Search Result

Search Results for " 细胞周期 "

Targets

454

Compounds

Natural Products

Libraries

Cat No.	Product Name	Synonyms	Targets
T9003	CVT-11127		Dehydrogenase
	CVT-11127 is an StearoylCoA Desaturase-1 (SCD1) inhibitor.		Dehydrogenase
T9244	σ1 Receptor antagonist-1		Sigma receptor
	σ1 Receptor antagonist-1 is a selective sigma 1 receptor antagonist.		Sigma receptor
T8331	NUN82647	CU-242	Others
	NUN82647 (CU-242) is an Inhibitor of cell cycle at G2 phase, and apoptosis inducer.		Others
T5822	BTR-1	5-Benzylidene-3-ethyl rhodanine	Apoptosis
	5-Benzylidene-3-ethyl rhodanine(BTR-1 (5-Benzylidene-3-ethyl rhodanine)) is an active anti-cancer agent. BTR-1 activates apoptosis and induces cell death.		Apoptosis
T9712	PF07104091	PF-07104091	CDK
	PF07104091 inhibits CDK2, which may lead to cell cycle arrest, induce apoptosis and inhibit tumor cell proliferation.		CDK
T2425	KPT185	KPT-185,KPT 185	CRM1
	KPT185 (KPT 185) is a selective CRM1 inhibitor, inducing apoptosis, cell-cycle arrest.		CRM1
T72057	H1k		CDK
	H1k is an eudistomin Y fluorescent derivative and lysosome-targeted antiproliferative agent that dose-dependently increases autophagy signalling and down-regulates the expression of cyclin-dependent kinase (CDK1) and cyc...		CDK
T8586	Cicloprofen		Others
	cicloprofen is Cell division cycle 7-related protein kinase (human) inhibitor.		Others
T3555	ML364		DUB
	ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2) and can be used for the research of breast cancer.		DUB
T19664	ON1231320	GBO-006	Apoptosis , PLK
	ON1231320 (GBO-006) is a Polo-like kinase 2 (PLK2) inhibitor.		Apoptosis , PLK
T7698	BS194		CDK
	BS194 is as a potent cyclin-dependent protein kinases (CDKs) inhibitor.		CDK
T3485	Probimane	AT-2153,MM-159	Others
	Probimane (AT-2153) had Anti-proliferative effects, cell cycle G2/M phase arrest and blocking of chromosome segregation in human tumor cell lines with MST-16.		Others
T27407	GDC0575 monohydrochloride	ARRY-575,GDC-0575,GDC 0575,ARRY575,GDC0575	Chk
	GDC0575 monohydrochloride (ARRY575) is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2 nM. GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells by...		Chk
T4189	4-Oxofenretinide	3-Keto fenretinide	cell cycle arrest
	4-Oxofenretinide (3-Keto fenretinide) , a recently identified fenretinide metabolite, induces marked G2-M cell cycle arrest and apoptosis.		cell cycle arrest
T3091	Carmustine	bis-chloroethylnitrosourea,Nitrumon,Gliadel,BCNU,BiCNU,Carmubris	DNA Alkylator/Crosslinker , DNA Alkylation
	Carmustine (bis-chloroethylnitrosourea) is a cell-cycle phase nonspecific alkylating antineoplastic agent.		DNA Alkylator/Crosslinker , DNA Alkylation
T77667	PI3Kδ-IN-16		Apoptosis , PI3K
	PI3Kδ-IN-16 is a selective and potent PI3Kδ inhibitor with anticancer and antiproliferative activity, induces cell cycle arrest and apoptosis.		Apoptosis , PI3K
T10268	AGX51		Others
	AGX51 is an antagonist of inhibitor of DNA binding (ID) proteins. AGX51 treatment lead to pan-Id degradation, cell cycle arrest, and cell death.		Others
T9812	Tubulin inhibitor 24		Microtubule Associated
	Tubulin inhibitor 24 is a potent inhibitor that can inhibit tubulin polymerization.		Microtubule Associated
T7664	Pyroxamide		Apoptosis , HDAC
	Pyroxamide is an histone deacetylases (HDACs) inhibitor with antineoplastic properties ( HDAC1;IC50: 0.1-0.2 μM).		Apoptosis , HDAC
T12617L	(R)-CR8	(R)-CR8,(R)-Isomer,CR8	Apoptosis , CDK
	(R)-CR8 ((R)-Isomer) is a potent and selective CDK inhibitor.		Apoptosis , CDK
T23589	9-Isopropylolomoucine	9 Isopropylolomoucine,N9 Isopropylolomoucine,N9Isopropylolomoucine,N9-Isopropylolomoucine	CDK
	9-Isopropylolomoucine (N9-Isopropylolomoucine), a cell cycle protein-dependent kinase inhibitor, is a thiopurine.		CDK
T12454	PI-273		Apoptosis , PI4K
	PI-273, a Substrate-Competitive, Specific Small-Molecule Inhibitor of PI4KIIα, Inhibits the Growth of Breast Cancer Cells		Apoptosis , PI4K
T21806	HNHA		HDAC
	HNHA is an inhibitor of HDAC.		HDAC
T0009	Flubendazole	Flumoxanal,Flumoxane,NSC 313680,Fluvermal	Apoptosis , Microtubule Associated , Parasite
	Flubendazole (Flumoxane) is available OTC in Europe that is an anthelmintic using to treat worm infection in humans.		Apoptosis , Microtubule Associated , Parasite
T16522	Phenoxodiol	Dehydroequol,Idronoxil,Haginin E	Apoptosis , IAP , Caspase , Topoisomerase , p53
	Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP) expression, and sensitizes the cancer cells to Fas-mediated apop...		Apoptosis , IAP , Caspase , Topoisomerase , p53
T78701	Tubulin inhibitor 32		Apoptosis
	Tubulin inhibitor 32 is an orally active novel microtubule inhibitor with antiproliferative and antitumor activity, inhibits microtubule polymerization, induces apoptosis and cell cycle arrest in G2/M phase.		Apoptosis
T4134	OTS514 hydrochloride	OTS-514 hydrochloride,OTS514 hydrochloride(1338540-63-8(free base))	Apoptosis , TOPK
	OTS514 hydrochloride is a highly effective TOPK(T-LAK cell-originated protein kinase) inhibitor (IC50: 2.6 nM).		Apoptosis , TOPK
T7673	ATH686	ATH 686	Apoptosis , FLT
	ATH686 is an potent and selective Inhibitor of FLT3.		Apoptosis , FLT
T21679	4'-bromo-Resveratrol		Sirtuin
	4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)		Sirtuin
TP1828	N-Acetyl-Ser-Asp-Lys-Pro		RAAS
	Acetyl Ser-Asp-Lys-Pro is formed in bone marrow cells by enzymatic processing of thymosin β4. It inhibits the entry of pluripotent hemopoietic stem cells into S-phase of the cell cycle and protects against Ara-C lethalit...		RAAS
T64923	Sodium citrate	Citrosodine,Natrocitral	Others
	Sodium citrate (Natrocitral) is the sodium salt of citric acid.Citric acid trisodium induces apoptosis and cell cycle arrest at G2/M phase and S phase. Sodium citrate cause oxidative damage of the liver by means of the d...		Others
T14066	9-ING-41		Apoptosis , GSK-3 , Autophagy
	9-ING-41 is a glycogen synthase kinase-3 inhibitor.		Apoptosis , GSK-3 , Autophagy
T5169	SGC-GAK-1		Serine/threonin kinase
	SGC-GAK-1 is a selective cyclin G-associated kinase (GAK) inhibitor (Ki: 3.1 nM).		Serine/threonin kinase
T36898	Sandacanol	Sandranol,2-Ethyl-4-(2,2,3-trimethylcyclopent-3-en-yl)-but-2-en-1-ol	Apoptosis
	Sandacanol（Sandranol） is a selective olfactory receptor (OR10H1) agonist. Sandacanol can induce cell cycle arrest and partial apoptosis in bladder cancer cells, and can reduce cell migration rate and proliferation rate.		Apoptosis
T8535	GAK inhibitor 49		Serine/threonin kinase
	GAK inhibitor 49 is a highly selective and ATP-competitive cyclin G associated kinase (GAK) inhibitor (IC50: 56 nM; Ki: 0.54 nM ).		Serine/threonin kinase
T7018	WZB117		transporter
	WZB117 is a Glucose Transporter 1 (GLUT1) inhibitor. when IC50 of WZB117 approximate 10 μM, it inhibits lung cancer A549 cells and breast cancer MCF7 cells proliferation.		transporter
T4321	Indisulam	E 7070	CDK , Carbonic Anhydrase
	Indisulam (E 7070) is a carbonic anhydrase inibitor and Antitumor CDK inhibitor. Indisulam targets the G1 phase of the cell cycle by depleting cyclin E. inducing p53 and p21, and inhibiting CDK2, causing a blockade in th...		CDK , Carbonic Anhydrase
T36983	Cyclic-di-GMP disodium	Cyclic diguanylate,5GP-5GP disodium,3',5'-Cyclic diguanylic acid,Cyclic di-GMP (sodium salt),cyclic diguanylate disodium,c-di-GMP,c-di-GMP disodium	STING , Endogenous Metabolite
	Cyclic-di-GMP disodium (5GP-5GP disodium) is a bacterial second messenger and a STING agonist involved in a variety of prokaryotic processes including biofilm formation, motility, and cell cycle progression.Cyclic-di-GMP...		STING , Endogenous Metabolite
T10745	CDK9-IN-7		CDK
	CDK9-IN-7 is a highly selective and orally active CDK9/cyclin T inhibitor (IC50: 11 nM), which exhibits more potent over other CDKs (CDK4/cyclinD: 148 nM; CDK6/cyclinD: 145 nM).		CDK
T60869	CDK-IN-10		CDK
	CDK-IN-10 is a cell cycle protein-dependent kinase (CDK) inhibitor with potential anticancer activity for cancer research.		CDK
T1844	KPT330,(E)-	(E)-RN,KPT-330,KPT330,KPT 330	Others , CRM1
	(E)-RN (KPT 330) is a CRM1-selective inhibitor of nuclear export. It inhibits protein trafficking from the nucleus and induces cell cycle arrest and apoptosis in mesothelioma cells.		Others , CRM1
T12642	(R)-Simurosertib	(R)-TAK-931	CDK
	(R)-Simurosertib ((R)-TAK-931) is an inhibitor of the ATP-competitive cell division cycle 7 (CDC7) kinase.		CDK
T73515	MC2590		Apoptosis , HDAC
	MC2590 is a potent and selective histone deacetylase (HDAC) inhibitor that inhibits HDAC1-3, -6, -8, and -10 activities, induces cell cycle arrest, and promotes apoptosis.		Apoptosis , HDAC
T6970	RK33	RK-33,RK 33	COX
	RK33 (RK 33) is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.		COX
T10343	AOH1160	N-(2-Oxo-2-(2-phenoxyphenylamino)ethyl)-1-naphthamide	Apoptosis , DNA/RNA Synthesis
	AOH1160 is an inhibitor of proliferating cell nuclear antigen (PCNA). AOH1160 induces apoptosis and causes cell-cycle arrest by interfering with DNA replication.		Apoptosis , DNA/RNA Synthesis
T5618	AK-1		Sirtuin
	AK-1 is a sirtuin 2 (SIRT2) inhibitor (IC50:12.5 µM).that prevents hippocampal neurodegeneration in Alzheimer's disease models and induces cell cycle arrest in colon carcinoma cells.		Sirtuin
T28886	Suprafenacine	N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide	Microtubule Associated
	Suprafenacine (N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide) is a cell-permeable microtubule destabilizer that induces cell cycle arrest and apoptosis in G2/M phase. Suprafenacine ...		Microtubule Associated
T23840	BUR1	BMP upregulator-1,BMP upregulator 1,BUR 1,BUR-1	CDK
	BUR1 is a selective BMP upregulator that acts by increasing the expression of Inhibitor of DNA binding 1 and inducing BMP2 and PTGS2 expression.		CDK
T19831	Sodium Oxamate	oxamate sodium,Oxamic acid sodium salt,Aminooxoacetic acid sodium salt,SO	Apoptosis , Dehydrogenase , CDK
	Sodium Oxamate (Oxamic acid sodium salt) is an LDH inhibitor that specifically inhibits LDHA. Sodium Oxamate has antitumor activity and induces cell cycle arrest and apoptosis.		Apoptosis , Dehydrogenase , CDK
T12642L	Simurosertib	TAK-931	CDK
	Simurosertib (TAK-931) is a selective and ATP-competitive cell division cycle 7 kinase inhibitor (IC50: <0.3 nM).		CDK

Compounds

CVT-11127

T9003

Synonym:

Target: Dehydrogenase

σ1 Receptor antagonist-1

T9244

Synonym:

Target: Sigma receptor

Synonym: 5-Benzylidene-3-ethyl rhodanine

Synonym: KPT-185,KPT 185

Target: Apoptosis, PLK

Synonym: AT-2153,MM-159

Target: Others

GDC0575 monohydrochloride

T27407

Synonym: ARRY-575,GDC-0575,GDC 0575,ARRY575,GDC0575

Target: Chk

4-Oxofenretinide

T4189

Synonym: 3-Keto fenretinide

Target: cell cycle arrest

Carmustine

T3091

Synonym: bis-chloroethylnitrosourea,Nitrumon,Gliadel,BCNU,BiCNU,Carmubris

Target: DNA Alkylator/Crosslinker, DNA Alkylation

PI3Kδ-IN-16

T77667

Synonym:

Target: Apoptosis, PI3K

Target: Microtubule Associated

Pyroxamide

T7664

Synonym:

Target: Apoptosis, HDAC

(R)-CR8

T12617L

Synonym: (R)-CR8,(R)-Isomer,CR8

Target: Apoptosis, CDK

9-Isopropylolomoucine

T23589

Synonym: 9 Isopropylolomoucine,N9 Isopropylolomoucine,N9Isopropylolomoucine,N9-Isopropylolomoucine

Target: Apoptosis, PI4K

Synonym: Flumoxanal,Flumoxane,NSC 313680,Fluvermal

Target: Apoptosis, Microtubule Associated, Parasite

Phenoxodiol

T16522

Synonym: Dehydroequol,Idronoxil,Haginin E

Target: Apoptosis, IAP, Caspase, Topoisomerase, p53

Synonym: OTS-514 hydrochloride,OTS514 hydrochloride(1338540-63-8(free base))

Target: Apoptosis, TOPK

ATH686

T7673

Synonym: ATH 686

Target: Apoptosis, FLT

N-Acetyl-Ser-Asp-Lys-Pro

Synonym: Citrosodine,Natrocitral

Target: Apoptosis, GSK-3, Autophagy

SGC-GAK-1

T5169

Synonym:

Target: Serine/threonin kinase

Sandacanol

T36898

Synonym: Sandranol,2-Ethyl-4-(2,2,3-trimethylcyclopent-3-en-yl)-but-2-en-1-ol

Target: Serine/threonin kinase

Target: CDK, Carbonic Anhydrase

Cyclic-di-GMP disodium

T36983

Synonym: Cyclic diguanylate,5GP-5GP disodium,3',5'-Cyclic diguanylic acid,Cyclic di-GMP (sodium salt),cyclic diguanylate disodium,c-di-GMP,c-di-GMP disodium

Target: STING, Endogenous Metabolite

Synonym: (E)-RN,KPT-330,KPT330,KPT 330

Target: Apoptosis, HDAC

Synonym: N-(2-Oxo-2-(2-phenoxyphenylamino)ethyl)-1-naphthamide

Target: Apoptosis, DNA/RNA Synthesis

Synonym: N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide

Target: Microtubule Associated

BUR1

T23840

Synonym: BMP upregulator-1,BMP upregulator 1,BUR 1,BUR-1

Target: CDK

Sodium Oxamate

T19831

Synonym: oxamate sodium,Oxamic acid sodium salt,Aminooxoacetic acid sodium salt,SO

Target: Apoptosis, Dehydrogenase, CDK

Cat No.	Product Name	Synonyms	Targets
T1882	Meisoindigo	N-Methylisoindigotin,Methylisoindigotin,Natura-α,Dian III	Apoptosis
	Meisoindigo (Natura-α) is a derivative of indigo natural, might induces apoptosis and myeloid differentiation of acute myeloid leukemia (AML).		Apoptosis
T6S2315	Polyphyllin VI		Apoptosis , Antibacterial , Pyroptosis
	1. Polyphyllin VI has hemostasis , expectorant , bacteriostasis, anticytotoxic, anti pregnancy kill sperm effects.		Apoptosis , Antibacterial , Pyroptosis
TN2103	PROCYANIDIN C1		Apoptosis
	Procyanidin C1 is a natural product, with anti-inflammatory effects, and induces apoptosis.		Apoptosis
T6407	β-Lapachone	Beta-Lapachone,NSC-26326,SL-11001,ARQ-501	IDO , Apoptosis , Topoisomerase , Autophagy
	β-Lapachone (ARQ-501) is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase.		IDO , Apoptosis , Topoisomerase , Autophagy
TN1421	Bacopaside II		Apoptosis
	Bacopaside II is a potential anti-angiogenic agent, it can reduce endothelial cell migration and tubulogenesis and induce apoptosis.		Apoptosis
TN1174	Schinifoline		Apoptosis , cell cycle arrest
	Schinifoline is a quinolone derivative extracted from Zanthoxylum schinifolium Sieb with cytotoxic activity that promotes radiosensitization of cancer cells, affects the cell cycle and apoptosis.		Apoptosis , cell cycle arrest
TCO2745	Cyclic AMP	Adenosine 3',5'-cyclophosphate,cAMP,Cyclic 3',5'-monophosphate adenosine,3',5'-AMP,Adenosine Cyclophosphate	Others , Endogenous Metabolite
	Cyclic AMP (cAMP) (Adenosine 3',5'-cyclophosphate) combined with vitamin C treatment of children with viral myocarditis has exact curative effect, and it can improve cardiac function of patients and improve immune functi...		Others , Endogenous Metabolite
T5795	Suberosin		Others , NF-κB
	Suberosin exhibits anti-inflammatory, and anticoagulant activities, it also shows biting deterrent activity against Aedes aegypti, it may be useful for use as mosquito larvicidal agent.		Others , NF-κB
T2974	Cyclovirobuxine D	CVB-D,Bebuxine,Cyclovirobuxin D	Apoptosis , Others , Akt , mTOR , Autophagy
	Cyclovirobuxine D (Bebuxine) is extracted from Buxus microphylla.		Apoptosis , Others , Akt , mTOR , Autophagy
T34398	Rotundifuran		Others
	Rotundifuran is extracted from the fruit of Vitex rotundifolia. Rotundifuran inhibits cell cycle progression and induces apoptosis in human myeloid leukemia cells.		Others
T3894	Polyphyllin II	Chonglou Saponin II	Apoptosis , Others
	Polyphyllin II (Chonglou Saponin II) has hemostasis, expectorant, bacteriostasis, anticytotoxic, anti-pregnancy kill sperm effects.		Apoptosis , Others
TN2190	Scoulerine		Apoptosis , Beta-Secretase , BACE , Parasite
	Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells.		Apoptosis , Beta-Secretase , BACE , Parasite
T1270	Vincristine sulfate	Leurocristine,22-Oxovincaleukoblastine sulfate,Leurocristine sulfate	Apoptosis , Microtubule Associated
	Vincristine sulfate (Leurocristine sulfate) binds irreversibly to microtubules and spindle proteins in S phase and interferes the formation of the mitotic spindle.		Apoptosis , Microtubule Associated
T5574	Guggulsterone	Guggulsterone E&Z	Apoptosis , FXR , Akt , Caspase , JNK , Autophagy
	Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.		Apoptosis , FXR , Akt , Caspase , JNK , Autophagy
T2S0820	Karanjin		Apoptosis , AMPK
	Karanjin is a flavonoid obtained from the seeds of the karanja tree.Karanjin induces GLUT4 translocation in skeletal muscle cells by increasing AMPK activity. Karanjin can induce cancer cell death through cell cycle arre...		Apoptosis , AMPK
T3150	Caudatin		Apoptosis , Others
	Caudatin is one of the species of C-21 steroidal glycosides mainly isolated from the root of Cynanchum bungei Decne and exhibits potent anticancer activities.		Apoptosis , Others
T5557	Propylparaben	Propyl 4-hydroxybenzoate,Propyl parahydroxybenzoate	Apoptosis , Endogenous Metabolite , Antibacterial
	Propylparaben (Propyl parahydroxybenzoate) is an antimicrobial agent, preservative, flavouring agent		Apoptosis , Endogenous Metabolite , Antibacterial
TN1658	Ganoderenic acid D		Apoptosis , Others
	Ganoderenic acid D is a natural product isolated from the effective compounds of Ganoderma lucidum extract (GLE). Ganoderenic acid D induces cell cycle arrest and apoptosis and inhibits the proliferation of cancer cells.		Apoptosis , Others
T1737	Genistein	NPI 031L	Apoptosis , EGFR , Endogenous Metabolite , Autophagy
	Genistein (NPI 031L) is an isoflavonoid derived from soy products. It inhibits protein-tyrosine kinase and topoisomerase-II (DNA TOPOISOMERASES, TYPE II), with antineoplastic and antitumor activities.		Apoptosis , EGFR , Endogenous Metabolite , Autophagy
T21437	DSPS	Phosphatidylserine(36:0),Dioctadecanoylphosphatidylserine,Distearoyl phosphatidylserine	Others
	DSPS (Dioctadecanoylphosphatidylserine) is a glycerophospholipid, an important phospholipid membrane component that plays a key role in cell cycle signaling. DSPS can regulate cellular activity and mediate apoptosis. DSP...		Others
TN1064	Aristolochic acid C		Others
	Aristolochic acid C could as the larval feeding stimulants.		Others
T1272	Cytarabine	Ara-C,Cytosine Arabinoside,Cytosine β-D-arabinofuranoside,Arabinocytidine	Apoptosis , Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis , Endogenous Metabolite , Autophagy , HSV
	Cytarabine (Ara-C) is a nucleoside analog, an inhibitor of DNA synthesis (IC50=16 nM). Cytarabine inhibits DNA polymerase and induces cell cycle arrest, autophagy, and apoptosis. Cytarabine has antitumor activity.
T3981	Acacetin	4'-Methoxyapigenin,5,7-Dihydroxy-4'-methoxyflavone,Linarigenin	Apoptosis , IAP , COX , Autophagy
	Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an O-methylated flavone found in various plants, shows antinociceptive, anti-inflammatory, and antioxidant activity in various research models.		Apoptosis , IAP , COX , Autophagy
T2902	Costunolide	Costus lactone,NSC 106404,Costunolid,(+)-Costunolide	Apoptosis , Endogenous Metabolite , Telomerase
	Costunolide (Costus lactone) has anti-inflammatory and anti-oxidant properties and mediates apoptosis.		Apoptosis , Endogenous Metabolite , Telomerase
S00015	Tea polyphenol		Apoptosis , Others , Autophagy
	Tea polyphenol, also called green tea extract, are a mixture of chemical compounds, such as flavanoids and tannins, found naturally in tea. Polyphenols are powerful antioxidants, which can reduce the risk of developing c...		Apoptosis , Others , Autophagy
T1508	Decitabine	Dacogen,NSC 127716,Deoxycytidine,5-Aza-2'-deoxycytidine	Apoptosis , Nucleoside Antimetabolite/Analog , DNA Methyltransferase
	Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity. Decitabine has antitumor activity and antimetabolic activity. Decitabine induces cell cycle arrest and apoptosis...
T3870	Cyasterone	Cyasteron	Apoptosis , EGFR
	Cyasterone (Cyasteron), a natural EGFR inhibitor, can inhibit the growth of A549 and MGC823 cells, via regulating EGFR signaling pathway, it may be a promising anti-cancer agent. Cyasterone has antifeeding activity.		Apoptosis , EGFR
T7032	Eupatorin		Others , P450
	Eupatorin has antiproliferative and antiangiogenic effects. Eupatorin has antiproliferative and cytostatic effects on MDA-MB-468 human breast cancer cells due to CYP1-mediated metabolism. Eupatorin-induced cell death is ...		Others , P450
T2S0886	Terrestrosin D		Apoptosis , Others
	Terrestrosin D can induce apoptotic cell death and inhibit angiogenesis in xenograft tumor cells, cell cycle arrest and induction of apoptosis in cancer cells and endothelial cells might be plausible mechanisms of action...		Apoptosis , Others
TN1677	Gartanin		BCL , Caspase , JNK
	Gartanin is an androgen receptor degradation enhancer, it is also a potential neuroprotective agent against glutamate-induced oxidative injury partially through increasing Nrf-2-independed HO-1 and AMPK/SIRT1/PGC-1α±sign...		BCL , Caspase , JNK
T2220	2-Methoxyestradiol	NSC-659853,2-MeOE2,2-ME2	Apoptosis , Reactive Oxygen Species , Microtubule Associated , Endogenous Metabolite , HIF , Autophagy
	2-Methoxyestradiol (2-ME2) is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endotheli...
T6S0221	Eriocitrin	eriodictyol 7-rutinoside,Eriodictyol-7-O-Rutinoside,Eriodictioside,Eriodictyol glycoside	Apoptosis , Carbonic Anhydrase
	1. Eriocitrin (Eriodictyol-7-O-Rutinoside) is powerful antioxidative flavonoid; (1) Prevents oxidative damages caused by acute exercise-induced oxidative stress.(2) Lipid-lowering effects in a rat model of high-fat diet....		Apoptosis , Carbonic Anhydrase
T7174	Urolithin A		Apoptosis , Reactive Oxygen Species , DNA/RNA Synthesis , Endogenous Metabolite , Autophagy , Drug Metabolite
	Urolithin A is a secondary metabolite of ellagic acid, a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties.
T5497	AMAROGENTIN		Apoptosis , AMPK
	Amarogentin is mainly extracted from Swertia and Gentiana roots. It plays cemopreventive/therapeutic role during liver carcinogenesis through modulation of cell cycle and apoptosis		Apoptosis , AMPK
T2S2043	Dracorhodin perchlorate	Dracorhodin perochlorate,Dracohodin perochlorate	Apoptosis , Others
	Dracorhodin perchlorate inhibits cell growth, and induces apoptosis in fibroblasts in a dose-and time-dependent manner, arresting cell cycle at G1 phase, may as a candidate for anti-breast cancer. Dracorhodin perchlorate...		Apoptosis , Others
TN1854	Lasiodin	Lasiokaurin	P450 , PARP , Caspase
	Lasiodin (Lasiokaurin) is a diterpene compound from the plant Camellia sinensis that inhibits the proliferation of NPC cells. Lasiodin has antioxidant, antitumor and antibacterial activities, induces cell cycle length an...		P450 , PARP , Caspase
T3771	Methyl protodioscin	Smilax saponin B,NSC-698790	Apoptosis
	Methyl protodioscin (Smilax saponin B) potentially increase HDL cholesterol while reducing LDL cholesterol and triglycerides. Methyl protodioscin has antitumor property. Methyl protodioscin induced apoptotic process in h...		Apoptosis
T3798	Ziyuglycoside I	Gouguside 7,Ziyu-glycoside I,3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester,Zigu-glucoside I,Kudinoside H	Apoptosis , Others
	Ziyuglycoside I (Gouguside 7) has anti-inflammatory activity, could be used as an active ingredient for cosmetics.		Apoptosis , Others
T37067	9-hydroxy Stearic Acid		HDAC
	9-hydroxy Stearic Acid is a hydroxy fatty acid that is the active metabolite of 9-PAHSA. 9-hydroxy Stearic Acid is formed from 9-PAHSA through carboxyl ester lipase in the liver and pancreas. The 9-hydroxy Stearic Acid (...		HDAC
TN5770	Gingerenone A		Nrf2
	Gingerenone A is an effective Nrf2-Gpx4 activator. It is a small molecule compound isolated from ginger. It has anti-cancer activity, can prolong the cell cycle of cancer cells, and can inhibit dextran sodium sulfate (DS...		Nrf2
TN1405	Arnicolide D		Akt , Caspase , PI3K , STAT , mTOR
	Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling path...		Akt , Caspase , PI3K , STAT , mTOR
T4958	(-)-Alkannin	Alkannin,Shikonin	Apoptosis , PI3K
	(-)-Alkannin (Shikonin) is a natural red naphthoquinone pigment, has antimicrobial, anti-tumor, and anti-inflammatory effects; a purified shikonin preparation is widely used for the production of medicinals, cosmetics, a...		Apoptosis , PI3K
T5S1467	Cucurbitacin E		CDK , Autophagy
	Cucurbitacin E is a natural product isolated from the climbing stem of Cucumic melo L. It significantly suppresses the activity of the cyclin B1/CDC2 complex.Cucurbitacin E has prevention of neurodegeneration, it has pot...		CDK , Autophagy
T2966	Beta-Sitosterol	Cupreol,Beta-Sitosterol,β-Sitosterol,Azuprostat,SKF 14463,22,23-Dihydrostigmasterol,Betaprost	Apoptosis , Lipase , Endogenous Metabolite
	Beta-Sitosterol (SKF 14463) has recently been shown to induce G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways. Beta-Sitosterol (SKF 14463) , a main dietary phytosterol foun...		Apoptosis , Lipase , Endogenous Metabolite
TN1880	Lucidenic acid B	Lucidenicacid B	Apoptosis , Caspase
	Lucidenic acid B (Lucidenicacid B), a natural compound extracted from Ganoderma lucidum, induces activation of caspase-9 and caspase-3 and cleavage of PARP, which can induce apoptosis in human leukemia cells through mito...		Apoptosis , Caspase
T4137	4,7-DIHYDROXYCOUMARIN		Others
	4,7-DIHYDROXYCOUMARIN is a naturally occurring coumarin derivative found in a variety of plants, including parsley and chamomile. It has been found to inhibit the activity of several enzymes, including cytochrome P450, c...		Others
T0186	Docetaxel trihydrate	RP-56976 (Trihydrate),RP56976 (NSC 628503) Trihydrate	Apoptosis , BCL , Microtubule Associated
	Docetaxel trihydrate (RP-56976 Trihydrate) is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis and that currently plays a central role in the therapy of many solid tumor i...		Apoptosis , BCL , Microtubule Associated
T5S0055	Chelidonine	Helidonine,Khelidonin,Stylophorin	Apoptosis , Others , Influenza Virus
	1. Chelidonine (Stylophorin) isolated from Chelidonium majus efficiently induced apoptosis in HeLa cells through possible alteration of p38-p53 and AKT/PI3 kinase signalling pathways. 2. Chelidonine is a promising model ...		Apoptosis , Others , Influenza Virus
T81818	Metachromins X
	Metachromin X, a sesquiterpene quinone, halts the cell cycle of HeLa/Fucci2 cells at the S/G2/M phase [1].
T78479	Manool
	Manool, a diterpene derived from Salvia officinalis, demonstrates selective cytotoxicity in cancer cells and causes cell cycle arrest at the G(2)/M phase [1] [2].
------------------------ More ------------------------

Natural Products

Meisoindigo

T1882

Synonym: N-Methylisoindigotin,Methylisoindigotin,Natura-α,Dian III

Target: Apoptosis, Antibacterial, Pyroptosis

Synonym: Beta-Lapachone,NSC-26326,SL-11001,ARQ-501

Target: IDO, Apoptosis, Topoisomerase, Autophagy

Target: Apoptosis, cell cycle arrest

Cyclic AMP

TCO2745

Synonym: Adenosine 3',5'-cyclophosphate,cAMP,Cyclic 3',5'-monophosphate adenosine,3',5'-AMP,Adenosine Cyclophosphate

Target: Others, Endogenous Metabolite

Suberosin

T5795

Synonym:

Target: Others, NF-κB

Cyclovirobuxine D

T2974

Synonym: CVB-D,Bebuxine,Cyclovirobuxin D

Target: Apoptosis, Others, Akt, mTOR, Autophagy

Synonym: Chonglou Saponin II

Target: Apoptosis, Others

Scoulerine

TN2190

Synonym:

Target: Apoptosis, Beta-Secretase, BACE, Parasite

Vincristine sulfate

T1270

Synonym: Leurocristine,22-Oxovincaleukoblastine sulfate,Leurocristine sulfate

Target: Apoptosis, Microtubule Associated

Guggulsterone

T5574

Synonym: Guggulsterone E&Z

Target: Apoptosis, FXR, Akt, Caspase, JNK, Autophagy

Karanjin

T2S0820

Synonym:

Target: Apoptosis, AMPK

Caudatin

T3150

Synonym:

Target: Apoptosis, Others

Propylparaben

T5557

Synonym: Propyl 4-hydroxybenzoate,Propyl parahydroxybenzoate

Target: Apoptosis, Endogenous Metabolite, Antibacterial

Ganoderenic acid D

TN1658

Synonym:

Target: Apoptosis, Others

Genistein

T1737

Synonym: NPI 031L

Target: Apoptosis, EGFR, Endogenous Metabolite, Autophagy

DSPS

T21437

Synonym: Phosphatidylserine(36:0),Dioctadecanoylphosphatidylserine,Distearoyl phosphatidylserine

Synonym: Ara-C,Cytosine Arabinoside,Cytosine β-D-arabinofuranoside,Arabinocytidine

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis, Endogenous Metabolite, Autophagy, HSV

Acacetin

T3981

Synonym: 4'-Methoxyapigenin,5,7-Dihydroxy-4'-methoxyflavone,Linarigenin

Target: Apoptosis, IAP, COX, Autophagy

Costunolide

T2902

Synonym: Costus lactone,NSC 106404,Costunolid,(+)-Costunolide

Target: Apoptosis, Endogenous Metabolite, Telomerase

Tea polyphenol

S00015

Synonym:

Target: Apoptosis, Others, Autophagy

Decitabine

T1508

Synonym: Dacogen,NSC 127716,Deoxycytidine,5-Aza-2'-deoxycytidine

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA Methyltransferase

Cyasterone

T3870

Synonym: Cyasteron

Target: Apoptosis, EGFR

Target: Apoptosis, Others

Gartanin

TN1677

Synonym:

Target: BCL, Caspase, JNK

2-Methoxyestradiol

T2220

Synonym: NSC-659853,2-MeOE2,2-ME2

Target: Apoptosis, Reactive Oxygen Species, Microtubule Associated, Endogenous Metabolite, HIF, Autophagy

Eriocitrin

T6S0221

Synonym: eriodictyol 7-rutinoside,Eriodictyol-7-O-Rutinoside,Eriodictioside,Eriodictyol glycoside

Target: Apoptosis, Carbonic Anhydrase

Urolithin A

T7174

Synonym:

Target: Apoptosis, Reactive Oxygen Species, DNA/RNA Synthesis, Endogenous Metabolite, Autophagy, Drug Metabolite

AMAROGENTIN

T5497

Synonym:

Target: Apoptosis, AMPK

Dracorhodin perchlorate

T2S2043

Synonym: Dracorhodin perochlorate,Dracohodin perochlorate

Target: Apoptosis, Others

Lasiodin

TN1854

Synonym: Lasiokaurin

Target: P450, PARP, Caspase

Methyl protodioscin

T3771

Synonym: Smilax saponin B,NSC-698790

Target: Apoptosis

Ziyuglycoside I

T3798

Synonym: Gouguside 7,Ziyu-glycoside I,3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester,Zigu-glucoside I,Kudinoside H

Target: Apoptosis, Others

9-hydroxy Stearic Acid

Target: Akt, Caspase, PI3K, STAT, mTOR

(-)-Alkannin

T4958

Synonym: Alkannin,Shikonin

Target: Apoptosis, PI3K

Cucurbitacin E

T5S1467

Synonym:

Target: CDK, Autophagy

Beta-Sitosterol

T2966

Synonym: Cupreol,Beta-Sitosterol,β-Sitosterol,Azuprostat,SKF 14463,22,23-Dihydrostigmasterol,Betaprost

Target: Apoptosis, Lipase, Endogenous Metabolite

Lucidenic acid B

TN1880

Synonym: Lucidenicacid B

Target: Apoptosis, Caspase

4,7-DIHYDROXYCOUMARIN

Synonym: RP-56976 (Trihydrate),RP56976 (NSC 628503) Trihydrate

Target: Apoptosis, BCL, Microtubule Associated

Chelidonine

T5S0055

Synonym: Helidonine,Khelidonin,Stylophorin

Target: Apoptosis, Others, Influenza Virus

--------- More ---------

Cat No.	Product Name
L8100	Cell Cycle Compound Library	695 compounds
	A unique collection of 695 cell cycle related compounds for high throughput screening (HTS) and high content screening (HCS);
L2151	Chemotherapy Drug Library	51 compounds
	51 Chemotherapeutic drugs that can be used for high-throughput and high-content screening.
L1380	Transcription Factor-Targeted Compound Library	704 compounds
	Well-chosen 704 compounds with unique structures targeting transcription factor;
L1110	Microtubule-Targeted Compound Library	155 compounds
	A unique collection of 155 microtubule-targeted compounds can be used in HTS and HCS;
L6100	Polyphenolic Natural Product Library	640 compounds
	A unique collection of 640 natural polyphenolic compounds for high throughput screening (HTS) and high content screening (HCS);
L2200	Tyrosine Kinase Inhibitor Library	1033 compounds
	A unique collection of 1033 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related diseases;
L2140	Cancer Cell Differentiation Compound Library	413 compounds
	A unique collection of 413 cancer cell differentiation inducing compounds for high throughput and high content screening;
L8600	Ubiquitination Compound Library	214 compounds
	A unique collection of 214 ubiquitination related small chemicals can be used for high throughput and high content screening；
L1300	PI3K-AKT-mTOR Compound Library	425 compounds
	A unique collection of 425 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with PI3K/Akt/mTOR signaling;
DO1200	SmartTM Library	53200 compounds

L7110	Anti-Hypertension Compound Library	719 compounds
	719 hypertension-related small molecules for high-throughput and high-content screening.
L9500	Target-Focused Phenotypic Screening Library	1832 compounds
	A unique collection of 1832 annotated bioactive compounds with clear targets, suitable for phenotypic screening；
L6120	Flavonoid Natural Product Library	477 compounds
	A unique collection of 477 flavonoids can be used for high throughput and high content screening；