esc

Elesclomol (STA-4783) is an oxidative stress inducer and a highly lipophilic copper ion carrier. Elesclomol induces apoptosis in tumor cells and is used in copper death related studies. Elesclomol also inhibits FDX1-mediated Fe-S cluster biosynthesis.

Sodium Aescinate (Escin sodium salt) is extracted from Aesculus wilsonii.

4-Methylesculetin (Methylesculetin) is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities.

Feruloylputrescine is a natural product.

Escitalopram (Seroplex) is a furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from tardive dyskinesia in preference to tricyclic antidepressants, which aggravate this condition.

Esculetin (Cichorigenin) is a coumarin derivative from various natural plant products with various biological and pharmaceutical properties including anti-edema, anti-inflammatory and anti-tumour effects. It inhibits lipoxygenases (LOs).

Fluoroscein NAD+ is a substrate for ADP-ribosylation, providing a convenient non-isotopic alternative to radiolabelled NAD for use in PARP assays. Allows direct measurement of NAD-dependent enzymes, such as PARP, by fluorescence microscopy. This product is a replacement for R&D Systems product 4673-500-01 81 μg is supplied as 250 μl of a 0.25 mM solution in water.

N-p-Coumaroyl-N'-caffeoylputrescine is a natural product of Exochorda, Rosaceae. The catalog number is TN6024 and the CAS number is 1138156-77-0. N-p-Coumaroyl-N'-caffeoylputrescine can be used as a reference standard.

Serratia marcescens nuclease, a nonspecific nuclease, exhibits broad utility owing to its robust digestive capacity for both DNA and RNA [1] [2].

(±)-H3RESCA-TFP is a tetrafluorophenyl ester derivative of restrained complexing agent (RESCA).

Fluorescein-PEG6-bis-NHS ester is a polyethylene glycol (PEG)-based linker used for the synthesis of proteolysis targeting chimeras (PROTACs)[1].

Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , these effects might contribute to the antitumor activity without severe side effects. Sophoflaves

Escin Ib inhibits gastric emptying, at least in part, mediated by capsaicin-sensitive sensory nerves, to stimulate the synthesis and/or release of dopamine, to act through central dopamine2 receptor, which in turn causes the release of PGs.

Enhanced Green Fluorescent Protein (EGFP) (200-208) is a reporter protein obtained from Aequorea Victoria jellyfish. EGFP is widely used as a marker gene product due to its strong fluorescence properties, making it easily detectable.

Protoescigenin is from horse chestnut saponin mixture and can be used as the substrate for exploratory chemistry towards selective protection.

Esculentic acid has anti-inflammatory effect, it has protective effects against LPS-induced endotoxic shock may be mediated, at least in part, by regulation the release of inflammatory cytokines and mediators, and protein expression of COX-2 in mice.

Isoescin Ie, a derivative of Aescine found in Aesculi Semen extract [1], exhibits properties related to the primary compound.

Fluorescein tyramide is a widely utilized green fluorescent reagent (λ abs : 494 nm; λ em : 517 nm), primarily employed for tyramide signal amplification (TSA) in low-abundance IHC, ICC, in situ hybridization (FISH), and flow cytometry (FCM) applications.

Esculin sesquihydrate, a coumarin glucoside with fluorescent properties and a constituent of ash bark, improves cognitive deficits associated with experimental diabetic nephropathy (DN). It also offers anti-oxidative and anti-inflammatory benefits through the MAPK signaling pathway [1] [2].

Fluorescein-DBCO is a non-cleavable linker employed for synthesizing antibody-drug conjugates (ADCs) [1].

Fluorescent DOTAP, a cationic lipid, facilitates research in nucleic acid and protein delivery [1].

Aesculioside D is a natural product for research related to life sciences. The catalog number is TN6212 and the CAS number is 254896-66-7.

Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone is a cell-permeable, non-toxic inhibitor that irreversibly binds to activated caspase-3 in apoptotic cells, with its fluorescence intensity measurable via flow cytometry, microwell plate reader, or fluorescence microscopy [1].

Arborescosidic acid (Deacetylalpinoside), a carboxylated iridoid glucoside, is derived from Veronica beccabunga (brooklime) [1].

Fluorescein lisicol, as an investigational marker of hepatic biliary transporter function, is a fluorescent-labeled bile salt.

Fluorescein diphosphate is a colorless and nonfluorescent substrate for alkaline phosphatases. The sequential alkaline phosphatase mediated hydrolysis of its two phosphate substituents yielding weakly fluorescent fluorescein monophosphate followed by stro

Glutamylputrescine catalyzes the gamma-glutamylation of putrescine.

Phytolaccoside B(Esculentoside B) is an antifungal monodesmoside triterpenoid glycoside, it has potent inhibitory activity against agrobacterial plant transformation.

N-trans-Feruloylputrescine, an alkaloid, can be isolated from Magnolia officinalis [1].

Isoaesculioside D is a natural product for research related to life sciences. The catalog number is TN6222 and the CAS number is 1184581-59-6.

Aesculioside C is a natural product for research related to life sciences. The catalog number is TN6223 and the CAS number is 254896-65-6.

Rescinnamine is an inhibitor of angiotensin-converting enzyme. It also is a vinca alkaloid obtained from Rauwolfia serpentina and other species of Rauwolfia. It used as an antihypertensive drug.

Lushanrubescensin E is a bioactive chemical.

Difluorinated H2S probe 1 is a fluorescent probe for hydrogen sulfide (H2S).1It selectively fluoresces in the presence of H2S over Zn2+, Fe3+, S2O32-, ClO-, SO32-, H2O2, NO2-, cysteine (Cys), homocysteine (Hcy), and glutathione (GSH) when used at a concentration of 1 μM. Difluorinated H2S probe 1 displays excitation/emission maxima of 365/450 nm, respectively. 1.Zhang, J., Gao, Y., Kang, X., et al.o,o-Difluorination of aromatic azide yields a fast-response fluorescent probe for H2S detection and for improved bioorthogonal reactionsOrg. Biomol. Chem.15(19)4212-4217(2017)

Vescalagin is a useful organic compound for research related to life sciences and the catalog number is T124951.

Fluorescein-thiourea-PEG2-azide is a PEG-derived linker commonly applied for the synthesis of PROTACs[1].

N-Caffeoylputrescine has antioxidant activity.

Desciclovir (DCV), a prodrug of the antiherpetic agent acyclovir (ACV), is converted in humans to ACV, presumably by xanthine oxidase.

N-(Azido-PEG3)-N-Fluorescein-PEG3-acid is a PEGylated PROTAC linker incorporating azide, fluorescein, and carboxylic acid functional groups.

Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist. Deschloroclozapine binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively.

Escin IIB has positive effects on acute inflammation in animals, it can inhibit the induced by serotonin in rats, the hind paw edema induced by carrageenin, and the scratching behavior induced by compound 48/80 in mice.

O-Desmethyl-N-deschlorobenzoyl indomethacin is a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor indomethacin .1It is formed from indomethacin in isolated rabbit hepatocytes. O-Desmethyl-N-deschlorobenzoyl indomethacin (600 μM) decreases the viability of HL-60 leukemia cells when cultured with glucose oxidase.2It has also been used in the synthesis of prostaglandin D2receptor antagonists.3 1.Evans, M.A., Papazafiratou, C., Bhat, R., et al.Indomethacin metabolism in isolated neonatal and fetal rabbit hepatocytesPediatr. Res.15(11)1406-1410(1981) 2.Morgan, A.G.M., Babu, D., Michail, K., et al.An evaluation of myeloperoxidase-mediated bio-activation of NSAIDs in promyelocytic leukemia (HL-60) cells for potential cytotoxic selectivityToxicol. Lett.28048-56(2017) 3.Torisu, K., Kobayashi, K., Iwahashi, M., et al.Discovery of new chemical leads for prostaglandin D2 receptor antagonistsBioorg. Med. Chem. Lett.14(17)4557-4562(2004)

Escin (Aescin) is biosynthesized from protoaescigenin and barringtogenol, occurring in the seeds of Aesculus.

Glabrescone C exhibits strong anti-inflammatory properties through direct binding to IKKα/β.

Rescinnamidine is an alkaloid.

Esculentin 1A, a potent antimicrobial peptide (AMP) derived from frog skin, demonstrates significant in vitro activity against Pseudomonas [1].

Fluorescent HIV Substrate is a HIV substrate.

Ivonescimab (AK112) is a PD-1/VEGF bispecific antibody, utilized in cancer research [1] [2] [3].

Lushanrubescensin H is a useful organic compound for research related to life sciences and the catalog number is T124811.

N-(Azido-PEG2)-N-Fluorescein-PEG3-acid is a polyethylene glycol (PEG)-derived PROTAC linker specifically designed for the synthesis of PROTACs[1].