hg-12-6

HG-12-6 is a type II inhibitor of IRAK4, demonstrating preferential binding to unphosphorylated inactive IRAK4 (IC50: 165 nM) and modulating IRAK4 activity in autoimmunity and inflammation.

ZIP acetate is a novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-ph

Cardiotoxin Analog IV (6-12) TFA, a partial peptide of Cardiotoxin Analog IV, is derived from the venom of the Taiwan Cobra, showcasing the unique properties of snake venom cardiotoxin[1].

(6S,9S,12S)-Benzyl 12-benzyl-9-isobutyl-2,2-dimethyl-4,7,10-trioxo-6-phenethyl-3-oxa-5,8,11-triazatridecan-13-oate is a useful organic compound for research related to life sciences. The catalog number is T66648 and the CAS number is 868540-15-2.

12-Hydroxy-6-epi-albrassitriol is a natural product for research related to life sciences. The catalog number is TN2597 and the CAS number is 178330-78-4.

Cardiotoxin Analog (CTX) IV (6-12) is a peptide fragment of Cardiotoxin Analog (CTX) IV, isolated from the venom of the Taiwan Cobra (Naja atra).

3(Z),6(Z),9(Z),12(Z),15(Z)-Octadecapentaenoic acid, a microalgal polyunsaturated fatty acid (PUFA), is identified in G. kowalevskii and serves as a chemotaxonomic biomarker for microalgae and dinoflagellates.

CDK4 6-IN-12 is a potent cyclin-dependent kinase 4 6 (CDK4 6) inhibitor with enzymatic inhibitory activity against CDK4 and CDK6, having IC50 values of 592.3 nM and 3090 nM, respectively. CDK4 6-IN-12 can be used in cancer research[1].

8-Oxoeremophil-6-en-12-oic aicd is a useful organic compound for research related to life sciences and the catalog number is T126063.

3-Hydroxy-12-oleanene-27,28-dioic acid, 3-O-(6-Deo is a useful organic compound for research related to life sciences. The catalog number is T126383 and the CAS number is 111665-41-9.

6-trans-12-epi-Leukotriene B4, a metabolite of arachidonic acid, acts as a potent anti-inflammatory agent.

GAT229 is a positive allosteric modulator of cannabinoid receptor 1 (CB1) and the S-(-) enantiomer of the CB1 modulator GAT211. It does not activate the receptor on its own but enhances the binding and activity of CB agonists. GAT229 (1 μM) enhances the binding of the CB1 full agonist CP 55,940 to CHO cells expressing human recombinant CB1 (hCB1), as well as the activity of 2-arachidonoyl glycerol , arachidonoyl ethanolamide , and CP 55,940 in arrestin2 recruitment assays and increases ERK1/2 and PLCβ3 phosphorylation in HEK293 cells expressing hCB1. GAT229 (1 μM) enhances depolarization-induced suppression of excitation but does not inhibit excitatory postsynaptic currents (EPSCs) in murine autaptic hippocampal neurons. GAT229 (0.2%, topical) reduces intraocular pressure by 5.8 and 7.7 mm Hg after 6 and 12 hours, respectively, in a transgenic mouse model of ocular hypertension using nose, ear, eye mutation (nee) mice.