p70s6k — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4488	GSK-25	GSK25	ROCK , S6 Kinase , mTOR
	GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested).		ROCK , S6 Kinase , mTOR
T9211	Mito-LND	Mito-Loidamine	OXPHOS , Reactive Oxygen Species , Mitochondrial Metabolism , Autophagy
	Mito-LND (Mito-Loidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation.
T8978	DD1	3,3'-Diamino-4'-methoxyflavone,HUN85111	Proteasome
	DD1 (HUN85111) is a proteasome inhibitor that induces human myeloid tumor-selective apoptosis.		Proteasome
T27471	GSK299115A	GSK 299115A,GSK-299115A	GRK
	GSK299115A (GSK-299115A) is a selective ROCK1 Inhibitor. GSK299115A exhibits IC50 of 8nM, 620nM, 560nM for ROCK1, RSK1, p70S6K, respectively.		GRK
T1746	LY-2584702 tosylate salt	LY2584702 tosylate	S6 Kinase
	LY-2584702 tosylate salt is a selective, ATP-competitive p70S6K inhibitor, used in trials studying the treatment of cancer.		S6 Kinase
T28652	S6K1-IN-DG2	S6K1 Inhibitor DG2,S6K1-Inhibitor-DG2,S6K1 IN DG2,S6K1INDG2,S6K1InhibitorDG2	mTOR
	S6K1-IN-DG2(S6K1InhibitorDG2) is a potent p70S6K inhibitor with an IC50 value of less than 100 nM.		mTOR
T27467	GSK270822A	GSK 270822A,GSK-270822A	GRK
	GSK270822A is a selective ROCK1 inhibitor. GSK270822A exhibits IC50 of 9nM, 1100nM, 1550nM for ROCK1, RSK1, p70S6K, respectively.		GRK
T11928	M2698	MSC2363318A	Akt , mTOR
	M2698 (MSC2363318A) is an inhibitor of p70S6K, Akt1 and Akt3 with IC50s of 1 nM. M2698 shows anti-cancer activity.		Akt , mTOR
T6159	LY-2584702 free base		S6 Kinase , mTOR
	LY2584702 is a selective, ATP-competitive p70S6K inhibitor(IC50: 4 nM).		S6 Kinase , mTOR
T2482	AT13148		ROCK , SGK , Akt , PKA , S6 Kinase
	AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.		ROCK , SGK , Akt , PKA , S6 Kinase
T6304	AT7867		Akt , PKA , S6 Kinase
	AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively; little activity outside the AGC kinase family.		Akt , PKA , S6 Kinase
T9652	SB-747651A Dihydrochloride		ROCK
	SB-747651A dihydrochloride is a chemical compound that serves as an ATP-competitive inhibitor for mitogen- and stress-activated kinase 1 (MSK1), featuring an IC50 of 11 nM. Additionally, this compound effectively inhibit...		ROCK
T6303L	CCT128930 hydrochloride	CCT128930 hydrochloride(885499-61-6 Free base)	Apoptosis , Akt , PKA , mTOR , Autophagy
	CCT128930 hydrochloride (CCT128930 hydrochloride) is a potent and selective inhibitor of AKT with IC50 of 6 nM. CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophagy. CCT128930 hydrochloride has 28...		Apoptosis , Akt , PKA , mTOR , Autophagy
T67836	AT-533		HSP , HSV
	AT-533 is a potent inhibitor of Hsp90 and HSV. AT-533 blocks the HIF-1α/VEGF/VEGFR-2 signaling pathway, leading to suppress tumor growth and angiogenesis. AT-533 also inhibits the activation of the downstream pathways, i...		HSP , HSV
T60675L	AMPK activator 2 hydrochloride( 2410961-69-0 Free base)	AMPK activator 2 hydrochloride( 2410961-69-0 Free base)	AMPK
	AMPK activator 2 hydrochloride is a fluoroguanidine-containing derivative that up-regulates the AMPK signaling pathway and down-regulates mTOR/4EBP1/p70S6K.AMPK activator 2 hydrochloride inhibits the proliferation and mi...		AMPK
T6303	CCT128930		Akt , PKA , S6 Kinase , Autophagy
	CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM, 28-fold greater selectivity for Akt2 than the closely related PKA kinase.		Akt , PKA , S6 Kinase , Autophagy
T68477	XL-418
	XL-418 is a selective, orally active small molecule, targeting protein kinase B (PKB or AKT) and ribosomal protein S6 Kinase (p70S6K), with potential antineoplastic activity. XL418 inhibits the activities of PKB and p70S...
T28695	SB-747651A	SB 747651A
	SB-747651A is a potent, ATP-competitive inhibitor of mitogen- and stress-activated kinase 1 (MSK1, IC50 = 11 nM). It targets the N-terminal kinase domain. SB-747651A inhibits MSK1, MSK2, PKA, PKB, RSK and p70S6K activity...
T75719	Akt/SKG Substrate Peptide TFA
	Akt/SKG Substrate Peptide TFA is a synthetic peptide designed as a substrate specifically for Akt/PKB and is not phosphorylated by p70S6K or MAPK1 [1].
T11900	LY-2584702 hydrochloride		S6 Kinase
	Ly-2584702 hydrochloride is a p70S6K selective ATP competitive inhibitor with IC50 of 4 nM.In the S6K1 enzyme assay, the IC50 of LY-2584702 was 2 nM.		S6 Kinase
T39958	(32-Carbonyl)-RMC-5552
	(32-Carbonyl)-RMC-5552 is a highly effective mTOR inhibitor, exhibiting inhibitory effects on both mTORC1 and mTORC2 substrate phosphorylation. Specifically, it significantly suppresses the phosphorylation of p-P70S6K-(T...
T21624	AT7867 dihydrochloride
	AT7867 dihydrochloride is a potent ATP-competitive inhibitor of Akt1 / Akt2 / Akt3 and p70S6K / PKA kinase with IC 50 s of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively. AT7867 dihydrochloride is able to induce pharmac...
T60675	AMPK activator 2		AMPK
	AMPK activator 2 is a chloroformin derivative with potential anticancer activity, which can up-regulate AMPK signaling pathway and down-regulate mTOR/4EBP1/p70S6K, and inhibit proliferation and migration of human cancer ...		AMPK
T10275	AKT-IN-3		Akt
	AKT-IN-3 is a potent, orally active low hERG blocking Akt inhibitor (IC50: 1.4 nM, 1.2 nM, and 1.7 nM for Akt1, Akt2, and Akt3). AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kin...		Akt
T79560	22-(4′-py)-JA	22-(4′-Pyridinecarbonyl) jorunnamycin A	Akt
	22-(4′-py)-JA, a semisynthetic derivative of junamycin A isolated from the Thai blue sponge (Xestospongia sp.), exhibits antimetastatic properties by inhibiting the AKT/mTOR/p70S6K signaling pathway. It also impedes tumo...		Akt
T2235	Dactolisib	BEZ235,NVP-BEZ235	ATM/ATR , PI3K , mTOR , Autophagy
	Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).		ATM/ATR , PI3K , mTOR , Autophagy

Compounds

GSK-25

T4488

Synonym: GSK25

Target: ROCK, S6 Kinase, mTOR

Mito-LND

T9211

Synonym: Mito-Loidamine

Target: OXPHOS, Reactive Oxygen Species, Mitochondrial Metabolism, Autophagy

DD1

T8978

Synonym: 3,3'-Diamino-4'-methoxyflavone,HUN85111

Target: Proteasome

GSK299115A

T27471

Synonym: GSK 299115A,GSK-299115A

Target: GRK

LY-2584702 tosylate salt

T1746

Synonym: LY2584702 tosylate

Target: S6 Kinase

S6K1-IN-DG2

T28652

Synonym: S6K1 Inhibitor DG2,S6K1-Inhibitor-DG2,S6K1 IN DG2,S6K1INDG2,S6K1InhibitorDG2

Target: mTOR

GSK270822A

T27467

Synonym: GSK 270822A,GSK-270822A

Target: S6 Kinase, mTOR

AT13148

T2482

Synonym:

Target: ROCK, SGK, Akt, PKA, S6 Kinase

AT7867

T6304

Synonym:

Target: Akt, PKA, S6 Kinase

SB-747651A Dihydrochloride

T9652

Synonym:

Target: ROCK

CCT128930 hydrochloride

T6303L

Synonym: CCT128930 hydrochloride(885499-61-6 Free base)

Target: Apoptosis, Akt, PKA, mTOR, Autophagy

AMPK activator 2 hydrochloride( 2410961-69-0 Free base)

T60675L

Synonym: AMPK activator 2 hydrochloride( 2410961-69-0 Free base)

Target: Akt, PKA, S6 Kinase, Autophagy

Akt/SKG Substrate Peptide TFA

T75719

Synonym:

Target:

LY-2584702 hydrochloride

T11900

Synonym:

Target: S6 Kinase

(32-Carbonyl)-RMC-5552

T39958

Synonym:

Target:

AT7867 dihydrochloride

Synonym: 22-(4′-Pyridinecarbonyl) jorunnamycin A

Target: Akt

Dactolisib

T2235

Synonym: BEZ235,NVP-BEZ235

Target: ATM/ATR, PI3K, mTOR, Autophagy

Cat No.	Product Name	Synonyms	Targets
T3981	Acacetin	4'-Methoxyapigenin,5,7-Dihydroxy-4'-methoxyflavone,Linarigenin	Apoptosis , IAP , COX , Autophagy
	Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an O-methylated flavone found in various plants, shows antinociceptive, anti-inflammatory, and antioxidant activity in various research models.		Apoptosis , IAP , COX , Autophagy
T2S2382	3'-Hydroxypterostilbene	3'-HPT	Apoptosis , Autophagy
	3'-Hydroxypterostilbene (3'-HPT), a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells with IC50s of 9.0, 40.2, and 70.9 μM for COLO 205, HCT-116, and HT-29 cells, respectively, b...		Apoptosis , Autophagy
T2995	Chrysophanol	3-Methylchrysazin,Chrysophanic Acid,Turkey Rhubarb	EGFR
	Chrysophanol (Turkey Rhubarb) is an EGFR/mTOR pathway inhibitor, which can be found in rhubarb, and sorrel.		EGFR
T6429	Caffeic Acid Phenethyl Ester	Phenylethyl Caffeate,CAPE	Apoptosis , NF-κB
	Caffeic Acid Phenethyl Ester (Phenylethyl Caffeate) (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways, with antineoplastic, cytoprotective...		Apoptosis , NF-κB
T38250	L-Sepiapterin
	L-Sepiapterin, also known as Sepiapterin, is a precursor compound crucial for the production of tetrahydrobiopterin (BH4), which serves as a coenzyme for endothelial nitric oxide synthase (eNOS). This compound demonstrat...