Search Result

Search Results for " tlr "

111

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T13932	TLR1		Others , MyD88
	TLR1 is a cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic and inhibits IL-1 receptor-mediated responses.		Others , MyD88
T8503	TLR4-IN-C34		TLR
	TLR4-IN-C34 is an inhibitor of TLR4, and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis		TLR
T13167	TLR7/8 agonist 3		TLR
	TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.		TLR
T4258	TLR7 agonist 2	TLR7-agonist-1,TLR7-IN-1	TLR
	TLR7 agonist 2 (TLR7-IN-1) is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM).		TLR
T39669	TLR7/8/9-IN-1	TLR7/8/9-IN-1	TLR
	TLR7/8/9-IN-1 is a potent inhibitor of Toll-like receptors 7/8/9 (TLR7/8/9) with an IC50 of 43 nM.		TLR
T22698	TLR3-IN-1	CU CPT 4a	TLR
	TLR3-IN-1 (CU CPT 4a) is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells). It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the production of TNF-α and IL-1β in whole cell...		TLR
T7317	CU-CPT-9a		TLR
	CU-CPT-9a is a potent TLR8 inhibitor (IC50 : 0.5 nM), that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells-		TLR
T15020	CU-CPT22		TLR
	CU-CPT22 is the first probe for the complex between toll-like receptors TLR1 and TLR2. CU-CPT22 binds at the interface of TLR1 and TLR2 (IC50 = 0.58 μM). It competes with the synthetic triacylated lipoprotein (Pam3CSK4) ...		TLR
T11598	IAXO-102		TLR
	IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experimental abdomin...		TLR
T10899	CU-CPT17e		TLR
	CU-CPT17e is a potent agonist of TLR(TLR3, TLR8, and TLR9).		TLR
T9570	Enpatoran		TLR
	Enpatoran is an inhibitor of TLR7(IC50 = 11.1 nM) and TLR8(IC50 = 24.1 nM). Enpatoran was found to be inactive against TLR3, TLR4, and TLR9 in vitro and in vivo.		TLR
T5561	TLR7/8 agonist 1 dihydrochloride	TLR7/8 agonist-5d	TLR
	TLR7/8 agonist 1 dihydrochloride (TLR7/8 agonist-5d) is a TLR7/8 agonist which shows prominent immunostimulatory activities.		TLR
T7672	MD2-TLR4-IN-1		TLR
	MD2-TLR4-IN-1 is a myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex inhibitor.		TLR
T4231	MD2-IN-1		TLR
	MD2-IN-1 is a Myeloid differentiation protein 2 (MD2) inhibitor with a KD of 189 μM for the recombinant human MD2 (rhMD2).		TLR
T15777	Loxoribine	RWJ 21757,7-Allyl-8-oxoguanosine	Influenza Virus , TLR
	Loxoribine (RWJ 21757) is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activities.Loxoribine is a potent new immunostimulant ...		Influenza Virus , TLR
T38078	TLR7/8-IN-1	TLR7/8-IN-1	TLR
	TLR7/8-IN-1, a crystalline TLR7/TLR8 inhibitor, is a valuable compound for autoimmune disease research[1].		TLR
T39654	Afimetoran	BMS-986256	TLR
	Afimetoran (BMS-986256) is a toll-like receptor antagonist. Afimetoran can be used in the research of inflammatory and autoimmune diseases.		TLR
T16506	PF-4878691	3M-852A	TLR
	PF-4878691 (3M-852A) is an effective and selective Toll-like receptor 7 agonists modelled. It is used to dissociate its antiviral and inflammatory activities.		TLR
T7347	CU-CPT-8m	TLR8-specific antagonist	TLR
	CU-CPT-8m (TLR8-specific antagonist) is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM)		TLR
T40423	L48H37
	L48H37 is a chemically stable analog of Curcumin. It exhibits potent inhibitory properties against myeloid differentiation protein 2 (MD2), acting as a specific inhibitor. Its mechanism involves inhibiting the interactio...
T3502	C29		TLR
	C29 is a novel inhibitor of TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages.		TLR
T15371	Gardiquimod		TLR , HIV Protease
	Gardiquimod is a TLR7/8 agonist. When used at concentrations below 10 μM, Gardiquimod specifically activates TLR7. Gardiquimod could inhibit HIV-1 infection of macrophages and activated peripheral blood mononuclear cells...		TLR , HIV Protease
T8727	TH1020		TLR , Antibacterial
	TH1020 is a novel Inhibitor of Toll-Like Receptor 5 (TLR5)/Flagellin Complex with promising activity (IC50 =0.85±0.12 μm) and specificity.		TLR , Antibacterial
T17032	Telratolimod	MEDI9197,3M-052	TLR
	Telratolimod (MEDI9197) is a toll-like receptors 7/8 agonist. It has an antitumor activity.		TLR
T7860	SM-324405	SM 324405	TLR
	SM-324405 is an agonist of TLR7.		TLR
T9765	TJ-M2010-5		MyD88
	TJ-M2010-5 is a MyD88 inhibitor that binds to the TIR domain to interfere with its homodimerization and suppress MyD88 signaling. TJ-M2010-5 can be used in myocardial ischemia/reperfusion injury studies.		MyD88
T38423	CL097	CL097	Reactive Oxygen Species , TLR
	CL097 is an effective agonist of TLR7 and TLR8. CL097 induces pro-inflammatory cytokines in macrophages and NADPH oxidase priming, thereby increasing the fMLF-stimulated ROS production.		Reactive Oxygen Species , TLR
T23171	Polyinosinic-polycytidylic acid	Poly(I:C)	TLR
	Polyinosinic-polycytidylic acid (Poly(I:C)) is a double-stranded RNA (dsRNA) and a TLR3 agonist. Polyinosinic-polycytidylic acid induces natural immunity in mammals.		TLR
T5521	Bropirimine	U-54461	TLR
	Bropirimine (U-54461) (U-54461) is a biological response modifier that is thought to act through the induction of lymphokines.		TLR
T12933	SM-276001		TLR , COX
	SM-276001 is a potent selective agonist of TLR7,and is an orally active interferon (IFN) inducer.		TLR , COX
T15017	CU-T12-9		TLR
	CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay). It acts by activating the NFkB pathway, upregulating proinflammatory cytokines, and enhancing TLR1 and TLR2 dimerization.CU-T12-9 activat...		TLR
T6898	Motolimod	VTX-378,VTX-2337	TLR
	Motolimod (VTX-378) (VTX-2337) is an effective and specific Toll-like receptor (TLR) 8 agonist (EC50: 100 nM), > 50-fold selectivity over TLR7.		TLR
T8316	1V209	TLR7 agonist T7	TLR
	1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects.		TLR
T7302	CU-CPT9b	CU-CPT-9b,TLR8-specific antagonist 1	TLR
	CU-CPT9b (TLR8-specific antagonist 1) is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM). It inhibits activation of NF- B induced by the TLR8 agonist R-848 in TLR8-overexpressing HEK-Blue cells with an IC50 valu...		TLR
T6846	Vesatolimod	GS-9620	Apoptosis , HCV Protease , HBV , TLR , HIV Protease
	Vesatolimod (GS-9620) is an effective and specific orally active agonist of Toll-like receptor 7.		Apoptosis , HCV Protease , HBV , TLR , HIV Protease
T6964	Resiquimod	R848,S28463	HCV Protease , TLR
	Resiquimod (R848) is an imidazoquinoline amine and Toll-like receptor (TLR) agonist with potential immune response modifying activity. Resiquimod exerts its effect through the TLR signaling pathway by binding to and acti...		HCV Protease , TLR
T9287	Hydroxychloroquine	2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol	SARS-CoV , TLR , Parasite , Autophagy
	Hydroxychloroquine (2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol) (HCQ) is an alkalinizing lysosomatropic drug that acts by inducing apoptosis of renal cancer cells in vitro and inhibiting TLR7/9. It i...		SARS-CoV , TLR , Parasite , Autophagy
T0951	Hydroxychloroquine sulfate	Acidum iopanoicum,HCQ sulfate	DNA , SARS-CoV , TLR , Parasite , Autophagy
	Hydroxychloroquine sulfate (Acidum iopanoicum) inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in ...		DNA , SARS-CoV , TLR , Parasite , Autophagy
T13168	TLR7 agonist 1		TLR
	TLR7 agonist 1 is a selective and oral TLR7 agonist (IC50: 90 nM).		TLR
T38614	TLR7 agonist 3
	TLR7 agonist 3 (Compound 2), a potent activator of toll-like receptor 7 (TLR7), plays a critical role in initiating immune responses, positioning it as a promising target for immunomodulator development.
T19675	SM360320	CL-087,SM 360320,CL 087,1V136,SM-360320,CL087	TLR
	SM360320 (CL-087) is an effective and selective agonist of TLR7. SM360320 inhibits HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity. SM360320 can be used for ...		TLR
T40039	TLR8 agonist 2	TLR8 agonist 2
	TLR8 agonist 2 is a highly effective and specific compound that activates TLR8, possessing an EC 50 of 3 nM in human TLR8. Notably, TLR8 agonist 2 demonstrates lower activity towards human TLR7, with an EC 50 of 33.33 μM...
T40040	TLR8 agonist 2 hydrochloride
	TLR8 agonist 2 hydrochloride is a highly potent and selective agonist for human TLR8, exhibiting an EC50 of 3 nM. However, its activity towards human TLR7 is considerably weaker, with an EC50 of 33.33 μM.
T12516	Polyinosinic-polycytidylic acid sodium	Poly(I:C) sodium	Apoptosis , Others , TLR
	Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MD...		Apoptosis , Others , TLR
T39969	TLR7/8 agonist 4 TFA
	TLR7/8 agonist 4 TFA (compound 41) is a highly potent TLR7/8 agonist that exhibits significant anti-cancer activity.
TP1067	Pam3CSK4 TFA (112208-00-1 free base)	Pam3CSK4 TFA,Pam3Cys-Ser-(Lys)4 TFA	TLR
	Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA) is an agonist of toll-like receptor 1/2 (TLR1/2) (EC50 of 0.47 ng/mL for human TLR1/2).		TLR
TQ0181	Resatorvid	CLI-095,TAK-242	TNF , TLR , Autophagy , Interleukin
	Resatorvid (TAK-242) is a selective inhibitor of Toll-like receptor 4 (TLR4). Resatorvid binds directly to Cys747 and prevents TLR4 from binding to TIRAP, thereby blocking downstream signaling. Resatorvid has antitumor a...		TNF , TLR , Autophagy , Interleukin
T0134	Imiquimod	R 837,S-26308	SARS-CoV , TLR , Autophagy , HSV
	Imiquimod (R 837) is an immune response modifier that acts as a toll-like receptor 7 agonist.		SARS-CoV , TLR , Autophagy , HSV
TP1938	RS 09		TLR
	TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. Acts as an adjuvant in vivo; enhances X-15 specific antibody serum concentrations, when adm...		TLR
T38547	TLR4-IN-C34-C2-COOH	TLR4-IN-C34-C2-COOH
	TLR4-IN-C34-C2-COO is a linker compound that incorporates TLR4 inhibitor TLR4-IN-C34. It effectively inhibits TLR4 activity in enterocytes and macrophages. Moreover, it demonstrates a notable ability to mitigate systemic...

Compounds

TLR1

T13932

Synonym:

Target: Others, MyD88

Synonym: TLR7-agonist-1,TLR7-IN-1

Target: TLR

TLR7/8/9-IN-1

T39669

Synonym: TLR7/8/9-IN-1

TLR7/8 agonist 1 dihydrochloride

T5561

Synonym: TLR7/8 agonist-5d

Synonym: RWJ 21757,7-Allyl-8-oxoguanosine

Target: Influenza Virus, TLR

TLR7/8-IN-1

T38078

Synonym: TLR7/8-IN-1

Synonym: TLR8-specific antagonist

Target: TLR, HIV Protease

TH1020

T8727

Synonym:

Target: TLR, Antibacterial

Telratolimod

T17032

Synonym: MEDI9197,3M-052

Target: Reactive Oxygen Species, TLR

Polyinosinic-polycytidylic acid

Synonym: VTX-378,VTX-2337

Target: TLR

1V209

T8316

Synonym: TLR7 agonist T7

Target: TLR

CU-CPT9b

T7302

Synonym: CU-CPT-9b,TLR8-specific antagonist 1

Target: Apoptosis, HCV Protease, HBV, TLR, HIV Protease

Resiquimod

T6964

Synonym: R848,S28463

Target: HCV Protease, TLR

Hydroxychloroquine

T9287

Synonym: 2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol

Target: SARS-CoV, TLR, Parasite, Autophagy

Hydroxychloroquine sulfate

T0951

Synonym: Acidum iopanoicum,HCQ sulfate

Target: DNA, SARS-CoV, TLR, Parasite, Autophagy

Synonym: CL-087,SM 360320,CL 087,1V136,SM-360320,CL087

Target: TLR

TLR8 agonist 2

T40039

Synonym: TLR8 agonist 2

Target:

TLR8 agonist 2 hydrochloride

T40040

Synonym:

Target:

Polyinosinic-polycytidylic acid sodium

T12516

Synonym: Poly(I:C) sodium

Target: Apoptosis, Others, TLR

TLR7/8 agonist 4 TFA

T39969

Synonym:

Target:

Pam3CSK4 TFA (112208-00-1 free base)

TP1067

Synonym: Pam3CSK4 TFA,Pam3Cys-Ser-(Lys)4 TFA

Target: TLR

Resatorvid

TQ0181

Synonym: CLI-095,TAK-242

Target: TNF, TLR, Autophagy, Interleukin

Imiquimod

T0134

Synonym: R 837,S-26308

Target: SARS-CoV, TLR, Autophagy, HSV

TLR4-IN-C34-C2-COOH

T38547

Synonym: TLR4-IN-C34-C2-COOH

Target:

Cat No.	Product Name	Synonyms	Targets
T2S0265	Robinin	NSC 9222	TLR
	Flavone glycoside from Robinia with antibacterial and diuretic properties; derived from kaempferol.The ability of robinin to reverse the multidrug resistance of the human colon cancer cell line Colo 320 expreβing MDR1/LR...		TLR
TN2008	Okanin		NF-κB , TLR
	Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect.		NF-κB , TLR
TQ0205	Procyanidin B1		TLR
	Procyanidin B1, isolated from commonly eaten fruits, binds to the TLR4/MD-2 complex and has anti-inflammatory activity.		TLR
T5S0167	Atractylenolide I		IL Receptor , TNF , TLR , JAK , STAT
	1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome, liver and kidney functions by reduction of pro-inflammatory cytokines and LPS. 2. Atractylenolide...		IL Receptor , TNF , TLR , JAK , STAT
T8689	Chloroquine		SARS-CoV , TLR , HIV Protease , Antibiotic , Parasite , Autophagy
	Chloroquine is a Toll-like receptor inhibitor that inhibits autophagy. Chloroquine has anti-malarial and anti-inflammatory activity and is widely used in the treatment of malaria and rheumatoid arthritis. Chloroquine als...
T3898	Schaftoside	APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE,Shaftoside	Dynamin , Antioxidant , TLR , MyD88 , Mitochondrial Metabolism , Autophagy
	Schaftoside (APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE) has antioxidant and anticancer activity.
T3826	Polygalasaponin F		NF-κB , TLR , Akt , PI3K
	Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Po...		NF-κB , TLR , Akt , PI3K
T5S0045	Isofraxidin	6,8-Dimethoxyumbelliferone,Phytodolor	MMP , ERK , p38 MAPK , TLR , COX
	1. Isofraxidin (Phytodolor) protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective effect against LPS-induced ALI, and the prote...		MMP , ERK , p38 MAPK , TLR , COX
T0194	Chloroquine phosphate	Chloroquine diphosphate,Aralen phosphate,Chingamin phosphate	SARS-CoV , TLR , HIV Protease , Antibiotic , Parasite , Autophagy
	Chloroquine phosphate (Aralen phosphate) is an aminoquinoline antimalarial and also is widely used as an autophagy inhibitor. Chloroquine also is an inhibitor of toll-like receptors (TLRs).
T6S1487	Ginsenoside Rg5		NF-κB , COX , IGF-1R
	1. Ginsenoside Rg5 could be a beneficial agent for the treatment of Alzheimer's disease. 2. Ginsenoside Rg5 suppresses LPS-induced nitric oxide (NO) production and proinflammatory TNF-α secretion. 3. Ginsenoside Rg5 can ...		NF-κB , COX , IGF-1R

Natural Products

Target: IL Receptor, TNF, TLR, JAK, STAT

Chloroquine

T8689

Synonym:

Target: SARS-CoV, TLR, HIV Protease, Antibiotic, Parasite, Autophagy

Schaftoside

T3898

Synonym: APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE,Shaftoside

Target: Dynamin, Antioxidant, TLR, MyD88, Mitochondrial Metabolism, Autophagy

Polygalasaponin F

T3826

Synonym:

Target: NF-κB, TLR, Akt, PI3K

Isofraxidin

T5S0045

Synonym: 6,8-Dimethoxyumbelliferone,Phytodolor

Target: MMP, ERK, p38 MAPK, TLR, COX

Chloroquine phosphate

T0194

Synonym: Chloroquine diphosphate,Aralen phosphate,Chingamin phosphate

Target: SARS-CoV, TLR, HIV Protease, Antibiotic, Parasite, Autophagy

Ginsenoside Rg5

T6S1487

Synonym:

Target: NF-κB, COX, IGF-1R

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-02904	TLR4 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	TLR4, also known as TLR-4, is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans...
TMPK-00406	TLR3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated	Human	HEK293
	TLR3 is expressed in the central nervous system (CNS), where it is required to control HSV-1, which spreads from the epithelium to the CNS via cranial nerves. TLR3 is also expressed in epithelial and dendritic cells, whi...
TMPK-00544	TLR3 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	TLR3 is expressed in the central nervous system (CNS), where it is required to control HSV-1, which spreads from the epithelium to the CNS via cranial nerves. TLR3 is also expressed in epithelial and dendritic cells, whi...
TMPY-02794	TLR2 Protein, Human, Recombinant (aa 1-587, His)	Human	Baculovirus-Insect Cells
	TLR2, also known as CD282, is a member of the Toll-like receptor (TLR) family. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They play a fundamental role in pathoge...
TMPY-01396	TLR3 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Toll-like receptor 3 (TLR3) also known as CD283 (cluster of differentiation 283) is a member of the Toll-like receptor family of pattern recognition receptors of the innate immune system. TLR3/CD283 plays a fundamental r...
TMPY-03042	TLR2 Protein, Rat, Recombinant (His)	Rat	Baculovirus-Insect Cells
	TLR2, also known as CD282, is a member of the Toll-like receptor (TLR) family. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They play a fundamental role in pathoge...
TMPY-06410	TLR3 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Toll-like receptor 3 (TLR3) also known as CD283 (cluster of differentiation 283) is a member of the Toll-like receptor family of pattern recognition receptors of the innate immune system. TLR3/CD283 plays a fundamental r...
TMPY-02930	TLR2 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus-Insect Cells
	TLR2, also known as CD282, is a member of the Toll-like receptor (TLR) family. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They play a fundamental role in pathoge...
TMPH-02211	TLR7 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine...
TMPH-02212	TLR8 Protein, Human, Recombinant (His)	Human	Yeast
	Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially proc...
TMPH-02937	TLR11 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
TMPH-02938	TLR7 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine...
TMPY-01894	SIGIRR Protein, Human, Recombinant (His)	Human	HEK293
	Single Ig IL-1-related receptor (SIGIRR) or TIR8 is a member of Toll-like receptor-interleukin 1 receptor signaling (TLR-IL-1R) receptor superfamily. Although SIGIRR/TIR8 shows the typical conserved motifs that character...
TMPY-01825	RP105/CD180 Protein, Human, Recombinant (His)	Human	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-04483	IRAK4 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4, and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, and Pelle subfamily. IRAK4...
TMPY-02590	HMGB1 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	High-mobility group box 1 protein (HMGB1), also known as HMG-1 or amphoterin previously, is a member of the HMGB family consisting of three members, HMGB1, HMGB2, and HMGB3. HMGB1 is a DNA-binding nuclear protein, releas...
TMPY-01848	HMGB1 Protein, Human, Recombinant (aa 1-215, His)	Human	HEK293
	High-mobility group box 1 protein (HMGB1), also known as HMG-1 or amphoterin previously, is a member of the HMGB family consisting of three members, HMGB1, HMGB2, and HMGB3. HMGB1 is a DNA-binding nuclear protein, releas...
TMPJ-00177	BAFF/TNFSF13B Protein, Human, Recombinant (Avi & hFc), Biotinylated	Human	Human Cells
	B-cell activating factor (BAFF), also known as BLyS, TALL-1, THANK, and TNFSF13B, is a transmembrane glycoprotein in the TNF ligand superfamily. BAFF is a cytokine and serves as a ligand for receptors TNFRSF13B (TACI), T...
TMPH-02803	NRROS Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifi...
TMPH-02231	NRROS Protein, Human, Recombinant (E. coli, His & Myc)	Human	E. coli
	Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifi...
TMPH-02230	NRROS Protein, Human, Recombinant (His & Myc)	Human	Baculovirus
	Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifi...
TMPH-01265	PELI3 Protein, Human, Recombinant (His)	Human	E. coli
	E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Me...
TMPH-02271	BTK Protein, Human, Recombinant (His)	Human	Baculovirus
	Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activatio...
TMPJ-01325	TOLLIP Protein, Human, Recombinant (His)	Human	E. coli
	Toll-Interacting Protein (TOLLIP) is a member of the tollip family. TOLLIP localizes to the cytoplasm. It contains one C2 domain and one CUE domain. TOLLIP is an inhibitory adaptor protein for Toll-like receptors (TLR). ...
TMPH-01702	SMAD6 Protein, Human, Recombinant (E. coli, His & Myc)	Human	E. coli
	Transforming growth factor-beta superfamily receptors signaling occurs through the Smad family of intracellular mediators. SMAD6 is an inhibitory Smad (i-Smad) that negatively regulates signaling downstream of type I tra...
TMPH-01264	PELI1 Protein, Human, Recombinant (His)	Human	Baculovirus
	E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Me...
TMPH-01701	SMAD6 Protein, Human, Recombinant (His & Myc)	Human	Baculovirus
	Transforming growth factor-beta superfamily receptors signaling occurs through the Smad family of intracellular mediators. SMAD6 is an inhibitory Smad (i-Smad) that negatively regulates signaling downstream of type I tra...
TMPH-01551	IFNLR1 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the ...
TMPH-03267	CD300f/CD300LF Protein, Rat, Recombinant (His & Myc & SUMO)	Rat	E. coli
	Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which...
TMPY-01002	SIGIRR Protein, Mouse, Recombinant (His & hFc)	Mouse	HEK293
	Single Ig IL-1-related receptor (SIGIRR) or TIR8 is a member of Toll-like receptor-interleukin 1 receptor signaling (TLR-IL-1R) receptor superfamily. Although SIGIRR/TIR8 shows the typical conserved motifs that character...
TMPY-01667	RP105/CD180 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPJ-01187	Siglec-E Protein, Mouse, Recombinant (hFc)	Mouse	Human Cells
	Siglecs are sialic acid specific I‑type lectins that are characterized by an extracellular domain (ECD) with an N‑terminal Ig‑like V‑set domain followed by varying numbers of Ig‑like C2‑set domains. Mouse Siglec‑E, also ...
TMPY-03529	SIGIRR Protein, Human, Recombinant (hFc)	Human	HEK293
	Single Ig IL-1-related receptor (SIGIRR) or TIR8 is a member of Toll-like receptor-interleukin 1 receptor signaling (TLR-IL-1R) receptor superfamily. Although SIGIRR/TIR8 shows the typical conserved motifs that character...
TMPY-06898	SIGIRR Protein, Human, Recombinant (His), Biotinylated	Human	HEK293
	Single Ig IL-1-related receptor (SIGIRR) or TIR8 is a member of Toll-like receptor-interleukin 1 receptor signaling (TLR-IL-1R) receptor superfamily. Although SIGIRR/TIR8 shows the typical conserved motifs that character...
TMPY-01666	RP105/CD180 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-01816	Pentraxin 3 Protein, Human, Recombinant (His)	Human	HEK293
	Pentraxin-related protein PTX3, also known as Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TSG-14, PTX3 and TNFAIP5, is a secreted protein that contains one pentaxin dom...
TMPY-04408	CAMKII beta/CAMK2B Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	Calcium/calmodulin-dependent protein kinase II beta (CAMK2B) is a member of the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. CaMKII is an important player in pro...
TMPY-00822	HMGB1 Protein, Human, Recombinant (hFc)	Human	HEK293
	High-mobility group box 1 protein (HMGB1), also known as HMG-1 or amphoterin previously, is a member of the HMGB family consisting of three members, HMGB1, HMGB2, and HMGB3. HMGB1 is a DNA-binding nuclear protein, releas...
TMPY-03427	HMGB1 Protein, Human, Recombinant (aa 57-158, His)	Human	E. coli
	High-mobility group box 1 protein (HMGB1), also known as HMG-1 or amphoterin previously, is a member of the HMGB family consisting of three members, HMGB1, HMGB2, and HMGB3. HMGB1 is a DNA-binding nuclear protein, releas...