chloramphenicol

Chloramphenicol (Chloromycetin), a broad-spectrum antibiotic, blocks bacterial protein synthesis.

Chloramphenicol succinate sodium is broad-spectrum antibiotic with antibacterial activity.

Chloramphenicol acetate, an acetylated and inactive derivative of chloramphenicol, is synthesized in E. coli and S. aureus through the action of the inducible enzyme chloramphenicol acetyltransferase, utilizing acetyl coenzyme A (acetyl-CoA), to impart resistance to chloramphenicol. This compound exhibits no antibiotic activity against S. sonnei in turbidimetric assays.

Chloramphenicol succinate is an inactive precursor of chloramphenicol. It is used for parenteral administration of chloramphenicol.

Levomecol, a broad-spectrum antibiotic derived from Streptomyces venezuelae, comprises Chloramphenicol and Methyluracil. It exerts its bacteriostatic effect by binding to the bacterial ribosome, inhibiting protein synthesis by blocking peptidyl transferase.