Search Result

Search Results for " 自噬 "

Targets

277

Compounds

101

Natural Products

Libraries

Cat No.	Product Name	Synonyms	Targets
T5181	CA-5f		Apoptosis , Autophagy
	CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion.		Apoptosis , Autophagy
T23716	AMDE-1	AMDE 1	Autophagy
	AMDE-1 is an autophagy modulator and triggers autophagy in an Atg5-dependent manner. AMDE-1 recruits Atg16 to the pre-autophagosomal site and causes LC3 lipidation.		Autophagy
T3955	AR7		Retinoid Receptor
	AR7 is a retinoic acid receptor α (RARα) antagonist.		Retinoid Receptor
T1908	MHY1485		mTOR , Autophagy
	MHY1485 is a mTOR activator. It inhibits the autophagic process by inhibition of fusion between autophagosomes and lysosomes, leading to the accumulation of LC3II protein and enlarged autophagosomes.		mTOR , Autophagy
T13809	P62-mediated mitophagy inducer	PMI	Mitophagy
	P62-mediated mitophagy inducer (PMI) is a regulator of mitophagy .		Mitophagy
T11142	EACC		Autophagy
	EACC, a reversible autophagy inhibitor, selectively impedes Stx17, an autophagosome-specific SNARE, from translocating, hence obstructing the fusion between autophagosomes and lysosomes. This compound effectively halts a...		Autophagy
T6945	Vps34-PIK-III	PIK-III,VPS34-IN2	PI3K , Autophagy
	Vps34-PIK-III (VPS34-IN2), a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and results in the stabilization of autophagy substrates.		PI3K , Autophagy
T4219	Autophinib		PI3K , Autophagy
	Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and rapamycin induced autophagy assay.		PI3K , Autophagy
T6223	U0126-EtOH	U0126 Ethanol,U0126	Mitophagy , Influenza Virus , MEK , Autophagy
	U0126-EtOH (U0126 Ethanol) is a non-ATP competitive specific inhibitor of MEK1/2 (IC50: 0.07/0.06 μM).		Mitophagy , Influenza Virus , MEK , Autophagy
T60036	ML-SA5		Autophagy
	ML-SA5 is an MCOLN1 agonist and arrests autophagic flux by perturbing fusion between autophagosomes and lysosomes.		Autophagy
T3436	LYS01	lys05 (free base)	Autophagy
	LYS01 free base is a new lysosomal autophagy inhibitor.		Autophagy
T3155	SMER28		Autophagy
	SMER28 is a small-molecule enhancer (SMER) of autophagy, inducing autophagy independently of rapamycin in mammalian cells via an mTOR-independent mechanism and prevented the accumulation of amyloid beta peptide.		Autophagy
T9013	Autogramin-2	tert-butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate	Autophagy
	Autogramin-2 (tert-butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate) potently inhibits autophagy induced by either starvation with IC50 of 0.27 μM, and inhibits mTORC1 (Rapamycin; IC50...		Autophagy
T14033	3BDO		Apoptosis , mTOR , Autophagy
	3BDO is an activator of mTOR. It can also inhibit autophagy..		Apoptosis , mTOR , Autophagy
T4663	QX77		Others , Autophagy
	QX77 is a chaperone-mediated autophagy (CMA) activator.		Others , Autophagy
T14346	Aumitin		Others , Autophagy
	Aumitin is a diaminopyrimidine-based autophagy inhibitor. Aumitin inhibits starvation- and rapamycin induced autophagy dose dependently with IC50s of 0.12 μM and 0.24 μM, respectively[1], and it inhibits mitochondrial re...		Others , Autophagy
T7679	UBCS039		Sirtuin , Autophagy
	UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)		Sirtuin , Autophagy
T73331	GSK3-IN-3		Mitophagy , GSK-3
	GSK3-IN-3 is a mitochondrial autophagy (mitophagy) inducer and GSK-3 inhibitor (IC50: 3.01 μM) that induces parkin-dependent mitochondrial autophagy. GSK3-IN-3 is non-ATP and non-substrate competitive and neuroprotective...		Mitophagy , GSK-3
T38861L	Tat-beclin 1 acetate	Tat-beclin 1 acetate(1423821-88-8 free base)	HIV Protease , Autophagy
	Tat-beclin 1 acetate is a potent inducer of autophagy and interacts with the negative regulator of autophagy, GAPR-1. Tat-beclin 1 acetate decreases the accumulation of polyglutamine expansion protein aggregates and the ...		HIV Protease , Autophagy
T3015	Olaparib	AZD2281,KU0059436	Mitophagy , PARP , Autophagy
	Olaparib (KU0059436) is a small molecule inhibitor of PARP1/PARP2 (IC50=5/1 nM), with weak inhibitory activity against PARP tankyrase-1 (IC50=1.5 μM), and is selective and orally active. Olaparib exhibits autophagy and m...		Mitophagy , PARP , Autophagy
T5211	NSC 185058	NSC185058	Cysteine Protease , Autophagy
	NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. It also can attenuate the autophagic activity.		Cysteine Protease , Autophagy
T6854	GSK621		Apoptosis , AMPK , Autophagy
	GSK621 is a specific and potent AMPK activator.		Apoptosis , AMPK , Autophagy
T63399L	MTOR/HDAC-IN-1 HCl	mTOR/HDAC-IN-1 HCl（2815286-02-1 Free base)	HDAC , mTOR
	mTOR/HDAC-IN-1 HCl is a potent dual inhibitor of mTOR and HDAC with potential anti-inflammatory, anti-proliferative, autophagy and apoptosis-inducing effects for cancer research.		HDAC , mTOR
T1764	Adezmapimod	PB 203580,RWJ 64809,SB203580	Mitophagy , p38 MAPK , Autophagy
	Adezmapimod (SB 203580) is a p38 MAPK inhibitor (IC50=0.3-0.5 μM) that is selective and ATP-competitive. Adezmapimod possesses autophagy and mitochondrial autophagy activating activity. Adezmapimod displays more than 100...		Mitophagy , p38 MAPK , Autophagy
T5338	MTOR inhibitor-1		mTOR , Autophagy
	C-4 is a potential ATP-competitive inhibitor of mTOR. C-4 could inhibit cell growth and proliferation.		mTOR , Autophagy
T6799	IITZ-01		Apoptosis , PI3K , Autophagy
	IITZ-01 is potent autophagy inhibitor with single-agent anticancer activity ( IC50 of 2.62 μM for PI3Kγ.)		Apoptosis , PI3K , Autophagy
T18968	Dansylcadaverine	Monodansyl cadaverine	Others , Autophagy
	Dansylcadaverine (Monodansyl cadaverine) is a fluorescent probe.		Others , Autophagy
T2145	Temsirolimus	NSC 683864,CCI-779	Apoptosis , mTOR , Autophagy
	Temsirolimus (CCI-779) is a specific mTOR inhibitor ( IC50: 1.76 μM), used in the treatment of advanced renal cell cancer.		Apoptosis , mTOR , Autophagy
T6991	Nitroprusside disodium dihydrate	Sodium Nitroferricyanide(III) Dihydrate,Sodium Nitroprusside Dihydrate	Guanylate cyclase , Autophagy
	Nitroprusside disodium dihydrate (Sodium Nitroprusside Dihydrate) is a potent vasodilator working through releasing NO spontaneously in blood.		Guanylate cyclase , Autophagy
T5403	ULK-101		Autophagy
	ULK-101 is a potent and selective ULK1 inhibitor ( IC50s: 8.3/30 nM for ULK1/ULK2). It can suppress autophagy.		Autophagy
T7844	4-IPP	4-Iodo-6-phenylpyrimidine	Others
	4-IPP (4-Iodo-6-phenylpyrimidine) is an irreversible inhibitor of macrophage migration inhibitory factor (MIF)		Others
T12831L	SAR405		PI3K , Autophagy
	SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor (IC50:1.2 nM; Kd:1.5 nM) that prevents autophagy and synergizes with MTOR inhibition in tumor cells. SAR405 treatment also inhibits autophagy induced either by sta...		PI3K , Autophagy
T1076	Dexamethasone	MK 125,Prednisolone F,NSC 34521,Hexadecadrol	Glucocorticoid Receptor , Mitophagy , IL Receptor , SARS-CoV , Antibacterial , Antibiotic , Autophagy , Complement System
	Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist and an IL receptor modulator. Dexamethasone has anti-inflammatory and immunosuppressive activity and induces autophagy. Dexamethasone inhibits LPS-induced...
T10413	Autogramin-1		mTOR , Autophagy
	Autogramin-1 potently inhibits autophagy induced by either mTORC1 inhibition (Rapamycin; IC50: 0.44 μM) or starvation (IC50: 0.17 μM).		mTOR , Autophagy
T16104	ML-9		Myosin , Akt
	ML-9 suppresses MLCK, PKA, and PKC activity with Ki values of 4, 32, and 54 μM, respectively. ML-9 is a selective and effective inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK), and stromal interaction ...		Myosin , Akt
T5538	DC661		Apoptosis , Autophagy
	DC661 is a palmitoyl-protein thioesterase 1 (PPT1) inhibitor that acts as an anti-lysosomal agent by inhibiting autophagy, demonstrating anti-cancer activity.		Apoptosis , Autophagy
T7149	S29434		NADPH , Autophagy
	S29434 (NMDPEF) is a potent, competitiveinhibitor of quinone reductase 2 (QR2;IC50:5-16nM).		NADPH , Autophagy
T71961	TUN-92046	DM-α-KG,T71961,Dimethyl 2-ketoglutarate,Dimethyl 2-oxoglutarate	Others
	TUN-92046 (Dimethyl 2-oxoglutarate) is a membrane-permeable alpha-ketoglutarate analogue that inhibits maladaptive autophagy in pressure overloading induced cardiomyopathy.		Others
T0476	Spironolactone	SC9420,Abbolactone	Glucocorticoid Receptor , Androgen Receptor , Autophagy
	Spironolactone (SC9420) is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.		Glucocorticoid Receptor , Androgen Receptor , Autophagy
T0711L	Niclosamide olamine	Niclosamide-olamine,Niclosamide Ethanolamine salt	Antibiotic , STAT , Parasite , Autophagy
	Niclosamide olamine (Niclosamide Ethanolamine salt) is an Repellent, Insect Attractant and Chemosterilant.		Antibiotic , STAT , Parasite , Autophagy
T7697	BIX-01294		Histone Methyltransferase , Autophagy
	BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).		Histone Methyltransferase , Autophagy
T9583	HJ-PI01	N-Acetylphenoxazine,10-acetylphenoxazine	Pim
	HJ-PI01 (HJ-PI01) is a Pim-2 inhibitor. HJ-PI01 (HJ-PI01) induces apoptosis and autophagic cell death in triple-negative human breast cancer.		Pim
T74025	AUTAC1		AUTACs
	AUTAC1 is a MetAP2-targeted autophagy-mediated degrader (AUTAC) with potential anticancer activity that degrades MetAP2 and FKBP12 proteins and can be used to synthesize PROTAC.		AUTACs
T1967	AZD-3463	ALK/IGF1R inhibitor	Apoptosis , IGF-1R , ALK , Autophagy
	AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.		Apoptosis , IGF-1R , ALK , Autophagy
T9062	CA77.1		Autophagy
	CA77.1(CA) is a novel chaperon-mediated autophagy (CMA) activator for the treatment of Alzheimer's disease (AD).		Autophagy
T1907	Mdivi-1	Mitochondrial division inhibitor 1	Apoptosis , Mitophagy , Dynamin , Autophagy
	Mdivi-1 (Mitochondrial division inhibitor 1) is a mitochondrial division inhibitor that inhibits DRP1 and Dynamin I (IC50=1-10 μM). Mdivi-1 inhibits mitochondrial autophagy.		Apoptosis , Mitophagy , Dynamin , Autophagy
T6683	STF-62247	STF 62247	Estrogen/progestogen Receptor , Autophagy
	STF-62247 is TGN inhibitor with IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells, respectively.		Estrogen/progestogen Receptor , Autophagy
T1789	Obeticholic Acid	INT-747,6-Ethylchenodeoxycholic acid,6-ECDCA	FXR , Autophagy
	Obeticholic Acid (6-ECDCA) is a Farnesoid X Receptor Agonist. The mechanism of action of obeticholic acid is as a Farnesoid X Receptor Agonist.		FXR , Autophagy
T6045	Torin 1		DNA-PK , PI3K , mTOR , Autophagy
	Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.		DNA-PK , PI3K , mTOR , Autophagy
T9211	Mito-LND	Mito-Loidamine	OXPHOS , Reactive Oxygen Species , Mitochondrial Metabolism , Autophagy
	Mito-LND (Mito-Loidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation.

Compounds

CA-5f

T5181

Synonym:

Target: Apoptosis, Autophagy

Target: Retinoid Receptor

MHY1485

T1908

Synonym:

Target: mTOR, Autophagy

P62-mediated mitophagy inducer

Synonym: PIK-III,VPS34-IN2

Target: PI3K, Autophagy

Autophinib

T4219

Synonym:

Target: PI3K, Autophagy

U0126-EtOH

T6223

Synonym: U0126 Ethanol,U0126

Target: Mitophagy, Influenza Virus, MEK, Autophagy

Synonym: lys05 (free base)

Synonym: tert-butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate

Target: Apoptosis, mTOR, Autophagy

QX77

T4663

Synonym:

Target: Others, Autophagy

Aumitin

T14346

Synonym:

Target: Others, Autophagy

UBCS039

T7679

Synonym:

Target: Sirtuin, Autophagy

GSK3-IN-3

T73331

Synonym:

Target: Mitophagy, GSK-3

Tat-beclin 1 acetate

T38861L

Synonym: Tat-beclin 1 acetate(1423821-88-8 free base)

Target: HIV Protease, Autophagy

Olaparib

T3015

Synonym: AZD2281,KU0059436

Target: Mitophagy, PARP, Autophagy

NSC 185058

T5211

Synonym: NSC185058

Target: Cysteine Protease, Autophagy

GSK621

T6854

Synonym:

Target: Apoptosis, AMPK, Autophagy

mTOR/HDAC-IN-1 HCl

T63399L

Synonym: mTOR/HDAC-IN-1 HCl（2815286-02-1 Free base)

Target: HDAC, mTOR

Adezmapimod

T1764

Synonym: PB 203580,RWJ 64809,SB203580

Target: Mitophagy, p38 MAPK, Autophagy

mTOR inhibitor-1

T5338

Synonym:

Target: mTOR, Autophagy

IITZ-01

T6799

Synonym:

Target: Apoptosis, PI3K, Autophagy

Dansylcadaverine

T18968

Synonym: Monodansyl cadaverine

Target: Others, Autophagy

Temsirolimus

T2145

Synonym: NSC 683864,CCI-779

Target: Apoptosis, mTOR, Autophagy

Nitroprusside disodium dihydrate

T6991

Synonym: Sodium Nitroferricyanide(III) Dihydrate,Sodium Nitroprusside Dihydrate

Target: Guanylate cyclase, Autophagy

Synonym: 4-Iodo-6-phenylpyrimidine

Target: PI3K, Autophagy

Dexamethasone

T1076

Synonym: MK 125,Prednisolone F,NSC 34521,Hexadecadrol

Target: Glucocorticoid Receptor, Mitophagy, IL Receptor, SARS-CoV, Antibacterial, Antibiotic, Autophagy, Complement System

Autogramin-1

T10413

Synonym:

Target: mTOR, Autophagy

Target: Apoptosis, Autophagy

S29434

T7149

Synonym:

Target: NADPH, Autophagy

TUN-92046

T71961

Synonym: DM-α-KG,T71961,Dimethyl 2-ketoglutarate,Dimethyl 2-oxoglutarate

Target: Others

Spironolactone

T0476

Synonym: SC9420,Abbolactone

Target: Glucocorticoid Receptor, Androgen Receptor, Autophagy

Niclosamide olamine

T0711L

Synonym: Niclosamide-olamine,Niclosamide Ethanolamine salt

Target: Antibiotic, STAT, Parasite, Autophagy

BIX-01294

T7697

Synonym:

Target: Histone Methyltransferase, Autophagy

HJ-PI01

T9583

Synonym: N-Acetylphenoxazine,10-acetylphenoxazine

Synonym: ALK/IGF1R inhibitor

Target: Apoptosis, IGF-1R, ALK, Autophagy

Synonym: Mitochondrial division inhibitor 1

Target: Apoptosis, Mitophagy, Dynamin, Autophagy

STF-62247

T6683

Synonym: STF 62247

Target: Estrogen/progestogen Receptor, Autophagy

Obeticholic Acid

T1789

Synonym: INT-747,6-Ethylchenodeoxycholic acid,6-ECDCA

Target: FXR, Autophagy

Torin 1

T6045

Synonym:

Target: DNA-PK, PI3K, mTOR, Autophagy

Mito-LND

T9211

Synonym: Mito-Loidamine

Target: OXPHOS, Reactive Oxygen Species, Mitochondrial Metabolism, Autophagy

Cat No.	Product Name	Synonyms	Targets
T5S1099	Liensinine		Apoptosis , Mitophagy , Others , Autophagy
	1. Liensinine, a kind of isoquinoline alkaloid, can antagonize the ventricular arrhythmias.		Apoptosis , Mitophagy , Others , Autophagy
T8166	Pennogenin 3-O-beta-chacotrioside		Autophagy
	Pennogenin 3-O-beta-chacotrioside is an active component isolated from Paris polyphylla with anti-colorectal cancer activity. It modulates autophagy via increasing the expressions of autophagy-related proteins LC3 and Be...		Autophagy
T3054	Daurisoline	(R,R)-Daurisoline	Others , Potassium Channel , Autophagy
	Daurisoline ((R,R)-Daurisoline) is a hERG inhibitor. Daurisoline is also an autophagy blocker.		Others , Potassium Channel , Autophagy
T7985	4,4'-Dimethoxychalcone	4,4-Dimethoxychalcone	Others , Autophagy
	4,4'-Dimethoxychalcone (4,4-Dimethoxychalcone) is a natural product.		Others , Autophagy
T6740	Bafilomycin A1		Apoptosis , Proton pump , Antibacterial , Antibiotic , Autophagy
	Bafilomycin A1 belongs to the macrolide class of antibiotics and is a V-ATPase (IC50=0.44 nM) that is specific and reversible. Bafilomycin A1 is an inhibitor of the late phase of autophagy, blocking the fusion of autopha...
T1922	Pseudolaric Acid B		Apoptosis , p38 MAPK , Ferroptosis , HBV , Autophagy , Antifungal
	Pseudolaric acid B, a natural diterpenoid compound, is isolated from Pseudolarix kaempferi.
T4S1102	Liensinine diperchlorate	Liensinine-Perchlorate	Mitophagy , Others , Autophagy
	Liensinine Diperchlorate is an isoquinoline alkaloid extracted from the embryonic seeds of the sacred lotus. It inhibits late autophagy by blocking autophagosome-lysosome fusion and exhibits biological activities such as...		Mitophagy , Others , Autophagy
TQ0089	Juglanin		Apoptosis , JNK , Autophagy
	Juglanin is a JNK activator. Juglanin with inflammation and anti-tumor activities. It can induce apoptosis and autophagy on human breast cancer cells.		Apoptosis , JNK , Autophagy
T5689	20-DEOXYINGENOL		Others , Autophagy
	20-DEOXYINGENOL is a natual product.		Others , Autophagy
TN6751	1-HEXACOSANOL		NPC1L1 , AMPK
	Hexacosanol activates AMPK and hepatic autophagy and inhibits SREBP2, resulting in hypocholesterolemic activities and improvement of hepatic steatosis.		NPC1L1 , AMPK
TN6705	Graveoline	2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-one,Foliosine	Autophagy
	Graveoline (2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-one) is an apoptosis and autophagy inducer in skin melanoma cancer cells		Autophagy
T6354	(+)-Usnic acid	D-Usnic Acid,(+)-Usniacin	Antiviral , Antibacterial , mTOR
	(+)-Usnic acid (D-Usnic Acid) is a naturally occurring dibenzofuran derivative found in several lichen species.		Antiviral , Antibacterial , mTOR
T3S1591	Notoginsenoside Fc		Others , Autophagy
	1. Notoginsenoside Fc has perfect anti-platelet aggregatory effect.		Others , Autophagy
T8200	Ginkgolide K		AMPK , Autophagy
	Ginkgolide K induces protective autophagy through the AMPK/mTOR/ULK1 signalling pathway. It possesses neuroprotective activity.		AMPK , Autophagy
T2758	Madecassic acid	6-Deoxy-L-Galactose,L-Fucose,Brahmic acid,L-fucopyranose	Others , TNF , COX , NO Synthase , Interleukin
	Madecassic acid (L-fucopyranose) is extracted from the whole herb of Centella asiatica.		Others , TNF , COX , NO Synthase , Interleukin
T0022	Taurine	2-Aminoethanesulfonic acid	LDL , Endogenous Metabolite , Autophagy
	Taurine (2-Aminoethanesulfonic acid), an organic acid, is distributed in various animal tissues.		LDL , Endogenous Metabolite , Autophagy
T2998	Dihydromyricetin	Ampelopsin,Ampeloptin	Influenza Virus , GABA Receptor , DNA/RNA Synthesis , mTOR , Autophagy
	Dihydromyricetin (Ampelopsin) is a natural antioxidant flavonoid from Ampelopsis grossedentata. Dihydromyricetin is a potent inhibitor of dihydropyrimidinase with an IC50 of 48 μM. Dihydromyricetin can activate autophagy...
T5793	Britannin		Apoptosis , AMPK , Autophagy
	Britannin, a sesquiterpene lactone, inhibits proliferation and induces apoptosis through the mitochondrial signaling pathway in human breast cancer cells.		Apoptosis , AMPK , Autophagy
T3981	Acacetin	4'-Methoxyapigenin,5,7-Dihydroxy-4'-methoxyflavone,Linarigenin	Apoptosis , IAP , COX , Autophagy
	Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an O-methylated flavone found in various plants, shows antinociceptive, anti-inflammatory, and antioxidant activity in various research models.		Apoptosis , IAP , COX , Autophagy
T5S0658	Corynoxine		Autophagy
	Corynoxine is a natural oxindole alkaloid and induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells.		Autophagy
T3843	Pinosylvin	3,5-stilbenediol,5-Styrylresorcinol	Apoptosis , Others , Antibacterial , Autophagy
	Pinosylvin (5-Styrylresorcinol) induces autophagy via AMPK activation. Pinosylvin is likely to act as a pro-angiogenic factor.		Apoptosis , Others , Antibacterial , Autophagy
T4519	Alisol A	Alisol-A	Autophagy
	Alisol A (Alisol-A) may be an autophagic inducer, it has anti-cancer activity, it presents inhibitory effects on cancer cell lines tested(HepG2, MDA-MB-231, and MCF-7 cells).		Autophagy
TMA0507	Tomatidine		NF-κB , JNK , Autophagy
	Tomatidine serves as an anti-inflammatory agent by inhibiting NF-κB and JNK signaling pathways. Additionally, it induces autophagy in both mammalian cells and C. elegans.		NF-κB , JNK , Autophagy
T7174	Urolithin A		Apoptosis , Reactive Oxygen Species , DNA/RNA Synthesis , Endogenous Metabolite , Autophagy , Drug Metabolite
	Urolithin A is a secondary metabolite of ellagic acid, a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties.
TN2225	Soyasapogenol B		Apoptosis , Autophagy
	Soyasapogenol B has anti-cancer, hypocholesterolemic, anticomplementary, hepatoprotective effects, it inhibits proliferation of cultured Hep-G2.		Apoptosis , Autophagy
T1879	3-Methyladenine	3-MA,NSC 66389	Mitophagy , PI3K , Endogenous Metabolite , Autophagy
	3-Methyladenine (3-MA) is a PI3K inhibitor that selectively inhibits class IB PI3Kγ (IC50=60 μM) and class III VPS34 (IC50=25 μM). 3-Methyladenine inhibits autophagy.		Mitophagy , PI3K , Endogenous Metabolite , Autophagy
T1537	Rapamycin	Sirolimus,AY 22989,NSC-2260804	Others , Endogenous Metabolite , Antibiotic , mTOR , Autophagy , Antifungal
	Rapamycin (AY 22989) is a natural product of macrolides, an mTOR inhibitor with specificity (HEK293 cells: IC50=0.1 nM). Rapamycin has immunosuppressive activity and induces autophagy.
T2974	Cyclovirobuxine D	CVB-D,Bebuxine,Cyclovirobuxin D	Apoptosis , Others , Akt , mTOR , Autophagy
	Cyclovirobuxine D (Bebuxine) is extracted from Buxus microphylla.		Apoptosis , Others , Akt , mTOR , Autophagy
T3408	Syringin	Lilacin,Syringoside,eleutheroside-b,Methoxyconiferine	NOS , Autophagy
	Syringin (eleutheroside-b) is a compound with antitumor, antiproliferative, immunomodulatory and platelet aggregation inhibiting effects.		NOS , Autophagy
T3419	Chelerythrine chloride		Apoptosis , BCL , PKC , Autophagy
	Chelerythrine Chloride is a cell-permeable inhibitor of protein kinase C, competitive with respect to the phosphate acceptor and non-competitive with respect to ATP.		Apoptosis , BCL , PKC , Autophagy
TN1546	Dactylorhin A		NO Synthase
	Dactylorhin A, a succinate derivative ester isolated from the rhizomes of Gymnadenia conopsea, demonstrates a moderate inhibitory effect on nitric oxide (NO) production in RAW 264.7 macrophage cells.		NO Synthase
T3318	Wogonoside	Glychionide B,Wogonin 7-O-glucuronide,Oroxindin	GABA Receptor , Autophagy
	Wogonoside (Wogonin 7-O-glucuronide) acts as a positive allosteric modulator of the benzodiazepine site of the GABAA receptor.		GABA Receptor , Autophagy
T3936	PATULIN	Expansin,Claviform,Clavacin	Apoptosis , Others , Antibacterial , Antibiotic , Autophagy
	Patulin (Claviform) is a mycotoxin produced by a variety of molds commonly found in rotting apples, including Aspergillus and Penicillium.		Apoptosis , Others , Antibacterial , Antibiotic , Autophagy
T4085	Paris saponin VII	Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII	Apoptosis , BCL , Others , PARP , p38 MAPK , Akt , Caspase , P-gp , Autophagy
	Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.
T6062	Brefeldin A	BFA,Ascotoxin,Cyanein,Decumbin	ATPase , Mitophagy , Antibiotic , Autophagy , HSV , CRISPR/Cas9
	Brefeldin A (Cyanein) belongs to the class of macrolide antibiotics and is an ATPase inhibitor (IC50=0.2 μM). Brefeldin A can induce tumor cell differentiation and apoptosis, and also possesses autophagy inhibitory activ...
T2881	Crustecdysone	Commisterone,B-ecdysone,Commisterone,20-Hydroxyecdysone,Ecdysterone,B-ecdysone,Hydroxyecdysone	Others , Caspase , Endogenous Metabolite , Autophagy
	Crustecdysone (Hydroxyecdysone) is a steroid hormone that regulates the processes of molting or ecdysis in insects.		Others , Caspase , Endogenous Metabolite , Autophagy
TN1006	Tirucallol		NOS , NO Synthase , Prostaglandin Receptor
	Tirucallol is an antiinflammatory agent isolated from Euphorbia lactea.Tirucallol exerts a topical anti-inflammatory effect in vivo, via a mechanism of action related to the neutrophil migration.		NOS , NO Synthase , Prostaglandin Receptor
T2174	Quercetin	Sophoretin	Apoptosis , Mitophagy , Reactive Oxygen Species , PI3K , Autophagy
	Quercetin (Sophoretin) is a natural flavonoid and is an agonist of SIRT1. Quercetin is also a PI3K inhibitor, inhibiting PI3Kγ, PI3Kδ, and PI3Kβ (IC50=2.4/3.0/5.4 μM). Quercetin can induce apoptosis and autophagy.
T0968	Paclitaxel	Taxol,NSC 125973	Apoptosis , Microtubule Associated , Autophagy
	Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer. Paclitaxel has anti-tumor activity and causes cell death by inducing mitotic arrest, apoptosis, and cell autophagy.		Apoptosis , Microtubule Associated , Autophagy
T8193	α-Thujone	Thujone,ALPHA-(-)-THUJONE	Apoptosis , Reactive Oxygen Species , GABA Receptor , AChR , Parasite , Autophagy
	α-Thujone is an inhibitor of ACh with an IC50 value of 24.7μM.
T1558	Resveratrol	trans-Resveratrol,SRT 501	Apoptosis , Mitophagy , IκB/IKK , Lipoxygenase , Sirtuin , COX , NADPH , DNA/RNA Synthesis , Nrf2 , Antibacterial , Antibiotic , Autophagy , Antifungal
	Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autop...
T1272	Cytarabine	Ara-C,Cytosine Arabinoside,Cytosine β-D-arabinofuranoside,Arabinocytidine	Apoptosis , Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis , Endogenous Metabolite , Autophagy , HSV
	Cytarabine (Ara-C) is a nucleoside analog, an inhibitor of DNA synthesis (IC50=16 nM). Cytarabine inhibits DNA polymerase and induces cell cycle arrest, autophagy, and apoptosis. Cytarabine has antitumor activity.
TN1087	Deoxypodophyllotoxin		Apoptosis , Microtubule Associated , Autophagy
	Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflammatory activities.		Apoptosis , Microtubule Associated , Autophagy
T5684	Ethyl 3,4-dihydroxybenzoate		Apoptosis , Others , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , NO Synthase , Autophagy
	Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.
TN1702	Glycycoumarin		P450 , JNK , AMPK , Autophagy
	Glycycoumarin is an estrogen agonist, it shows moderate inhibitory effects against CYP1A2 and CYP2B6.		P450 , JNK , AMPK , Autophagy
T2230	Paeoniflorin	Peoniflorin	HSP , COX
	Paeoniflorin (Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall.		HSP , COX
T1703	SN-38	NK012,SN 38	DNA/RNA Synthesis , Topoisomerase , Autophagy
	SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM). SN-38 has antitumor activity and induces autophagy.		DNA/RNA Synthesis , Topoisomerase , Autophagy
T3814	Isorhapontigenin	Isorhapotogenin	Others , Autophagy
	Isorhapontigenin (Isorhapotogenin) is a tetrahydroxylated stilbenoid with a methoxy group. It is an isomer of rhapontigenin and an analog of resveratrol. It is found in the Chinese herb Gnetum cleistostachyum, in Gnetum ...		Others , Autophagy
T0132	Etoposide	VP-16,VP-16-213	Apoptosis , Mitophagy , Topoisomerase , Antibacterial , Antibiotic , Autophagy
	Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 μM). Etoposide has antitumor activity and induces apoptosis and autophagy.
T5070	LC3-mHTT-IN-AN2	5,7-Dihydroxy-4-phenylcoumarin	Antibacterial , Autophagy , ATTECs
	LC3-mHTT-IN-AN2 (5,7-Dihydroxy-4-phenylcoumarin) is found in the plant Passiflora serratodigitata with the antibacterial activity.		Antibacterial , Autophagy , ATTECs
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Natural Products

Liensinine

T5S1099

Synonym:

Target: Apoptosis, Mitophagy, Others, Autophagy

Pennogenin 3-O-beta-chacotrioside

Synonym: (R,R)-Daurisoline

Target: Others, Potassium Channel, Autophagy

4,4'-Dimethoxychalcone

T7985

Synonym: 4,4-Dimethoxychalcone

Target: Others, Autophagy

Bafilomycin A1

T6740

Synonym:

Target: Apoptosis, Proton pump, Antibacterial, Antibiotic, Autophagy

Pseudolaric Acid B

T1922

Synonym:

Target: Apoptosis, p38 MAPK, Ferroptosis, HBV, Autophagy, Antifungal

Liensinine diperchlorate

T4S1102

Synonym: Liensinine-Perchlorate

Target: Mitophagy, Others, Autophagy

Juglanin

TQ0089

Synonym:

Target: Apoptosis, JNK, Autophagy

20-DEOXYINGENOL

T5689

Synonym:

Target: Others, Autophagy

Synonym: 2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-one,Foliosine

Target: Autophagy

(+)-Usnic acid

T6354

Synonym: D-Usnic Acid,(+)-Usniacin

Target: Antiviral, Antibacterial, mTOR

Notoginsenoside Fc

T3S1591

Synonym:

Target: Others, Autophagy

Ginkgolide K

T8200

Synonym:

Target: AMPK, Autophagy

Madecassic acid

T2758

Synonym: 6-Deoxy-L-Galactose,L-Fucose,Brahmic acid,L-fucopyranose

Target: Others, TNF, COX, NO Synthase, Interleukin

Taurine

T0022

Synonym: 2-Aminoethanesulfonic acid

Target: LDL, Endogenous Metabolite, Autophagy

Dihydromyricetin

T2998

Synonym: Ampelopsin,Ampeloptin

Target: Influenza Virus, GABA Receptor, DNA/RNA Synthesis, mTOR, Autophagy

Britannin

T5793

Synonym:

Target: Apoptosis, AMPK, Autophagy

Acacetin

T3981

Synonym: 4'-Methoxyapigenin,5,7-Dihydroxy-4'-methoxyflavone,Linarigenin

Target: Apoptosis, IAP, COX, Autophagy

Synonym: 3,5-stilbenediol,5-Styrylresorcinol

Target: Apoptosis, Others, Antibacterial, Autophagy

Target: NF-κB, JNK, Autophagy

Urolithin A

T7174

Synonym:

Target: Apoptosis, Reactive Oxygen Species, DNA/RNA Synthesis, Endogenous Metabolite, Autophagy, Drug Metabolite

Soyasapogenol B

TN2225

Synonym:

Target: Apoptosis, Autophagy

3-Methyladenine

T1879

Synonym: 3-MA,NSC 66389

Target: Mitophagy, PI3K, Endogenous Metabolite, Autophagy

Rapamycin

T1537

Synonym: Sirolimus,AY 22989,NSC-2260804

Target: Others, Endogenous Metabolite, Antibiotic, mTOR, Autophagy, Antifungal

Cyclovirobuxine D

T2974

Synonym: CVB-D,Bebuxine,Cyclovirobuxin D

Target: Apoptosis, Others, Akt, mTOR, Autophagy

Syringin

T3408

Synonym: Lilacin,Syringoside,eleutheroside-b,Methoxyconiferine

Target: NOS, Autophagy

Chelerythrine chloride

T3419

Synonym:

Target: Apoptosis, BCL, PKC, Autophagy

Synonym: Glychionide B,Wogonin 7-O-glucuronide,Oroxindin

Target: GABA Receptor, Autophagy

PATULIN

T3936

Synonym: Expansin,Claviform,Clavacin

Target: Apoptosis, Others, Antibacterial, Antibiotic, Autophagy

Paris saponin VII

T4085

Synonym: Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII

Target: Apoptosis, BCL, Others, PARP, p38 MAPK, Akt, Caspase, P-gp, Autophagy

Brefeldin A

T6062

Synonym: BFA,Ascotoxin,Cyanein,Decumbin

Target: ATPase, Mitophagy, Antibiotic, Autophagy, HSV, CRISPR/Cas9

Crustecdysone

T2881

Synonym: Commisterone,B-ecdysone,Commisterone,20-Hydroxyecdysone,Ecdysterone,B-ecdysone,Hydroxyecdysone

Target: Others, Caspase, Endogenous Metabolite, Autophagy

Tirucallol

TN1006

Synonym:

Target: NOS, NO Synthase, Prostaglandin Receptor

Quercetin

T2174

Synonym: Sophoretin

Target: Apoptosis, Mitophagy, Reactive Oxygen Species, PI3K, Autophagy

Paclitaxel

T0968

Synonym: Taxol,NSC 125973

Target: Apoptosis, Microtubule Associated, Autophagy

α-Thujone

T8193

Synonym: Thujone,ALPHA-(-)-THUJONE

Target: Apoptosis, Reactive Oxygen Species, GABA Receptor, AChR, Parasite, Autophagy

Resveratrol

T1558

Synonym: trans-Resveratrol,SRT 501

Target: Apoptosis, Mitophagy, IκB/IKK, Lipoxygenase, Sirtuin, COX, NADPH, DNA/RNA Synthesis, Nrf2, Antibacterial, Antibiotic, Autophagy, Antifungal

Cytarabine

T1272

Synonym: Ara-C,Cytosine Arabinoside,Cytosine β-D-arabinofuranoside,Arabinocytidine

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis, Endogenous Metabolite, Autophagy, HSV

Deoxypodophyllotoxin

TN1087

Synonym:

Target: Apoptosis, Microtubule Associated, Autophagy

Ethyl 3,4-dihydroxybenzoate

T5684

Synonym:

Target: Apoptosis, Others, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, NO Synthase, Autophagy

Glycycoumarin

TN1702

Synonym:

Target: P450, JNK, AMPK, Autophagy

Target: DNA/RNA Synthesis, Topoisomerase, Autophagy

Isorhapontigenin

T3814

Synonym: Isorhapotogenin

Target: Others, Autophagy

Etoposide

T0132

Synonym: VP-16,VP-16-213

Target: Apoptosis, Mitophagy, Topoisomerase, Antibacterial, Antibiotic, Autophagy

LC3-mHTT-IN-AN2

T5070

Synonym: 5,7-Dihydroxy-4-phenylcoumarin

Target: Antibacterial, Autophagy, ATTECs

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Cat No.	Product Name
L3200	Autophagy Compound Library	1248 compounds
	A unique collection of 1248 compounds with defined autophagy-inducing or -inhibitory activity for research in autophagy, high throughput screening (HTS) and high content screening (HCS) for new drugs;
L1300	PI3K-AKT-mTOR Compound Library	425 compounds
	A unique collection of 425 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with PI3K/Akt/mTOR signaling;
L9000	Apoptosis Compound Library	1796 compounds
	A unique collection of 1796 apoptosis-related compounds for apoptosis research, research in tumorigenesis, and anti-cancer drug screening;
L8200	Anti-Aging Compound Library	3324 compounds
	A unique collection of 3324 anti-aging compounds for high throughput screening (HTS) and high content screening (HCS);
L8700	Ferroptosis Compound Library	800 compounds
	A unique collection of 800 ferroptosis signaling pathway related compounds, a powerful tool for new target identification, drug discovery, and mechanism study；
L2550	Glutamine Metabolism Compound Library	580 compounds
	A unique collection of 580 glutamine metabolism related compounds can be used for high throughput screening (HTS) and high content screening (HCS), and also is an effective tool for research in glutamine metabolism and ...
L6810	Traditional Chinese Medicine Monomer Library	2771 compounds
	A unique collection of 2771 compounds (TCM monomers) sourcing from traditional Chinese Medicines, is a powerful tool for drug discovery and research in mechanism；
L6800	Chinese Pharmacopoeia Natural Product Library	2070 compounds
	A unique collection of 2070 natural products included in Chinese Pharmacopoeia (CP), a powerful tool for drug development and pharmacological study;