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Search Results for " rrna "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T3532	5S rRNA modificator	FAI,Furoyl Acylimidazole	Others
	5S rRNA modificator (FAI), used in 5S rRNA RNA modification, is a suitable electrophile for 2'-hydroxyl acylation on structured RNA molecules.		Others
T8643	NAI	5S rRNA modificator 2	Others
	NAI (5S rRNA modificator 2) is an RNA SHAPE reagent.		Others
T9726	2’-OMe-Guanosine		Apoptosis , Nucleoside Antimetabolite/Analog
	2'-OMe-Guanosine is a modified nucleoside produced by the action of tRNA guanosine-2'-o-methyltransferase. 2'-OMe-Guanosine has a certain pro-apoptotic effect.		Apoptosis , Nucleoside Antimetabolite/Analog
T35648	4-Thiouridine		Others
	4-Thiouridine (4-SU) is a photoactivatable ribonucleoside analog that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labeling. The crosslinking thio moiety is attached directl...		Others
T16698	Pyronin Y	C.I. 45005,Pyronine G	Others
	Pyronin Y (Pyronine G) is an intercalating cationic dye that shows specificity towards RNA.		Others
T2100	CX-5461		DNA/RNA Synthesis
	CX-5461, a selective inhibitor of rRNA synthesis, suppresses Pol I-driven transcription of rRNA.		DNA/RNA Synthesis
T22297	Clindamycin hydrochloride monohydrate	Clindamycin alcoholate	Antibiotic
	Clindamycin hydrochloride monohydrate (Clindamycin alcoholate) is a protein synthesis inhibitor used orally, capable of diminishing virulence factor expression in Staphylococcus aureus at sub-minimum inhibitory concentra...		Antibiotic
T1349	5-Fluorouridine		Others , DNA/RNA Synthesis
	5-fluorouridine is also known as FUrd, 5-Fluorouracil 1-beta-D-ribofuranoside, 5-Fur, or 5-Fluoro-uridine. 5-fluorouridine is a solid. This compound belongs to the pyrimidine nucleosides and analogues. These are compound...		Others , DNA/RNA Synthesis
T10067	2',5-Difluoro-2'-deoxycytidine		HCV Protease
	2',5-Difluoro-2'-deoxycytidine has potent anti-HCV activity and toxicity to rRNA.		HCV Protease
T1707	EA25		Others
	EA25 has been identified in the clone library of the bacterial 16S rRNA gene sequence.		Others
T61121	NusB-IN-1
	NusB-IN-1 (Compound 22r) is a highly effective bacterial rRNA synthesis inhibitor, administered orally. It exhibits potent antimicrobial activity against MRSA and VRSA [1].
T64150	CX-5461 dihydrochloride
	CX-5461 dihydrochloride is a potent, orally active inhibitor of Pol I-mediated rRNA synthesis that acts on HCT-116 cells (IC50: 142 nM), A375 cells (IC50: 113 nM) and MIA PaCa-2 cells (IC50: 54 nM), and to a lesser exten...
T27165	Diazaborine	Diazaborine compound 2b18,Pkf 84.474,Pkf 84474,Pkf-84474,SA-84474
	Diazaborine inhibits maturation of rRNAs for the large ribosomal subunit. Diazaborine blocks ribosome biogenesis by inhibiting the AAA-ATPase Drg1. Diazaborine treatment causes, within minutes, a rapid redistribution of ...
T69908	Pidnarulex HCl
	Pidnarulex HCl is the salt form of CX-5461, a first-in-class non-genotoxic small molecule targeted inhibitor of RNA polymerase I (Pol I) that activates the p53 pathway without causing DNA damage. CX-5461 selectively inhi...
T79015	SEQ-9
	SEQ-9 is an orally active inhibitor targeting the Mycobacterium tuberculosis (Mtb) 23S bacterial ribosome, demonstrating an inhibitory concentration (IC50) around 170 nM against unmethylated Mtb ribosomes and showing pot...
T37154	7-Methylguanosine 5'-diphosphate sodium
	7-Methylguanosine 5’-diphosphate (7-Methyl-GDP) sodium, a cap analog, is utilized in the synthesis of mRNA cap analogues[1].

Compounds

5S rRNA modificator

T3532

Synonym: FAI,Furoyl Acylimidazole

Target: Others

NAI

T8643

Synonym: 5S rRNA modificator 2

Target: Apoptosis, Nucleoside Antimetabolite/Analog

Synonym: C.I. 45005,Pyronine G

Target: DNA/RNA Synthesis

Clindamycin hydrochloride monohydrate

T22297

Synonym: Clindamycin alcoholate

Target: Others, DNA/RNA Synthesis

2',5-Difluoro-2'-deoxycytidine

CX-5461 dihydrochloride

Synonym: Diazaborine compound 2b18,Pkf 84.474,Pkf 84474,Pkf-84474,SA-84474

7-Methylguanosine 5'-diphosphate sodium

T37154

Synonym:

Target:

Cat No.	Product Name	Synonyms	Targets
T13499	3-Methyluridine		Endogenous Metabolite
	3-Methyluridine is a modified nucleoside of cellular RNA.		Endogenous Metabolite
T4S0554	Theaflavine-3,3'-digallate	TFBG,theaflavin digallate	Others
	1. Theaflavine-3,3'-digallate (theaflavin digallate) and lactic acid together could reduce herpes simplex virus transmission.		Others
TN7106	2′-O-Methyluridine		Others
	2′-O-Methyluridine is a natural product that found in RNA such as rRNA, snRNA, snoRNA and tRNA in Archaea, Bacteria, and Eukaryota.		Others

Natural Products

3-Methyluridine

T13499

Synonym:

Target: Endogenous Metabolite

Theaflavine-3,3'-digallate

T4S0554

Synonym: TFBG,theaflavin digallate

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-03645	Alpha-TCS Protein, Trichosanthes kirilowii, Recombinant (His)	Trichosanthes kirilowii	E. coli
	Alpha-TCS Protein, Trichosanthes kirilowii, Recombinant (His) is expressed in E. coli.
TMPJ-00778	HER2/ERBB2 Protein, Human, Recombinant (His)	Human	Human Cells
	Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 plays a key role in development, cell proliferation and different...
TMPH-00561	30S ribosomal protein S4 Protein, E. coli, Recombinant (His)	E. coli	E. coli
	One of two assembly initiator proteins for the 30S subunit, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.; With S5 and S12 plays an important role in translational accuracy; ma...
TMPH-01712	TRMT112 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Acts as an activator of both rRNA/tRNA and protein methyltransferases. Together with methyltransferase BUD23, methylates the N(7) position of a guanine in 18S rRNA. The heterodimer with HEMK2/N6AMT1 catalyzes N5-methylat...
TMPH-00559	30S ribosomal protein S15 Protein, E. coli, Recombinant (His)	E. coli	E. coli
	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. Binds to its own mR...
TMPH-02999	UL2 Protein, Mycobacterium tuberculosis, Recombinant (His)	Mycobacterium tuberculosis	E. coli
	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase acti...
TMPH-00854	RPS18 Protein, Human, Recombinant (GST)	Human	E. coli
	Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.
TMPH-00558	30S ribosomal protein S11 Protein, E. coli, Recombinant (His)	E. coli	E. coli
	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
TMPH-00562	30S ribosomal protein S7 Protein, E. coli, Recombinant (His)	E. coli	E. coli
	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, where it has be...
TMPH-00053	50S ribosomal protein L22, Anaplasma phagocytophilum, Recombinant (His & Myc)	Anaplasma phagocytophilum	E. coli
	This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with differen...
TMPH-02335	RIOK3 Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitme...
TMPJ-01357	NHP2 Protein, Human, Recombinant (His)	Human	E. coli
	NHP2 belongs to the H/ACA snoRNPs gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been organized into 2 families: C/D and H/ACA. NHP2 forms a small ribonucleoprotein part...
TMPH-00015	Abrin-d Protein, Abrus precatorius, Recombinant (His & Myc)	Abrus precatorius	E. coli
	The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA.; The B chain is a galactose-specific lectin th...
TMPH-03411	Ricin Protein, Ricinus communis, Recombinant (His)	Ricinus communis	E. coli
	Ricin is highly toxic to animal cells, and to a lesser extent to plant cells.; Acts as a glycosidase that removes a specific adenine residue from an exposed loop of the 28S rRNA (A4324 in mammals), leading to rRNA breaka...
TMPH-03193	Alba Protein, Pyrococcus furiosus, Recombinant (His & SUMO)	Pyrococcus furiosus	E. coli
	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DN...
TMPH-00014	Abrin-c Protein, Abrus precatorius, Recombinant (His & Myc)	Abrus precatorius	E. coli
	The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. Abrin-a is more toxic than ricin.; The B chain...
TMPY-02883	C1D Protein, Human, Recombinant (GST)	Human	E. coli
	C1D nuclear receptor corepressor belongs to the C1D family. It is a DNA binding and apoptosis-inducing protein.C1D nuclear receptor corepressorinteracts with TSNAX and DNA-PKcs. It acts as a corepressor for the thyroid h...
TMPH-00012	Abrin-a Protein, Abrus precatorius, Recombinant (E. coli, His)	Abrus precatorius	E. coli
	The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. Abrin-a is more toxic than ricin.; The B chain...
TMPH-00013	Abrin-a Protein, Abrus precatorius, Recombinant (Yeast, His)	Abrus precatorius	Yeast
	The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. Abrin-a is more toxic than ricin.; The B chain...
TMPH-03707	Viscumin Protein, Viscum album, Recombinant (His)	Viscum album	Yeast
	The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. The B chain binds to cell receptors and probab...
TMPH-00864	RO60 Protein, Human, Recombinant (His)	Human	E. coli
	RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation. Binds to endogeno...
TMPH-00856	RPSA Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions...
TMPJ-01046	RPS7 Protein, Human, Recombinant (His)	Human	E. coli
	40S ribosomal protein S7(RPS7) belongs to the S7E family of ribosomal proteins. It is phosphorylated by NEK6 during post-translational modification. RPS7 is located in the cytoplasm, binds IPO9 with high affinity. it als...
TMPH-02506	ANG Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S...
TMPH-01800	Nucleolin Protein, Human, Recombinant (His)	Human	Yeast
	Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is ...
TMPJ-01395	NIP7 Protein, Human, Recombinant (His)	Human	E. coli
	60S Ribosome Subunit Biogenesis Protein NIP7 Homolog (NIP7) belongs to the NIP7 family. NIP7 contains one PUA domain, it is essential for the process of proper 27S pre-rRNA and 60S ribosome subunit assembly. NIP7 is a mo...
TMPH-01247	POLR3K Protein, Human, Recombinant (His)	Human	Baculovirus
	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs....
TMPH-02380	RPB5 Protein, Kluyveromyces marxianus, Recombinant (His)	Kluyveromyces marxianus	E. coli
	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precurs...
TMPY-04073	MRPL44 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	MRPL44 (Mitochondrial Ribosomal Protein L44) is a Protein Coding gene. MRPL44 encodes a protein in the large subunit of the mitochondrial ribosome and is suggested to locate near the tunnel exit of the yeast mitochondria...
TMPJ-00947	RPS19 Protein, Human, Recombinant	Human	E. coli
	40S Ribosomal Protein S19 (RPS19) is a ribosomal protein that Belongs to the ribosomal protein S19e family. RPS19 is located in the nucleoli, and higher level expression is seen in colon carcinoma tissue than normal colo...
TMPH-02132	Spindlin-1 Protein, Human, Recombinant (GST)	Human	E. coli
	Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstr...
TMPY-02844	EBP1 Protein, Human, Recombinant (His)	Human	E. coli
	EBP1, also known as PA2G4, is an RNA-binding protein that belongs to the peptidase M24 family. It can be detected n several cell lines tested, including primary and transformed cell lines. EBP1 also present in pre-riboso...
TMPJ-00776	HER2/ERBB2 Protein, Human, Recombinant (hFc & Avi), Biotinylated	Human	Human Cells
	Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 plays a key role in development, cell proliferation and different...
TMPJ-00777	HER2/ERBB2 Protein, Human, Recombinant (aa 23-652, hFc)	Human	Human Cells
	Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 plays a key role in development, cell proliferation and different...
TMPH-02815	Nucleophosmin Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome ...
TMPH-02315	XRCC5 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a...
TMPH-02314	XRCC5 Protein, Human, Recombinant (His & MBP)	Human	Baculovirus
	Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a...
TMPH-01246	POLR3A Protein, Human, Recombinant (His)	Human	E. coli
	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs,...
TMPH-01310	EIF3G Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and ...
TMPH-00847	2-5A-dependent Rnase Protein, Human, Recombinant (Myc)	Human	E. coli
	Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stran...
TMPH-00617	MazF Protein, E. coli, Recombinant (His)	E. coli	Yeast
	Toxic component of a type II toxin-antitoxin (TA) system. A sequence-specific endoribonuclease it inhibits protein synthesis by cleaving mRNA and inducing bacterial stasis. It is stable, single-strand specific with mRNA ...