	Isorhapontigenin (Isorhapotogenin) is a tetrahydroxylated stilbenoid with a methoxy group. It is an isomer of rhapontigenin and an analog of resveratrol. It is found in the Chinese herb Gnetum cleistostachyum, in Gnetum ...		Others , Autophagy
T2900	Paeonol	Peonol	MAO , Autophagy , Monoamine Oxidase
	Paeonol (Peonol) is an active extraction from Paeonia suffruticosa. Paeonol inhibits MAO-A and MAO-B with IC50 of 54.6 μM and 42.5 μM, respectively.		MAO , Autophagy , Monoamine Oxidase
T0579	Myricetin	Cannabiscetin	Apoptosis , PI3K , Endogenous Metabolite , Autophagy
	Myricetin (Cannabiscetin) is a naturally-occurring flavonoid found in many grapes, berries, fruits, vegetables, herbs, as well as other plants. Walnuts are a rich dietary source. It has been shown that myricetin has anti...		Apoptosis , PI3K , Endogenous Metabolite , Autophagy
T6062	Brefeldin A	BFA,Ascotoxin,Cyanein,Decumbin	ATPase , Mitophagy , Antibiotic , Autophagy , HSV , CRISPR/Cas9
	Brefeldin A (Cyanein) belongs to the class of macrolide antibiotics and is an ATPase inhibitor (IC50=0.2 μM). Brefeldin A can induce tumor cell differentiation and apoptosis, and also possesses autophagy inhibitory activ...
T5S1467	Cucurbitacin E		CDK , Autophagy
	Cucurbitacin E is a natural product isolated from the climbing stem of Cucumic melo L. It significantly suppresses the activity of the cyclin B1/CDC2 complex.Cucurbitacin E has prevention of neurodegeneration, it has pot...		CDK , Autophagy
TQ0089	Juglanin		Apoptosis , JNK , Autophagy
	Juglanin is a JNK activator. Juglanin with inflammation and anti-tumor activities. It can induce apoptosis and autophagy on human breast cancer cells.		Apoptosis , JNK , Autophagy
TMA0507	Tomatidine		NF-κB , JNK , Autophagy
	Tomatidine serves as an anti-inflammatory agent by inhibiting NF-κB and JNK signaling pathways. Additionally, it induces autophagy in both mammalian cells and C. elegans.		NF-κB , JNK , Autophagy
T1659	Melatonin	Melatonine,N-Acetyl-5-methoxytryptamine	CaMK , Apoptosis , Mitophagy , Estrogen/progestogen Receptor , Melatonin Receptor , Glutathione Peroxidase , Endogenous Metabolite , ROR , Autophagy
	Melatonin (Melatonine) is a biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin...
T1879	3-Methyladenine	3-MA,NSC 66389	Mitophagy , PI3K , Endogenous Metabolite , Autophagy
	3-Methyladenine (3-MA) is a PI3K inhibitor that selectively inhibits class IB PI3Kγ (IC50=60 μM) and class III VPS34 (IC50=25 μM). 3-Methyladenine inhibits autophagy.		Mitophagy , PI3K , Endogenous Metabolite , Autophagy
T3800	Typhaneoside	Aervitrin	Others , Autophagy
	Typhaneoside (Aervitrin) is a flavonoid glycoside plant extract with potential ability to treat primary dysmenorrhea through the Shaofu Zhuyu decoction.		Others , Autophagy
T2781	Sanguinarine	Sanguinarin,Pseudochelerythrine	Apoptosis , Antioxidant , Autophagy
	Sanguinarine (Pseudochelerythrine) is a specific inhibitor of Rac1b with anti-microbial, anti-oxidant and anti-inflammatory properties.		Apoptosis , Antioxidant , Autophagy
TQ0309	Glaucocalyxin B		Autophagy
	Glaucocalyxin B is a diterpenoid isolated from Rabdosia japonica with anticancer and antitumor activity. It decreases the growth of HL-60 cells (IC50: 5.86 μM).		Autophagy
T8200	Ginkgolide K		AMPK , Autophagy
	Ginkgolide K induces protective autophagy through the AMPK/mTOR/ULK1 signalling pathway. It possesses neuroprotective activity.		AMPK , Autophagy
TN6735	Bigelovin		Apoptosis , Reactive Oxygen Species , Retinoid Receptor , Autophagy , RAR/RXR
	Bigelovin is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation.It is also known as a pote...
T1314	Triclosan	Irgasan,Cloxifenolum	NADPH , Antibacterial , Antibiotic , Autophagy , Antifungal
	Triclosan (Irgasan) is an antibacterial and antifungal agent.
T4519	Alisol A	Alisol-A	Autophagy
	Alisol A (Alisol-A) may be an autophagic inducer, it has anti-cancer activity, it presents inhibitory effects on cancer cell lines tested(HepG2, MDA-MB-231, and MCF-7 cells).		Autophagy
T1131	Ivermectin	MK-933	Mitophagy , GluCls , P2X Receptor , SARS-CoV , HIV Protease , Antibiotic , Parasite , Autophagy , HSV
	Ivermectin (MK-933) is a glutamate-gated chloride channel (GluCls) activator, with antiparasitic activity.
T6677	Sophocarpine		ERK , p38 MAPK , NF-κB , TLR , COX , HER , JNK , STAT
	Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.		ERK , p38 MAPK , NF-κB , TLR , COX , HER , JNK , STAT
TN2225	Soyasapogenol B		Apoptosis , Autophagy
	Soyasapogenol B has anti-cancer, hypocholesterolemic, anticomplementary, hepatoprotective effects, it inhibits proliferation of cultured Hep-G2.		Apoptosis , Autophagy
T1558	Resveratrol	trans-Resveratrol,SRT 501	Apoptosis , Mitophagy , IκB/IKK , Lipoxygenase , Sirtuin , COX , NADPH , DNA/RNA Synthesis , Nrf2 , Antibacterial , Antibiotic , Autophagy , Antifungal
	Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autop...
T2933	Wogonin	Vogonin	Apoptosis , Wnt/beta-catenin , CDK , Autophagy
	Wogonin (Vogonin) is a cell-permeable and orally available flavonoid that displays anti-inflammatory and anticancer properties.		Apoptosis , Wnt/beta-catenin , CDK , Autophagy
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Natural Products

Sedanolide

T5763

Synonym:

Target: Others, Autophagy

D-glutamine

T6468

Synonym:

Target: Mitophagy, Ferroptosis, Endogenous Metabolite, GluR, Autophagy

Ligustilide

T5S1287

Synonym:

Target: Apoptosis, Autophagy

Britannin

T5793

Synonym:

Target: Apoptosis, AMPK, Autophagy

Liensinine

T5S1099

Synonym:

Target: Apoptosis, Mitophagy, Others, Autophagy

Naringin

T0595

Synonym: Naringoside

Target: Mitophagy, P450, Endogenous Metabolite, Autophagy

Onjisaponin B

TN1140

Synonym:

Target: AMPK, mTOR, Autophagy

Bakuchiol

T3400

Synonym:

Target: p38 MAPK, DNA/RNA Synthesis, Autophagy

Vancomycin

T8641

Synonym:

Target: Antibacterial, Antibiotic, Autophagy

Polydatin

T3427

Synonym: Piceid,Polydotin Peceid

Target: Apoptosis, Mitophagy, NF-κB, Autophagy

Dehydropachymic acid

TN1563

Synonym:

Target: Autophagy, Immunology/Inflammation related

Hemin

T5515

Synonym: Hemin chloride

Target: Mitophagy, Ferroptosis, Autophagy

Quercetin

T2174

Synonym: Sophoretin

Target: Apoptosis, Mitophagy, Reactive Oxygen Species, PI3K, Autophagy

Clematichinenoside AR

TN1507

Synonym:

Target: TNF, Autophagy

Licochalcone A

T3600

Synonym:

Target: Caspase, UGT, Autophagy

Parthenolide

T2140

Synonym: (-)-Parthenolide

Target: Apoptosis, Mitophagy, NF-κB, HDAC, Autophagy

Tripterin

T3028

Synonym: Celastrol,Tripterine

Target: Apoptosis, Mitophagy, Proteasome, Autophagy

Tea polyphenol

S00015

Synonym:

Target: Apoptosis, Others, Autophagy

Glycycoumarin

TN1702

Synonym:

Target: P450, JNK, AMPK, Autophagy

Salvigenin

TMS1743

Synonym:

Target: MAO, Autophagy, ROS Kinase

Hesperetin

T2565

Synonym:

Target: Apoptosis, p38 MAPK, 5-HT Receptor, Autophagy, TGF-beta/Smad

Salicylic acid

T0649

Synonym: 2-Hydroxybenzoic acid

Target: Apoptosis, Mitophagy, COX, Endogenous Metabolite, Autophagy

Brevilin A

T4672

Synonym:

Target: Apoptosis, Anti-infection, JAK, STAT, Autophagy

Aloperine

T6377

Synonym:

Target: Apoptosis, Virus Protease, HIV Protease, Antibiotic, Autophagy

Synonym: Kempferol,Robigenin

Target: Apoptosis, Estrogen Receptor/ERR, Mitophagy, Estrogen/progestogen Receptor, HIV Protease, Endogenous Metabolite, Parasite, Autophagy

Actein

T7190

Synonym:

Target: Apoptosis, Akt, JNK, Autophagy

Berbamine

T3S0807

Synonym:

Target: CaMK, NF-κB, Autophagy

Liensinine diperchlorate

T4S1102

Synonym: Liensinine-Perchlorate

Target: Mitophagy, Others, Autophagy

Isorhapontigenin

T3814

Synonym: Isorhapotogenin

Target: Others, Autophagy

Paeonol

T2900

Synonym: Peonol

Target: MAO, Autophagy, Monoamine Oxidase

Myricetin

T0579

Synonym: Cannabiscetin

Target: Apoptosis, PI3K, Endogenous Metabolite, Autophagy

Brefeldin A

T6062

Synonym: BFA,Ascotoxin,Cyanein,Decumbin

Target: ATPase, Mitophagy, Antibiotic, Autophagy, HSV, CRISPR/Cas9

Cucurbitacin E

T5S1467

Synonym:

Target: CDK, Autophagy

Juglanin

TQ0089

Synonym:

Target: Apoptosis, JNK, Autophagy

Tomatidine

TMA0507

Synonym:

Target: NF-κB, JNK, Autophagy

Melatonin

T1659

Synonym: Melatonine,N-Acetyl-5-methoxytryptamine

Target: CaMK, Apoptosis, Mitophagy, Estrogen/progestogen Receptor, Melatonin Receptor, Glutathione Peroxidase, Endogenous Metabolite, ROR, Autophagy

3-Methyladenine

T1879

Synonym: 3-MA,NSC 66389

Target: Mitophagy, PI3K, Endogenous Metabolite, Autophagy

Typhaneoside

T3800

Synonym: Aervitrin

Target: Others, Autophagy

Sanguinarine

T2781

Synonym: Sanguinarin,Pseudochelerythrine

Target: Apoptosis, Antioxidant, Autophagy

Target: AMPK, Autophagy

Bigelovin

TN6735

Synonym:

Target: Apoptosis, Reactive Oxygen Species, Retinoid Receptor, Autophagy, RAR/RXR

Triclosan

T1314

Synonym: Irgasan,Cloxifenolum

Target: NADPH, Antibacterial, Antibiotic, Autophagy, Antifungal

Target: Mitophagy, GluCls, P2X Receptor, SARS-CoV, HIV Protease, Antibiotic, Parasite, Autophagy, HSV

Sophocarpine

T6677

Synonym:

Target: ERK, p38 MAPK, NF-κB, TLR, COX, HER, JNK, STAT

Soyasapogenol B

TN2225

Synonym:

Target: Apoptosis, Autophagy

Resveratrol

T1558

Synonym: trans-Resveratrol,SRT 501

Target: Apoptosis, Mitophagy, IκB/IKK, Lipoxygenase, Sirtuin, COX, NADPH, DNA/RNA Synthesis, Nrf2, Antibacterial, Antibiotic, Autophagy, Antifungal

Wogonin

T2933

Synonym: Vogonin

Target: Apoptosis, Wnt/beta-catenin, CDK, Autophagy

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Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-01003	ATG14 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidyletha...
TMPJ-01192	ELAPOR1 Protein, Human, Recombinant (His)	Human	Human Cells
	Endosome/lysosome-associated apoptosis and autophagy regulator (ELAPOR1), also known as EIG121 protein, is a type I transmembrane protein induced by estrogen. The estrogen-induced gene 121 (EIG121) has been associated wi...
TMPH-00340	ATG1 Protein, Candida glabrata, Recombinant (His)	Candida glabrata	E. coli
	Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein ...
TMPJ-01329	ATG5 Protein, Human, Recombinant	Human	E. coli
	ATG5 is an E2 ubiquitin ligase which is necessary for autophagy. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity, dramatically highly expressed in apoptotic ce...
TMPJ-01250	ATG4A Protein, Human, Recombinant (His)	Human	E. coli
	Cysteine Protease ATG4A (ATG4A) is a cytoplasmic protein that belongs to the peptidase C54 family. ATG4A is widely expressed in many tissues at a low level, but the highest expression is observed in skeletal muscle and b...
TMPJ-01327	ATG10 Protein, Human, Recombinant (His, T7)	Human	E. coli
	Ubiquitin-Like-Conjugating Enzyme ATG10 (ATG10) is a ubiquitous 28kDa member of the ATG10 family protein. ATG10 acts as an E2-like enzyme, catalyzes the transfer of ATG12 to ATG5 during in the initial stages of autophage...
TMPJ-01354	ATG3 Protein, Human, Recombinant	Human	E. coli
	Ubiquitin-like-conjugating enzyme ATG3 (ATG3), also known as Apg3L and Apg3p, functions as a regulatory component of autophagosome biogenesis necessary for autophagy. ATG3 exhibits 98% aa sequence identity with both its ...
TMPJ-01321	MAP1LC3B Protein, Human, Recombinant	Human	E. coli
	Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) is a member of the highly conserved ATG8 protein family. ATG8 proteins are present in all known eukaryotic organisms. MAP1LC3B is one of the four genes in t...
TMPY-06842	BMP-4 Protein, Human, Recombinant (E399D)	Human	E. coli
	BMP4 (bone morphogenetic protein-4)-directed differentiation of human embryonic stem cells (ESCd). Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP...
TMPY-02431	BCL-XL Protein, Human, Recombinant (His)	Human	E. coli
	B-cell lymphoma-extra large (Bcl-xl) is a transmembrane molecule in the mitochondria. Bcl-xL (BCL2L1), belongs to the Bcl-2 family. Members of the bcl-2 family encode proteins that function either to promote or to inhibi...
TMPY-00431	BMP-4 Protein, Mouse, Recombinant (rFc)	Mouse	HEK293
	BMP4 (bone morphogenetic protein-4)-directed differentiation of human embryonic stem cells (ESCd). Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP...
TMPY-03268	GABARAPL1 Protein, Human, Recombinant (His)	Human	E. coli
	ATG8, also known as GABARAPL1, is a ubiquitin-like protein that has a crystal structure. ATG8 consists of a 5-stranded β-sheet, which is enclosed by two α-helices at one side and one α-helix at the other side and exhibit...
TMPY-00473	NRBF2 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	NRBF2 (Nuclear Receptor Binding Factor 2) is a Protein Coding gene. The encoded protein may modulate transcriptional activation by target nuclear receptors. It is widely expressed in the appendix, placenta, and other tis...
TMPH-01287	TUFM Protein, Human, Recombinant (His)	Human	E. coli
	Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays also a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochon...
TMPH-02247	TRIM5 Protein, Human, Recombinant (B2M & His)	Human	E. coli
	Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting a...
TMPH-01363	Galectin-8/LGALS8 Protein, Human, Recombinant (GST)	Human	E. coli
	Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy. Detects membrane rupture by binding bet...
TMPH-03245	BCL2 Protein, Rat, Recombinant (His)	Rat	in vitro E. coli expression system
	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a fee...
TMPH-01684	MAP1LC3C Protein, Human, Recombinant (His)	Human	E. coli
	Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits all ATG8 family members to infecting bacteria such as S.Typhimurium. May also p...
TMPH-02520	BCL2 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a fee...
TMPH-00847	2-5A-dependent Rnase Protein, Human, Recombinant (Myc)	Human	E. coli
	Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stran...
TMPY-05160	PFKP Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	PFKP plays a critical role in cell proliferation in breast cancer cells. PFKP is necessary for starvation-mediated autophagy, glycolysis, and EMT, thereby promoting the malignant progression of OSCC. The Snail-PFKP axis ...
TMPY-02564	BCL-XL Protein, Mouse, Recombinant (aa 1-212, His)	Mouse	E. coli
	B-cell lymphoma-extra large (Bcl-xl) is a transmembrane molecule in the mitochondria. Bcl-xL (BCL2L1), belongs to the Bcl-2 family. Members of the bcl-2 family encode proteins that function either to promote or to inhibi...
TMPY-00587	GABARAP Protein, Human, Recombinant (His & MBP)	Human	E. coli
	The Atg8/LC3/GABARAP family of proteins, a group that has structural homology with ubiquitin, connects with a large set of binding partners to function in macroautophagy (hereafter autophagy). GABARAP in tumorigenesis in...
TMPH-02334	RAB12 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bou...
TMPY-02572	TXNDC17 Protein, Human, Recombinant	Human	E. coli
	Thioredoxin-related protein of 14 kDa (TRP14, also called TXNDC17 for thioredoxin domain containing 17, or TXNL5 for thioredoxin-like 5) is an evolutionarily well-conserved member of the thioredoxin (Trx)-fold protein fa...
TMPH-03499	IL-4 Protein, Sheep, Recombinant (His)	Sheep	Yeast
	Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both...
TMPH-01814	Optineurin Protein, Human, Recombinant (His)	Human	Baculovirus
	Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role i...
TMPH-01657	MAGEA3 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a as repressor of autophagy. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubi...
TMPH-03498	IL-4 Protein, Sheep, Recombinant (B2M & His & Myc)	Sheep	E. coli
	Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both...
TMPY-03416	TNFAIP8 Protein, Human, Recombinant (His)	Human	E. coli
	Tumor necrosis factor (TNF)-alpha-induced protein 8 (TNFAIP8) family is a newly identified protein with vital roles in maintaining immune homeostasis. Tumor necrosis factor-alpha-inducible protein 8 (TNFAIP8) is a TNF-al...
TMPH-03296	Galectin-3/LGALS3 Protein, Rat, Recombinant (His)	Rat	E. coli
	Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute infl...
TMPH-02633	TRIM21 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus
	E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of...
TMPH-02387	IL-4 Protein, Lama glama, Recombinant (His)	Lama glama	Yeast
	Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both...
TMPH-02457	IL-4 Protein, Mesocricetus auratus, Recombinant (His)	Mesocricetus auratus	Yeast
	Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both...
TMPH-01815	Optineurin Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role i...
TMPH-02632	TRIM21 Protein, Mouse, Recombinant (E. coli, His)	Mouse	E. coli
	E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of...
TMPJ-00924	Decorin Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	Decorin, also known as PG40 and DCN, is a member of the class I family of small leucine-rich proteoglycans (SLRPs) that is expressed in the stroma of various forms of cancer and has been recently proposed to act as a gua...
TMPH-01710	Mucolipin-1/MCOLN1 Protein, Human, Recombinant (His)	Human	in vitro E. coli expression system
	Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to t...
TMPY-03749	LC3B Protein, Human, Recombinant (His)	Human	E. coli
	MAP1LC3B (Microtubule Associated Protein 1 Light Chain 3 beta, also known as LC3B) is a Protein Coding gene. The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are in...
TMPH-00289	NOD2 Protein, Bovine, Recombinant (His & KSI)	Bovine	E. coli
	Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, ...
TMPJ-00016	GABARAP Protein, Human, Recombinant (GST)	Human	E. coli
	Gamma-Aminobutyric Acid Receptor-Associated Protein (GABARAP) is a ligand-gated chloride channel protein that mediates inhibitory neurotransmission and belongs to the MAP1 LC3 family. GABARAP is highly positively charged...
TMPH-02538	Beclin-1 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways...
TMPH-01328	FBXL2 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target...
TMPH-01004	Beclin-1 Protein, Human, Recombinant (His)	Human	E. coli
	Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane traffickin...
TMPH-02282	Ubiquilin-1 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pa...
TMPJ-00015	GABARAP Protein, Human, Recombinant (His & hFc)	Human	E. coli
	Gamma-Aminobutyric Acid Receptor-Associated Protein (GABARAP) is a ligand-gated chloride channel protein that mediates inhibitory neurotransmission and belongs to the MAP1 LC3 family. GABARAP is highly positively charged...
TMPH-01631	DCP2 Protein, Human, Recombinant (His)	Human	E. coli
	Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the ...
TMPH-02526	Arginase-2/ARG2 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synth...
TMPH-01788	NFE2L2 Protein, Human, Recombinant (His)	Human	E. coli
	Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzyme...
TMPH-02478	PRKAA1 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus
	Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activat...
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ATG14 Protein, Human, Recombinant (His & Myc)

TMPH-01003

Species: Human

Expression System: E. coli

ELAPOR1 Protein, Human, Recombinant (His)

TMPJ-01192

Species: Human

Expression System: Human Cells

ATG1 Protein, Candida glabrata, Recombinant (His)

TMPH-00340

Species: Candida glabrata

Expression System: E. coli

ATG5 Protein, Human, Recombinant

TMPJ-01329

Species: Human

Expression System: E. coli

ATG4A Protein, Human, Recombinant (His)

TMPJ-01250

Species: Human

Expression System: E. coli

ATG10 Protein, Human, Recombinant (His, T7)

TMPJ-01327

Species: Human

Expression System: E. coli

ATG3 Protein, Human, Recombinant

TMPJ-01354

Species: Human

Expression System: E. coli

MAP1LC3B Protein, Human, Recombinant

TMPJ-01321

Species: Human

Expression System: E. coli

BMP-4 Protein, Human, Recombinant (E399D)

TMPY-06842

Species: Human

Expression System: E. coli

BCL-XL Protein, Human, Recombinant (His)

TMPY-02431

Species: Human

Expression System: E. coli

BMP-4 Protein, Mouse, Recombinant (rFc)

TMPY-00431

Species: Mouse

Expression System: HEK293

GABARAPL1 Protein, Human, Recombinant (His)

TMPY-03268

Species: Human

Expression System: E. coli

NRBF2 Protein, Human, Recombinant (His & GST)

TMPY-00473

Species: Human

Expression System: Baculovirus-Insect Cells

TUFM Protein, Human, Recombinant (His)

TMPH-01287

Species: Human

Expression System: E. coli

TRIM5 Protein, Human, Recombinant (B2M & His)

TMPH-02247

Species: Human

Expression System: E. coli

Galectin-8/LGALS8 Protein, Human, Recombinant (GST)

TMPH-01363

Species: Human

Expression System: E. coli

BCL2 Protein, Rat, Recombinant (His)

TMPH-03245

Species: Rat

Expression System: in vitro E. coli expression system

MAP1LC3C Protein, Human, Recombinant (His)

TMPH-01684

Species: Human

Expression System: E. coli

BCL2 Protein, Mouse, Recombinant (His)

TMPH-02520

Species: Mouse

Expression System: E. coli

2-5A-dependent Rnase Protein, Human, Recombinant (Myc)

TMPH-00847

Species: Human

Expression System: E. coli

PFKP Protein, Human, Recombinant (His & GST)

TMPY-05160

Species: Human

Expression System: Baculovirus-Insect Cells

BCL-XL Protein, Mouse, Recombinant (aa 1-212, His)

TMPY-02564

Species: Mouse

Expression System: E. coli

GABARAP Protein, Human, Recombinant (His & MBP)

TMPY-00587

Species: Human

Expression System: E. coli

RAB12 Protein, Human, Recombinant (His & Myc)

TMPH-02334

Species: Human

Expression System: E. coli

TXNDC17 Protein, Human, Recombinant

TMPY-02572

Species: Human

Expression System: E. coli

IL-4 Protein, Sheep, Recombinant (His)

TMPH-03499

Species: Sheep

Expression System: Yeast

Optineurin Protein, Human, Recombinant (His)

TMPH-01814

Species: Human

Expression System: Baculovirus

MAGEA3 Protein, Human, Recombinant (His & Myc)

TMPH-01657

Species: Human

Expression System: E. coli

IL-4 Protein, Sheep, Recombinant (B2M & His & Myc)

TMPH-03498

Species: Sheep

Expression System: E. coli

TNFAIP8 Protein, Human, Recombinant (His)

TMPY-03416

Species: Human

Expression System: E. coli

Galectin-3/LGALS3 Protein, Rat, Recombinant (His)

TMPH-03296

Species: Rat

Expression System: E. coli

TRIM21 Protein, Mouse, Recombinant (His)

TMPH-02633

Species: Mouse

Expression System: Baculovirus

IL-4 Protein, Lama glama, Recombinant (His)

TMPH-02387

Species: Lama glama

Expression System: Yeast

IL-4 Protein, Mesocricetus auratus, Recombinant (His)

TMPH-02457

Species: Mesocricetus auratus

Expression System: Yeast

Optineurin Protein, Human, Recombinant (E. coli, His)

TMPH-01815

Species: Human

Expression System: E. coli

TRIM21 Protein, Mouse, Recombinant (E. coli, His)

TMPH-02632

Species: Mouse

Expression System: E. coli

Decorin Protein, Mouse, Recombinant (His)

TMPJ-00924

Species: Mouse

Expression System: Human Cells

Mucolipin-1/MCOLN1 Protein, Human, Recombinant (His)

TMPH-01710

Species: Human

Expression System: in vitro E. coli expression system

LC3B Protein, Human, Recombinant (His)

TMPY-03749

Species: Human

Expression System: E. coli

NOD2 Protein, Bovine, Recombinant (His & KSI)

TMPH-00289

Species: Bovine

Expression System: E. coli

GABARAP Protein, Human, Recombinant (GST)

TMPJ-00016

Species: Human

Expression System: E. coli

Beclin-1 Protein, Mouse, Recombinant (His & SUMO)

TMPH-02538

Species: Mouse

Expression System: E. coli

FBXL2 Protein, Human, Recombinant (His & SUMO)

TMPH-01328

Species: Human

Expression System: E. coli

Beclin-1 Protein, Human, Recombinant (His)

TMPH-01004

Species: Human

Expression System: E. coli

Ubiquilin-1 Protein, Human, Recombinant (His & Myc)

TMPH-02282

Species: Human

Expression System: E. coli

GABARAP Protein, Human, Recombinant (His & hFc)

TMPJ-00015

Species: Human

Expression System: E. coli

DCP2 Protein, Human, Recombinant (His)

TMPH-01631

Species: Human

Expression System: E. coli

Arginase-2/ARG2 Protein, Mouse, Recombinant (His & SUMO)

TMPH-02526

Species: Mouse

Expression System: E. coli

NFE2L2 Protein, Human, Recombinant (His)

TMPH-01788

Species: Human

Expression System: E. coli

PRKAA1 Protein, Mouse, Recombinant (His)

TMPH-02478

Species: Mouse

Expression System: Baculovirus

--------- More ---------

Cat No.	Product Name
L3200	Autophagy Compound Library	1248 compounds
	A unique collection of 1248 compounds with defined autophagy-inducing or -inhibitory activity for research in autophagy, high throughput screening (HTS) and high content screening (HCS) for new drugs;
L1120	AMPK-Targeted Compound Library	80 compounds
	80 well-chosen unique AMPK-targeted small molecules；
L6810	Traditional Chinese Medicine Monomer Library	2771 compounds
	A unique collection of 2771 compounds (TCM monomers) sourcing from traditional Chinese Medicines, is a powerful tool for drug discovery and research in mechanism；
L6800	Chinese Pharmacopoeia Natural Product Library	2070 compounds
	A unique collection of 2070 natural products included in Chinese Pharmacopoeia (CP), a powerful tool for drug development and pharmacological study;
L2550	Glutamine Metabolism Compound Library	580 compounds
	A unique collection of 580 glutamine metabolism related compounds can be used for high throughput screening (HTS) and high content screening (HCS), and also is an effective tool for research in glutamine metabolism and ...

Libraries

Autophagy Compound Library

L3200

Compounds: 1248

AMPK-Targeted Compound Library

L1120

Compounds: 80

Traditional Chinese Medicine Monomer Library

L6810

Compounds: 2771

Chinese Pharmacopoeia Natural Product Library

L6800

Compounds: 2070

Glutamine Metabolism Compound Library

L2550

Compounds: 580