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Cat No. | Product Name | Synonyms | Targets |
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T38622 | Bcl-xL antagonist 2 | BCL | |
Bcl-xL antagonist 2 is an effective and selective antagonist of Bcl-xL with an IC50 of 91 nM and a Ki of 65 nM. Bcl-xL antagonist 2 induces apoptosis in cancer cells and can be used in studies about chronic lymphocytic l... | |||
T77571 | Bcl-B inhibitor 1 | Apoptosis , BCL | |
Bcl-B inhibitor 1 is a Bcl-B inhibitor with antitumor activity that binds to and inactivates pro-apoptotic proteins in the BH3 structural domain. | |||
T10483 | Lisaftoclax | Bcl-2/Bcl-xl inhibitor 1,APG-2575 | BCL |
Lisaftoclax (Bcl-2/Bcl-xl inhibitor 1) is an oral dual inhibitor of Bcl-2 and Bcl-xl, with IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively. Lisaftoclax is used to treat chronic lymphocytic leukemia (CLL... | |||
T39961 | Bcl-2-IN-2 | ||
Bcl-2-IN-2 is a highly potent and selective inhibitor targeting Bcl-2 and Bcl-xL. It displays an IC50 value of 0.034 nM, suggesting its strong inhibitory activity specifically against Bcl-2. Additionally, Bcl-2-IN-2 exhi... | |||
T11969 | MCL-1/BCL-2-IN-2 | Others | |
MCL-1/BCL-2-IN-2 is a potent and selective Bcl-2 and Mcl-1 dual inhibitor. | |||
T11970 | MCL-1/BCL-2-IN-3 | Others | |
MCL-1/BCL-2-IN-3 is a selective and potent Mcl-1 and Bcl-2 dual inhibitor with IC50s of 5.95 and 4.78 μM, respectiely. | |||
T11971 | MCL-1/BCL-2-IN-4 | Others | |
MCL-1/BCL-2-IN-4 is a selective and potent Mcl-1 and Bcl-2 dual inhibitor. | |||
T11968 | MCL-1/BCL-2-IN-1 | BCL | |
MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective dual inhibitor of Mcl-1 and Bcl-2 with IC 50 s of 4.45 and 3.18 μM, respectively [1]. | |||
T79171 | Bcl-2-IN-11 | ||
Bcl-2-IN-11 (compound 6) is a potent and selective inhibitor of Bcl-2 activity, exhibiting an IC50 of 0.9 nM, and demonstrates minimal inhibition against Bcl-xl (IC50 > 1000 nM). This compound is utilized in researching ... | |||
T82910 | Bcl-2-IN-16 | ||
Bcl-2-IN-16 is a Bcl-2 (B-cell lymphoma 2) inhibitor [1]. | |||
T64053 | Bcl-2-IN-8 | ||
Bcl-2-IN-8 is a potent anti-cancer agent. bcl-2-IN-8 exhibits anti-proliferative effects on both drug-sensitive and drug-resistant cancer cells. bcl-2-IN-8 inhibits cell migration in a dose-dependent manner. bcl-2-IN-8 b... | |||
T80221 | TAT-BH4 (Bcl-xL) | Apoptosis | |
TAT-BH4 (Bcl-xL), primarily localized at the mitochondria, inhibits apoptotic cell death. This compound comprises an N-terminal eosin-labeled cysteine and the protein transduction domain of the HIV TAT protein (amino aci... | |||
T74297 | Bcl-2-IN-4 | ||
Bcl-2-IN-4, an orally active and selective inhibitor of Bcl-2, demonstrates potent efficacy with an IC50 value of 1.5 nM and exhibits more than 200-fold selectivity over Bcl-xL (IC50 of 411 nM). Additionally, it effectiv... | |||
T82912 | Bcl-2-IN-14 | ||
Bcl-2-IN-14 (Compound 13c), a BCL-2 inhibitor, exhibits an inhibitory concentration (IC 50) of 0.471 μM, and is applicable in cancer research [1]. | |||
T63676 | Bcl-2-IN-6 | ||
Bcl-2-IN-6 is a potent inhibitor of Bcl-2 (b-cell lymphoma-2) that downregulates Bcl-2 expression and increases the expression of p53, Bax, and caspase-7 mRNA. bcl-2-IN-7 induces cell cycle arrest and apoptosis in breast... | |||
T74298 | Bcl-2-IN-5 | ||
Bcl-2-IN-5 is a potent inhibitor of BCL-2, demonstrating inhibitory concentrations (IC50) of 0.12 nM, 0.14 nM, and 0.22 nM against wild type Bcl-2, Bcl-2 D103Y, and Bcl-2 G101V, respectively. Additionally, it effectively... | |||
T63757 | Bcl-2-IN-9 | ||
Bcl-2-IN-9 is a novel, pro-apoptotic, low cytotoxic Bcl-2 inhibitor (IC50: 2.9 μM). Bcl-2-IN-9 downregulates Bcl-2 expression, induces apoptosis in cancer cells, and exhibits high selectivity for leukemia cells. | |||
T82914 | Bcl-2-IN-12 | ||
Bcl-2-IN-12 (Compound 1) is a potent Bcl-2 inhibitor with an IC50 value of 6 nM, utilized in cancer research [1]. | |||
T82913 | Bcl-2-IN-13 | ||
Bcl-2-IN-13 is a potent inhibitor of Bcl-2, exhibiting an IC50 of 17 nM, and holds potential for use in cancer research [1]. | |||
T82911 | Bcl-2-IN-15 | ||
Bcl-2-IN-15 (Compound 13d) is a Bcl-2 inhibitor with an IC50 of 363 nM, which impedes the proliferation of the NCI leukemia cancer cell line [1]. | |||
T63521 | Bcl-2-IN-7 | ||
Bcl-2-IN-7 is a potent inhibitor of Bcl-2 (b-cell lymphoma-2), which can downregulate the expression of Bcl-2, increase the expression of p53, Bax, caspase-7 mRNA, and induce cell cycle arrest and apoptosis in MCF-7 cell... | |||
T74138 | PROTAC Bcl-xL degrader-2 | ||
PROTAC Bcl-xL degrader-2, based on von Hippel-Lindau ligand, is a potent degrader of Bcl-xL (a Bcl-2 family member), demonstrating an IC 50 of 0.6 nM. | |||
T73999 | PROTAC Bcl-xL degrader-3 | ||
PROTAC Bcl-xL degrader-3 is a potent ROTAC Bcl-xL degrader. | |||
T80222 | TAT-BH4 (Bcl-xL) (TFA) | Apoptosis | |
"TAT-BH4 (Bcl-xL) TFA, primarily localized at the mitochondria, inhibits apoptotic cell death. This compound comprises an eosin-labeled cysteine at the N-terminal and the protein transduction domain from the HIV TAT prot... | |||
T62941 | Bcl-2/Mcl-1-IN-3 | ||
Bcl-2/Mcl-1-IN-3 is a Bcl-2/Mcl-1 inhibitor that acts on Mcl-1 (Ki: 0.14 μM) and Bcl-2 (Ki: 0.23 μM) and can be used in cancer research. | |||
T82902 | Beclin1-Bcl-2 interaction inhibitor 1 | ||
Beclin1-Bcl-2 Interaction Inhibitor 1 effectively disrupts the binding of Beclin 1 to Bcl-2, and is utilized in cancer and neurodegeneration research [1]. | |||
T74137 | PROTAC Bcl-xL ligand-1 | ||
PROTAC Bcl-xL ligand-1 serves as a ligand targeting Bcl-xL, essential in synthesizing PROTACs [1]. | |||
T73957 | PROTAC Bcl-xL degrader-1 | ||
PROTAC Bcl-xL degrader-1 is a potent PROTAC composed of a Bcl-xL (Bcl-2 family member) ligand-binding group, a linker, and an IAP E3 ligases binding group, demonstrating effectiveness as a Bcl-xL degrader. It exhibits to... | |||
T12824L | S55746 | BLC201 | BCL |
S55746 (BLC201) is an effective and selective BCL-2 inhibitor (Ki: 1.3 nM and a Kd of 3.9 nM). | |||
T33467 | MOMIPP | PI3K | |
MOMIPP is a PIKfyve inhibitor and a macropinocytosis inducer. MOMIPP readily penetrates the blood-brain barrier and is moderately effective in suppressing progression of intracerebral glioblastoma xenografts[1][2]. | |||
T62249 | Bcl-2/Mcl-1-IN-1 | ||
Bcl-2/Mcl-1-IN-1 is an inhibitor of Bcl-2 (Ki: 4.53 μM) and Mcl-1 (Ki: 1.19 μM).Bcl-2/Mcl-1-IN-1 can be used in cancer research. | |||
T62443 | Bcl-2/Mcl-1-IN-2 | ||
Bcl-2/Mcl-1-IN-2 is a Bcl-2 (Ki: 4.70 μM) and Mcl-1 (Ki: 0.88 μM) inhibitor.Bcl-2/Mcl-1-IN-2 can be used in cancer research. | |||
T17018 | TCPOBOP | BCL | |
TCPOBOP is a constitutive androstane receptor agonist that induces robust hepatocyte proliferation and hepatomegaly. TCPOBOP decreases Fas-induced murine liver injury by altering Bcl-2 proteins. | |||
T10487 | BCL6-IN-3 | BCL , Others , DNA | |
BCL6-IN-3 is a potent BCL6 inhibitor with GI50 of 70 nM in SU-DHL4 cells. BCL6-in-3 regulates cell activation, differentiation, DNA damage and apoptosis, and has antitumor activity. | |||
T18363 | Monoethyl pimelate | Others , PROTAC Linker | |
Monoethyl pimelate is a <b >PROTAC linker, which refers to the alkyl/ether composition. Monoethyl pimelate can be used in the synthesis of (S,R,S)-AHPC-Me-C7 ester, a specific BCL-XL PROTAC degrader[1]. | |||
T2099 | ABT-737 | Mitophagy , BCL , Autophagy | |
ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w (EC50s: 78.7/30.3/197.8 nM). | |||
T11944 | Maritoclax | Marinopyrrole A | BCL |
Maritoclax (Marinopyrrole A) (Marinopyrrole A) is a novel and specific Mcl-1 inhibitor, shows >8 fold selectivity than BCL-xl (IC50 > 80 μM),with an IC50 value of 10.1 μM. | |||
T14376 | AZD4320 | BCL | |
AZD4320 is an inhibitor of BH3-mimicking dual BCL2/BCLxL. For KPUM-MS3, KPUM-UH1, and STR-428 cells, the IC50s values are 26 nM, 17 nM, and 170 nM , respectively. | |||
T5346 | S63845 | BCL | |
S63845 is a selective MCL-1 inhibitor(Kd: 0.19 nM) | |||
T14071 | A-385358 | BCL | |
A-385358 is a selective Bcl-xL inhibitor with Kis of 0.80 nM for Bcl-xL and 67 nM for Bcl-2, respectively. | |||
T6650 | Sabutoclax | BI-97C1 | BCL |
Sabutoclax (BI-97C1)(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively. | |||
T1980 | HA14-1 | BCL | |
HA14-1, a Bcl-2/Bcl-XL antagonist, is a non-peptidic ligand of a Bcl-2 surface pocket (IC50: ~9 μM). | |||
T14561 | BI-3812 | BCL | |
BI-3812 is an inhibitor of BCL6. Which inhibiting the BTB domain of BCL6 (IC50: 3 nM). BI-3812 also has antitumor activity. | |||
T6749 | A-1331852 | BCL | |
A-1331852 is a potent and selectiveBCL-XL inhibitor and may be useful in the treatment of cancer, immune and autoimmune diseases. | |||
T2453 | BAM7 | BCL | |
BAM 7 is a direct and specific activator of proapoptotic Bax (EC50: 3.3 μM). | |||
T5108 | ML311 | BCL | |
ML311 is a selective inhibitor of the Mcl-1/Bim interaction. | |||
T5408 | BI-3802 | BCL | |
BI-3802, a highly potent BCL6 degrader, targets and inhibits the Bric-à-brac (BTB) domain of BCL6, exhibiting an IC50 value of ≤3 nM. It induces polymerization of BCL6 and facilitates its degradation in a manner dependen... | |||
T2632 | A-1210477 | Apoptosis , BCL | |
A-1210477 is an effective and specific MCL-1 and Bcl-2 inhibitor (Ki/IC50: 0.454/26.2 nM). | |||
T6281 | TW-37 | TW 37 | BCL |
TW-37 is an nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 (Ki: 0.29/1.11/0.26 μM). | |||
T4089 | FX1 | Apoptosis , BCL | |
FX1 is an effective and selective BCL6 inhibitor (IC50: 35 μM). |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T3824 | Jaceosidin | Apoptosis , BCL , COX , UGT | |
Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway... | |||
T8213 | Isolinderalactone | NOS , STAT | |
Isolinderalactone shows anti-inflammatory and anticancer capacity, and it exhibits moderate iNOS inhibitory activity, with the IC50 value of 0.30 uM. | |||
TN1406 | Dihydrokaempferol | Aromadendrin | Apoptosis , BCL |
Dihydrokaempferol (Aromadendrin) is a natural product. It induces apoptosis and inhibits Bcl-2 and Bcl-xL expression, possesses anti-inflammatory, antioxidant, and anti-diabetic properties, it exhibits anti-inflammatory ... | |||
TN3967 | Epieriocalyxin A | ERK , BCL , ROS , Caspase , DNA/RNA Synthesis , JNK | |
Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future. | |||
T6518 | Gossypol | Pogosin,BL 193,NSC 56817 | BCL , Dehydrogenase |
Gossypol (BL 193) Acetate is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. | |||
T6S1653 | Albiflorin | Alibiflorin | Reactive Oxygen Species |
1. Albiflorin (Alibiflorin) has anticonvulsant effect for pain relief. 2. Albiflorin and paeoniflorin has neuroprotective action against Glu toxicity. 3. Albiflorin and paeoniflorin significantly ameliorated Glu-induced ... | |||
T6S0052 | Chelerythrine | Toddalin,Broussonpapyrine,Cheleritrine | Apoptosis , BCL , PKC , Autophagy |
1. Chelerythrine (Broussonpapyrine) may have antimanic effect . 2. Chelerythrine can inhibit telomerase activity. 3. Chelerythrine is a well-known protein kinase C inhibitor . 4. Chelerythrine has potential antiprolifera... | |||
T3419 | Chelerythrine chloride | Apoptosis , BCL , PKC , Autophagy | |
Chelerythrine Chloride is a cell-permeable inhibitor of protein kinase C, competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. | |||
T2S0500 | Ilexsaponin A | Ilexsaponin A1 | Others |
1. Ilexsaponin A (Ilexsaponin A1) shows protective effects on ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway. | |||
T5S2358 | Dehydrocorydaline | Dehydrocorydalin,13-Methylpalmatine | BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy |
1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimeriz... | |||
T7979 | 2-Hydroxychalcone | 2-(2-Hydroxybenzal)Acetophenone | Apoptosis , BCL , Others , NF-κB |
2-Hydroxychalcone (2-(2-Hydroxybenzal)Acetophenone) can be used as antiparasitic hit compounds when Methoxylated.It can inhibit invasion of triple negative breast cancer cells. | |||
T10990 | Dehydrocorydaline chloride | 13-Methylpalmatine chloride | BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy |
Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of p38 MAPK. | |||
T6185 | Gambogic Acid | Beta-Guttiferrin,Guttatic Acid,Guttic Acid | BCL , Autophagy |
Gambogic Acid (Guttic Acid) ( EC50=0.78-1.64 uM) activates caspases. Gambogic Acid competitively suppresses Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1. The IC50s of Gambogic Acid for Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 ... | |||
T2S2362 | Dehydrocorydaline nitrate | BCL , Others , PARP , p38 MAPK , Caspase , Parasite , Autophagy | |
1. Dehydrocorydaline(DHC) not only inhibits antibody-mediated allergic reactions but also influences cell-mediated allergic reactions, and the inhibitory effect of Corydalis Tuber on allergic reactions may be partially a... | |||
T3322 | Trans-Chalcone | Chalcone,Cinnamophenone,Chalkone | Apoptosis , Others , Antifungal , Fatty Acid Synthase |
trans-Chalcone (Chalkone) is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones. | |||
T5679 | (E)-Ferulic acid | trans-Ferulic acid,(E)-Coniferic acid | BCL , Ferroptosis , Wnt/beta-catenin , Endogenous Metabolite |
(E)-Ferulic acid ((E)-Coniferic acid) causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pr... | |||
T3344 | Ciwujianoside B | yemuoside YM,acanthopanax senticosides B,Ciwujianoside-B | BCL , Others |
Ciwujianoside B (acanthopanax senticosides B) is the main component of Acanthopanax, can relieve fatigue, enhance memory, and improve human cognition. | |||
T2764 | (S)-10-Hydroxycamptothecin | 10-Hydroxycamptothecin,10-HCPT | Apoptosis , Topoisomerase |
(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma. | |||
T2730 | Gossypol (acetic acid) | (±)-Gossypol-acetic acid,Pogosin,AT101,Gossypol acetic acid | BCL |
Gossypol acetic acid (AT101), a polyphenolic compound isolated from cottonseeds, binds with Bcl-2, Bcl-xL, Mcl-1, and does not inhibit BIR3 domain and BID. | |||
T2163 | Dihydrocapsaicin | CCRIS1589,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide | Others , TRP/TRPV Channel |
Dihydrocapsaicin (CCRIS1589) is isolated from Capsicum fruit. Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper. Like capsaicin, dihydrocapsaicin is an... | |||
T2851 | Daphnetin | 7,8-Dihydroxycoumarin,Daphnetol | EGFR , PKA , PKC , Parasite , Autophagy |
Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μM), also exhibit anti-oxidant and anti-... | |||
T4085 | Paris saponin VII | Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII | Apoptosis , BCL , Others , PARP , p38 MAPK , Akt , Caspase , P-gp , Autophagy |
Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation. | |||
T7060 | Amantadine | 1-Aminoadamantane,1-Adamantanamine,1-Adamantylamine | Others |
Amantadine (1-Aminoadamantane) is an antiviral, is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release, and blocks dopamine reuptake. | |||
T6S1917 | Schisandrol B | Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B | P450 , Reactive Oxygen Species , Autophagy |
1. Schisandrol B (Besigomsin) may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs signaling pathways. 2. Schisandrol B has a... | |||
T1034 | Docetaxel | NSC 628503,RP-56976 | Apoptosis , Microtubule Associated , Endogenous Metabolite |
Docetaxel (RP-56976) is a semi-synthetic analog of paclitaxel, a microtubule depolymerization inhibitor (IC50=0.2 μM). Docetaxel attenuates the effects of bcl-2 and bcl-xL gene expression and exhibits apoptosis-inducing,... | |||
T2S0410 | Euphorbia factor L1 | Euphorbiasteroid | Apoptosis , P-gp |
Euphorbia factor L1 (Euphorbiasteroid) can reduce Bcl-2, PI3K, AKT, and mTOR protein and mRNA levels, and up-regulate caspase-9 and caspase-3 protein levels. It induces autophagy and has anti-cancer, anti-adipogenic, ant... | |||
T3857 | Magnolin | (+)-Magnolin | ERK |
Magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro. Magnolin has anti-inflammatory and antioxidative effects. | |||
T6S1529 | Cynarin | Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1R,3R,4S,5R)-,Cynarine,1,5-Dicaffeoylquinic acid | Antioxidant , Antiviral , Influenza Virus , Reactive Oxygen Species |
Cynarin (1,5-Dicaffeoylquinic acid) has neuroprotective, and antioxidant effects, it can inhibition of GSK3β as well as the modulation of Bcl-2/Bax. | |||
T3867 | Alpinetin | (-)-alpinetin | BCL , PPAR |
Alpinetin ((-)-alpinetin) has antibacterial activity.Alpinetin has anti-inflammatory activity.Alpinetin can enhance the sensitivity of HepG2 hepatoma cells to the chemotherapeutic agent CDDP. Alpinetin has strong anti-he... | |||
T7027 | EURYCOMANONE | Pasakbumin A | Others |
Eurycomanone (Pasakbumin A) is cytotoxic on HepG2 cells by inducing apoptosis through the up-regulation of p53 and Bax, and down-regulation of Bcl-2.Eurycomanone has anti-cancer activity, inhibits A549 lung cancer cell p... | |||
T5S2083 | Puerarin 6''-O-Xyloside | Apoptosis , Caspase | |
Puerarin 6''-O-xyloside possesses significant anti-osteoporotic activity on ovariectomy mice, it has significant antitumour activities, the mechanisms are related to increased levels of caspase-3, caspase-7, caspase-9 an... | |||
T2795 | Amygdalin | Laetrile | Others |
Amygdalin (Laetrile) has antifibrotic, antitumor, anti-inflammatory and analgesic effects, amygdalin joint HSYA could inhibit the degeneration of the endplate chondrocytes derived from intervertebral discs of rats induce... | |||
T6S1418 | Praeruptorin C | Antioxidant , Calcium Channel | |
1. Praeruptorin C has been widely used as an antioxidant and a calcium antagonist to treat diseases. 2. Praeruptorin C partially protects cortical neurons by inhibiting the expression of GluN2B-containing NMDA receptors ... | |||
TN2103 | PROCYANIDIN C1 | Apoptosis | |
Procyanidin C1 is a natural product, with anti-inflammatory effects, and induces apoptosis. | |||
T2860 | Vanillyl Alcohol | 4-Hydroxy-3-methoxybenzenemethanol,3-Methoxy-4-hydroxybenzyl alcohol,4-Hydroxy-3-methoxybenzyl alcohol,Vanillin alcohol,Vanillic alcohol | Apoptosis , Others |
Vanillyl Alcohol (3-Methoxy-4-hydroxybenzyl alcohol) possesses anti-angiogenic, anticonvulsive, anti-inflammatory, anti-oxidant, neuroprotective, and anti-nociceptive activities. Vanillyl alcohol can effectively inhibit ... | |||
TN2254 | Taccalonolide A | Apoptosis , Microtubule Associated | |
Taccalonolide A is the first microtubule stabilizing agent to be discovered from a plant since identification of the mechanism of action of paclitaxel and it is the first natural product steroid identified to have these ... | |||
T2823 | Crocin | Gardenia Yellow,Alpha-Crocin | Others |
Crocin (Gardenia Yellow) is a water-soluble carotenoid pigment of saffron (Crocus sativus L. ) that has been used as a spice for flavoring and coloring food preparations, and in Chinese traditional medicine as an anodyne... | |||
T3864 | Erianin | BCL , Antibacterial | |
Erianin is a nature product extracted from Dendrobium chrysotoxum, has notable antitumour activity , can cause extensive tumour necrosis, growth delay. Erianin has antiangiogenic action by inhibiting endothelial metaboli... | |||
T3895 | Polyphyllin I | Apoptosis , Akt , JNK , PDK , mTOR , Autophagy | |
Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D ha... | |||
T0186 | Docetaxel trihydrate | RP-56976 (Trihydrate),RP56976 (NSC 628503) Trihydrate | Apoptosis , BCL , Microtubule Associated |
Docetaxel trihydrate (RP-56976 Trihydrate) is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis and that currently plays a central role in the therapy of many solid tumor i... | |||
T6S0653 | Linarin | Buddleoflavonoloside,Buddleoside,Acacetin-7-O-rutinoside,Acaciin,Linarine | TNF , AChE |
1. Linarin (Acacetin-7-O-rutinoside) (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviates GalN/LPS-induced liver injury by suppressing TNF-α-mediat... | |||
T3S2344 | β,β-Dimethylacrylshikonin | Dimethylacrylshikonin,β, β-Dimethylacrylshikonin | ERK , HIF/HIF Prolyl-Hydroxylase |
1. β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combined with IR treatment significant... | |||
T2966 | Beta-Sitosterol | Cupreol,Beta-Sitosterol,β-Sitosterol,Azuprostat,SKF 14463,22,23-Dihydrostigmasterol,Betaprost | Apoptosis , Lipase , Endogenous Metabolite |
Beta-Sitosterol (SKF 14463) has recently been shown to induce G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways. Beta-Sitosterol (SKF 14463) , a main dietary phytosterol foun... | |||
T3923 | Calycosin | Cyclosin,3'-Hydroxyformononetin | Apoptosis , Tyrosinase |
Calycosin (Cyclosin) acts as a selective estrogen receptor modulator. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Calycosin suppresses breast cancer c... | |||
T6S0735 | Flavokawain B | Flavokavain B,Flavokawin B,2'-Hydroxy-4',6'-Dimethoxychalcone | Apoptosis , Others |
1. Flavokawain B (Flavokavain B) has potent anti-inflammatory activity, can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. 2. Flavokawain B, the hepatotoxic constituent from kava root, in... | |||
T3729 | Ethyl gallate | Nipagallin A,Phyllemblin,gallic acid ethyl ester | MMP , NF-κB , Akt , Antibacterial |
Ethyl gallate (gallic acid ethyl ester) obviously decreases cell proliferation in MDA-MB-231 and MCF-7 cells in a dose- and time-dependent manner, exhibits cytotoxicity in a dose-dependent manner. Ethyl gallate can inhib... | |||
T2698 | Asperosaponin VI | Akebia saponin D,Asperosaponin Ⅵ | Apoptosis , Others , Caspase |
Asperosaponin VI (Akebia saponin D) , the most abundant constituent of the rhizome of Dipsacus asper, has been used for the treatment of lower back pain, traumatic hematoma and bone fractures. | |||
T5S0661 | Koumine | Others | |
1. Koumine can treat the diabetic neuropathy. 2. Koumine has antineoplastic effect, may be a future breast cancer chemotherapeutic agent. 3. Koumine has a significant analgesic effect in rodent behavioral models of infla... | |||
T5526 | Glycoborinine | BCL , PARP , ROS , Caspase | |
Glycoborinine is a potential molecule against cancer cells, it can induce HepG2 apoptosis through the mitochondrial-dependent pathway. Glycoborinine has photo-activated antimicrobial activity, it shows moderate inhibitio... | |||
T81229 | Safflor yellow B | ||
Safflor Yellow B mitigates angiotensin II-induced injury in human umbilical vein cells by modulating Bcl-2/p22(phox) expression and demonstrates neuroprotective effects [1]. | |||
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Cat No. | Product Name | Species | Expression System |
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TMPY-02431 | BCL-XL Protein, Human, Recombinant (His) | Human | E. coli |
B-cell lymphoma-extra large (Bcl-xl) is a transmembrane molecule in the mitochondria. Bcl-xL (BCL2L1), belongs to the Bcl-2 family. Members of the bcl-2 family encode proteins that function either to promote or to inhibi... | |||
TMPY-02564 | BCL-XL Protein, Mouse, Recombinant (aa 1-212, His) | Mouse | E. coli |
B-cell lymphoma-extra large (Bcl-xl) is a transmembrane molecule in the mitochondria. Bcl-xL (BCL2L1), belongs to the Bcl-2 family. Members of the bcl-2 family encode proteins that function either to promote or to inhibi... | |||
TMPY-02004 | BCL-W Protein, Human, Recombinant (His) | Human | E. coli |
Beta1,4-Galactosyltransferase-I (B4GALT1), one of seven beta1,4-galactosyltransferases, is an enzyme commonly found in the trans-Golgi complex that adds galactose to oligosaccharides. They have an N-terminal hydrophobic ... | |||
TMPY-02700 | BCL2 Protein, Human, Recombinant (His) | Human | E. coli |
BCL2 (B-cell leukemia/lymphoma 2, N-Histidine-tagged), also known as Bcl-2, belongs to the Bcl-2 family. Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. It is a large protein family a... | |||
TMPH-03245 | BCL2 Protein, Rat, Recombinant (His) | Rat | in vitro E. coli expression system |
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a fee... | |||
TMPH-02520 | BCL2 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a fee... | |||
TMPJ-00584 | Bc1-w Protein, Human, Recombinant (His) | Human | E. coli |
Bcl-2-like protein 2 (BCL2L2) belongs to the Bcl-2 family. BCL2L2 is highly expressed in thebrain, spinal cord, testis, pancreas, heart, spleen, and mammary glands. BCL2L2 is a peripheral membrane protein containing thre... | |||
TMPH-02534 | BAG3 Protein, Mouse, Recombinant (His) | Mouse | Yeast |
Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleoti... | |||
TMPH-02535 | BAG3 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleoti... | |||
TMPH-01001 | BCL10 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation. Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing... | |||
TMPH-03509 | Simian immunodeficiency virus (SIV) (isolate PBj14/BCL-3) Vpx Protein (His & SUMO) | SIV | E. coli |
Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by... | |||
TMPH-01000 | BCL6 Protein, Human, Recombinant | Human | E. coli |
BCL6 Protein, Human, Recombinant is expressed in E. coli. | |||
TMPJ-00717 | BAG2 Protein, Human, Recombinant (His) | Human | E. coli |
BAG Family Molecular Chaperone Regulator 2 (BAG2) is a member of the Bag family whose members compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. BAG2 contains 1 BAG domain and is... | |||
TMPH-00999 | BCL6 Protein, Human, Recombinant (His) | Human | E. coli |
BCL6 Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPH-01359 | CCND1 Protein, Human, Recombinant (His) | Human | E. coli |
Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylat... | |||
TMPY-02430 | BCL6 Protein, Human, Recombinant (aa 1-150, His & Trx) | Human | E. coli |
The protein encoded by this gene is an evolutionarily conserved 95-kDa protein containing six C-terminal zinc-finger motifs and an N-terminal POZ domain. It has been reported that BCL-6 is present in DNA-binding complexe... | |||
TMPY-04936 | BCL2A1 Protein, Human, Recombinant (His) | Human | E. coli |
B-cell lymphoma 2-related protein A1 (BCL2A1) is a member of the BCL-2 family of anti-apoptotic proteins that confers resistance to treatment with anti-cancer drugs. Immunohistochemical expression of Wnt11 and BCL2A1 in... | |||
TMPY-03748 | BCL2L12 Protein, Human, Recombinant (GST) | Human | E. coli |
BCL2-like 12 (BCL2L12 ) is a new member of the apoptosis-related BCL2 gene family, members of which are implicated in various malignancies. The mRNA expression of BCL2L12 may constitute a novel biomarker for the predicti... | |||
TMPY-04052 | IL-17RB Protein, Human, Recombinant (His) | Human | HEK293 |
IL17RB (Interleukin 17 Receptor B) is a Protein Coding gene. IL17RB is the receptor for IL17E, the only member of the IL17 family promoting Th2 reactions. IL17RB is induced on human macrophages by IL4 and enhanced by TGF... | |||
TMPY-06842 | BMP-4 Protein, Human, Recombinant (E399D) | Human | E. coli |
BMP4 (bone morphogenetic protein-4)-directed differentiation of human embryonic stem cells (ESCd). Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP... | |||
TMPY-02603 | STAT6 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that is activated by interleukin-4 (IL-4)-induced tyrosine phosphorylation and mediates most of the IL-4-induced gene expression. STAT6... | |||
TMPY-04632 | IL-15 Protein, Human, Recombinant | Human | E. coli |
The protein encoded by the IL15 gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common h... | |||
TMPJ-00038 | IL-7 Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
Mouse interleukin-7(IL-7) is the member of hemopoietin family which is important to the differentiation, proliferation, and survival of lymphocyte. Mouse IL-7 shares approximately 88% aa sequence identity with rat IL-7 a... | |||
TMPY-03974 | Bim Protein, Human, Recombinant (His) | Human | E. coli |
BCL2L11, also known as Bim, belongs to the BCL-2 protein family. Members of this family form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. ... | |||
TMPK-00636 | BID Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Bid, BH3-interacting domain death agonist, was initially cloned based in its ability to interact with both Bcl-2 and Bax. Bid contains only the BH3 domain, which is required for its interaction with the Bcl-2 family prot... | |||
TMPH-00535 | Epstein-Barr virus (strain B95-8) BHRF1 Protein (His) | EBV | E. coli |
Prevents premature death of the host cell during virus production, which would otherwise reduce the amount of progeny virus. Acts as a host B-cell leukemia/lymphoma 2 (Bcl-2) homolog, and interacts with pro-apoptotic pro... | |||
TMPY-04768 | PRPS2 Protein, Human, Recombinant (His) | Human | E. coli |
PRPS2, a subset of PRS, is reported to be a potential protein associated with Sertoli-cell only syndrome. PRPS2 expression correlates with Sertoli-cell only syndrome and inhibits the apoptosis of TM4 Sertoli cells via th... | |||
TMPY-02065 | BID Protein, Mouse, Recombinant (His & GST) | Mouse | E. coli |
The BH3 interacting domain death agonist (BID) is a pro-apoptotic member of the Bcl-2 protein family, which contains only the BH3 domain, and is required for its interaction with the Bcl-2 family proteins and for its pro... | |||
TMPY-02027 | BID Protein, Human, Recombinant | Human | E. coli |
The BH3 interacting domain death agonist (BID) is a pro-apoptotic member of the Bcl-2 protein family, which contains only the BH3 domain, and is required for its interaction with the Bcl-2 family proteins and for its pro... | |||
TMPY-02001 | RTN4 Protein, Human, Recombinant (GST) | Human | E. coli |
Reticulon-4, also known as Foocen, Neurite outgrowth inhibitor, Nogo protein, Neuroendocrine-specific protein, Neuroendocrine-specific protein C homolog, RTN-x, Reticulon-5 and RTN4, is a multi-pass membrane protein that... | |||
TMPY-00431 | BMP-4 Protein, Mouse, Recombinant (rFc) | Mouse | HEK293 |
BMP4 (bone morphogenetic protein-4)-directed differentiation of human embryonic stem cells (ESCd). Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP... | |||
TMPJ-01066 | CYCS Protein, Human, Recombinant (His) | Human | E. coli |
Cytochrome C (CYCS) is a small heme protein that belongs to the cytochrome c family. It is found loosely associated with the inner membrane of the mitochondrion. Cytochrome C is a highly soluble protein that functions as... | |||
TMPY-00352 | IL-17RB Protein, Rhesus, Recombinant (His) | Rhesus | HEK293 |
IL17RB (Interleukin 17 Receptor B) is a Protein Coding gene. IL17RB is the receptor for IL17E, the only member of the IL17 family promoting Th2 reactions. IL17RB is induced on human macrophages by IL4 and enhanced by TGF... | |||
TMPY-03850 | IL-17RB Protein, Human, Recombinant (hFc) | Human | HEK293 |
IL17RB (Interleukin 17 Receptor B) is a Protein Coding gene. IL17RB is the receptor for IL17E, the only member of the IL17 family promoting Th2 reactions. IL17RB is induced on human macrophages by IL4 and enhanced by TGF... | |||
TMPY-03471 | IL-17RB Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
IL17RB (Interleukin 17 Receptor B) is a Protein Coding gene. IL17RB is the receptor for IL17E, the only member of the IL17 family promoting Th2 reactions. IL17RB is induced on human macrophages by IL4 and enhanced by TGF... | |||
TMPY-04162 | IL-17RB Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
IL17RB (Interleukin 17 Receptor B) is a Protein Coding gene. IL17RB is the receptor for IL17E, the only member of the IL17 family promoting Th2 reactions. IL17RB is induced on human macrophages by IL4 and enhanced by TGF... | |||
TMPY-04706 | IL-17RB Protein, Rhesus, Recombinant (hFc) | Rhesus | HEK293 |
IL17RB (Interleukin 17 Receptor B) is a Protein Coding gene. IL17RB is the receptor for IL17E, the only member of the IL17 family promoting Th2 reactions. IL17RB is induced on human macrophages by IL4 and enhanced by TGF... | |||
TMPJ-00455 | SLAMF5 Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
CD84, also called SLAMF5, is a member of the CD2 subgroup of the immunoglobulin receptor superfamily. Members of this CD2 subgroup mediate signal transduction through the interaction of its immunoreceptor tyrosine-based ... | |||
TMPY-04049 | IL-15 Protein, Human, Recombinant (His) | Human | E. coli |
The protein encoded by the IL15 gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common h... | |||
TMPJ-00681 | EDIL3 Protein, Human, Recombinant (His) | Human | Human Cells |
EGF-Like Repeat and Discoidin I-Like Domain-Containing Protein 3 (EDIL3) is a 52 kDa extracellular matrix protein that is expressed by endothelial tissues during embryonic vascular development. EDIL3 becomes quiescent at... | |||
TMPY-01824 | Caspase-14 Protein, Human, Recombinant (His) | Human | E. coli |
Caspase 14 is a member of the caspase family. Caspases are a kind of cysteine proteinase consisting of a prodomain plus large and small catalytic subunits, that play a central role in cell apoptosis. Caspase 14 possesses... | |||
TMPY-04417 | DAPK1 Protein, Human, Recombinant (aa 1-363, His & GST) | Human | Baculovirus-Insect Cells |
Death-associated protein kinase 1, also known as DAP kinase 1, DAPK1 and DAPK, is a cytoplasm protein which belongs to theprotein kinase superfamily, CAMK Ser / Thr protein kinase family and DAP kinase subfamily. DAPK... | |||
TMPY-03795 | EIF5A2 Protein, Human, Recombinant (His) | Human | E. coli |
Eukaryotic translation initiation factor 5A2 (EIF5A2) has been demonstrated to be upregulated in numerous types of human cancer and is associated with cancer progression. Silencing of EIF5A2 in the NSCLC cells resulted i... | |||
TMPY-04084 | ANGPTL1 Protein, Canine, Recombinant (hFc) | Canine | HEK293 |
Angiopoietin-like protein 1 (ANGPTL1) has been reported to suppress migration and invasion in lung and breast cancer, acting as a novel tumor suppressor candidate. Downregulation of tumor suppressor signaling plays an im... | |||
TMPH-03264 | P53 Protein, Rat, Recombinant (His) | Rat | E. coli |
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negativel... | |||
TMPH-02574 | P53 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negativel... | |||
TMPH-01075 | P53 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negativel... | |||
TMPH-01255 | DNM1L Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondri... |
Cat No. | Product Name | ||
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L9000 | Apoptosis Compound Library | 1796 compounds | |
A unique collection of 1796 apoptosis-related compounds for apoptosis research, research in tumorigenesis, and anti-cancer drug screening; |