Search Result

Search Results for " gpr "

Targets

Compounds

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T76288	GPR
	GPR, a tripeptide, shows promise in Alzheimer's disease (AD) research by protecting cultured rat hippocampal neurons from amyloid-beta (Aβ)-induced death through the inhibition of caspase-3/p53-dependent apoptosis.
T36951	N-(p-Tosyl)-GPR-pNA acetate		Others
	N-(p-Tosyl)-GPR-pNA acetate is a colorimetric substrate for thrombin that can act as a measure of thrombin activity.		Others
TP1026	Tos-Gly-Pro-Arg-ANBA-IPA	tos-GPR-ANBA-IPA
	Tos-Gly-Pro-Arg-ANBA-IPA is a chromogenic peptide substrate. Tos-Gly-Pro-Arg-ANBA-IPA is used for the rapid and specific photometric assay of recombinant hirudin (r-hirudin).
TP1025	Tos-Gly-Pro-Arg-ANBA-IPA acetate	tos-GPR-ANBA-IPA acetate
	Tos-Gly-Pro-Arg-ANBA-IPA (acetate) is a peptide substrate for luminescence measurement.
T11458	GPR40/FFAR1 modulator 1		GPR
	GPR40/FFAR1 modulator 1 is a Gq-coupled free fatty acid receptor 1 (GPR40/FFAR1) agonist and allosteric modulator.		GPR
T9975	GPR183	3-(3,4-difluorophenyl)-N-[3-fluoro-5-(morpholin-4-yl)phenyl]propanamide	Others
	GPR183 (3-(3,4-difluorophenyl)-N-[3-fluoro-5-(morpholin-4-yl)phenyl]propanamide) is a chemotactic receptor known for its role in the maturation of B cells, and the endogenous ligand is the oxysterol 7α,25-dihydroxycholes...		Others
T23434	GPR35 agonist 2	TC-G 1001	GPR , Arrestin
	GPR35 agonist 2 (TC-G 1001) is a potent GPR35 agonist.The EC50 values of GPR35 agonist 2 in the β-arrestin and Ca2+ release assays were 26 and 3.2 nM, respectively.		GPR , Arrestin
T15413	GPR120 Agonist 3	GPR120-IN-1	GPR
	GPR120 Agonist 3 (GPR120-IN-1) is a selective agonist of Gpr120 ( logEC50: -7.62).		GPR
T4312	GPR120 Agonist 2	GPR120 receptor agonist	GPR
	GPR120 Agonist 2 is a potent and selective GPR120 receptor agonist.		GPR
T11455	GPR35 agonist 1		Others
	GPR35 agonist 1 is a highly effective and specific GPR35/CXCR8 agonist (EC50: 5.8 nM).		Others
T15267	GPR40 agonist 4		Others
	GPR40 agonist 4 is a potent free fatty acid agonist of receptor 1 (pEC50: 7.54).		Others
T11453	GPR120 modulator 1		Others
	GPR120 modulator 1 is useful for modulating GPR120.		Others
T11452	GPR120 Agonist 1		GPR
	GPR120 Agonist 1 is a selective GPR120 agonist. In GPR120 transfected HEK293 cells, GPR120 Agonist 1 displays good EC50 of 42 nM and 77 nM for human and mouse GPR120 (the calcium flux assay), respectively.		GPR
T11460	GPR4 antagonist 1		GPR
	GPR4 antagonist 1 is a GPR4 antagonist (IC50: 189 nM).		GPR
T11456	GPR40 Activator 1		Others
	GPR40 Activator 1 is a potent GPR40 activator for treatment of type 2 diabetes.		Others
T11457	GPR40 Activator 2		Others
	GPR40 Activator 2 is a highly effective activator of the GPR40 receptor.		Others
T11462	GPR84 antagonist 8		GPR
	GPR84 antagonist 8 is a selective GPR84 antagonist.		GPR
T10507	GPR40 Agonist 2		GPR
	GPR40 Agonist 2 is a GPR40 agonist. It can be used in the research of diabetes.		GPR
T11454	GPR120 modulator 2		Others
	GPR120 modulator 2 is useful for modulating GPR120.		Others
T11459	GPR40 agonist 1		Others
	GPR40 agonist 1 is an effective new GPR40 agonist (EC50s: 17 nM and 2 nM for rGPR40 and hGPR40).		Others
T8848	GPR34 receptor antagonist 2	Tyrosine, N-[(2E)-3-(4'-chloro[1,1'-biphenyl]-4-yl)-1-oxo-2-propen-1-yl]-O-(phenylmethyl)-,gpr34-receptor-antagonist-2	Others
	GPR34 receptor antagonist 2 (Tyrosine, N-[(2E)-3-(4'-chloro[1,1'-biphenyl]-4-yl)-1-oxo-2-propen-1-yl]-O-(phenylmethyl)-) is an anti-inflammatory agent.		Others
T40517	GPR30 agonist-1	GPR30 agonist-1
	GPR30 agonist-1 is a compound that acts as an agonist for G protein-coupled receptor 30 (GPR30), inducing vasorelaxation.
T12104	MRGPRX1 agonist 1		Others
	MRGPRX1 agonist 1 is a highly potent MRGPRX1 (Mas-related G-protein-coupled receptor X1)agonist(EC50 of 50 nM).		Others
T62656	GPR81 agonist 1		GPR
	GPR81 agonist 1 is a potent and selective GPR81 agonist with high affinity for human and mouse GPR81.GPR81 agonist 1 inhibits lipolysis of differentiated 3T3-L1 adipocytes, improves insulin sensitivity and glycaemic cont...		GPR
T11560	HGPR91 antagonist 1		GHSR
	hGPR91 antagonist 1 is a potent and selective hGPR91 antagonist (IC50: 7 μM).		GHSR
TP1060	GPRP acetate (67869-62-9 free base)	Pefabloc FG,Pefa 6003,GPRP acetate	Others
	GPRP acetate (Pefabloc FG) is fibrinogen-related peptides, which inhibit the interaction of fibrinogen with the platelet membrane glycoprotein IIbIIIa complex (GPIIbIIIa).		Others
T62420	P2Y2R/GPR17 antagonist 1		GPR
	P2Y2R/GPR17 antagonist 1 (Compound 14m) is a dual P2Y2R (IC50: 3.17 μM) and GPR17 (IC50: 1.67 μM) antagonist.		GPR
T63812	MrgprX2 antagonist-8		Others
	MrgprX2 antagonist-8 is an MrgprX2 antagonist that can be used to study inflammatory diseases.		Others
T62261	GPR84 antagonist 1
	GPR84 antagonist 1 is a highly selective, high-affinity competitive antagonist of human GPR84.
T40271	MrgprX2 antagonist-3	MrgprX2 antagonist-3
	MrgprX2 antagonist-3 is a potent inhibitor of MrgprX2. It holds promising potential for investigating skin inflammatory disorders.
T40273	MrgprX2 antagonist-2	MrgprX2 antagonist-2
	MrgprX2 antagonist-2 is a potent antagonist of MrgprX2. It holds potential for investigating skin inflammatory disorders.
T62542	GPR40 agonist 5
	GPR40 agonist 5 is an orally active GPR40 (G protein-coupled receptor 40) agonist (EC50: 47 nM). gPR40 agonist 5 reduces blood glucose levels and improves glucose tolerance. gPR40 agonist 5 shows adequate control of hype...
T27419	GPRP	Gly-Pro-Arg-Pro Acetate,Gly-Pro-Arg-Pro Acetate salt
	Gly-Pro-Arg-Pro Acetate, an inhibitor of fibrinogen aggregation, acts by binding to fibrinopeptide A.
T79744	GPR55 agonist 4
	GPR55 agonist 4 (Compound 28), with an EC50 of 131 nM for hGPR55 and 1.41 nM for rGPR55, effectively induces β-arrestin recruitment to human GPR55 [1].
T78100	GPR109 receptor agonist-2
	Compound 5, a selective GPR109a agonist, exhibits a pEC50 value of 5.53 [1].
T82265	GPR3 agonist-2
	GPR3 agonist-2 (compound 32) is a potent full agonist of the G protein-coupled receptor 3 (GPR3), exhibiting an IC50 value of 260 nM [1].
T82959	ASGPR ligand-1
	ASGPR ligand-1 is a compound that targets the asialoglycoprotein receptor (ASGPR) and is utilized in various disease research contexts [1].
T72536	GPR84 antagonist 2
	GPR84 Antagonist 2, a potent and selective GPR84 antagonist (IC 50 = 8.95 nM), demonstrates oral activity and significantly enhances potency in calcium mobilization assays. It effectively inhibits neutrophil and macropha...
T60466	MRGPRX1 agonist 2
	MRGPRX1 agonist 2 (compound 1a) is a potent positive allosteric modulator of Mas-related G protein-coupled receptor X1 (MRGPRX1) with an EC 50 value of 0.48 μM. MRGPRX1 agonist 2 has the potential to be used in neuropath...
T63766	MrgprX2 antagonist-7
	MrgprX2 antagonist-7 is an anti-allergic agent with significant anti-allergic effects and inhibits mast cell degranulation.
T82958	ASGPR modulator-1
	Compound 5TJX (ASGPR modulator-1) is a macrocyclic compound utilized in the study of protein-protein interactions [1].
T40270	MrgprX2 antagonist-1	MrgprX2 antagonist-1
	MrgprX2 antagonist-1, is a novel MrgprX2 antagonist compound. It exhibits potential for exploration in studying cutaneous inflammatory disorders.
T40176	MrgprX2 antagonist-5	MrgprX2 antagonist-5
	MrgprX2 antagonist-5, which acts as a potent antagonist of MrgprX2. It exhibits the ability to effectively inhibit the activity of MrgprX2, making it an ideal candidate for research related to inflammatory skin disorders...
T72772	GPR81 agonist 2
	GPR81 agonist 2 is a potent agonist targeting the GPR81 receptor, demonstrating EC50 values of 0.023 µM for hGPR81 and 0.123 µM for hGPR109A, respectively.
T63964	DPP-4/GPR119 modulator 2
	DPP-4/GPR119 modulator 2 is an inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC50: 0.22 μM) and an agonist of GPR119 (EC50: 0.95 μM).
T82266	GPR139 agonist-2
	GPR139 agonist-2 (compound 20a), a potent GPR139 agonist with an EC50 of 24.7 nM, has demonstrated efficacy in rescuing social interaction deficits and alleviating cognitive deficits in murine schizophrenia models, indic...
T61332	MRGPRX4 modulator-1
	MRGPRX4 modulator-1 (compound 31-2) is a potent antagonist of the mas-related g-protein receptor X4 (MRGPR X4) with an IC50 < 100 nM against MRGPR4. It is utilized for the investigation of MRGPR X4 dependent diseases inc...
T62918	GPR84 antagonist 3
	GPR84 Antagonist 3 (compound 42), a potent inhibitor of the G-protein-coupled receptor 84 (GPR84), exhibits a pIC50 value of 8.28, indicating strong antagonistic activity by inhibiting GTPγS. Additionally, it possesses a...
T61183	MRGPRX4 modulator-2
	MRGPRX4 modulator-2 (compound 1-55) is a highly potent modulator of MRGPR X4, displaying antagonist activity against this receptor with an IC50 value of less than 100 nM. Its application in the research of autoimmune dis...
T60497	MRGPRX1 agonist 3
	MRGPRX1 agonist 3 (compound 1f) is a potent positive allosteric modulator of Mas-related G protein-coupled receptor X1 (MRGPRX1) with an EC50 of 0.22 μM. MRGPRX1 agonist 3 can be used for neuropathic pain research[1].

Compounds

N-(p-Tosyl)-GPR-pNA acetate

T36951

Synonym:

Target: Others

Tos-Gly-Pro-Arg-ANBA-IPA

TP1026

Synonym: tos-GPR-ANBA-IPA

Target:

Tos-Gly-Pro-Arg-ANBA-IPA acetate

TP1025

Synonym: tos-GPR-ANBA-IPA acetate

Target:

GPR40/FFAR1 modulator 1

Synonym: 3-(3,4-difluorophenyl)-N-[3-fluoro-5-(morpholin-4-yl)phenyl]propanamide

Target: GPR, Arrestin

GPR120 Agonist 3

T15413

Synonym: GPR120-IN-1

Target: GPR

GPR120 Agonist 2

T4312

Synonym: GPR120 receptor agonist

GPR34 receptor antagonist 2

T8848

Synonym: Tyrosine, N-[(2E)-3-(4'-chloro[1,1'-biphenyl]-4-yl)-1-oxo-2-propen-1-yl]-O-(phenylmethyl)-,gpr34-receptor-antagonist-2

Target: Others

GPR30 agonist-1

T40517

Synonym: GPR30 agonist-1

GPRP acetate (67869-62-9 free base)

TP1060

Synonym: Pefabloc FG,Pefa 6003,GPRP acetate

Target: Others

P2Y2R/GPR17 antagonist 1

Synonym: MrgprX2 antagonist-3

Target:

MrgprX2 antagonist-2

T40273

Synonym: MrgprX2 antagonist-2

Synonym: Gly-Pro-Arg-Pro Acetate,Gly-Pro-Arg-Pro Acetate salt

GPR109 receptor agonist-2

Synonym: MrgprX2 antagonist-1

Target:

MrgprX2 antagonist-5

T40176

Synonym: MrgprX2 antagonist-5

DPP-4/GPR119 modulator 2

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-00626	GPR Protein, E. coli, Recombinant (His)	E. coli	E. coli
	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
TMPK-00896	CCR8 Protein, Human, Recombinant (hFc)	Human	HEK293
	CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. CCR8 may regulate monocyte chemotaxis and ...
TMPK-01316	CCR8 Protein, Cynomolgus, Recombinant (mFc)	Cynomolgus	HEK293
	CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. CCR8 may regulate monocyte chemotaxis and ...
TMPK-00897	CCR8 Protein, Human, Recombinant (mFc)	Human	HEK293
	CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. CCR8 may regulate monocyte chemotaxis and ...
TMPY-04270	GPR133 Protein, Human, Recombinant (His)	Human	HEK293
	ADGRD1 (Adhesion G Protein-Coupled Receptor D1, also known as GPR133) is a Protein Coding gene. 4 alternatively spliced human isoforms have been reported. ADGRD1, an orphan member of the adhesion family of G-protein-coup...
TMPY-02837	GPR114 Protein, Human, Recombinant (hFc)	Human	HEK293
	GPR114 belongs to the G-protein coupled receptor 2 family. Members of this family share a common molecular architecture which consists of seven transmembrane domains, three extracellular loops, three intracellular loops,...
TMPK-00743	LGR-5 Protein, Human, Recombinant (hFc)	Human	HEK293
	G protein-coupled receptor 5 (LGR5), known as a stem cell marker for colon cancer and gastric cancer, can serve as a novel GSC marker involved in EMT and a therapeutic target in glioma.LGR5 is a new functional GSC marker...
TMPH-01066	CCR6 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Receptor for the C-C type chemokine CCL20. Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels. Although CCL20 is its major ligand it can also act as a receptor for non-...
TMPY-06806	GPRC5D Protein, Human, Recombinant, Fluorescent	Human	HEK293
	Orphan G-protein-coupled receptor family C group 5 member D (GPRC5D) has seven transmembrane segments forming the core of the receptor, as well as an intracellular C-tail and an extracellular N-terminal domain. GPRC5D is...
TMPY-06601	GPRC5D Protein, Human, Recombinant, Biotinylated	Human	HEK293
	Orphan G-protein-coupled receptor family C group 5 member D (GPRC5D) has seven transmembrane segments forming the core of the receptor, as well as an intracellular C-tail and an extracellular N-terminal domain. GPRC5D is...
TMPY-06719	GPRC5D Protein, Human, Recombinant (His & FLAG)	Human	HEK293
	Orphan G-protein-coupled receptor family C group 5 member D (GPRC5D) has seven transmembrane segments forming the core of the receptor, as well as an intracellular C-tail and an extracellular N-terminal domain. GPRC5D is...
TMPK-01193	GPRC5D Protein-VLP, Mouse, Recombinant	Mouse	HEK293
	Chimeric antigen receptor (CAR) T cells, a type of cell-based immunotherapy, have shown some promising results in multiple myeloma, a bone marrow cancer.The orphan G protein–coupled receptor, class C group 5 member D (GP...
TMPJ-00725	HGPRT Protein, Human, Recombinant (His)	Human	E. coli
	Hypoxanthine-Guanine Phosphoribosyltransferase (HGPRT) has an important role in the generation of purine nucleotides through the purine salvage pathway. HPRT1 functions to salvage purines from degraded DNA to renewed pur...
TMPH-01410	GPR84 Protein, Human, Recombinant (hFc)	Human	Yeast
	GPR84 Protein, Human, Recombinant (hFc) is expressed in Yeast.
TMPH-02838	GPR146 Protein, Mouse, Recombinant (His)	Mouse	in vitro E. coli expression system
	Orphan receptor.
TMPH-01640	MRGPRX2 Protein, Human, Recombinant (His)	Human	in vitro E. coli expression system
	Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Recognizes and binds small molecules ...
TMPY-02276	GPR56 Protein, Human, Recombinant (His)	Human	HEK293
	ADGRG1 (Adhesion G Protein-Coupled Receptor G1, also known as GPR56) is a Protein Coding gene. GPR56 is a member of an adhesion G protein-coupled receptor family with a very long N-terminal stalk and seven transmembrane ...
TMPY-02717	GPR37 Protein, Human, Recombinant (His)	Human	HEK293
	GPR37 (cathepsin Z) is an orphan receptor that belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors are a large protein family comprised of transmembrane receptors that sense molecules outside ...
TMPK-00528	GPRC5D Protein-VLP, Cynomolgus, Recombinant	Cynomolgus	HEK293
	Chimeric antigen receptor (CAR) T cells, a type of cell-based immunotherapy, have shown some promising results in multiple myeloma, a bone marrow cancer.The orphan G protein–coupled receptor, class C group 5 member D (GP...
TMPY-06718	GPRC5D Protein, Human, Recombinant (His & FLAG), Detergent	Human	HEK293
	Orphan G-protein-coupled receptor family C group 5 member D (GPRC5D) has seven transmembrane segments forming the core of the receptor, as well as an intracellular C-tail and an extracellular N-terminal domain. GPRC5D is...
TMPY-06807	GPRC5D Protein, Mouse, Recombinant (Flag)	Mouse	HEK293
	Orphan G-protein-coupled receptor family C group 5 member D (GPRC5D) has seven transmembrane segments forming the core of the receptor, as well as an intracellular C-tail and an extracellular N-terminal domain. GPRC5D is...
TMPY-06494	GPRC5D Protein-VLP, Human, Recombinant	Human	HEK293
	Orphan G-protein-coupled receptor family C group 5 member D (GPRC5D) has seven transmembrane segments forming the core of the receptor, as well as an intracellular C-tail and an extracellular N-terminal domain. GPRC5D is...
TMPH-00269	GPR52 Protein, Bovine, Recombinant (His & KSI)	Bovine	E. coli
	G- protein coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization. May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA...
TMPH-01936	GPR107 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	GPR107 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
TMPH-02032	GPRC5A Protein, Human, Recombinant (GST)	Human	E. coli
	GPRC5A Protein, Human, Recombinant (GST) is expressed in E. coli.
TMPH-01907	GPR146 Protein, Human, Recombinant (His)	Human	in vitro E. coli expression system
	GPR146 Protein, Human, Recombinant (His) is expressed in in vitro E. coli expression system.