Search Result

Search Results for " 血管生成 "

Targets

233

Compounds

Natural Products

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T4435	E7820	ER68203-00	Integrin
	E7820 (ER68203-00) is an angiogenesis inhibitor by suppressing integrin a2 (a cell adhesion molecule expressed on endothelial cells).		Integrin
T8560	Angiotensin II human acetate	Ang II acetate,DRVYIHPF acetate,Angiotensin II acetate	Apoptosis , RAAS
	Angiotensin II human acetate (DRVYIHPF acetate) is a vasoconstrictor that mainly acts on the AT1 receptor.		Apoptosis , RAAS
TP1528	Angiotensin I/II (1-5)	Angiotensin I/II 1-5	RAAS , Others
	Angiotensin I/II (1-5) is a peptide (ASP-ARG-VAL-TYR-ILE) that contains the amino acids 1-5 and is converted from Angiotensin I/II.		RAAS , Others
TQ0317	R1530	R-1530,R 1530	VEGFR , FGFR , FLT , PDGFR
	R1530 is a multikinase inhibitor with antineoplastic and antiangiogenesis activities.		VEGFR , FGFR , FLT , PDGFR
TP1579	Angiotensin I/II (1-6)	Angiotensin I/II 1-6	RAAS , Others
	Angiotensin I/II (1-6) is a peptide (ASP-ARG-VAL-TYR-ILE-HIS) that contains the amino acids 1-6 and is converted from Angiotensin I/II peptide.		RAAS , Others
T79860	TIE-2/VEGFR-2 kinase-IN-5		VEGFR , Tie-2
	TIE-2/VEGFR-2 kinase-IN-5 is a potent TIE-2 and VEGFR-2 tyrosine kinase receptor inhibitor with anti-angiogenic activity and is commonly used in biomedical research related to angiogenesis.		VEGFR , Tie-2
T9963	MPT0B390		HDAC
	MPT0B390 is an inhibitor of HDAC and a TIMP3 inducer inhibiting tumor growth, metastasis, and angiogenesis.		HDAC
T6885	Marimastat	BB2516,KB-R8898,TA2516	MMP
	Marimastat (BB2516) (BB-2516) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor. MMP-9 (IC50=3 nM), MMP-1 (IC50=5 nM), MMP-2 (IC50=6 nM), MMP-14 (IC50=9 nM)and MMP-7 (IC50=13 nM).		MMP
T9127	MYLS22		Others
	MYLS22 is a first-in-class and selective inhibitor of optic atrophy 1 (OPA1) . MYLS22 can target endothelial OPA1 to curtail tumor growth and inhibits angiogenesis by impinging on NFkB activity and on angiogenic gene exp...		Others
T13050	SYP-5		HIF/HIF Prolyl-Hydroxylase , HIF
	SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.		HIF/HIF Prolyl-Hydroxylase , HIF
T4425	JK-P3		VEGFR
	JK-P3 is a pyrazole-based inhibitor of VEGFR-2 (IC50: 7.8 μM). JK-P3 inhibits FGFR 1/3 kinase activity in vitro, but has no effect on FGFR signaling in cell-based assays. The compound blocks wound healing and tube format...		VEGFR
T26046	Razoxane		Topoisomerase
	Razoxane is used as an antimitotic agent with immunosuppressive properties.		Topoisomerase
T68455	AP23846	AP-23846	Src
	AP23846 is a novel and potent Src family kinase inhibitor that reduces vascular endothelial growth factor and interleukin-8 expression and abrogates downstream angiogenic processes in human solid tumor cell lines.		Src
T0002	Ethamsylate	Cyclonamine,Etamsylate,Dicynene,Aglumin	Prostaglandin Receptor
	Ethamsylate (Dicynene) usually is used as a hemostatic drug, which increases capillary endothelial resistance and platelet adhesion, and inhibits biosynthesis and action of prostaglandins.		Prostaglandin Receptor
T35570	Chiauranib	CS2164	c-Fms , VEGFR , FLT , PDGFR , c-Kit , Aurora Kinase
	Chiauranib is a multi-target inhibitor against tumor angiogenesis and exhibits potent anticancer effects. Chiauranib potently inhibits the angiogenesis-related kinases (VEGFR1, VEGFR2, VEGFR3, PDGFRα and c-Kit), mitosis-...		c-Fms , VEGFR , FLT , PDGFR , c-Kit , Aurora Kinase
T7575L1	[Sar1, Ile8]-Angiotensin II acetate		RAAS
	[Sar1, Ile8]-Angiotensin II acetate activates both the NADPH and NADH oxidases, and stimulates superoxide anion formation in vascular smooth muscle cells. [Sar1, Ile8]-Angiotensin II acetate has multiple effects on vascu...		RAAS
TP1328	TB500		Others
	TB-500 is a synthesised peptide, essentially a short-chain version of the naturally occurring Thymosin Beta-4.		Others
T21806	HNHA		HDAC
	HNHA is an inhibitor of HDAC.		HDAC
T73368	UniPR505		Ephrin Receptor
	UniPR505 is a potent EphA2 antagonist (IC50: 0.95 µM), a novel 3α-carbamoyloxy derivative with antiangiogenic properties.		Ephrin Receptor
T7339	Angiotensin (1-7)	Ang-(1-7),Angiotensin 1-7,ASP-ARG-VAL-TYR-ILE-HIS-PRO	RAAS , Endogenous Metabolite
	Angiotensin (1-7) (ASP-ARG-VAL-TYR-ILE-HIS-PRO) is a synthetic heptapeptide identical to endogenous angiotensin-(1-7) , inhibits purified canine ACE activity (IC50=0.65 μM) with vasodilator and antiproliferative activiti...		RAAS , Endogenous Metabolite
T67746	IMS2186		Others
	IMS2186 is a reagent with activity of antichoroidal neovascularization (CNV). IMS2186 could arrest cancer cell cycle in G2/M phase, result in exerting anti-proliferation and anti-angiogenesis effects. IMS2186 reduces the...		Others
T17105	TM6089		HIF/HIF Prolyl-Hydroxylase
	TM6089 is an inhibitor of Prolyl Hydroxylase that stimulates HIF activity without iron chelation, induces angiogenesis, and protects organ against ischemia.		HIF/HIF Prolyl-Hydroxylase
T24804	SM27	SM-27,NSC-37204,SM 27,NSC37204	FGFR
	SM27 is a fibroblast growth factor 2 (FGF2) inhibitor with anti-angiogenic activity and can be used to study tumours.		FGFR
T1777	Nintedanib	BIBF 1120,Intedanib	VEGFR , FGFR , FLT , PDGFR , Src
	Nintedanib (Intedanib) is a triple vascular kinase inhibitor that inhibits VEGFR1, VEGFR2, and VEGFR3 (IC50=34/13/13 nM), FGFR1, FGFR2, and FGFR3 (IC50=69/37/108 nM), PDGFRα, and PDGFRβ (IC50=59/65 nM). Nintedanib has an...		VEGFR , FGFR , FLT , PDGFR , Src
T15574	Incyclinide	COL-3,CMT-3	MMP
	Incyclinide (COL-3) is a matrix metalloproteinase (MMP) inhibitor. Thereby causing extracellular matrix degradation, tumor growth and invasion, and inhibiting angiogenesis, and metastasis.		MMP
T7493	AG-13958	AG-013958	VEGFR
	AG-13958 (AG-013958) (AG-013958), a potent VEGFR tyrosine kinase inhibitor, for the treatment of age-related macular degeneration.		VEGFR
T2309	Ganetespib	STA-9090	Apoptosis , HSP , HIF
	Ganetespib (STA-9090) is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.		Apoptosis , HSP , HIF
T2644	(E)-Daporinad	Daporinad,(E)-N-[4-(1-BENZOYL-PIPERIDIN-4-YL)-BUTYL]-3-PYRIDIN-3-YL-ACRYLAMIDE,APO866,FK866	NAMPT , Transferase , Autophagy
	(E)-Daporinad (FK866) is a small molecule inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase), with potential antineoplastic and antiangiogenic activities.		NAMPT , Transferase , Autophagy
T10680	Carebastine		Histamine Receptor
	Carebastine, the active metabolite of Ebastine, is an antagonist of the histamine H1 receptor.		Histamine Receptor
T5535	ERK5-IN-2		ERK
	ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively.		ERK
T8491	Vorolanib	CM082,X-82	VEGFR , PDGFR
	Vorolanib (X-82) is an orally active VEGFR/PDGFR dual inhibitor.		VEGFR , PDGFR
T10397	ATN-161 trifluoroacetate salt	ATN-161 TFA salt	Integrin
	ATN-161 trifluoroacetate salt (ATN-161 TFA salt) is a novel integrin α5β1 antagonist that inhibits angiogenesis and growth of liver metastases and improves survival in a murine model.		Integrin
T4412	Roquinimex	Linomide,LS2616,FCF89,ABR212616	TNF
	Roquinimex (FCF89) (Linomide) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity; inhibits angiogenesis and reduces the secretion of TNF alpha.		TNF
TP1345	Kisspeptin-10, human (TFA)(374675-21-5,FREE)		GPR , Kisspeptin
	Kisspeptin-10, human TFA is a potent vasoconstrictor and angiogenesis inhibitor. Kisspeptin-10, human TFA acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role i...		GPR , Kisspeptin
T35834L	(Sar¹)-Angiotensin II acetate		RAAS
	(Sar¹)-Angiotensin II acetate, an analogue of Angiotensin II, is a specific agonist of angiotensin AT1 receptor. It binds to brain membrane-rich particles, with a Kd of 2.7 nM. It can stimulate protein synthesis and cell...		RAAS
T8541	Lenvatinib mesylate	E7080 (mesylate)	VEGFR , FGFR , c-RET , PDGFR , c-Kit
	Lenvatinib mesylate (E7080 (mesylate)) is an oral and multi-targeted inhibitor of VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, with potent antitumor activities.		VEGFR , FGFR , c-RET , PDGFR , c-Kit
T2676	PF-04217903		c-Met/HGFR
	MET Tyrosine Kinase Inhibitor PF-04217903 is an orally bioavailabe, small-molecule tyrosine kinase inhibitor with potential antineoplastic activity.		c-Met/HGFR
T1178	Temozolomide	NSC 362856,TZM,CCRG 81045,TMZ	Apoptosis , DNA Alkylator/Crosslinker , DNA/RNA Synthesis , Autophagy
	Temozolomide (TMZ) is a DNA alkylating agent with blood-brain barrier permeability and oral activity. Temozolomide has antitumor activity and antiangiogenic activity, and also induces apoptosis and autophagy.
T3389	Antitumor agent-21	TRX818	Others
	Antitumor agent-21 (TRX818) is an orally bioavailable agent with potential antineoplastic and anti-vasculogenic mimicry (VM) activities.		Others
T39986	LOX-IN-3 dihydrochloride		Lipoxygenase
	LOX-IN-3 dihydrochloride is an inhibitor of lysyl oxidase (LOX). LOX-IN-3 dihydrochloride inhibited bovine LOX (IC50<10 μM) and human LOXL2 (IC50<1 μM)activities.		Lipoxygenase
T4632	NSC 6038	4-chloro-N,N-dipropylbenzamide,4-Chloro-N,N-di-n-propylbenzaMide	Others
	NSC-6038 (4-chloro-N,N-dipropylbenzamide) is a benzamide-based bioactive compound with a wide range of biological activities and has been shown to possess anti-inflammatory, antioxidant and anti-angiogenic activities, an...		Others
T2384	Pomalidomide	CC-4047	Apoptosis , TNF , Ligand for E3 Ligase , Molecular Glues
	Pomalidomide (CC-4047) inhibits TNF-α release in LPS stimulated human PBMCs (IC50: 13 nM). It is an anti-angiogenic agent and an immunomodulator.		Apoptosis , TNF , Ligand for E3 Ligase , Molecular Glues
T7541	PTP inhibitor 1	PTP Inhibitor II	Phosphatase
	PTP inhibitor 1 is an inhibitor of cell-permeable protein tyrosine phosphatase (PTP) that covalently binds the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1(ΔSH2)),with Ki of128 μM.		Phosphatase
T39520	Vamifeport	VIT-2763	Ferroptosis
	Vamifeport (VIT-2763) is a novel orally active inhibitor that targets iron transport proteins and reduces markers of hemolysis in the SCD Townes model.VIT-2763 improves anemia and erythropoiesis, ameliorates vascular inf...		Ferroptosis
T21334	Bucillamine	DE-019,Thiobutarit,Tiobutarit,SA96,DE 019,DE019	VEGFR , Antioxidant
	Bucillamine (DE019) protects against Ischemia/reperfusion injury in high-risk organ transplants and inhibits the production of VEGF. Bucillamine is an orally active sulfhydryl donor and antioxidant with antirheumatic and...		VEGFR , Antioxidant
TP2308	TB500 acetate(885340-08-9 free base)	Frag17-23 Acetate,TB500 Acetate	Others
	TB500 acetate(885340-08-9 free base) (Frag17-23 Acetate) is a synthetic version of an active region of thymosin β4. It promote endothelial cell differentiation, angiogenesis in dermal tissues, keratinocyte migration, col...		Others
T14524	Befetupitant	Ro67-5930	Neurokinin receptor
	Befetupitant (Ro67-5930) is a potent and selective tachykinin 1 receptor (NK1R) antagonist for the study of corneal neovascularization.		Neurokinin receptor
T8616	Fasentin	N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide	transporter
	Fasentin (N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide) is an inhibitor of GluT1.		transporter
T6381	Amifostine trihydrate	Ethyol trihydrate,WR2721,Amifostine	Others , HIF/HIF Prolyl-Hydroxylase
	Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.		Others , HIF/HIF Prolyl-Hydroxylase
T5122	Alofanib	RPT835	Apoptosis , FGFR
	Alofanib (RPT835) is a selective allosteric inhibitor of FGFR2 and has a dramatic inhibitory effect on FGF2-induced phosphorylation of FRS2a in KATO III cells (IC50 <10 nM). It has no direct effect on FGF2-dependent FGFR...		Apoptosis , FGFR

Compounds

Angiotensin II human acetate

T8560

Synonym: Ang II acetate,DRVYIHPF acetate,Angiotensin II acetate

Target: Apoptosis, RAAS

Angiotensin I/II (1-5)

TP1528

Synonym: Angiotensin I/II 1-5

Target: RAAS, Others

R1530

TQ0317

Synonym: R-1530,R 1530

Target: VEGFR, FGFR, FLT, PDGFR

Angiotensin I/II (1-6)

TP1579

Synonym: Angiotensin I/II 1-6

Target: RAAS, Others

TIE-2/VEGFR-2 kinase-IN-5

Synonym: BB2516,KB-R8898,TA2516

Target: HIF/HIF Prolyl-Hydroxylase, HIF

Target: Topoisomerase

Synonym: Cyclonamine,Etamsylate,Dicynene,Aglumin

Target: Prostaglandin Receptor

Chiauranib

T35570

Synonym: CS2164

Target: c-Fms, VEGFR, FLT, PDGFR, c-Kit, Aurora Kinase

[Sar1, Ile8]-Angiotensin II acetate

Target: Ephrin Receptor

Angiotensin (1-7)

T7339

Synonym: Ang-(1-7),Angiotensin 1-7,ASP-ARG-VAL-TYR-ILE-HIS-PRO

Target: RAAS, Endogenous Metabolite

Target: HIF/HIF Prolyl-Hydroxylase

SM27

T24804

Synonym: SM-27,NSC-37204,SM 27,NSC37204

Target: FGFR

Nintedanib

T1777

Synonym: BIBF 1120,Intedanib

Target: VEGFR, FGFR, FLT, PDGFR, Src

Target: Apoptosis, HSP, HIF

(E)-Daporinad

T2644

Synonym: Daporinad,(E)-N-[4-(1-BENZOYL-PIPERIDIN-4-YL)-BUTYL]-3-PYRIDIN-3-YL-ACRYLAMIDE,APO866,FK866

Target: NAMPT, Transferase, Autophagy

Carebastine

T10680

Synonym:

Target: Histamine Receptor

ATN-161 trifluoroacetate salt

T10397

Synonym: ATN-161 TFA salt

Target: Integrin

Roquinimex

T4412

Synonym: Linomide,LS2616,FCF89,ABR212616

Target: TNF

Kisspeptin-10, human (TFA)(374675-21-5,FREE)

TP1345

Synonym:

Target: GPR, Kisspeptin

(Sar¹)-Angiotensin II acetate

Synonym: E7080 (mesylate)

Target: VEGFR, FGFR, c-RET, PDGFR, c-Kit

Synonym: NSC 362856,TZM,CCRG 81045,TMZ

Target: Apoptosis, DNA Alkylator/Crosslinker, DNA/RNA Synthesis, Autophagy

LOX-IN-3 dihydrochloride

Synonym: 4-chloro-N,N-dipropylbenzamide,4-Chloro-N,N-di-n-propylbenzaMide

Target: Apoptosis, TNF, Ligand for E3 Ligase, Molecular Glues

PTP inhibitor 1

T7541

Synonym: PTP Inhibitor II

Synonym: DE-019,Thiobutarit,Tiobutarit,SA96,DE 019,DE019

Target: VEGFR, Antioxidant

TB500 acetate(885340-08-9 free base)

TP2308

Synonym: Frag17-23 Acetate,TB500 Acetate

Target: Neurokinin receptor

Fasentin

T8616

Synonym: N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide

Target: transporter

Amifostine trihydrate

T6381

Synonym: Ethyol trihydrate,WR2721,Amifostine

Target: Others, HIF/HIF Prolyl-Hydroxylase

Alofanib

T5122

Synonym: RPT835

Target: Apoptosis, FGFR

Cat No.	Product Name	Synonyms	Targets
T9155	Fumagillol		Others , Antibacterial
	Fumagillol is a direct precursor of the potent angiogenesis inhibitors TNP-470 and fumagillin.		Others , Antibacterial
T8846	Beta-Escin	B-escin,AESCINE	Immunology/Inflammation related
	beta-Escin is a natural mixture of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, can be used as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent.		Immunology/Inflammation related
T3005	4-Hydroxychalcone	P-Cinnamoylphenol	Others , NF-κB
	4-Hydroxychalcone (P-Cinnamoylphenol) attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice.		Others , NF-κB
T5S0331	Isoliquiritin	Neoisoliquritin	p53 , Antifungal
	1. Isoliquiritin (Neoisoliquritin) has antitussive effects. 2. Isoliquiritin has antidepressant-like effects. 3. Isoliquiritin, liquiritin and isoliquirigenin inhibits the p53-dependent pathway and shows crosstalk betwee...		p53 , Antifungal
T4183	Lavendustin A	RG-14355,NSC 678027	EGFR , Tyrosinase
	lavendustin A (RG-14355) is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase.		EGFR , Tyrosinase
T25476	Gypsogenin		Bcr-Abl
	Gypsogenin (639-14-5) is a naturally occurring biochemical that shows anti-ABL1 kinase and anti-chronic Myelogenous Leukemia activities.		Bcr-Abl
T3056	Bavachinin	Bavachinin A,7-O-Methylbavachin	PPAR
	Bavachinin (Bavachinin A)(7-O-Methylbavachin) is a natural compound isolated from the Chinese herb Fructus Psoraleae with potent anti-angiogenic activity.		PPAR
TN1828	Kahweol		Apoptosis , NF-κB , AMPK
	Kahweol has anticarcinogenic, anti-angiogenic,and anti-inflammatory activities, it can block the LPS-induced activation of NF-kappaB by preventing IkappaB degradation and inhibiting IkappaB kinase activity.		Apoptosis , NF-κB , AMPK
T5761	Notoginsenoside Ft1		Others , HIF/HIF Prolyl-Hydroxylase
	Notoginsenoside Ft1 is a saponin originally isolated from P. notoginseng with diverse biological activities		Others , HIF/HIF Prolyl-Hydroxylase
T2961	Notoginsenoside R1	Sanqi glucoside R1,Sanchinoside R1	Apoptosis , ERK , Beta Amyloid
	Notoginsenoside R1 (Sanchinoside R1) has been shown to exhibit antioxidant, antiapoptotic, anti-inflammatory, and immune-stimulatory properties.		Apoptosis , ERK , Beta Amyloid
T0724	Formononetin	Biochanin B,Flavosil,Formononetol	Apoptosis , FGFR
	Formononetin (Flavosil) is an O-methylated isoflavone and a phytoestrogen from the root of Astragalus membranaceus.		Apoptosis , FGFR
T17280	(Z)-Guggulsterone		Apoptosis , VEGFR , Akt
	(Z)-Guggulsterone inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis.		Apoptosis , VEGFR , Akt
T5656	(±)-Norcantharidin	Endothall anhydride,Norcantharidin	EGFR , c-Met/HGFR
	(±)-Norcantharidin (Endothall anhydride) is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers.		EGFR , c-Met/HGFR
T10117	3'-O-Acetylhamaudol		Others
	3'- O- Acetylhamaudol, isolated from the roots of Angelica japonica, exhibits anti-tumor activity through dual actions, anti-angiogenesis and intestinal intraepithelial lymphocyte activation.		Others
TN1087	Deoxypodophyllotoxin		Apoptosis , Microtubule Associated , Autophagy
	Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflammatory activities.		Apoptosis , Microtubule Associated , Autophagy
T67708	Thiolutin	Acetopyrrothin	Antibacterial , Antibiotic
	Thiolutin (Acetopyrrothin) is an inhibitor of endothelial cell adhesion and produced by Streptomyces. Thiolutin shows antibiotic and anti-angiogenic properties. Thiolutin induces the phosphorylation of Hsp27 rapidly.		Antibacterial , Antibiotic
T4962	Zingibroside R1	Ginsenoside Z-R1	HIV Protease
	Zingibroside R1 (Ginsenoside Z-R1) has anti-HIV-1 activity.		HIV Protease
T6S0657	Isorhynchophylline	IsoRhy,Isorhyncophylline,Isorhychophylline,7-Isorhyncophylline	Others
	1. Isorhynchophylline (7-Isorhyncophylline) and rhyncophylline can directly inhibit the contractile responses induced by several agonists in small blood vessels of rat, they also can inhibit the hypertensive effect of an...		Others
TN1112	Morellic acid		Others
	Morellic acid has anti-cancer activity, it strongly inhibited the migration of HUVEC at a low concentration of 0.5 μM in HUVEC cell migration assay in vitro. Morellic acid also has antiangiogenic activity.		Others
T2774	Lycorine hydrochloride	Licorine hydrochloride,Galanthidine hydrochloride,Narcissine hydrochloride,Lycorine chloride,Amarylline hydrochloride	Virus Protease , HCV Protease , Antibacterial , Autophagy
	Lycorine hydrochloride (Narcissine hydrochloride) is VE-cadherin inhibitor,and has IC50 of 1.2μM in Hey1B cell.It is an HCV inhibitor with strong activity.		Virus Protease , HCV Protease , Antibacterial , Autophagy
T3001	Honokiol	NSC 293100	ERK , HCV Protease , MEK , Akt , Autophagy
	Honokiol (NSC-293100) is the active principle of magnolia extract. It inhibits the activation of Akt and enhances the phosphorylation of ERK1/ERK2.		ERK , HCV Protease , MEK , Akt , Autophagy
T2906	Tanshinone IIA	Tanshinone B,Dan Shen ketone	VEGFR
	Tanshinone IIA (Tanshinone B)(Tanshinone B) is the diterpene quinone in Danshen, which is utilized in the treatment of cardiovascular and inflammatory.		VEGFR
T3878	Raddeanin A	NSC382873,Anemodeanin A,Raddeanin R3	Apoptosis , HDAC
	Raddeanin A (NSC-382873) has moderate inhibitory activity against histone deacetylases (HDACs). Raddeanin A has high antiangiogenic potency, antitumor activity.		Apoptosis , HDAC
T7437	3-(3-Hydroxyphenyl)propionic Acid	m-Hydroxyphenylpropionic acid,3-Hydroxyhydrocinnamic acid	Others , Endogenous Metabolite
	3-(3-Hydroxyphenyl)propionic Acid (m-Hydroxyphenylpropionic acid) is one of the major metabolites of ingested caffeic acid.it inhibited osteoclastogenesis and bone osteoclastic resorptive activity.		Others , Endogenous Metabolite
T7040	Angiotensin II human	DRVYIHPF,Angiotensin II,Hypertensin II,Ang II	Apoptosis , RAAS
	Angiotensin II human (Ang II) is a biologically active peptide, a vasoconstrictor. Angiotensin II interacts with AT1R and AT2R to regulate blood pressure, stimulate sympathetic nerves, and increase aldosterone biosynthes...		Apoptosis , RAAS
TN1651	Furanodiene		Apoptosis , PARP , Reactive Oxygen Species , Caspase , CDK , P-gp
	Furanodiene has anti-inflammatory and antioxidant activities, it is active against gram-positive bacteria and Candida albicans.
T10619	Bromelain		Apoptosis , Others
	Bromelain is an anti-inflammatory drug derived from pineapple stem. It acts through down-regulation of plasma kininogen, degradation of advanced glycation end-product receptors, inhibition of Prostaglandin E2 expression,...		Apoptosis , Others
T2S1396	3-O-Acetyloleanolic acid		Apoptosis
	3-O-acetyloleanolic acid dose-dependently inhibited the viability of HCT-116 cells. Apoptosis was characterized by detection of cell surface annexin V and sub-G1 apoptotic cell populations.		Apoptosis
T1335	Mycophenolic acid	Mycophenolate,RS-61443	Apoptosis , Dehydrogenase , Endogenous Metabolite , Antibacterial , Antibiotic , UGT , Antifungal
	Mycophenolic acid (Mycophenolate) is an inosine monophosphate dehydrogenase(IMPDH) inhibitor with anti-proliferative activity.
T3324	Lycorine	Galanthidine,Narcissine,Amarylline,Belamarine,Licorine	Apoptosis , Virus Protease , Antibacterial , AChR , Fatty Acid Synthase
	Lycorine (Narcissine) inhibits protein synthesis and may inhibit ascorbic acid biosynthesis, although studies on the latter are controversial and inconclusive.
TN2429	Capsiate		Antioxidant , TRP/TRPV Channel
	Capsiate is an orally active TRPV1 agonist, a non-irritating capsaicin analog that acts as an antiallergic agent with anti-inflammatory, antioxidant, hypoglycemic, and inhibitory angiogenic activity.		Antioxidant , TRP/TRPV Channel
T6947	Piperlongumine	PPLGM,Piplartine	Apoptosis , ERK , Ferroptosis , Reactive Oxygen Species , ROS , Antibacterial , Autophagy
	Piperlongumine (Piplartine) is a natural alkaloid from Piper longum L. It selectively kills cancer cells and strengthens the level of reactive oxygen species (ROS).
T1644	Dopamine hydrochloride	Dopamine HCl,ASL279	Ferroptosis , Dopamine Receptor , 5-HT Receptor , Endogenous Metabolite
	Dopamine hydrochloride (ASL279) is a naturally occurring catecholamine formed by decarboxylation of dihydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine hydrochloride binds to alpha-1- and b...
T3150	Caudatin		Apoptosis , Others
	Caudatin is one of the species of C-21 steroidal glycosides mainly isolated from the root of Cynanchum bungei Decne and exhibits potent anticancer activities.		Apoptosis , Others
T38248	2-Ethylpyrazine		Endogenous Metabolite , NO Synthase
	2-Ethylpyrazine is present in roasted coffee beans and is a volatile compound .2-Ethylpyrazine induces vasodilation through the activity of endothelium-derived relaxing factors.2-Ethylpyrazine activates NO synthesis thro...		Endogenous Metabolite , NO Synthase
T2834	Nobiletin	Hexamethoxyflavone	Apoptosis , MMP , Reactive Oxygen Species , ROR , Autophagy
	Nobiletin (Hexamethoxyflavone) is a natural polymethoxylated flavone isolated from citrus peels with anti-inflammatory and anti-tumor activities. Nobiletin is practically insoluble (in water) and an extremely weak acidic...		Apoptosis , MMP , Reactive Oxygen Species , ROR , Autophagy
T19711	Desmosterol	Desmesterol,24-Dehydrocholesterol	Endogenous Metabolite
	Desmosterol (24-Dehydrocholesterol) is a cholesterol biosynthesis intermediate that inhibits macrophage inflammatory vesicle activation and prevents vascular inflammation and atherosclerosis.		Endogenous Metabolite
T1737	Genistein	NPI 031L	Apoptosis , EGFR , Endogenous Metabolite , Autophagy
	Genistein (NPI 031L) is an isoflavonoid derived from soy products. It inhibits protein-tyrosine kinase and topoisomerase-II (DNA TOPOISOMERASES, TYPE II), with antineoplastic and antitumor activities.		Apoptosis , EGFR , Endogenous Metabolite , Autophagy
T1082	Benzyl isothiocyanate	Benzoylthiocarbimide,Isothiocyanic Acid Benzoyl Ester	Apoptosis , Antibacterial , Antibiotic
	Benzyl isothiocyanate (Benzoylthiocarbimide) (BITC) is an isothiocyanate originally found in cruciferous vegetables. It shows immunomodulatory, anti-parasitic, antibiotic, antioxidative, anti-atherosclerotic, anti-angiog...		Apoptosis , Antibacterial , Antibiotic
TN1244	3'-Demethylnobiletin		LDL , NF-κB , Integrin , Lipoxygenase , DNA/RNA Synthesis
	3'-Demethylnobiletin has chemopreventive effects on colon carcinogenesis, it can significantly inhibit the growth of human colon cancer cells, cause cell-cycle arrest, induce apoptosis, and profoundly modulate signaling ...		LDL , NF-κB , Integrin , Lipoxygenase , DNA/RNA Synthesis
T2S1200	Sinapine		Antioxidant , P-gp , AChE
	1. Sinapine, an alkaloid from seeds of the cruciferous species, can be used as an effective natural compound for chemo-resistance. 2. Sinapine has antioxidant and radio-protective activities.		Antioxidant , P-gp , AChE
T11363	Ganoderic acid F		Others
	Ganoderic acid F exhibits antitumor and antimetastatic activities through inhibition of angiogenesis and alteration of proteins involving cell proliferation and/or cell death, carcinogenesis, oxidative stress, calcium si...		Others
T6S0735	Flavokawain B	Flavokavain B,Flavokawin B,2'-Hydroxy-4',6'-Dimethoxychalcone	Apoptosis , Others
	1. Flavokawain B (Flavokavain B) has potent anti-inflammatory activity, can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. 2. Flavokawain B, the hepatotoxic constituent from kava root, in...		Apoptosis , Others
T3342	Xanthohumol		Apoptosis , Others , Influenza Virus , COX , Acyltransferase , HSV
	Xanthohumol, also known as 2', 4, 4'-trihydroxy-6'-methoxy-3'-prenylchalcone or desmethylxanthohumol, is a member of the class of compounds known as 3-prenylated chalcones. It inhibits COX-1 and COX-2 activity and shows ...
T2S0886	Terrestrosin D		Apoptosis , Others
	Terrestrosin D can induce apoptotic cell death and inhibit angiogenesis in xenograft tumor cells, cell cycle arrest and induction of apoptosis in cancer cells and endothelial cells might be plausible mechanisms of action...		Apoptosis , Others
T3860	Isoliquiritin apioside		MMP , p38 MAPK , NF-κB
	Isoliquiritin apioside, isolated from Glycyrrhizae radix rhizome, significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresse...		MMP , p38 MAPK , NF-κB
T10086	24-Hydroxycholesterol	Cholest-5-ene-3beta,24-diol	Liver X Receptor , NMDAR
	24-Hydroxycholesterol (Cholest-5-ene-3beta,24-diol) is an oxysterol compound that is an activator of the n-methyl-d-aspartate receptor (NMDA) and the transcription factor LXR, which has been used in the study of cardioge...		Liver X Receptor , NMDAR
T2220	2-Methoxyestradiol	NSC-659853,2-MeOE2,2-ME2	Apoptosis , Reactive Oxygen Species , Microtubule Associated , Endogenous Metabolite , HIF , Autophagy
	2-Methoxyestradiol (2-ME2) is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endotheli...
T4706	Uridine-5'-diphosphate disodium salt	UDP disodium salt,Uridine 5'-diphosphate disodium salt hyd	DNA/RNA Synthesis , Endogenous Metabolite , P2Y Receptor
	Uridine-5'-diphosphate disodium salt (UDP disodium salt) is a specific agonist of the P2Y6 receptors (EC50 = 13 nM for human P2Y6), stimulating the production of inflammatory mediators, phagocytosis, and vasoconstriction...		DNA/RNA Synthesis , Endogenous Metabolite , P2Y Receptor
T6670	Silymarin	Silybin B	SARS-CoV
	Silymarin (Silybin B) (Silybin B) is a polyphenolic flavonoid that extracts from the milk thistle or seeds of Silybum marianum. It is used in the prevention and treatment of liver diseases.		SARS-CoV
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Natural Products

Fumagillol

T9155

Synonym:

Target: Others, Antibacterial

beta-Escin

T8846

Synonym: B-escin,AESCINE

Target: Immunology/Inflammation related

4-Hydroxychalcone

T3005

Synonym: P-Cinnamoylphenol

Target: Others, NF-κB

Isoliquiritin

T5S0331

Synonym: Neoisoliquritin

Target: p53, Antifungal

lavendustin A

T4183

Synonym: RG-14355,NSC 678027

Target: EGFR, Tyrosinase

Synonym: Bavachinin A,7-O-Methylbavachin

Target: Apoptosis, NF-κB, AMPK

Notoginsenoside Ft1

T5761

Synonym:

Target: Others, HIF/HIF Prolyl-Hydroxylase

Notoginsenoside R1

T2961

Synonym: Sanqi glucoside R1,Sanchinoside R1

Target: Apoptosis, ERK, Beta Amyloid

Formononetin

T0724

Synonym: Biochanin B,Flavosil,Formononetol

Target: Apoptosis, FGFR

(Z)-Guggulsterone

T17280

Synonym:

Target: Apoptosis, VEGFR, Akt

(±)-Norcantharidin

T5656

Synonym: Endothall anhydride,Norcantharidin

Target: EGFR, c-Met/HGFR

Target: Apoptosis, Microtubule Associated, Autophagy

Thiolutin

T67708

Synonym: Acetopyrrothin

Target: Antibacterial, Antibiotic

Zingibroside R1

T4962

Synonym: Ginsenoside Z-R1

Target: HIV Protease

Isorhynchophylline

T6S0657

Synonym: IsoRhy,Isorhyncophylline,Isorhychophylline,7-Isorhyncophylline

Lycorine hydrochloride

T2774

Synonym: Licorine hydrochloride,Galanthidine hydrochloride,Narcissine hydrochloride,Lycorine chloride,Amarylline hydrochloride

Target: Virus Protease, HCV Protease, Antibacterial, Autophagy

Honokiol

T3001

Synonym: NSC 293100

Target: ERK, HCV Protease, MEK, Akt, Autophagy

Tanshinone IIA

T2906

Synonym: Tanshinone B,Dan Shen ketone

Target: VEGFR

Raddeanin A

T3878

Synonym: NSC382873,Anemodeanin A,Raddeanin R3

Target: Apoptosis, HDAC

3-(3-Hydroxyphenyl)propionic Acid

T7437

Synonym: m-Hydroxyphenylpropionic acid,3-Hydroxyhydrocinnamic acid

Target: Others, Endogenous Metabolite

Angiotensin II human

T7040

Synonym: DRVYIHPF,Angiotensin II,Hypertensin II,Ang II

Target: Apoptosis, RAAS

Furanodiene

TN1651

Synonym:

Target: Apoptosis, PARP, Reactive Oxygen Species, Caspase, CDK, P-gp

Bromelain

T10619

Synonym:

Target: Apoptosis, Others

3-O-Acetyloleanolic acid

Synonym: Mycophenolate,RS-61443

Target: Apoptosis, Dehydrogenase, Endogenous Metabolite, Antibacterial, Antibiotic, UGT, Antifungal

Lycorine

T3324

Synonym: Galanthidine,Narcissine,Amarylline,Belamarine,Licorine

Target: Apoptosis, Virus Protease, Antibacterial, AChR, Fatty Acid Synthase

Capsiate

TN2429

Synonym:

Target: Antioxidant, TRP/TRPV Channel

Piperlongumine

T6947

Synonym: PPLGM,Piplartine

Target: Apoptosis, ERK, Ferroptosis, Reactive Oxygen Species, ROS, Antibacterial, Autophagy

Dopamine hydrochloride

T1644

Synonym: Dopamine HCl,ASL279

Target: Ferroptosis, Dopamine Receptor, 5-HT Receptor, Endogenous Metabolite

Caudatin

T3150

Synonym:

Target: Apoptosis, Others

2-Ethylpyrazine

T38248

Synonym:

Target: Endogenous Metabolite, NO Synthase

Nobiletin

T2834

Synonym: Hexamethoxyflavone

Target: Apoptosis, MMP, Reactive Oxygen Species, ROR, Autophagy

Desmosterol

T19711

Synonym: Desmesterol,24-Dehydrocholesterol

Target: Endogenous Metabolite

Genistein

T1737

Synonym: NPI 031L

Target: Apoptosis, EGFR, Endogenous Metabolite, Autophagy

Benzyl isothiocyanate

T1082

Synonym: Benzoylthiocarbimide,Isothiocyanic Acid Benzoyl Ester

Target: Apoptosis, Antibacterial, Antibiotic

3'-Demethylnobiletin

TN1244

Synonym:

Target: LDL, NF-κB, Integrin, Lipoxygenase, DNA/RNA Synthesis

Sinapine

T2S1200

Synonym:

Target: Antioxidant, P-gp, AChE

Synonym: Flavokavain B,Flavokawin B,2'-Hydroxy-4',6'-Dimethoxychalcone

Target: Apoptosis, Others

Xanthohumol

T3342

Synonym:

Target: Apoptosis, Others, Influenza Virus, COX, Acyltransferase, HSV

Terrestrosin D

T2S0886

Synonym:

Target: Apoptosis, Others

Isoliquiritin apioside

T3860

Synonym:

Target: MMP, p38 MAPK, NF-κB

24-Hydroxycholesterol

T10086

Synonym: Cholest-5-ene-3beta,24-diol

Target: Liver X Receptor, NMDAR

2-Methoxyestradiol

T2220

Synonym: NSC-659853,2-MeOE2,2-ME2

Target: Apoptosis, Reactive Oxygen Species, Microtubule Associated, Endogenous Metabolite, HIF, Autophagy

Uridine-5'-diphosphate disodium salt

T4706

Synonym: UDP disodium salt,Uridine 5'-diphosphate disodium salt hyd

Target: DNA/RNA Synthesis, Endogenous Metabolite, P2Y Receptor

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Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-00763	ANG Protein, Human, Recombinant	Human	E. coli
	Angiogenin belongs to the pancreatic ribonuclease family. Angiogenin is primarily expressed in the liver. It may act as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular t...
TMPJ-00303	ANG2 Protein, Mouse, Recombinant (hFc)	Mouse	Human Cells
	Angiopoietin-2 (Ang-2; also ANGPT2) is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation. Both Ang-2 and the related Angiopoietin-1 (Ang-1) are ligands for the receptor tyrosine kinase Ti...
TMPJ-01435	ANG2 Protein, Rhesus macaque, Recombinant (hFc)	Rhesus Macaque	Human Cells
	Angiopoietin-2 (Ang-2; also ANGPT2) is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation. Both Ang-2 and the related Angiopoietin-1 (Ang-1) are ligands for the receptor tyrosine kinase Ti...

ANG Protein, Human, Recombinant

TMPJ-00763

Species: Human

Expression System: E. coli

ANG2 Protein, Mouse, Recombinant (hFc)

TMPJ-00303

Species: Mouse

Expression System: Human Cells

ANG2 Protein, Rhesus macaque, Recombinant (hFc)

TMPJ-01435

Species: Rhesus Macaque

Expression System: Human Cells

Cat No.	Product Name
L4800	Angiogenesis related Compound Library	1370 compounds
	A unique collection of 1370 proangiogenic and antiangiogenic compounds for new targets identification, research in mechanisms of angiogenesis, and high throughput screening (HTS) and high content screening (HCS);
L5400	Anti-Cardiovascular Disease Compound Library	1428 compounds
	A unique collection of 1428 cardiovascular diseases related compounds for high throughput screening (HTS) and high content screening (HCS);
L7500	Coagulation and Anticoagulation Compound Library	154 compounds
	A unique collection of 154 procoagulation and anticoagulation related compounds for high throughput screening (HTS) and high content screening (HCS);
L6750	PBCRBS Traditional Chinese Medicine Compound Library	588 compounds
	A unique collection of 588 compounds derived from traditional Chinese medicines (TCMs) for promoting blood circulation and removing blood stasis.
L1100	Protease Inhibitor Library	344 compounds
	A unique collection of 344 protease and proteasome inhibitors for research in chemical genomics, and drug screening;
L8500	HIF-1 Signaling Pathway Compound Library	1352 compounds
	A unique collection of 1352 HIF-1 related small chemicals can be used for drug discovery in ischemic disease and cancer and related mechanism studies；
L2300	Ion Channel Inhibitor Library	946 compounds
	A unique collection of 946 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery;
L2160	Anti-Cancer Active Compound Library	3250 compounds
	A unique collection of 3250 compounds with known anti-cancer activity for high throughput screening (HTS) and high content screening (HCS);
L2120	Anti-Cancer Clinical Compound Library	2614 compounds
	A unique collection of 2614 anti-cancer compounds for high throughput screening (HTS) and high content screening (HCS);
L5900	CNS-Penetrant Compound Library	516 compounds
	A unique collection of 516 CNS-Penetrant compounds for high throughput screening (HTS) and high content screening (HCS);
L2560	Metabolism Compound Library	2350 compounds
	A unique collection of 2350 metabolic pathway-related bioactive small molecule compounds for high-throughput, high-content screening.
L2110	Anti-Cancer Approved Drug Library	1825 compounds
	A unique collection of 1825 approved anti-cancer drugs for high throughput screening (HTS) and high content screening (HCS);
L2150	Anti-Cancer Drug Library	3159 compounds
	A unique collection of 3159 anticancer drugs for high throughput screening (HTS) and high content screening (HCS);
L6140	Saccharide and Glycoside Natural Product Library	364 compounds
	A unique collection of 364 saccharides and glycosides compounds can be used for HTS and HCS；
L2180	Anti-Cancer Compound Library Plus	1468 compounds
	Well-chosen 1468 anti-tumor compounds with unique structures;
L4700	Immunology/Inflammation Compound Library	3483 compounds
	A unique collection of 3483 anti-inflammation compounds effective for high throughput screening and high content screening.
L2910	Antioxidant Compound Library	1330 compounds
	Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species (ROS) and a biological system's ability to readily detoxify the reactive intermediates or repair the resulting damage. ...
L2200	Tyrosine Kinase Inhibitor Library	1033 compounds
	A unique collection of 1033 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related diseases;
L2100	Anti-Cancer Compound Library	7360 compounds
	A unique collection of 7360 compounds with anti-cancer activity for high throughput screening (HTS) and high content screening (HCS);
L1300	PI3K-AKT-mTOR Compound Library	425 compounds
	A unique collection of 425 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with PI3K/Akt/mTOR signaling;
L8600	Ubiquitination Compound Library	214 compounds
	A unique collection of 214 ubiquitination related small chemicals can be used for high throughput and high content screening；
L8720	Pyroptosis Compound Library	1077 compounds
	1077 types of active small molecules associated with pyroptosis for high-throughput and high-content screening.
L6120	Flavonoid Natural Product Library	477 compounds
	A unique collection of 477 flavonoids can be used for high throughput and high content screening；
L6400	Marine Natural Product Library	148 compounds
	A unique collection of 148 marine natural products for high throughput screening (HTS) and high content screening (HCS);
L7100	Anti-Obesity Compound Library	2286 compounds
	A unique collection of 2286 anti-obesity compounds for high throughput and high content screening;
L1610	FDA-Approved Kinase Inhibitor Library	266 compounds
	A unique collection of 266 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.
L4300	Wnt/Hedgehog/Notch Compound Library	240 compounds
	A unique collection of 240 Wnt/Hedgehog/Notch signaling targeted compounds for high throughput and high content screening;
L6820	Tobacco Monomer Library	750 compounds
	A unique collection of 750 tobacco monomer compounds for high throughput screening and high content screening;